KEGG   PATHWAY: uah04728
Entry
uah04728                    Pathway                                
Name
Dopaminergic synapse - Ursus arctos (brown bear)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
uah04728  Dopaminergic synapse
uah04728

Other DBs
GO: 0001963
Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113243914  TH; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
113257543  DDC; aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
113270073  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
113251976  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
113264115  DRD1; D(1A) dopamine receptor [KO:K04144]
113266675  DRD5; D(1B) dopamine receptor [KO:K05840]
113252095  CALY; neuron-specific vesicular protein calcyon [KO:K15493]
113269831  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
113244175  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
113258346  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
113242038  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
113258243  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
113257114  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
113257782  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
113243814  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
113241090  calmodulin-like [KO:K02183]
113241128  calmodulin-like protein 3 [KO:K02183]
113240902  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
113256068  calmodulin-1-like [KO:K02183]
113243394  CALM3; calmodulin-3 [KO:K02183]
113245972  CALM2; calmodulin-2 [KO:K02183]
113267365  CALM1; calmodulin-1 isoform X2 [KO:K02183]
113270682  CALML6; calmodulin-like protein 6 [KO:K02183]
113257849  CAMK2B; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
113255589  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
113259192  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7 [KO:K04515] [EC:2.7.11.17]
113263946  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X3 [KO:K04515] [EC:2.7.11.17]
113270001  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
113263105  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
113259177  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
113265250  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
113267584  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113247385  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
113270317  FOS; protein c-Fos [KO:K04379]
113258768  GNAS; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
113258223  neuroendocrine secretory protein 55 [KO:K04632]
113245925  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
113252326  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
113254486  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113247197  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
113250525  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
113250749  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
113241758  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113264990  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
113264732  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
113245324  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
113260470  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
113242823  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
113262153  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
113243741  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
113243854  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
113243852  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113263180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113261548  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113243106  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
113265518  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
113244033  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
113266966  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
113240761  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
113250820  sodium channel protein type 1 subunit alpha [KO:K04833]
113258052  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
113256986  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
113247199  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
113248411  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
113250873  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
113258629  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
113246727  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
113259740  KCNJ5; G protein-activated inward rectifier potassium channel 4 isoform X1 [KO:K04999]
113256431  DRD3; D(3) dopamine receptor isoform X1 [KO:K04146]
113248798  DRD4; D(4) dopamine receptor [KO:K04147]
113259201  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
113244920  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
113256902  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
113252256  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534]
113270618  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
113267850  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
113257958  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
113254767  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
113269635  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
113242381  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
113246953  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
113258997  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
113254482  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
113242789  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
113243396  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
113260317  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
123000897  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
130543375  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
113260097  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
113254546  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
113247141  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X2 [KO:K04347]
113245403  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
113260088  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
113265599  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
113260043  DRD2; D(2) dopamine receptor isoform X2 [KO:K04145]
113269326  ARRB1; beta-arrestin-1 isoform X2 [KO:K04439]
113271089  ARRB2; beta-arrestin-2 [KO:K04439]
113262137  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113261737  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
113247257  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
113260072  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
113269966  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
113252071  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
113255341  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
113266692  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
113266124  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
113253964  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
113262671  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
113244148  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
113261281  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
113246356  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
113267251  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [KO:K11584]
113267192  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113243572  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
113262966  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113243514  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
113251972  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113270811  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
113257861  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
113263993  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
113255793  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
113270923  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
113260120  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
113250901  KIF5C; kinesin heavy chain [KO:K10396]
113244238  KIF5B; kinesin-1 heavy chain [KO:K10396]
113256376  KIF5A; kinesin heavy chain [KO:K10396]
113262508  CLOCK; circadian locomoter output cycles protein kaput isoform X1 [KO:K02223] [EC:2.3.1.48]
113246271  BMAL1; basic helix-loop-helix ARNT-like protein 1 isoform X7 [KO:K02296]
113260791  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
113265899  uncharacterized protein LOC113265899 [KO:K00274] [EC:1.4.3.4]
113265900  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
113245980  COMT; catechol O-methyltransferase isoform X2 [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
uah00350  Tyrosine metabolism
uah04020  Calcium signaling pathway
uah04721  Synaptic vesicle cycle
uah04724  Glutamatergic synapse
uah05012  Parkinson disease
KO pathway
ko04728   
LinkDB

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