KEGG   PATHWAY: pprl03013
Entry
pprl03013                   Pathway                                
Name
Nucleocytoplasmic transport - Poeciliopsis prolifica (blackstripe livebearer)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pprl03013  Nucleocytoplasmic transport
pprl03013

Other DBs
GO: 0050658
Organism
Poeciliopsis prolifica (blackstripe livebearer) [GN:pprl]
Gene
129351493  nup37; nucleoporin Nup37 [KO:K14302]
129351889  xpot; exportin-T isoform X1 [KO:K14288]
129351898  nup107; nuclear pore complex protein Nup107 [KO:K14301]
129351902  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
129351942  tnpo3; LOW QUALITY PROTEIN: transportin-3 [KO:K15436]
129352893  nup50; nuclear pore complex protein Nup50 [KO:K14295]
129354017  pom121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
129354752  ipo8; importin-8 isoform X1 [KO:K18755]
129355288  rae1; mRNA export factor isoform X1 [KO:K14298]
129355397  kpnb3; importin-5 isoform X1 [KO:K20222]
129355765  [KO:K14310]
129356043  [KO:K13025] [EC:5.6.2.7]
129356231  [KO:K14309]
129356424  [KO:K13025] [EC:5.6.2.7]
129356425  ddx19b; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
129356976  sumo1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
129358116  ipo9; importin-9 [KO:K20224]
129358236  thoc7; THO complex subunit 7 homolog [KO:K13176]
129358348  cse1l; exportin-2 [KO:K18423]
129358688  snupn; snurportin-1 [KO:K13151]
129359418  nup88; nucleoporin 88 [KO:K14318]
129359602  eef1a1a; LOW QUALITY PROTEIN: elongation factor 1-alpha 1a [KO:K03231]
129359755  xpo1b; exportin-1 isoform X1 [KO:K14290]
129359756  [KO:K14289]
129359849  [KO:K14309]
129360250  [KO:K20724]
129360258  [KO:K20724]
129360649  [KO:K12882]
129360652  [KO:K12882]
129360754  [KO:K14328]
129360763  [KO:K14328]
129360898  xpo4; exportin-4 [KO:K25203]
129361031  kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
129361034  ranbp2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
129361502  sumo3b; small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
129361504  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
129361518  nup62l; nucleoporin 62 like [KO:K14306]
129361623  tpra; nucleoprotein TPR [KO:K09291]
129361708  acin1a; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
129361985  [KO:K25202]
129362184  thoc1; THO complex subunit 1 isoform X1 [KO:K12878]
129362395  ran; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
129362405  thoc3; THO complex subunit 3 [KO:K12880]
129362425  nxt2; NTF2-related export protein 2 [KO:K14285]
129362455  nxf1a; nuclear RNA export factor 1 isoform X1 [KO:K14284]
129362476  [KO:K14310]
129363283  xpo6; exportin-6 [KO:K25204]
129363394  kpna2; importin subunit alpha-1 [KO:K15043]
129363457  [KO:K18727]
129363542  [KO:K14325]
129363707  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
129363746  nup85; nuclear pore complex protein Nup85 [KO:K14304]
129363748  sumo2b; small ubiquitin-related modifier 2 [KO:K12160]
129363809  rangap1a; ran GTPase-activating protein 1a isoform X1 [KO:K14319]
129363871  [KO:K10577]
129364086  ahctf1; LOW QUALITY PROTEIN: protein ELYS [KO:K25129]
129364330  ipo7; importin-7 [KO:K20223]
129364537  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
129364581  eef1a1l3; LOW QUALITY PROTEIN: elongation factor 1-alpha-like [KO:K03231]
129364625  ipo4; importin-4 [KO:K20221]
129364873  kpna1; importin subunit alpha-5 [KO:K23940]
129365114  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
129365356  senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
129365406  nup160; nuclear pore complex protein Nup160 [KO:K14303]
129365514  pnn; pinin [KO:K13114]
129365552  sumo3a; small ubiquitin-related modifier 3-like [KO:K12160]
129366092  gle1; LOW QUALITY PROTEIN: mRNA export factor GLE1 [KO:K18723]
129366158  ipo11; importin-11 [KO:K25201]
129366308  nup214; nuclear pore complex protein Nup214 [KO:K14317]
129366592  nup155; nuclear pore complex protein Nup155 [KO:K14312]
129366846  [KO:K15043]
129367013  [KO:K12881]
129367029  tnpo2b; LOW QUALITY PROTEIN: transportin-2 [KO:K18727]
129367039  kpna7; importin subunit alpha-8 [KO:K15043]
129367289  [KO:K03231]
129367445  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
129368493  thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
129369735  kpna4; importin subunit alpha-3 [KO:K23583]
129370012  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
129370119  pym1; partner of Y14 and mago [KO:K14294]
129370321  aaas; aladin isoform X1 [KO:K14320]
129370429  nup210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
129370609  nup98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
129370798  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
129371756  tprb; translocated promoter region b, nuclear basket protein isoform X1 [KO:K09291]
129372199  thoc5; THO complex subunit 5 homolog [KO:K13174]
129372360  upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
129372890  sec13; protein SEC13 homolog [KO:K14004]
129373212  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
129373757  kpnb1; LOW QUALITY PROTEIN: importin subunit beta-1 [KO:K14293]
129373779  thoc6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
129374034  casc3; protein CASC3 [KO:K14323]
129374105  tnpo1; transportin-1 isoform X1 [KO:K18752]
129374254  nup54; nucleoporin p54 isoform X1 [KO:K14308]
129374337  nup188; LOW QUALITY PROTEIN: nucleoporin NUP188 [KO:K14311]
129374579  [KO:K25202]
129374975  nup153; nuclear pore complex protein Nup153 [KO:K14296]
129375295  nup43; nucleoporin Nup43 [KO:K14305]
129375771  [KO:K03231]
129375772  [KO:K03231]
129376149  phax; phosphorylated adapter RNA export protein [KO:K14291]
129376291  kpna6; importin subunit alpha-7 [KO:K15042]
129377212  ddx19a; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
129377529  rangap1b; ran GTPase-activating protein 1b [KO:K14319]
129377801  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
129377996  ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
129378495  nup42; nucleoporin NUP42 [KO:K14321]
129379062  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
129379124  nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
129379389  acin1b; apoptotic chromatin condensation inducer 1b [KO:K12875]
129379700  magoh; protein mago nashi homolog [KO:K12877]
129379798  xpo7; exportin-7 [KO:K18460]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pprl03015  mRNA surveillance pathway
KO pathway
ko03013   

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