KEGG   PATHWAY: stru04115
Entry
stru04115                   Pathway                                
Name
p53 signaling pathway - Salmo trutta (river trout)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
stru04115  p53 signaling pathway
stru04115

Organism
Salmo trutta (river trout) [GN:stru]
Gene
115206406  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
115164873  serine/threonine-protein kinase Chk2-like isoform X1 [KO:K06641] [EC:2.7.11.1]
115199789  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
115196220  LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR-like [KO:K06640] [EC:2.7.11.1]
115204711  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
115158757  gorab; RAB6-interacting golgin isoform X1 [KO:K19748]
115182075  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
115182930  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
115150673  mdm4; protein Mdm4 isoform X1 [KO:K10127]
115154926  cellular tumor antigen p53 [KO:K04451]
115194175  cellular tumor antigen p53-like [KO:K04451]
115198177  cellular tumor antigen p53-like isoform X1 [KO:K04451]
115206702  ppp1r13l; relA-associated inhibitor [KO:K27356]
115180438  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115150615  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
115207794  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115198721  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115152358  G1/S-specific cyclin-D1-like [KO:K04503]
115167492  G1/S-specific cyclin-D1 [KO:K04503]
115202965  G1/S-specific cyclin-D1-like [KO:K04503]
115197603  G1/S-specific cyclin-D1-like [KO:K04503]
115152238  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
115180633  G1/S-specific cyclin-D2-like [KO:K10151]
115170698  G1/S-specific cyclin-D2-like [KO:K10151]
115197442  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
115204775  G1/S-specific cyclin-D2-like [KO:K10151]
115198916  G1/S-specific cyclin-D2-like [KO:K10151]
115150620  G1/S-specific cyclin-D2-like [KO:K10152]
115150473  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
115207950  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
115174024  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
115175534  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
115171057  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
115176645  G1/S-specific cyclin-E2-like [KO:K06626]
115167446  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
115179606  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
115202935  G1/S-specific cyclin-E1-like [KO:K06626]
115150457  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
115207965  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
115168818  protein reprimo A-like [KO:K10128]
115156092  rprm; protein reprimo [KO:K10128]
115159595  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115203015  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
115204043  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115163682  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
115167247  G2/mitotic-specific cyclin-B2-like [KO:K21770]
115193676  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115153283  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115192326  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115158081  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
115169986  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115158595  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
115160226  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115160227  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115164187  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115156711  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115151646  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
115200447  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115202749  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115202750  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115192765  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
115167832  zinc finger protein 385A-like isoform X1 [KO:K26543]
115207825  zinc finger protein 385A-like isoform X1 [KO:K26543]
115150581  zinc finger protein 385A-like isoform X1 [KO:K26543]
115165489  zinc finger protein 385A-like isoform X1 [KO:K26543]
115153220  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
115193754  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
115192930  uncharacterized protein LOC115192930 isoform X1 [KO:K10130]
115159678  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
115164264  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
115203974  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
115200388  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
115169467  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115155490  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
115160794  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115157338  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115171149  apoptosis regulator BAX-like [KO:K02159]
115167497  apoptosis regulator BAX-like [KO:K02159]
115202897  apoptosis regulator BAX-like [KO:K02159]
115198352  apoptosis regulator BAX-like [KO:K02159]
115198360  apoptosis regulator BAX-like [KO:K02159]
115170832  apoptosis regulator BAX-like [KO:K02159]
115192161  apoptosis regulator BAX-like isoform X1 [KO:K02159]
115162384  apoptosis regulatory protein Siva-like isoform X1 [KO:K22744]
115172665  apoptosis regulatory protein Siva-like [KO:K22744]
115168617  bcl-2-like protein 1 [KO:K04570]
115165991  bcl-2-like protein 1 [KO:K04570]
115150840  bcl-2-like protein 1 [KO:K04570]
115207590  bcl-2-like protein 1 [KO:K04570]
115169669  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
115157106  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
115150453  apoptosis regulator Bcl-2-like [KO:K02161]
115195542  apoptosis regulator Bcl-2-like [KO:K02161]
115161971  tp53i3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
115154360  etoposide-induced protein 2.4 homolog [KO:K10134]
115148900  etoposide-induced protein 2.4 homolog [KO:K10134]
115149965  protein shisa-5-like isoform X1 [KO:K10135]
115207216  protein shisa-4-like [KO:K10135]
115152840  p53 apoptosis effector related to PMP-22-like [KO:K10136]
115201494  p53 apoptosis effector related to PMP-22-like [KO:K10136]
115192471  zinc finger matrin-type protein 3-like isoform X1 [KO:K10137]
115158423  zmat3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
115151925  E3 ubiquitin-protein ligase Siah1-like isoform X1 [KO:K04506] [EC:2.3.2.27]
115196839  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
115173932  cytochrome c iso-1/iso-2-like [KO:K08738]
115155485  cytochrome c [KO:K08738]
115160790  cytochrome c-like [KO:K08738]
115179380  cytochrome c [KO:K08738]
115180292  apoptotic protease-activating factor 1-like isoform X1 [KO:K02084]
115199073  apoptotic protease-activating factor 1-like isoform X1 [KO:K02084]
115167973  caspase-9-like [KO:K04399] [EC:3.4.22.62]
115165630  casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
115192071  caspase-3-like [KO:K02187] [EC:3.4.22.56]
115164279  caspase-3-like [KO:K02187] [EC:3.4.22.56]
115205518  caspase-3-like [KO:K02187] [EC:3.4.22.56]
115193877  aifm2; apoptosis-inducing factor 2 [KO:K22745]
115192277  insulin-like growth factor-binding protein 3 [KO:K10138]
115169642  insulin-like growth factor-binding protein 3 [KO:K10138]
115158654  insulin-like growth factor-binding protein 3 [KO:K10138]
115157128  insulin-like growth factor-binding protein 3 [KO:K10138]
115180501  insulin-like growth factor I isoform X1 [KO:K05459]
115198940  insulin-like growth factor I isoform X1 [KO:K05459]
115194599  plasminogen activator inhibitor 1-like [KO:K03982]
115198564  plasminogen activator inhibitor 1-like [KO:K03982]
115173302  adhesion G protein-coupled receptor B1-like [KO:K04596]
115181953  adhesion G protein-coupled receptor B1-like isoform X1 [KO:K04596]
115176753  adhesion G protein-coupled receptor B1-like isoform X1 [KO:K04596]
115152433  CD82 antigen-like [KO:K06509]
115166694  CD82 antigen-like [KO:K06509]
115203583  CD82 antigen-like [KO:K06509]
115197702  CD82 antigen-like [KO:K06509]
115200978  leukocyte antigen CD37-like [KO:K06509]
115175127  thrombospondin-1-like [KO:K16857]
115162365  thrombospondin-1-like [KO:K16857]
115156330  thrombospondin-1-like [KO:K16857]
115172646  thrombospondin-1-like [KO:K16857]
115192953  DNA damage-binding protein 2-like isoform X1 [KO:K10140]
115174977  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
115176241  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
115194956  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
115174433  sestrin-1-like isoform X1 [KO:K10141]
115176573  sestrin-1-like isoform X1 [KO:K10141]
115154466  sestrin-3-like isoform X1 [KO:K10141]
115172402  sestrin-3-like [KO:K10141]
115149007  sestrin-3-like [KO:K10141]
115205226  sestrin-3-like [KO:K10141]
115189372  sestrin-2-like isoform X1 [KO:K20394]
115193756  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115153219  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115157104  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115201167  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115147613  tsc2; tuberin isoform X1 [KO:K07207]
115161077  metalloreductase STEAP2-like [KO:K10142] [EC:1.16.1.-]
115179628  metalloreductase STEAP3-like isoform X1 [KO:K10142] [EC:1.16.1.-]
115196070  metalloreductase STEAP3-like isoform X1 [KO:K10142] [EC:1.16.1.-]
115169777  cop1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
115156993  E3 ubiquitin-protein ligase COP1-like isoform X1 [KO:K10143] [EC:2.3.2.27]
115164786  RING finger and CHY zinc finger domain-containing protein 1-like isoform X1 [KO:K10144] [EC:2.3.2.27]
115199867  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
115167423  cyclin-G1-like isoform X1 [KO:K10145]
115205693  cyclin-G1-like [KO:K10145]
115164773  cyclin-G2-like [KO:K10146]
115160147  cyclin-G2-like [KO:K10146]
115149508  cyclin-G2-like [KO:K10146]
115199877  cyclin-G2-like isoform X1 [KO:K10146]
115154589  protein phosphatase 1D-like isoform X1 [KO:K10147] [EC:3.1.3.16]
115163815  protein phosphatase 1D-like isoform X1 [KO:K10147] [EC:3.1.3.16]
115206679  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
115166096  tp73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
stru04110  Cell cycle
stru04210  Apoptosis
stru04218  Cellular senescence
KO pathway
ko04115   
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