KEGG   PATHWAY: tcf04120
Entry
tcf04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Tigriopus californicus (tidepool copepod)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
tcf04120  Ubiquitin mediated proteolysis
tcf04120

Other DBs
GO: 0016567
Organism
Tigriopus californicus (tidepool copepod) [GN:tcf]
Gene
131893552  polyubiquitin-B [KO:K08770]
131883812  ubiquitin-like [KO:K02927]
131885231  ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
131892895  ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
131882523  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
131889085  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
131892937  SUMO-activating enzyme subunit 1-like [KO:K10684] [EC:6.2.1.45]
131884622  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
131887950  NEDD8-activating enzyme E1 catalytic subunit-like [KO:K10686] [EC:6.2.1.64]
131892962  ubiquitin-conjugating enzyme E2-17 kDa [KO:K10573] [EC:2.3.2.23]
131886763  ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
131877844  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
131891553  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
131885318  ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
131884621  NEDD8-conjugating enzyme UBE2F-like [KO:K10687] [EC:2.3.2.34]
131893528  ubiquitin-conjugating enzyme E2 G1-like isoform X1 [KO:K10575] [EC:2.3.2.23]
131883328  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
131890627  ubiquitin-conjugating enzyme E2 H-like [KO:K10576] [EC:2.3.2.23]
131887149  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
131879975  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
131880892  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
131886604  ubiquitin-conjugating enzyme E2-22 kDa-like [KO:K04649] [EC:2.3.2.23]
131888649  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
131893213  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
131886410  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
131879039  ubiquitin-conjugating enzyme E2 Q2-like [KO:K10582] [EC:2.3.2.23]
131878689  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
131893619  ubiquitin-conjugating enzyme E2 S-like [KO:K10583] [EC:2.3.2.23]
131885825  ubiquitin-conjugating enzyme E2 W-like isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
131893058  LOW QUALITY PROTEIN: ubiquitin-protein ligase E3B-like [KO:K10588] [EC:2.3.2.26]
131893426  ubiquitin-protein ligase E3C-like [KO:K10589] [EC:2.3.2.26]
131887677  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
131877218  E3 ubiquitin-protein ligase wwp-1-like [KO:K05633] [EC:2.3.2.26]
131877410  E3 ubiquitin-protein ligase TRIP12-like [KO:K10590] [EC:2.3.2.26]
131885882  E3 ubiquitin-protein ligase NEDD4-like [KO:K10591] [EC:2.3.2.26]
131877758  E3 ubiquitin-protein ligase HUWE1-like isoform X1 [KO:K10592] [EC:2.3.2.26]
131889976  E3 ubiquitin-protein ligase UBR5-like [KO:K10593] [EC:2.3.2.26]
131892976  probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
131884822  ubiquitin conjugation factor E4 A-like [KO:K10596] [EC:2.3.2.27]
131882807  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
131880851  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
131886294  RING-type E3 ubiquitin-protein ligase PPIL2-like [KO:K10598] [EC:5.2.1.8]
131887833  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
131889760  E3 ubiquitin-protein ligase CBL-B-A-like [KO:K04707] [EC:2.3.2.27]
131883033  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
131893285  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
131890288  E3 ubiquitin-protein ligase SIAH1B-like [KO:K04506] [EC:2.3.2.27]
131885524  E3 ubiquitin-protein ligase SIAH1B-like [KO:K04506] [EC:2.3.2.27]
131886018  uncharacterized protein LOC131886018 [KO:K04506] [EC:2.3.2.27]
131877150  E3 ubiquitin-protein ligase SIAH2-like [KO:K04506] [EC:2.3.2.27]
131878649  E3 ubiquitin-protein ligase SIAH1B-like [KO:K04506] [EC:2.3.2.27]
131889650  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
131892824  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
131893289  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
131880247  baculoviral IAP repeat-containing protein 7-A-like [KO:K16060]
131876924  death-associated inhibitor of apoptosis 2-like [KO:K16061]
131876904  E3 SUMO-protein ligase PIAS1-like isoform X1 [KO:K04706] [EC:2.3.2.-]
131877383  E3 SUMO-protein ligase PIAS2-like isoform X1 [KO:K04706] [EC:2.3.2.-]
131883465  E3 ubiquitin-protein ligase synoviolin A-like [KO:K10601] [EC:2.3.2.27]
131882958  E3 ubiquitin-protein ligase FANCL-like [KO:K10606] [EC:2.3.2.27]
131888314  E3 ubiquitin-protein ligase TRIM37-like [KO:K10608] [EC:2.3.2.27]
131889053  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
131880516  cullin-1-like [KO:K03347]
131880888  S-phase kinase-associated protein 1 [KO:K03094]
131883698  beta-TrCP-like [KO:K03362]
131886295  F-box/WD repeat-containing protein 11-like [KO:K03362]
131877108  F-box and WD repeat domain-containing 11-A-like [KO:K03362]
131888070  beta-TrCP-like isoform X1 [KO:K03362]
131888128  F-box/WD repeat-containing protein 11-like [KO:K03362]
131889011  beta-TrCP-like isoform X1 [KO:K03362]
131889794  S-phase kinase-associated protein 2-like [KO:K03875]
131891158  F-box/WD repeat-containing protein 7-like [KO:K10260]
131877461  F-box/WD repeat-containing protein 7-like [KO:K10260]
131878559  F-box only protein 4-like [KO:K10291]
131882573  cullin-2-like [KO:K03870]
131892770  elongin-C [KO:K03872]
131893555  elongin-B-like [KO:K03873]
131877489  cullin-3-B-like [KO:K03869]
131880682  rho-related BTB domain-containing protein 1-like [KO:K07868]
131883283  cullin-4A-like [KO:K10609]
131887816  DNA damage-binding protein 1-like [KO:K10610]
131883007  DNA damage-binding protein 2-like [KO:K10140]
131885848  DNA excision repair protein ERCC-8-like isoform X1 [KO:K10570]
131891006  DET1 homolog [KO:K10571]
131886217  RING-box protein 2-like [KO:K10611]
131884133  cullin-5-like [KO:K10612]
131884731  anaphase-promoting complex subunit 2-like [KO:K03349]
131887298  cell division cycle protein 20 homolog [KO:K03363]
131889477  cell division cycle protein 20 homolog [KO:K03363]
131876830  fizzy-related protein homolog [KO:K03364]
131892297  anaphase-promoting complex subunit 1-like [KO:K03348]
131884967  cell division cycle protein 27 homolog [KO:K03350]
131888267  anaphase-promoting complex subunit 4-like [KO:K03351]
131891899  anaphase-promoting complex subunit 5-like [KO:K03352]
131883209  cell division cycle protein 16 homolog [KO:K03353]
131880654  anaphase-promoting complex subunit 7-like [KO:K03354]
131879879  cell division cycle protein 23 homolog [KO:K03355]
131889310  anaphase-promoting complex subunit 10-like [KO:K03357]
131880700  anaphase-promoting complex subunit CDC26-like [KO:K03359]
131886984  anaphase-promoting complex subunit 13-like [KO:K12456]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
tcf03050  Proteasome
KO pathway
ko04120   
LinkDB

DBGET integrated database retrieval system