KEGG   PATHWAY: pcad04151
Entry
pcad04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Physeter macrocephalus (sperm whale)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcad04151  PI3K-Akt signaling pathway
pcad04151

Other DBs
GO: 0043491
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973168  IGF2; insulin-like growth factor II [KO:K13769]
102973446  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X2 [KO:K03259]
102973496  [KO:K04736]
102973542  TGFA; protransforming growth factor alpha isoform X4 [KO:K08774]
102973643  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
102973747  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
102973751  KITLG; kit ligand isoform X1 [KO:K05461]
102973970  [KO:K02991]
102973993  MYB; transcriptional activator Myb isoform X2 [KO:K09420]
102974009  OSM; oncostatin-M [KO:K05418]
102974068  FGF3; fibroblast growth factor 3 [KO:K04358]
102974155  LAMA5; laminin subunit alpha-5 [KO:K06240]
102974176  ANGPT4; angiopoietin-4 [KO:K05467]
102974198  RELA; transcription factor p65 isoform X1 [KO:K04735]
102974293  CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453]
102974323  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
102974331  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102974369  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
102974372  FGF19; fibroblast growth factor 19 [KO:K22603]
102974550  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102974557  COL1A2; collagen alpha-2(I) chain [KO:K06236]
102974655  BAD; bcl2-associated agonist of cell death [KO:K02158]
102974802  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102974882  EFNA2; ephrin-A2 [KO:K05462]
102974888  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102974912  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102975112  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
102975311  SPP1; osteopontin [KO:K06250]
102975365  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102975387  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
102975467  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102975548  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102975550  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
102975555  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102975576  COMP; cartilage oligomeric matrix protein [KO:K04659]
102975676  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
102975726  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
102975734  OSMR; oncostatin-M-specific receptor subunit beta isoform X3 [KO:K05057]
102975750  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102975888  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102976080  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
102976160  PRL; LOW QUALITY PROTEIN: prolactin [KO:K05439]
102976319  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
102976320  RBL2; retinoblastoma-like protein 2 [KO:K16332]
102976342  TLR2; toll-like receptor 2 [KO:K10159]
102976409  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
102976416  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
102976421  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102976485  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102976519  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102976588  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
102976623  GYS1; glycogen [starch] synthase, muscle isoform X2 [KO:K00693] [EC:2.4.1.11]
102976706  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102976773  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102976783  IL7; interleukin-7 [KO:K05431]
102976793  ITGB7; integrin beta-7 [KO:K06590]
102976885  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102976971  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
102976992  FGF10; fibroblast growth factor 10 [KO:K04358]
102977108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102977125  KRAS; GTPase KRas isoform X1 [KO:K07827]
102977142  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102977227  THBS4; thrombospondin-4 [KO:K04659]
102977339  YWHAQ; LOW QUALITY PROTEIN: 14-3-3 protein theta [KO:K16197]
102977369  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102977392  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102977431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102977668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
102977795  ITGA2; integrin alpha-2 [KO:K06481]
102977826  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
102977934  BDNF; brain-derived neurotrophic factor isoform X6 [KO:K04355]
102977938  ITGA4; integrin alpha-4 [KO:K06483]
102978016  [KO:K12457]
102978131  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
102978142  FN1; fibronectin isoform X1 [KO:K05717]
102978151  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102978154  EREG; proepiregulin [KO:K09784]
102978403  [KO:K04079]
102978436  AREG; amphiregulin isoform X1 [KO:K09782]
102978518  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
102978662  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
102978697  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
102978702  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102978798  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
102978811  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
102978896  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102978925  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
102978952  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102979009  FGF1; fibroblast growth factor 1 isoform X2 [KO:K18496]
102979109  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102979127  [KO:K05438]
102979195  [KO:K04392]
102979209  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
102979244  PGF; placenta growth factor isoform X1 [KO:K16859]
102979304  [KO:K06238]
102979617  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
102979827  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
102979864  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102980033  VWF; von Willebrand factor [KO:K03900]
102980052  ITGA7; integrin alpha-7 isoform X6 [KO:K06583]
102980055  CD19; B-lymphocyte antigen CD19 [KO:K06465]
102980083  [KO:K04079]
102980091  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102980125  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102980126  IL6; interleukin-6 [KO:K05405]
102980314  [KO:K05414]
102980346  EIF4B; eukaryotic translation initiation factor 4B isoform X5 [KO:K03258]
102980439  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
102980451  EPOR; erythropoietin receptor [KO:K05079]
102980523  VEGFD; vascular endothelial growth factor D [KO:K05449]
102980851  ITGAV; integrin alpha-V [KO:K06487]
102980945  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
102980964  IKBKG; NF-kappa-B essential modulator [KO:K07210]
102980970  FOXO3; forkhead box protein O3 isoform X2 [KO:K09408]
102981134  FGF6; fibroblast growth factor 6 [KO:K04358]
102981135  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102981323  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
102981443  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102981524  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102981656  LAMA2; laminin subunit alpha-2 [KO:K05637]
102981677  [KO:K03099]
102981679  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102981739  VEGFA; vascular endothelial growth factor A isoform X7 [KO:K05448]
102981762  EPO; erythropoietin [KO:K05437]
102981902  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102982040  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
102982044  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102982053  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
102982121  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
102982229  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102982240  FGFR3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
102982286  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
102982318  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102982328  NRTN; neurturin [KO:K25414]
102982332  PKN2; serine/threonine-protein kinase N2 isoform X2 [KO:K23691]
102982361  MTCP1; protein p13 MTCP-1 [KO:K16837]
102982420  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
102982443  LAMC2; laminin subunit gamma-2 [KO:K06246]
102982565  PRLR; prolactin receptor [KO:K05081]
102982641  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
102982672  ITGB8; integrin beta-8 [KO:K06591]
102982691  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102982705  LAMC1; laminin subunit gamma-1 [KO:K05635]
102982885  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102982984  FGF5; fibroblast growth factor 5 [KO:K04358]
102983001  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102983008  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
102983046  ITGA5; integrin alpha-5 [KO:K06484]
102983076  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
102983116  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
102983262  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
102983371  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
102983421  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102983555  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
102983610  [KO:K11584]
102983891  F2R; proteinase-activated receptor 1 [KO:K03914]
102983897  IL4; interleukin-4 [KO:K05430]
102984074  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
102984157  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102984179  [KO:K16197]
102984195  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102984255  YWHAB; LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha [KO:K16197]
102984305  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102984497  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
102984521  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
102984551  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102984604  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
102984702  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
102984762  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102984774  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102984824  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
102984868  TNXB; tenascin-X isoform X1 [KO:K06252]
102985008  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102985047  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102985179  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
102985243  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
102985278  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
102985473  TSC2; tuberin isoform X9 [KO:K07207]
102985479  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
102985532  RPS6; 40S ribosomal protein S6 [KO:K02991]
102985635  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
102985658  TP53; cellular tumor antigen p53 [KO:K04451]
102985729  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102985759  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102985805  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
102985806  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
102985889  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102985937  FGF16; fibroblast growth factor 16 [KO:K04358]
102985939  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
102986078  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3 [KO:K09048]
102986098  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102986162  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
102986172  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102986281  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
102986411  VTN; vitronectin [KO:K06251]
102986425  YWHAG; 14-3-3 protein gamma isoform X1 [KO:K16198]
102986483  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102986597  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
102986665  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
102986670  GDNF; glial cell line-derived neurotrophic factor isoform X3 [KO:K05452]
102986674  TNN; tenascin-N isoform X1 [KO:K06252]
102986704  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102986738  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
102986739  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
102986785  KDR; vascular endothelial growth factor receptor 2 isoform X5 [KO:K05098] [EC:2.7.10.1]
102986837  [KO:K04450]
102986927  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102987031  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102987032  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102987078  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102987169  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102987194  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102987302  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
102987336  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
102987349  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102987463  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
102987522  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102987616  TNR; tenascin-R [KO:K06252]
102987866  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
102987884  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
102987942  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
102988128  MYC; myc proto-oncogene protein [KO:K04377]
102988182  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102988264  CSF3; granulocyte colony-stimulating factor [KO:K05423]
102988570  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102988669  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
102988692  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102988740  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
102988829  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
102988868  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102989017  FGF2; fibroblast growth factor 2 [KO:K18497]
102989074  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102989082  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102989089  EFNA1; ephrin-A1 isoform X2 [KO:K05462]
102989372  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102989448  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
102989458  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102989482  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102989531  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
102989551  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102989664  [KO:K06247]
102989754  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
102989848  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102989984  VEGFC; vascular endothelial growth factor C isoform X2 [KO:K05449]
102990012  FGF9; fibroblast growth factor 9 [KO:K04358]
102990026  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102990076  RPTOR; regulatory-associated protein of mTOR isoform X2 [KO:K07204]
102990087  [KO:K04456] [EC:2.7.11.1]
102990138  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
102990155  IFNB1; interferon beta [KO:K05415]
102990164  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102990192  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
102990275  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
102990276  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102990399  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102990518  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102990550  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102990592  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2 [KO:K01596] [EC:4.1.1.32]
102990654  IL2; interleukin-2 [KO:K05429]
102990733  HSP90B1; endoplasmin [KO:K09487]
102991034  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102991161  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
102991192  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102991442  TSC1; hamartin isoform X1 [KO:K07206]
102991456  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102991493  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
102991639  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102991779  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102991940  STK11; serine/threonine-protein kinase STK11 isoform X5 [KO:K07298] [EC:2.7.11.1]
102991966  FGF23; fibroblast growth factor 23 [KO:K22428]
102992030  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3 [KO:K05631]
102992091  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
102992144  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102992184  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
102992191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102992196  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102992290  IRS1; insulin receptor substrate 1 [KO:K16172]
102992382  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102992401  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
102992439  [KO:K07828]
102992532  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
102992556  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102992563  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102992659  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
102992685  LAMA1; laminin subunit alpha-1 [KO:K05637]
102992726  FGF20; fibroblast growth factor 20 [KO:K04358]
102992873  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
102993186  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
102993220  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
102993259  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102993417  FGF18; fibroblast growth factor 18 [KO:K04358]
102993444  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
102993492  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
102993677  [KO:K02539]
102993796  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102993808  [KO:K16197]
102994051  ITGA2B; integrin alpha-IIb isoform X5 [KO:K06476]
102994057  [KO:K03258]
102994150  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102994151  PSPN; LOW QUALITY PROTEIN: persephin [KO:K25416]
102994154  FGF7; fibroblast growth factor 7 [KO:K04358]
102994335  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102994349  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102994418  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102994451  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102994517  RHEB; GTP-binding protein Rheb [KO:K07208]
102994576  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
102994621  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
102994673  IBSP; bone sialoprotein 2 [KO:K06253]
102994715  HRAS; GTPase HRas isoform X2 [KO:K02833]
102994805  TNC; tenascin isoform X1 [KO:K06252]
102994835  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
102994898  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
102994918  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102995000  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102995068  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102995205  ITGB5; integrin beta-5 [KO:K06588]
102995371  ANGPT1; angiopoietin-1 [KO:K05465]
102995420  THBS1; thrombospondin-1 [KO:K16857]
102995437  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102995518  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
102995638  YWHAH; 14-3-3 protein eta [KO:K16198]
102995661  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102995915  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102995923  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
102995933  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102996119  LAMB1; laminin subunit beta-1 [KO:K05636]
102996184  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
102996270  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102996314  GHR; growth hormone receptor isoform X2 [KO:K05080]
102996744  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
102996862  [KO:K05090] [EC:2.7.10.1]
102996909  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
102996914  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102997033  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
112061831  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
112061832  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
112062012  [KO:K04542]
112062628  INS; insulin [KO:K04526]
112063837  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
112063854  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112064782  [KO:K04542]
112065033  [KO:K13302] [EC:2.7.11.1]
112065332  ARTN; artemin [KO:K25415]
112065747  [KO:K05414]
112066479  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
112066563  GNGT2; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
112067178  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
112067418  FGF4; fibroblast growth factor 4 [KO:K04358]
112067524  [KO:K16197]
112067655  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
114483863  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
114483947  [KO:K04364]
114485485  [KO:K07210]
114487451  LAMC3; laminin subunit gamma-3 [KO:K06247]
129391322  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pcad00010  Glycolysis / Gluconeogenesis
pcad04010  MAPK signaling pathway
pcad04012  ErbB signaling pathway
pcad04062  Chemokine signaling pathway
pcad04064  NF-kappa B signaling pathway
pcad04068  FoxO signaling pathway
pcad04110  Cell cycle
pcad04115  p53 signaling pathway
pcad04150  mTOR signaling pathway
pcad04210  Apoptosis
pcad04370  VEGF signaling pathway
pcad04510  Focal adhesion
pcad04620  Toll-like receptor signaling pathway
pcad04630  JAK-STAT signaling pathway
pcad04662  B cell receptor signaling pathway
pcad04910  Insulin signaling pathway
KO pathway
ko04151   

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