KEGG   PATHWAY: tmu04820
Entry
tmu04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Trichechus manatus latirostris (Florida manatee)
Class
Cellular Processes; Cell motility
Pathway map
tmu04820  Cytoskeleton in muscle cells
tmu04820

Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101354262  collagen alpha-1(I) chain [KO:K06236]
101341020  collagen alpha-2(I) chain isoform X2 [KO:K06236]
101359491  collagen alpha-1(III) chain [KO:K19720]
101348905  collagen alpha-1(XXIV) chain isoform X1 [KO:K19721]
101357024  collagen alpha-1(XXVII) chain [KO:K19721]
101344545  collagen alpha-3(V) chain [KO:K19721]
101354865  collagen alpha-2(V) chain [KO:K19721]
101348485  collagen alpha-2(XI) chain isoform X1 [KO:K19721]
101350228  collagen alpha-1(XI) chain [KO:K19721]
101353199  collagen alpha-1(V) chain [KO:K19721]
101344924  collagen alpha-3(IX) chain [KO:K08131]
101352859  collagen alpha-2(IX) chain [KO:K08131]
101358160  collagen alpha-1(IX) chain [KO:K08131]
101351816  versican core protein isoform X1 [KO:K06793]
105756545  LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
101344163  collagen alpha-3(VI) chain [KO:K06238]
101359051  collagen alpha-4(VI) chain-like [KO:K06238]
101341513  collagen alpha-2(VI) chain [KO:K06238]
101359739  collagen alpha-6(VI) chain [KO:K06238]
101347197  collagen alpha-1(VI) chain [KO:K06238]
101344047  thrombospondin-1 [KO:K16857]
101352874  thrombospondin-4 [KO:K04659]
101352934  thrombospondin-3 isoform X1 [KO:K04659]
101358103  thrombospondin-2 [KO:K04659]
101348197  cartilage oligomeric matrix protein [KO:K04659]
101355639  fibrillin-1 [KO:K06825]
101342437  fibrillin-2 [KO:K23342]
101348179  fibrillin-3 [KO:K23342]
101358346  collagen alpha-4(IV) chain [KO:K06237]
101349964  collagen alpha-5(IV) chain isoform X2 [KO:K06237]
101345305  collagen alpha-1(IV) chain [KO:K06237]
101345564  collagen alpha-2(IV) chain [KO:K06237]
101349706  collagen alpha-6(IV) chain [KO:K06237]
101355897  collagen alpha-3(IV) chain [KO:K06237]
101348519  fibulin-1 isoform X1 [KO:K17307]
101342038  fibulin-2 isoform X1 [KO:K17307]
101349957  basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
101344447  nidogen-2 [KO:K06826]
101357029  nidogen-1 [KO:K06826]
101361092  fibronectin isoform X3 [KO:K05717]
101350098  syndecan-1 [KO:K06257]
101358809  syndecan-2 [KO:K16336]
101342982  syndecan-3 isoform X2 [KO:K16337]
101350431  syndecan-4 [KO:K16338]
101343627  agrin [KO:K06254]
101359520  biglycan isoform X1 [KO:K08118]
101349838  desmocollin-2 isoform X1 [KO:K07601]
101351801  desmoglein-2 [KO:K07597]
101353217  plakophilin-2 isoform X1 [KO:K12642]
101355667  junction plakoglobin [KO:K10056]
101354982  desmoplakin isoform X1 [KO:K10381]
101351342  vimentin [KO:K07606]
101352530  desmin [KO:K07610]
101356509  laminin subunit alpha-2 [KO:K05637]
101347367  laminin subunit alpha-1 [KO:K05637]
101348015  integrin alpha-1 [KO:K06480]
101358848  integrin alpha-2 [KO:K06481]
101348507  integrin alpha-IIb [KO:K06476]
101356045  integrin alpha-3 [KO:K06482]
101351755  integrin alpha-4 [KO:K06483]
101340808  integrin alpha-5 [KO:K06484]
101342079  integrin alpha-6 isoform X1 [KO:K06485]
101359730  integrin alpha-7 isoform X1 [KO:K06583]
101345639  integrin alpha-8 [KO:K06584]
101342329  integrin alpha-9 [KO:K06585]
101352987  integrin alpha-10 isoform X1 [KO:K06586]
101353305  LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
101356496  integrin alpha-V isoform X1 [KO:K06487]
101360881  integrin beta-1 [KO:K05719]
101359355  integrin beta-3 [KO:K06493]
101357545  integrin beta-4 isoform X2 [KO:K06525]
101345527  integrin beta-5 [KO:K06588]
101360058  integrin beta-6 isoform X1 [KO:K06589]
101357623  integrin beta-7 isoform X1 [KO:K06590]
101355358  integrin beta-8 [KO:K06591]
101352866  talin-1 [KO:K06271]
101348675  talin-2 [KO:K06271]
101350153  vinculin isoform X4 [KO:K05700]
101350996  alpha-actinin-3 [KO:K21073]
101355593  alpha-actinin-2 [KO:K21073]
101358156  actin, cytoplasmic 1 [KO:K05692]
101344372  actin, cytoplasmic 2 [KO:K05692]
101350857  actin, gamma-enteric smooth muscle isoform X1 [KO:K12315]
101358535  dystroglycan [KO:K06265]
101354843  alpha-sarcoglycan isoform X1 [KO:K12565]
101361815  epsilon-sarcoglycan isoform X3 [KO:K27061]
101351876  beta-sarcoglycan [KO:K12566]
101349002  delta-sarcoglycan [KO:K12563]
101342788  gamma-sarcoglycan [KO:K12564]
101361629  zeta-sarcoglycan isoform X1 [KO:K27062]
101348194  sarcospan isoform X1 [KO:K22194]
101357999  dystrophin [KO:K10366]
101360030  alpha-1-syntrophin [KO:K24063]
101353769  beta-2-syntrophin [KO:K24064]
101357454  beta-1-syntrophin [KO:K24064]
101344074  dystrobrevin alpha isoform X2 [KO:K26998]
101344651  filamin-C isoform X1 [KO:K27393]
101361490  LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
101355408  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
101345071  sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
101361788  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
101343204  sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
101343098  protein ATP1B4 isoform X3 [KO:K01540]
101358687  sodium/potassium-transporting ATPase subunit beta-1 isoform X1 [KO:K01540]
101352110  sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
101344437  ankyrin-3 [KO:K09259]
101353650  spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
101357863  spectrin beta chain, non-erythrocytic 4 [KO:K06115]
101352804  spectrin beta chain, non-erythrocytic 5 [KO:K06115]
101352418  spectrin beta chain, non-erythrocytic 1 [KO:K06115]
101348535  spectrin beta chain, non-erythrocytic 2 [KO:K23932]
101343557  cysteine and glycine-rich protein 3 [KO:K09377]
101343864  cysteine and glycine-rich protein 1 [KO:K09377]
101343628  cysteine and glycine-rich protein 2 [KO:K09377]
101341734  myosin-8 isoform X3 [KO:K24220]
101340901  myosin-1 isoform X1 [KO:K24220]
101340630  myosin-2 [KO:K24220]
101340371  myosin-3 [KO:K24220]
101356849  LOW QUALITY PROTEIN: myosin-7B [KO:K24220]
101341322  myosin-4 isoform X1 [KO:K24220]
101351758  LOW QUALITY PROTEIN: myosin-13 [KO:K24220]
101353289  myosin-7 [KO:K17751]
101341147  myosin-11 isoform X1 [KO:K10352]
101344292  myosin-10 isoform X2 [KO:K10352]
101352355  myosin-9 isoform X2 [KO:K10352]
101360338  myosin-14 [KO:K10352]
101358929  myosin light chain 1/3, skeletal muscle isoform [KO:K05738]
101342128  myosin light chain 3 [KO:K12749]
101359616  myosin light chain 4 [KO:K12750]
101351770  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101343534  myosin light chain 5 [KO:K12753]
101346602  myosin regulatory light chain 2, atrial isoform [KO:K12754]
101346277  myosin regulatory light polypeptide 9 [KO:K12755]
101348975  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101359445  myosin-binding protein C, slow-type [KO:K12557]
101341759  myosin-binding protein C, fast-type [KO:K12558]
101361471  myosin-binding protein C, cardiac-type [KO:K12568]
101358482  myosin-binding protein H isoform X2 [KO:K24494]
101356000  LOW QUALITY PROTEIN: myosin-binding protein H-like [KO:K24494]
101345310  actin, alpha skeletal muscle isoform X1 [KO:K10354]
101341415  actin, alpha cardiac muscle 1 isoform X1 [KO:K12314]
101353698  troponin C, slow skeletal and cardiac muscles [KO:K05865]
101344534  troponin I, slow skeletal muscle [KO:K10371]
101355794  troponin T, slow skeletal muscle isoform X1 [KO:K10372]
101348734  troponin C, skeletal muscle [KO:K12042]
101356431  troponin I, fast skeletal muscle [KO:K12043]
101356931  troponin T, fast skeletal muscle [KO:K12046]
101356235  troponin I, cardiac muscle isoform X1 [KO:K12044]
101344780  troponin T, cardiac muscle isoform X3 [KO:K12045]
101353480  tropomyosin alpha-1 chain isoform X7 [KO:K10373]
101353128  tropomyosin beta chain isoform X2 [KO:K10374]
101341529  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
101353940  tropomyosin alpha-4 chain isoform X1 [KO:K10375]
101353907  titin [KO:K12567] [EC:2.7.11.1]
101356647  myotilin [KO:K19875]
101354591  telethonin [KO:K19879]
101345578  synaptopodin-2 isoform X1 [KO:K24066]
101350884  nebulin [KO:K18267]
101347353  nebulette isoform X2 [KO:K25865]
101352908  myozenin-1 [KO:K26050]
101345831  myozenin-2 [KO:K26050]
101357496  myozenin-3 [KO:K26050]
101347307  PDZ and LIM domain protein 1 [KO:K23353]
101347936  PDZ and LIM domain protein 2 isoform X1 [KO:K23353]
101355981  PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
101356825  PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
101345336  F-actin-capping protein subunit alpha-2 [KO:K10364]
101351074  F-actin-capping protein subunit alpha-1 [KO:K10364]
101342722  F-actin-capping protein subunit alpha-3 [KO:K10364]
101348261  F-actin-capping protein subunit beta isoform X1 [KO:K10365]
101360582  xin actin-binding repeat-containing protein 1 [KO:K27381]
101354073  xin actin-binding repeat-containing protein 2 isoform X2 [KO:K27381]
101346043  nebulin-related-anchoring protein isoform X2 [KO:K24421]
101341944  myopalladin isoform X1 [KO:K22028]
101340426  PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
101344576  PDZ and LIM domain protein 5 isoform X9 [KO:K19867]
101342278  LIM domain-binding protein 3 isoform X1 [KO:K19867]
101345680  tropomodulin-4 isoform X1 [KO:K10370]
101341054  tropomodulin-1 [KO:K10370]
101351499  tropomodulin-2 [KO:K10370]
101351936  tropomodulin-3 [KO:K10370]
101361450  zyxin [KO:K06273]
101355279  four and a half LIM domains protein 1 isoform X2 [KO:K14365]
101356268  four and a half LIM domains protein 2 [KO:K14380]
101359952  four and a half LIM domains protein 3 [KO:K24414]
101342918  leiomodin-1 [KO:K22030]
101361817  leiomodin-2 [KO:K22030]
101352960  leiomodin-3 [KO:K22030]
101359941  ankyrin repeat domain-containing protein 1 [KO:K21433]
101355151  LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 2 [KO:K21434]
101343819  LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 23 [KO:K21438]
101343682  formin-like protein 1 [KO:K23957]
101344463  formin-like protein 2 isoform X1 [KO:K23957]
101356590  formin-like protein 3 [KO:K23957]
101359716  inverted formin-2 [KO:K23958]
101342810  disheveled-associated activator of morphogenesis 1 [KO:K04512]
101346061  disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
101356233  protein diaphanous homolog 1 isoform X1 [KO:K05740]
101361435  protein diaphanous homolog 2 isoform X2 [KO:K05741]
101356583  protein diaphanous homolog 3 isoform X1 [KO:K05745]
101349368  formin-2 [KO:K02184]
101350168  myomesin-1 isoform X4 [KO:K24495]
101342990  myomesin-2 isoform X1 [KO:K24495]
101346911  myomesin-3 [KO:K24495]
101358342  alpha-enolase [KO:K01689] [EC:4.2.1.11]
101346571  beta-enolase [KO:K01689] [EC:4.2.1.11]
101356999  gamma-enolase [KO:K01689] [EC:4.2.1.11]
101354866  ankyrin-2 isoform X1 [KO:K09255]
101353575  creatine kinase M-type isoform X1 [KO:K27382] [EC:2.7.3.2]
101359813  tripartite motif-containing protein 54 [KO:K10653]
101344941  tripartite motif-containing protein 55 isoform X1 [KO:K10654]
101344379  E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
101345409  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
101349755  AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
101344478  AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
101356561  calpain-3 isoform X9 [KO:K08573] [EC:3.4.22.54]
101348801  plectin isoform X1 [KO:K10388]
101346486  nesprin-3 [KO:K21761]
101350762  nesprin-1 isoform X17 [KO:K19326]
101350775  nesprin-2 [KO:K19346]
101342911  SUN domain-containing protein 2 isoform X2 [KO:K19347]
101344158  SUN domain-containing protein 1 [KO:K19347]
101341523  transmembrane protein 43 [KO:K27488]
101343833  emerin [KO:K12569]
101353559  lamin-B receptor isoform X1 [KO:K19532] [EC:1.3.1.70]
101345325  lamin isoform X1 [KO:K12641]
101348357  lamin-B2 [KO:K07611]
101340484  lamin-B1 [KO:K07611]
Reference
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
tmu04512  ECM-receptor interaction
tmu04814  Motor proteins
KO pathway
ko04820   
LinkDB

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