KEGG   PATHWAY: rno04640
Entry
rno04640                    Pathway                                
Name
Hematopoietic cell lineage - Rattus norvegicus (rat)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
rno04640  Hematopoietic cell lineage
rno04640

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
103691134  Flt3lg; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
114103  Il5ra; interleukin-5 receptor subunit alpha precursor [KO:K05067]
114517  Itga6; integrin alpha-6 precursor [KO:K06485]
116630  Csf2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
116727  Gp1bb; platelet glycoprotein Ib beta chain precursor [KO:K06262]
117022  Il1r2; interleukin-1 receptor type 2 precursor [KO:K04387]
120093085  Cd36-ps1; platelet glycoprotein 4-like [KO:K06259]
134486712  [KO:K06259]
140635  Flt3; receptor-type tyrosine-protein kinase FLT3 precursor [KO:K05092] [EC:2.7.10.1]
170921  Itga2; integrin alpha-2 precursor [KO:K06481]
171040  Il11; interleukin-11 precursor [KO:K05417]
171075  Fcer2; low affinity immunoglobulin epsilon Fc receptor isoform a [KO:K06468]
24335  Epo; erythropoietin precursor [KO:K05437]
24336  Epor; erythropoietin receptor precursor [KO:K05079]
24493  Il1a; interleukin-1 alpha [KO:K04383]
24494  Il1b; interleukin-1 beta [KO:K04519]
24495  Il3; interleukin-3 precursor [KO:K04736]
24497  Il5; interleukin-5 precursor [KO:K05428]
24498  Il6; interleukin-6 precursor [KO:K05405]
24499  Il6r; interleukin-6 receptor subunit alpha precursor [KO:K05055]
24500  Il9r; interleukin-9 receptor [KO:K05073]
24590  Mme; neprilysin [KO:K01389] [EC:3.4.24.11]
245983  Il11ra1; interleukin-11 receptor subunit alpha precursor [KO:K05056]
246144  Il3ra; interleukin-3 receptor subunit alpha precursor [KO:K04737]
24835  Tnf; tumor necrosis factor [KO:K03156]
24930  Cd8a; T-cell surface glycoprotein CD8 alpha chain precursor [KO:K06458]
24931  Cd8b; T-cell surface glycoprotein CD8 beta chain precursor [KO:K06459]
24932  Cd4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
24936  Cd9; CD9 antigen [KO:K06460]
24981  RT1-Db2; RT1 class II, locus Db2 precursor [KO:K06752]
24984  RT1-DOa; RT1 class II, locus DOa precursor [KO:K06752]
24986  RT1-Ha; RT1 class II, locus Ha precursor [KO:K06752]
25021  Itgam; integrin alpha-M precursor [KO:K06461]
25084  Il4r; interleukin-4 receptor subunit alpha precursor [KO:K05071]
25109  Cd1d1; antigen-presenting glycoprotein CD1d precursor [KO:K06448]
25118  Itga1; integrin alpha-1 precursor [KO:K06480]
25145  Cd24; signal transducer CD24 precursor [KO:K06469]
25259  Gp5; platelet glycoprotein V precursor [KO:K06260]
25406  Cd44; CD44 antigen precursor [KO:K06256]
25407  Cd59b; CD59 glycoprotein precursor [KO:K04008]
25610  Csf3; granulocyte colony-stimulating factor precursor [KO:K05423]
25647  Il7; interleukin-7 precursor [KO:K05431]
25663  Il1r1; interleukin-1 receptor type 1 precursor [KO:K04386]
25668  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
25704  Il2ra; interleukin-2 receptor subunit alpha precursor [KO:K05068]
25710  Cd3d; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450]
287287  Il4; interleukin-4 precursor [KO:K05430]
289395  Cr2; complement receptor type 2 precursor [KO:K04012]
29184  Cd36; platelet glycoprotein 4 [KO:K06259]
29185  Cd37; leukocyte antigen CD37 [KO:K06475]
29302  Itgb3; integrin beta-3 precursor [KO:K06493]
294051  Dntt; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
294269  RT1-Da; RT1 class II, locus Da precursor [KO:K06752]
294270  RT1-Db1; rano class II histocompatibility antigen, D-1 beta chain precursor [KO:K06752]
294273  RT1-DMb; RT1 class II, DM beta precursor [KO:K06752]
294274  RT1-DMa; RT1 class II, DM alpha precursor [KO:K06752]
294797  Il7r; interleukin-7 receptor subunit alpha precursor [KO:K05072]
295279  Fcgr1a; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
298518  Csf3r; granulocyte colony-stimulating factor receptor precursor [KO:K05061]
300678  Cd3g; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
303747  Cd7; T-cell antigen CD7 precursor [KO:K06457]
305081  Cd34; hematopoietic progenitor cell antigen CD34 isoform 1 precursor [KO:K06474]
307403  Csf1r; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
308501  Cd22; B-cell receptor CD22 precursor [KO:K06467]
309217  Ms4a1; B-lymphocyte antigen CD20 [KO:K06466]
309621  RT1-Ba; rano class II histocompatibility antigen, B alpha chain precursor [KO:K06752]
309622  RT1-Bb; rano class II histocompatibility antigen, B-1 beta chain precursor [KO:K06752]
311144  Itga4; integrin alpha-4 [KO:K06483]
315346  Itga5; integrin alpha-5 [KO:K06484]
315609  Cd3e; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
360606  Itga3; integrin alpha-3 isoform 1 [KO:K06482]
361584  Siglech; sialic acid binding Ig-like lectin H precursor [KO:K06473]
365367  Cd19; B-lymphocyte antigen CD19 precursor [KO:K06465]
365542  RT1-DOb; RT1 class II, DO beta isoform 1 [KO:K06752]
497761  Cd2; T-cell surface antigen CD2 precursor [KO:K06449]
499985  Cd36l1; CD36 molecule like 1 [KO:K06259]
502858  Gp9; platelet glycoprotein IX precursor [KO:K06263]
54236  Cd5; T-cell surface glycoprotein CD5 precursor [KO:K06455]
54243  Cr1l; complement component receptor 1-like protein isoform 2 precursor [KO:K04011]
60350  Cd14; monocyte differentiation antigen CD14 precursor [KO:K04391]
60427  Kitlg; kit ligand isoform 1 precursor [KO:K05461]
64030  Kit; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
64036  Cd55; complement decay-accelerating factor precursor [KO:K04006]
64678  Tfrc; transferrin receptor protein 1 [KO:K06503]
652957  Csf2ra; granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor [KO:K05066]
685269  Itga2b; integrin alpha-IIb precursor [KO:K06476]
688972  Gypa; glycophorin-A [KO:K06575]
690492  Cd33; myeloid cell surface antigen CD33 isoform X1 [KO:K06473]
691992  Gp1ba; platelet glycoprotein Ib alpha chain precursor [KO:K06261]
78965  Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
81641  Anpep; aminopeptidase N precursor [KO:K11140] [EC:3.4.11.2]
81811  Thpol1; thrombopoietin precursor [KO:K06854]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   

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