KEGG   PATHWAY: rro04620
Entry
rro04620                    Pathway                                
Name
Toll-like receptor signaling pathway - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
rro04620  Toll-like receptor signaling pathway
rro04620

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104653954  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
104654038  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654431  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
104655825  LBP; lipopolysaccharide-binding protein isoform X2 [KO:K05399]
104656469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104657182  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
104657273  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
104657448  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
104657616  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
104657888  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104658364  TRAF6; LOW QUALITY PROTEIN: TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104658520  TLR4; toll-like receptor 4 isoform X2 [KO:K10160]
104658748  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
104658750  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
104658873  CXCL8; LOW QUALITY PROTEIN: interleukin-8 [KO:K10030]
104660767  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104660769  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104661228  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
104661734  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
104661913  TNF; tumor necrosis factor isoform X1 [KO:K03156]
104661932  TLR5; toll-like receptor 5 isoform X1 [KO:K10168]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104662315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104662694  IRF9; interferon regulatory factor 9 [KO:K04693]
104662981  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104664204  [KO:K12964]
104664278  JUN; transcription factor AP-1 [KO:K04448]
104664341  TLR6; toll-like receptor 6 [KO:K10169]
104664342  TLR1; toll-like receptor 1 [KO:K05398]
104664488  LY96; lymphocyte antigen 96 [KO:K05400]
104664497  [KO:K05408]
104664613  SPP1; osteopontin [KO:K06250]
104664815  RELA; transcription factor p65 [KO:K04735]
104665012  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665406  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
104665487  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104665823  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104666046  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
104667046  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104667206  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
104667916  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
104668007  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104668074  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
104669104  IL12B; interleukin-12 subunit beta [KO:K05425]
104670273  [KO:K05414]
104670275  IFNA8; interferon alpha-8 [KO:K05414]
104670276  [KO:K05414]
104670278  IFNA6; interferon alpha-6 [KO:K05414]
104670280  [KO:K05414]
104670290  [KO:K05414]
104670292  [KO:K05414]
104670295  IFNB1; interferon beta [KO:K05415]
104670479  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104671864  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
104672345  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
104672547  IL1B; interleukin-1 beta [KO:K04519]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104673151  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
104673153  CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672]
104673156  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
104673676  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
104673812  TLR3; toll-like receptor 3 isoform X2 [KO:K05401]
104674441  IRF5; interferon regulatory factor 5 isoform X2 [KO:K09446]
104675233  IL6; interleukin-6 isoform X1 [KO:K05405]
104675282  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104676194  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104676257  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104677132  FADD; FAS-associated death domain protein [KO:K02373]
104677388  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
104677590  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
104677747  TLR2; toll-like receptor 2 [KO:K10159]
104678073  TLR8; toll-like receptor 8 isoform X1 [KO:K10170]
104678074  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
104678447  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104678467  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X3 [KO:K04432] [EC:2.7.12.2]
104678511  [KO:K12964]
104678812  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
104679497  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
104679596  CCL5; C-C motif chemokine 5 [KO:K12499]
104679802  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104680726  TOLLIP; toll-interacting protein [KO:K05402]
104680728  [KO:K05414]
104680828  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
104681068  CTSK; cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104681766  CD14; monocyte differentiation antigen CD14 [KO:K04391]
104682560  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
104682867  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104682868  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
104682894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
115893905  [KO:K04456] [EC:2.7.11.1]
115893964  [KO:K05414]
115893973  [KO:K05414]
115894708  [KO:K05408]
115894723  [KO:K05408]
115894851  [KO:K12964]
115894852  [KO:K05408]
115894914  [KO:K12964]
115897716  [KO:K04693]
115899261  [KO:K04404]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
rro04010  MAPK signaling pathway
rro04060  Cytokine-cytokine receptor interaction
rro04064  NF-kappa B signaling pathway
rro04120  Ubiquitin mediated proteolysis
rro04151  PI3K-Akt signaling pathway
rro04210  Apoptosis
rro04610  Complement and coagulation cascades
rro04630  JAK-STAT signaling pathway
KO pathway
ko04620   

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