KEGG   PATHWAY: stru04210
Entry
stru04210                   Pathway                                
Name
Apoptosis - Salmo trutta (river trout)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
stru04210  Apoptosis
stru04210

Other DBs
GO: 0006915
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115190083  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
115151840  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
115159678  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
115164264  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
115203974  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
115200388  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
115192444  tumor necrosis factor ligand superfamily member 6-like isoform X1 [KO:K04389]
115158458  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
115153220  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
115193754  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
115167502  FAS-associated death domain protein-like [KO:K02373]
115202892  FAS-associated death domain protein-like [KO:K02373]
115174125  tumor necrosis factor-like [KO:K03156]
115175311  tumor necrosis factor-like [KO:K03156]
115187990  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
115176742  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
115167216  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
115203119  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
115180808  cflar; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
115169467  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115155490  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
115160794  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115157338  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115191732  caspase-6-like isoform X1 [KO:K04396] [EC:3.4.22.59]
115194754  caspase-6-like [KO:K04396] [EC:3.4.22.59]
115192071  caspase-3-like [KO:K02187] [EC:3.4.22.56]
115164279  caspase-3-like [KO:K02187] [EC:3.4.22.56]
115205518  caspase-3-like [KO:K02187] [EC:3.4.22.56]
115159745  caspase-3-like [KO:K04397] [EC:3.4.22.60]
115200994  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
115171149  apoptosis regulator BAX-like [KO:K02159]
115167497  apoptosis regulator BAX-like [KO:K02159]
115202897  apoptosis regulator BAX-like [KO:K02159]
115198352  apoptosis regulator BAX-like [KO:K02159]
115198360  apoptosis regulator BAX-like [KO:K02159]
115170832  apoptosis regulator BAX-like [KO:K02159]
115192161  apoptosis regulator BAX-like isoform X1 [KO:K02159]
115154499  diablo homolog, mitochondrial-like [KO:K10522]
115163397  diablo homolog, mitochondrial-like [KO:K10522]
115206321  diablo homolog, mitochondrial-like [KO:K10522]
115155026  septin-5-like [KO:K16943]
115155027  septin-5-like isoform X1 [KO:K16943]
115163359  septin-4-like isoform X1 [KO:K16943]
115206288  septin-5 isoform X1 [KO:K16943]
115201642  serine protease HTRA2, mitochondrial-like [KO:K08669] [EC:3.4.21.108]
115173932  cytochrome c iso-1/iso-2-like [KO:K08738]
115155485  cytochrome c [KO:K08738]
115160790  cytochrome c-like [KO:K08738]
115179380  cytochrome c [KO:K08738]
115180292  apoptotic protease-activating factor 1-like isoform X1 [KO:K02084]
115199073  apoptotic protease-activating factor 1-like isoform X1 [KO:K02084]
115167973  caspase-9-like [KO:K04399] [EC:3.4.22.62]
115165630  casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
115164977  perforin-1-like [KO:K07818]
115168640  perforin-1-like [KO:K07818]
115175830  perforin-1-like isoform X1 [KO:K07818]
115171501  perforin-1-like [KO:K07818]
115177827  perforin-1-like [KO:K07818]
115147649  perforin-1-like [KO:K07818]
115194360  perforin-1-like [KO:K07818]
115194361  perforin-1-like [KO:K07818]
115203642  perforin-1-like [KO:K07818]
115198359  perforin-1-like isoform X1 [KO:K07818]
115161404  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
115161424  granzyme B-like isoform X1 [KO:K01353] [EC:3.4.21.79]
115158213  granzyme-like protein 2 [KO:K01353] [EC:3.4.21.79]
115160566  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
115160567  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
115151806  duodenase-1-like [KO:K01353] [EC:3.4.21.79]
115161416  tubulin alpha chain-like [KO:K07374]
115161432  tubulin alpha chain-like [KO:K07374]
115167908  tubulin alpha chain [KO:K07374]
115167909  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
115168036  tubulin alpha-8 chain-like [KO:K07374]
115180866  tubulin alpha-1A chain-like [KO:K07374]
115180867  tubulin alpha chain-like isoform X1 [KO:K07374]
115182087  tubulin alpha-1A chain-like [KO:K07374]
115182088  tubulin alpha chain-like isoform X1 [KO:K07374]
115165565  tubulin alpha chain [KO:K07374]
115165566  tubulin alpha chain-like isoform X1 [KO:K07374]
115165568  tubulin alpha-1C chain [KO:K07374]
115165691  tubulin alpha-8 chain-like [KO:K07374]
115155434  tubulin alpha chain-like [KO:K07374]
115155435  tubulin alpha chain [KO:K07374]
115155436  tubulin alpha chain-like [KO:K07374]
115179717  tubulin alpha chain-like [KO:K07374]
115150460  tubulin alpha chain-like [KO:K07374]
115150462  tubulin alpha-1C chain-like [KO:K07374]
115150463  tubulin alpha chain-like [KO:K07374]
115149489  tubulin alpha-8 chain-like [KO:K07374]
115149498  tubulin alpha-8 chain-like [KO:K07374]
115207961  tubulin alpha chain isoform X1 [KO:K07374]
115207962  tubulin alpha chain-like [KO:K07374]
115196403  tubulin alpha chain-like [KO:K07374]
115197383  tubulin alpha-8 chain-like [KO:K07374]
115203876  tubulin alpha chain, testis-specific-like [KO:K07374]
115203877  tubulin alpha chain, testis-specific [KO:K07374]
115176776  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
115178942  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
115188892  actin, cytoplasmic 1 [KO:K05692]
115188893  actin, cytoplasmic 1 [KO:K05692]
115159978  sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
115203754  spectrin alpha chain, non-erythrocytic 1-like isoform X1 [KO:K06114]
115176110  lamin-A-like [KO:K12641]
115176815  lamin-A-like [KO:K12641]
115178684  lamin-A-like [KO:K12641]
115158823  lmnb2; lamin-B2 [KO:K07611]
115160051  lmnb1; lamin-B1 [KO:K07611]
115166896  lamin-L(III)-like isoform X1 [KO:K07611]
115203416  lamin-B1-like isoform X1 [KO:K07611]
115186918  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
115155776  parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 [KO:K10798] [EC:2.4.2.30]
115157293  parp2; poly [ADP-ribose] polymerase 2 [KO:K10798] [EC:2.4.2.30]
115150529  parp3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.30]
115147802  protein mono-ADP-ribosyltransferase PARP3-like [KO:K10798] [EC:2.4.2.30]
115165924  dffa; DNA fragmentation factor subunit alpha [KO:K02310]
115168178  DNA fragmentation factor subunit beta-like [KO:K02311] [EC:3.-.-.-]
115165848  DNA fragmentation factor subunit beta-like [KO:K02311] [EC:3.-.-.-]
115164882  endog; endonuclease G, mitochondrial [KO:K01173]
115149103  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
115171664  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
115171666  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
115205339  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
115205365  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
115205407  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
115159584  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115159699  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115164249  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115203961  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115204052  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115150503  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115150859  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115207563  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115207911  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
115152168  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115197365  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115168596  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
115165965  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
115161930  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
115161931  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115161932  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115155639  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115172948  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
115194504  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115201754  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
115208448  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115204450  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
115198469  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
115155631  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115155640  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115201755  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115201756  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115208449  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115208455  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
115161813  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
115162042  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
115174610  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
115172304  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
115170922  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
115178533  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
115147454  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
115196317  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
115151076  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
115161960  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115190111  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115172214  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115206584  dipeptidyl peptidase 1-like isoform X1 [KO:K01275] [EC:3.4.14.1]
115206587  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
115192717  cathepsin D-like isoform X1 [KO:K01379] [EC:3.4.23.5]
115170923  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
115166723  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
115196324  cathepsin D-like isoform X1 [KO:K01379] [EC:3.4.23.5]
115203603  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
115168960  cathepsin F-like isoform X1 [KO:K01373] [EC:3.4.22.41]
115205568  cathepsin F-like isoform X1 [KO:K01373] [EC:3.4.22.41]
115196734  pro-cathepsin H-like [KO:K01366] [EC:3.4.22.16]
115203334  pro-cathepsin H-like [KO:K01366] [EC:3.4.22.16]
115176788  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
115178886  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
115191546  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
115159190  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
115159192  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
115159193  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
115159194  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
115159195  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
115159196  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
115162579  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
115172882  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
115149355  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
115208514  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
115170744  ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
115176789  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
115178898  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
115157612  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
115150442  cathepsin Z-like isoform X1 [KO:K08568] [EC:3.4.18.1]
115207978  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
115153797  inhibitor of apoptosis protein-like isoform X1 [KO:K16060]
115204697  baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060]
115168034  E3 ubiquitin-protein ligase XIAP-like isoform X1 [KO:K04725] [EC:2.3.2.27]
115205647  E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
115152911  birc5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
115165488  baculoviral IAP repeat-containing protein 5.1-A-like [KO:K08731]
115153318  bcl-2-like protein 11 [KO:K16341]
115193636  bcl-2-like protein 11 isoform X1 [KO:K16341]
115168617  bcl-2-like protein 1 [KO:K04570]
115165991  bcl-2-like protein 1 [KO:K04570]
115150840  bcl-2-like protein 1 [KO:K04570]
115207590  bcl-2-like protein 1 [KO:K04570]
115169669  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
115157106  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
115150453  apoptosis regulator Bcl-2-like [KO:K02161]
115195542  apoptosis regulator Bcl-2-like [KO:K02161]
115173542  death domain-associated protein 6-like [KO:K02308]
115175928  death domain-associated protein 6-like [KO:K02308]
115169632  receptor-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K02861] [EC:2.7.11.1]
115157139  ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
115164884  disabled homolog 2-interacting protein-like isoform X1 [KO:K19901]
115159792  disabled homolog 2-interacting protein-like isoform X1 [KO:K19901]
115203862  disabled homolog 2-interacting protein-like isoform X1 [KO:K19901]
115199781  disabled homolog 2-interacting protein-like isoform X1 [KO:K19901]
115193987  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
115174881  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
115176896  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
115177194  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
115194041  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115157756  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115174527  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115152965  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115159070  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115149487  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115201108  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115204538  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115184996  bcl2-associated agonist of cell death-like [KO:K02158]
115154667  uncharacterized protein LOC115154667 isoform X1 [KO:K02158]
115204267  bcl2-associated agonist of cell death-like [KO:K02158]
115192441  transcription factor AP-1-like [KO:K04448]
115169534  transcription factor AP-1-like [KO:K04448]
115158459  transcription factor AP-1-like [KO:K04448]
115157247  transcription factor AP-1-like [KO:K04448]
115149542  transcription factor AP-1-like [KO:K04448]
115160168  transcription factor AP-1-like [KO:K04448]
115175159  proto-oncogene c-Fos-like [KO:K04379]
115175160  proto-oncogene c-Fos-like [KO:K04379]
115162327  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
115172608  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
115147345  proto-oncogene c-Fos-like [KO:K04379]
115151505  proto-oncogene c-Fos-like [KO:K04379]
115154926  cellular tumor antigen p53 [KO:K04451]
115194175  cellular tumor antigen p53-like [KO:K04451]
115198177  cellular tumor antigen p53-like isoform X1 [KO:K04451]
115158237  uncharacterized protein LOC115158237 [KO:K04466] [EC:2.7.11.25]
115171147  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
115198333  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
115158948  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115162780  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
115201018  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115200286  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
115168741  NF-kappa-B essential modulator-like [KO:K07210]
115165245  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
115174991  NF-kappa-B inhibitor alpha-like [KO:K04734]
115162129  NF-kappa-B inhibitor alpha-like [KO:K04734]
115172401  NF-kappa-B inhibitor alpha-like [KO:K04734]
115196043  NF-kappa-B inhibitor alpha-like [KO:K04734]
115173310  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
115205318  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
115194158  transcription factor p65-like isoform X1 [KO:K04735]
115198165  putative transcription factor p65 homolog [KO:K04735]
115149488  ptpn13; tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
115192326  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115158081  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
115169986  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115158595  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
115160226  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115160227  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115164187  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115156711  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115151646  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
115200447  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115202749  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115202750  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115164885  TNF receptor-associated factor 1-like [KO:K03172]
115206406  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
115192930  uncharacterized protein LOC115192930 isoform X1 [KO:K10130]
115187894  caspase-2-like isoform X1 [KO:K02186] [EC:3.4.22.55]
115176571  casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
115166403  nerve growth factor-like [KO:K02582]
115151005  nerve growth factor-like [KO:K02582]
115207427  nerve growth factor-like [KO:K02582]
115176899  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
115178403  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
115170915  interleukin-4 receptor subunit alpha-like isoform X1 [KO:K04738]
115196267  cytokine receptor common subunit beta-like isoform X1 [KO:K04738]
115170061  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115158422  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115165908  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115163651  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
115156658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115206538  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
115192204  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115169527  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115158103  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115169950  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115158753  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115159695  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
115156743  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115167650  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
115157257  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115151679  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115203963  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115171189  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
115159572  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
115200924  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
115198728  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
115191758  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115174699  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115162386  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115154910  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115163684  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115178760  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115172667  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115206563  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115201509  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115208587  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115204542  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115152114  GTPase HRas-like [KO:K02833]
115197299  GTPase HRas isoform X1 [KO:K02833]
115152163  GTPase KRas isoform X1 [KO:K07827]
115171866  GTPase HRas-like [KO:K07827]
115207704  GTPase HRas-like [KO:K07827]
115197360  GTPase KRas isoform X1 [KO:K07827]
115168396  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
115166136  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
115149903  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115192967  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115192626  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115169411  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115158253  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
115157409  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115165075  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115192138  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115170800  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115200671  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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c-FLIP, a master anti-apoptotic regulator.
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The role of mitochondria in apoptosis.
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Mitochondria in cell death.
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The role of BH3-only proteins in the immune system.
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Caspase activation cascades in apoptosis.
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Granzymes in cancer and immunity.
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Related
pathway
stru04010  MAPK signaling pathway
stru04020  Calcium signaling pathway
stru04115  p53 signaling pathway
stru04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   
LinkDB

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