KEGG   PATHWAY: sara04622
Entry
sara04622                   Pathway                                
Name
RIG-I-like receptor signaling pathway - Sorex araneus (European shrew)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
sara04622  RIG-I-like receptor signaling pathway
sara04622

Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101536840  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101536977  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101537410  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
101537598  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101537684  TKFC; bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
101537769  FADD; FAS-associated death domain protein [KO:K02373]
101538094  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
101538389  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101538553  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101538832  PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
101538970  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101539350  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
101539403  IL12A; interleukin-12 subunit alpha [KO:K05406]
101540064  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
101540333  ZNFX1; NFX1-type zinc finger-containing protein 1 [KO:K27391]
101540472  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101542348  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101542406  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101542553  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
101542768  IL12B; interleukin-12 subunit beta [KO:K05425]
101542890  IRF3; interferon regulatory factor 3 [KO:K05411]
101543078  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101543163  RELA; transcription factor p65 [KO:K04735]
101543216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101544346  TBKBP1; TANK-binding kinase 1-binding protein 1 [KO:K12652]
101545136  OTUD5; OTU domain-containing protein 5 [KO:K12655] [EC:3.4.19.12]
101545292  IRF7; interferon regulatory factor 7 [KO:K09447]
101545321  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101546102  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101548268  IFNB1; interferon beta [KO:K05415]
101548317  TMEM173; stimulator of interferon genes protein [KO:K12654]
101548536  [KO:K05440]
101549180  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
101549580  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101549593  [KO:K05414]
101549684  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X2 [KO:K08601] [EC:3.4.19.12]
101550002  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101550362  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
101550376  [KO:K05440]
101550636  IFNE; interferon epsilon [KO:K05442]
101550851  DHX58; probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]
101551021  RNF125; E3 ubiquitin-protein ligase RNF125 [KO:K12170] [EC:2.3.2.27]
101552345  AZI2; 5-azacytidine-induced protein 2 [KO:K12651]
101552797  NLRX1; NLR family member X1 [KO:K12653]
101552901  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101553112  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
101553146  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
101553986  [KO:K12159]
101554044  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101554394  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101555428  IFNK; interferon kappa [KO:K05441]
101556063  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556557  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556810  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101556886  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
101557300  DDX58; LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
101557571  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101557907  SIKE1; suppressor of IKBKE 1 [KO:K12656]
101558664  TNF; tumor necrosis factor [KO:K03156]
101559134  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
101559441  CXCL8; interleukin-8 [KO:K10030]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
sara04010  MAPK signaling pathway
sara04120  Ubiquitin mediated proteolysis
sara04210  Apoptosis
sara04630  JAK-STAT signaling pathway
KO pathway
ko04622   

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