KEGG   PATHWAY: stru04218
Entry
stru04218                   Pathway                                
Name
Cellular senescence - Salmo trutta (river trout)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
stru04218  Cellular senescence
stru04218

Other DBs
GO: 0090398
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115147613  tsc2; tuberin isoform X1 [KO:K07207]
115148508  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
115148557  [KO:K05862]
115149144  [KO:K03362]
115149273  [KO:K04348] [EC:3.1.3.16]
115149285  [KO:K15041]
115149318  [KO:K21776]
115149427  [KO:K04674] [EC:2.7.11.30]
115149462  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
115149903  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115149935  [KO:K04443] [EC:2.7.11.1]
115149991  [KO:K08826] [EC:2.7.11.1]
115150081  [KO:K17332]
115150267  [KO:K07208]
115150457  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
115150473  [KO:K02089] [EC:2.7.11.22]
115150503  [KO:K04958]
115150574  [KO:K07208]
115150615  [KO:K06625]
115150620  [KO:K10152]
115150859  [KO:K04958]
115150893  [KO:K21769]
115150898  [KO:K08015]
115150950  calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
115151057  [KO:K04441] [EC:2.7.11.24]
115151122  [KO:K04377]
115151646  [KO:K04402]
115151679  [KO:K02649]
115151907  [KO:K13377]
115152114  [KO:K02833]
115152163  [KO:K07827]
115152168  [KO:K04959]
115152195  [KO:K04441] [EC:2.7.11.24]
115152207  [KO:K08826] [EC:2.7.11.1]
115152238  [KO:K10151]
115152244  e2f4; transcription factor E2F4 [KO:K04682]
115152272  [KO:K08826] [EC:2.7.11.1]
115152297  [KO:K17333]
115152303  [KO:K16332]
115152358  [KO:K04503]
115152905  [KO:K21124]
115152999  [KO:K11411] [EC:2.3.1.286]
115153074  [KO:K02183]
115153077  [KO:K18753]
115153219  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115153283  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115153358  [KO:K15040]
115153520  [KO:K04433] [EC:2.7.12.2]
115153538  [KO:K15040]
115154021  [KO:K05862]
115154055  [KO:K02678]
115154441  rb1; retinoblastoma-associated protein [KO:K06618]
115154601  [KO:K03362]
115154660  [KO:K02183]
115154720  [KO:K04377]
115154758  [KO:K13375]
115154811  [KO:K05863]
115154819  [KO:K04348] [EC:3.1.3.16]
115154910  [KO:K04456] [EC:2.7.11.1]
115154926  [KO:K04451]
115154939  foxo1; forkhead box protein O1 [KO:K07201]
115155518  [KO:K06751]
115155553  [KO:K07831]
115155631  [KO:K03853] [EC:3.4.22.53]
115155639  [KO:K01367] [EC:3.4.22.52]
115155640  [KO:K03853] [EC:3.4.22.53]
115155646  [KO:K04388] [EC:2.7.11.30]
115155826  [KO:K20858]
115156000  [KO:K06268]
115156503  myc; myc proto-oncogene protein [KO:K04377]
115156658  [KO:K00922] [EC:2.7.1.153]
115156711  [KO:K04402]
115156743  [KO:K02649]
115156777  [KO:K04682]
115157085  [KO:K04674] [EC:2.7.11.30]
115157104  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115157128  [KO:K10138]
115157257  [KO:K02649]
115157289  [KO:K17334]
115157409  [KO:K04369] [EC:2.7.12.2]
115157597  [KO:K07208]
115158081  [KO:K04402]
115158103  [KO:K02649]
115158253  [KO:K04369] [EC:2.7.12.2]
115158422  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115158469  [KO:K02183]
115158595  [KO:K04402]
115158654  [KO:K10138]
115158753  [KO:K02649]
115158934  [KO:K21124]
115159237  [KO:K21776]
115159273  [KO:K15041]
115159283  [KO:K04348] [EC:3.1.3.16]
115159506  [KO:K07206]
115159595  [KO:K05868]
115159695  [KO:K02649]
115160226  [KO:K04402]
115160227  [KO:K04402]
115160872  [KO:K07831]
115160989  [KO:K04388] [EC:2.7.11.30]
115160993  [KO:K18753]
115161930  [KO:K01367] [EC:3.4.22.52]
115161931  [KO:K01367] [EC:3.4.22.52]
115161932  [KO:K01367] [EC:3.4.22.52]
115161985  [KO:K09408]
115162025  [KO:K18753]
115162136  calm1; calmodulin-1 [KO:K02183]
115162302  [KO:K06269] [EC:3.1.3.16]
115162330  [KO:K13377]
115162346  [KO:K21775]
115162386  [KO:K04456] [EC:2.7.11.1]
115162409  [KO:K10752]
115162585  [KO:K09389]
115162898  [KO:K10030]
115162984  [KO:K02183]
115163017  [KO:K18753]
115163022  [KO:K18753]
115163039  hipk4; homeodomain-interacting protein kinase 4 isoform X1 [KO:K08826] [EC:2.7.11.1]
115163536  [KO:K02678]
115163569  [KO:K06269] [EC:3.1.3.16]
115163651  [KO:K00922] [EC:2.7.1.153]
115163682  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
115163684  [KO:K04456] [EC:2.7.11.1]
115163727  mre11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
115163933  [KO:K07201]
115164187  [KO:K04402]
115164273  [KO:K04348] [EC:3.1.3.16]
115164352  [KO:K15041]
115164452  [KO:K07205]
115164515  [KO:K21774]
115164663  [KO:K06269] [EC:3.1.3.16]
115164783  [KO:K04500]
115164852  [KO:K04973]
115164873  [KO:K06641] [EC:2.7.11.1]
115165075  [KO:K04371] [EC:2.7.11.24]
115165421  [KO:K04441] [EC:2.7.11.24]
115165434  [KO:K04441] [EC:2.7.11.24]
115165591  [KO:K17332]
115165612  [KO:K08826] [EC:2.7.11.1]
115165830  [KO:K17454]
115165908  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115165965  [KO:K04960]
115166084  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
115166089  [KO:K04441] [EC:2.7.11.24]
115166136  [KO:K04366] [EC:2.7.11.1]
115166217  [KO:K04851]
115166326  [KO:K04443] [EC:2.7.11.1]
115166794  [KO:K23605]
115166807  [KO:K02183]
115166847  [KO:K08826] [EC:2.7.11.1]
115166972  [KO:K04982] [EC:2.7.11.1]
115167022  [KO:K16332]
115167085  [KO:K07830]
115167192  [KO:K04682]
115167247  [KO:K21770]
115167446  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
115167492  [KO:K04503]
115167650  [KO:K02649]
115167676  tsc1; hamartin isoform X1 [KO:K07206]
115167938  [KO:K17332]
115167960  [KO:K08826] [EC:2.7.11.1]
115168160  [KO:K17454]
115168317  [KO:K04851]
115168396  [KO:K04366] [EC:2.7.11.1]
115168456  [KO:K04443] [EC:2.7.11.1]
115168596  [KO:K04960]
115168917  [KO:K13376]
115169006  [KO:K04441] [EC:2.7.11.24]
115169019  [KO:K04441] [EC:2.7.11.24]
115169125  [KO:K04348] [EC:3.1.3.16]
115169411  [KO:K04369] [EC:2.7.12.2]
115169508  [KO:K17334]
115169527  [KO:K02649]
115169642  [KO:K10138]
115169694  [KO:K04674] [EC:2.7.11.30]
115169950  [KO:K02649]
115169986  [KO:K04402]
115170061  [KO:K00922] [EC:2.7.1.153]
115170290  [KO:K06627]
115170620  [KO:K05864] [EC:5.2.1.8]
115170621  [KO:K10030]
115170698  [KO:K10151]
115170759  rras; ras-related protein R-Ras [KO:K07830]
115170800  [KO:K04371] [EC:2.7.11.24]
115171017  [KO:K14381]
115171057  [KO:K02091] [EC:2.7.11.22]
115171360  [KO:K10030]
115171496  [KO:K06269] [EC:3.1.3.16]
115171844  [KO:K04433] [EC:2.7.12.2]
115171866  [KO:K07827]
115171925  rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
115172236  [KO:K09408]
115172279  [KO:K18753]
115172411  [KO:K02183]
115172575  [KO:K05863]
115172613  [KO:K13377]
115172629  [KO:K21775]
115172667  [KO:K04456] [EC:2.7.11.1]
115172688  [KO:K10752]
115172886  [KO:K09389]
115172948  [KO:K01367] [EC:3.4.22.52]
115173233  [KO:K05405]
115173307  [KO:K04388] [EC:2.7.11.30]
115173310  [KO:K02580]
115173373  [KO:K04446]
115173518  [KO:K03362]
115174024  [KO:K02091] [EC:2.7.11.22]
115174430  [KO:K09408]
115174458  [KO:K21773]
115174568  [KO:K06269] [EC:3.1.3.16]
115174590  zfp36l1; mRNA decay activator protein ZFP36L1 [KO:K18753]
115174612  [KO:K02183]
115174699  [KO:K04456] [EC:2.7.11.1]
115175155  [KO:K13377]
115175363  [KO:K05405]
115175534  [KO:K02091] [EC:2.7.11.22]
115175550  [KO:K13376]
115175905  [KO:K06751]
115175916  [KO:K06751]
115175918  [KO:K06751]
115175919  [KO:K06751]
115175920  [KO:K06751]
115176037  [KO:K04388] [EC:2.7.11.30]
115176114  [KO:K04446]
115176121  [KO:K04446]
115176297  [KO:K10752]
115176324  [KO:K06620]
115176439  foxo3; forkhead box protein O3 [KO:K09408]
115176645  [KO:K06626]
115177327  [KO:K04446]
115177346  [KO:K21774]
115177416  [KO:K13376]
115177511  [KO:K10867]
115177589  [KO:K06268]
115178760  [KO:K04456] [EC:2.7.11.1]
115179161  [KO:K07831]
115179606  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
115180162  [KO:K09406]
115180302  [KO:K04441] [EC:2.7.11.24]
115180375  [KO:K04441] [EC:2.7.11.24]
115180438  [KO:K06625]
115180633  [KO:K10151]
115181710  [KO:K06620]
115181720  [KO:K06620]
115182075  [KO:K06643] [EC:2.3.2.27]
115182930  [KO:K06643] [EC:2.3.2.27]
115184904  [KO:K07208]
115184937  [KO:K06620]
115186347  [KO:K21773]
115187062  [KO:K10867]
115188778  [KO:K10752]
115190418  [KO:K21771]
115191070  gata4; transcription factor GATA-4 [KO:K09183]
115191708  [KO:K04685]
115191758  [KO:K04456] [EC:2.7.11.1]
115192065  slc25a4; ADP/ATP translocase 1 [KO:K05863]
115192116  [KO:K07830]
115192138  [KO:K04371] [EC:2.7.11.24]
115192204  [KO:K02649]
115192277  [KO:K10138]
115192326  [KO:K04402]
115192626  [KO:K04369] [EC:2.7.12.2]
115192958  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
115192967  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115193589  [KO:K15040]
115193676  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115193756  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115193932  [KO:K18753]
115193937  [KO:K02183]
115194015  [KO:K11411] [EC:2.3.1.286]
115194116  [KO:K21124]
115194158  [KO:K04735]
115194159  [KO:K06269] [EC:3.1.3.16]
115194175  [KO:K04451]
115194217  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115194504  [KO:K01367] [EC:3.4.22.52]
115194599  [KO:K03982]
115195529  hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
115195564  [KO:K07208]
115195639  [KO:K04674] [EC:2.7.11.30]
115195764  [KO:K04377]
115196009  [KO:K07831]
115196220  [KO:K06640] [EC:2.7.11.1]
115197130  [KO:K02183]
115197216  [KO:K07201]
115197299  [KO:K02833]
115197360  [KO:K07827]
115197365  [KO:K04959]
115197396  [KO:K04441] [EC:2.7.11.24]
115197406  [KO:K08826] [EC:2.7.11.1]
115197442  [KO:K10151]
115197458  [KO:K04682]
115197487  [KO:K08826] [EC:2.7.11.1]
115197507  [KO:K17333]
115197515  [KO:K16332]
115197603  [KO:K04503]
115198165  [KO:K04735]
115198169  [KO:K06269] [EC:3.1.3.16]
115198177  [KO:K04451]
115198233  [KO:K04348] [EC:3.1.3.16]
115198469  [KO:K01367] [EC:3.4.22.52]
115198564  [KO:K03982]
115198721  [KO:K06625]
115198903  [KO:K04441] [EC:2.7.11.24]
115198904  [KO:K04441] [EC:2.7.11.24]
115198916  [KO:K10151]
115199015  [KO:K09406]
115199789  [KO:K06641] [EC:2.7.11.1]
115199811  trpv4; transient receptor potential cation channel subfamily V member 4 isoform X1 [KO:K04973]
115199870  [KO:K04500]
115199971  rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
115199972  [KO:K06269] [EC:3.1.3.16]
115200186  [KO:K07205]
115200380  [KO:K04348] [EC:3.1.3.16]
115200447  [KO:K04402]
115200671  [KO:K04371] [EC:2.7.11.24]
115201167  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115201509  [KO:K04456] [EC:2.7.11.1]
115201607  [KO:K10030]
115201616  [KO:K10030]
115201695  [KO:K04433] [EC:2.7.12.2]
115201712  [KO:K15040]
115201738  [KO:K06268]
115201747  [KO:K20858]
115201754  [KO:K01367] [EC:3.4.22.52]
115201755  [KO:K03853] [EC:3.4.22.53]
115201756  [KO:K03853] [EC:3.4.22.53]
115202056  [KO:K05863]
115202749  [KO:K04402]
115202750  [KO:K04402]
115202935  [KO:K06626]
115202965  [KO:K04503]
115203015  [KO:K05868]
115203140  [KO:K04682]
115203241  [KO:K07830]
115203296  [KO:K16332]
115203318  [KO:K17333]
115203342  [KO:K04982] [EC:2.7.11.1]
115203411  [KO:K06269] [EC:3.1.3.16]
115203478  [KO:K08826] [EC:2.7.11.1]
115203522  [KO:K02183]
115203963  [KO:K02649]
115204043  [KO:K05868]
115204136  [KO:K07206]
115204259  [KO:K02183]
115204365  [KO:K13375]
115204416  [KO:K05863]
115204432  [KO:K04348] [EC:3.1.3.16]
115204450  [KO:K01367] [EC:3.4.22.52]
115204542  [KO:K04456] [EC:2.7.11.1]
115204637  ccna1; cyclin-A1 [KO:K06627]
115204711  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
115204775  [KO:K10151]
115205091  [KO:K06627]
115205104  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
115205128  sqstm1; sequestosome-1 [KO:K14381]
115205255  [KO:K05863]
115205318  [KO:K02580]
115205340  [KO:K03362]
115205560  [KO:K04348] [EC:3.1.3.16]
115205573  [KO:K13376]
115205945  [KO:K02183]
115205976  [KO:K18753]
115205985  [KO:K18753]
115206406  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
115206445  [KO:K02678]
115206538  [KO:K00922] [EC:2.7.1.153]
115206560  [KO:K06751]
115206563  [KO:K04456] [EC:2.7.11.1]
115206692  [KO:K13375]
115207266  [KO:K08826] [EC:2.7.11.1]
115207356  [KO:K04441] [EC:2.7.11.24]
115207525  [KO:K08015]
115207529  [KO:K21769]
115207531  [KO:K04433] [EC:2.7.12.2]
115207563  [KO:K04958]
115207704  [KO:K07827]
115207794  [KO:K06625]
115207837  [KO:K07208]
115207911  [KO:K04958]
115207950  [KO:K02089] [EC:2.7.11.22]
115207965  [KO:K02206] [EC:2.7.11.22]
115208210  [KO:K04851]
115208402  [KO:K04377]
115208414  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
115208448  [KO:K01367] [EC:3.4.22.52]
115208449  [KO:K03853] [EC:3.4.22.53]
115208455  [KO:K03853] [EC:3.4.22.53]
115208572  [KO:K06268]
115208587  [KO:K04456] [EC:2.7.11.1]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
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Related
pathway
stru04020  Calcium signaling pathway
stru04068  FoxO signaling pathway
stru04110  Cell cycle
stru04115  p53 signaling pathway
stru04150  mTOR signaling pathway
KO pathway
ko04218   

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