KEGG   PATHWAY: pcad04152
Entry
pcad04152                   Pathway                                
Name
AMPK signaling pathway - Physeter macrocephalus (sperm whale)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcad04152  AMPK signaling pathway
pcad04152

Other DBs
GO: 2000479
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973184  RAB10; ras-related protein Rab-10 [KO:K07903]
102973323  [KO:K06259]
102973545  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
102973565  RAB2A; ras-related protein Rab-2A isoform X1 [KO:K07877]
102973638  CCNA1; cyclin-A1 [KO:K06627]
102973776  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
102973780  ADIPOR1; adiponectin receptor protein 1 isoform X4 [KO:K07297]
102974100  CAB39; calcium-binding protein 39 [KO:K08272]
102974204  CIDEA; cell death activator CIDE-A [KO:K25893]
102974323  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
102974359  [KO:K06259]
102974912  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102975125  PFKFB2; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
102975387  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
102975405  [KO:K06259]
102975555  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102975836  PFKL; ATP-dependent 6-phosphofructokinase, liver type isoform X1 [KO:K00850] [EC:2.7.1.11]
102976080  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
102976365  ACACA; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
102976416  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
102976623  GYS1; glycogen [starch] synthase, muscle isoform X2 [KO:K00693] [EC:2.4.1.11]
102976885  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102976967  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
102976971  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
102977108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102977392  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102977826  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
102977867  RAB14; ras-related protein Rab-14 [KO:K07881]
102978230  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
102978952  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102979483  [KO:K17532]
102979520  [KO:K19030] [EC:2.7.1.105 3.1.3.46]
102979870  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
102979895  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4 [KO:K07202]
102980504  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X2 [KO:K19523] [EC:2.3.1.21]
102980680  FOXO1; forkhead box protein O1 [KO:K07201]
102980970  FOXO3; forkhead box protein O3 isoform X2 [KO:K09408]
102980991  STRADA; STE20-related kinase adapter protein alpha isoform X3 [KO:K08271]
102981516  MLYCD; malonyl-CoA decarboxylase, mitochondrial isoform X2 [KO:K01578] [EC:4.1.1.9]
102981524  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102982040  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
102982336  [KO:K17445]
102982394  PFKM; ATP-dependent 6-phosphofructokinase, muscle type [KO:K00850] [EC:2.7.1.11]
102982412  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
102983040  HMGCR; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1 [KO:K00021] [EC:1.1.1.34]
102983202  PFKFB1; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X10 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
102983421  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102983610  [KO:K11584]
102984463  [KO:K08271]
102984521  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
102984681  PFKP; ATP-dependent 6-phosphofructokinase, platelet type [KO:K00850] [EC:2.7.1.11]
102984927  TBC1D1; TBC1 domain family member 1 isoform X14 [KO:K18341]
102985008  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102985473  TSC2; tuberin isoform X9 [KO:K07207]
102985635  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
102985730  [KO:K17532]
102985759  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102985946  ADIPOR2; adiponectin receptor protein 2 isoform X1 [KO:K07297]
102986078  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3 [KO:K09048]
102986098  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102986162  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
102986482  ADIPOQ; adiponectin [KO:K07296]
102986529  PPARG; peroxisome proliferator-activated receptor gamma isoform X3 [KO:K08530]
102986563  [KO:K07877]
102986587  CCNA2; cyclin-A2 [KO:K06627]
102986738  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
102987031  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102987078  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102987194  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102987746  HNF4A; hepatocyte nuclear factor 4-alpha isoform X1 [KO:K07292]
102988534  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
102988582  [KO:K07297]
102988757  EEF2K; eukaryotic elongation factor 2 kinase isoform X2 [KO:K08292] [EC:2.7.11.20]
102989082  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102989235  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
102989579  IRS4; insulin receptor substrate 4 [KO:K17446]
102990076  RPTOR; regulatory-associated protein of mTOR isoform X2 [KO:K07204]
102990087  [KO:K04456] [EC:2.7.11.1]
102990138  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
102990173  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
102990399  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102990481  [KO:K05424]
102990550  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102990592  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2 [KO:K01596] [EC:4.1.1.32]
102990899  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X5 [KO:K07200]
102990917  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
102990922  ELAVL1; ELAV-like protein 1 [KO:K13088]
102991192  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102991362  CAB39L; calcium-binding protein 39-like [KO:K08272]
102991442  TSC1; hamartin isoform X1 [KO:K07206]
102991456  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102991493  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
102991779  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102991940  STK11; serine/threonine-protein kinase STK11 isoform X5 [KO:K07298] [EC:2.7.11.1]
102992065  PFKFB3; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X6 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
102992184  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
102992290  IRS1; insulin receptor substrate 1 [KO:K16172]
102992365  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
102992378  [KO:K08765] [EC:2.3.1.21]
102992659  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
102992865  ACACB; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
102993114  RAB8A; ras-related protein Rab-8A isoform X2 [KO:K07901]
102993364  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X3 [KO:K11411] [EC:2.3.1.286]
102993441  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
102993492  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
102993498  RAB11B; ras-related protein Rab-11B [KO:K07905]
102993617  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
102993796  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102993868  EEF2; elongation factor 2 [KO:K03234]
102994517  RHEB; GTP-binding protein Rheb [KO:K07208]
102994621  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
102994835  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
102995068  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102995296  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
102995727  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102996013  [KO:K07297]
102996184  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
102996324  LEPR; leptin receptor [KO:K05062]
102996407  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
102996416  FBP2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
102996701  [KO:K03841] [EC:3.1.3.11]
102996789  SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
102996909  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
102996914  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102997033  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
112061832  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
112062628  INS; insulin [KO:K04526]
112064787  IRS2; insulin receptor substrate 2 isoform X2 [KO:K07187]
112066338  [KO:K07297]
112066353  [KO:K05424]
129391322  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
pcad00010  Glycolysis / Gluconeogenesis
pcad00061  Fatty acid biosynthesis
pcad00500  Starch and sucrose metabolism
pcad01040  Biosynthesis of unsaturated fatty acids
pcad04110  Cell cycle
pcad04140  Autophagy - animal
pcad04150  mTOR signaling pathway
pcad04151  PI3K-Akt signaling pathway
pcad04910  Insulin signaling pathway
pcad04920  Adipocytokine signaling pathway
KO pathway
ko04152   

DBGET integrated database retrieval system