KEGG   PATHWAY: setr04530
Entry
setr04530                   Pathway                                
Name
Tight junction - Suncus etruscus (white-toothed pygmy shrew)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
setr04530  Tight junction
setr04530

Other DBs
GO: 0005923
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
125994825  [KO:K04393]
125995104  CLDN5; claudin-5 [KO:K06087]
125996409  EZR; ezrin isoform X1 [KO:K08007]
125996484  CLDN20; claudin-20 [KO:K06087]
125996560  TJAP1; tight junction-associated protein 1 [KO:K06105]
125997101  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
125997373  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
125997463  CGN; cingulin [KO:K06102]
125998015  CLDN7; claudin-7 [KO:K06087]
125998029  MYH10; myosin-10 isoform X1 [KO:K10352]
125998649  CLDN2; claudin-2 [KO:K06087]
125998658  RAP2C; ras-related protein Rap-2c [KO:K07839]
125998704  [KO:K04393]
125999174  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
125999195  MSN; moesin [KO:K05763]
125999254  WAS; actin nucleation-promoting factor WAS [KO:K05747]
125999496  AMOT; angiomotin [KO:K16819]
126000044  PRKAA1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
126000882  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
126001165  TUBA4A; tubulin alpha-4A chain [KO:K07374]
126001170  [KO:K06109]
126001208  [KO:K07374]
126001286  CLDN6; claudin-6 [KO:K06087]
126001287  CLDN9; claudin-9 [KO:K06087]
126001499  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
126001501  OCLN; occludin [KO:K06088]
126001663  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
126001786  [KO:K10591] [EC:2.3.2.26]
126001850  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
126001937  [KO:K05762]
126001941  CLDN12; claudin-12 [KO:K06087]
126001964  [KO:K05756]
126002062  MPDZ; multiple PDZ domain protein [KO:K06095]
126003303  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
126003452  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
126003668  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
126003803  [KO:K12757]
126003804  [KO:K12757]
126003878  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
126003979  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
126004000  PALS1; protein PALS1 [KO:K06091]
126004516  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
126005813  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
126005915  BVES; blood vessel epicardial substance [KO:K21108]
126005939  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126006109  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
126006358  MYH9; myosin-9 [KO:K10352]
126006416  SYNPO; LOW QUALITY PROTEIN: synaptopodin [KO:K21112]
126006854  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
126006875  CLDN23; claudin-23 [KO:K06087]
126007178  [KO:K06087]
126007179  [KO:K06087]
126008779  RAB8B; ras-related protein Rab-8B [KO:K07902]
126008934  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
126009209  ACTR3; actin-related protein 3 [KO:K18584]
126009218  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
126009220  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
126009670  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
126010795  PATJ; inaD-like protein [KO:K06092]
126010846  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
126010865  CLDN11; claudin-11 [KO:K06087]
126010949  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
126010979  JUN; transcription factor Jun [KO:K04448]
126010983  PRKAA2; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
126011245  [KO:K07374]
126011282  CLDN19; claudin-19 [KO:K06087]
126011308  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
126012126  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
126012129  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
126012173  CLDN18; claudin-18 [KO:K06087]
126012176  CLDN1; claudin-1 [KO:K06087]
126012195  CLDN16; claudin-16 [KO:K06087]
126013230  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
126013289  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
126013353  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
126013498  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
126013539  ACTG1; actin, cytoplasmic 2 [KO:K05692]
126013654  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
126013868  F11R; junctional adhesion molecule A [KO:K06089]
126013907  [KO:K07374]
126013914  MAGI1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
126013943  ITGB1; integrin beta-1 [KO:K05719]
126013945  [KO:K05756]
126014129  RHOA; LOW QUALITY PROTEIN: transforming protein RhoA [KO:K04513]
126014825  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
126015545  AMOTL1; angiomotin-like protein 1 [KO:K06104]
126015663  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126015681  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
126015831  CLDN25; putative claudin-25 [KO:K06087]
126016114  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
126016130  RDX; radixin isoform X1 [KO:K05762]
126016165  CLDN10; claudin-10 isoform X1 [KO:K06087]
126016360  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
126016368  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
126017330  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
126017425  PCNA; proliferating cell nuclear antigen [KO:K04802]
126017460  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
126017958  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
126018296  [KO:K04802]
126018299  [KO:K04393]
126019056  CTTN; src substrate cortactin isoform X1 [KO:K06106]
126019074  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
126019150  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
126020123  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
126020327  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
126020566  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
126020693  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
126020754  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
126020797  RAB13; ras-related protein Rab-13 [KO:K06109]
126020954  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
126021813  TJP1; tight junction protein ZO-1 [KO:K05701]
126021872  LLGL2; LLGL scribble cell polarity complex component 2 [KO:K06094]
126022108  [KO:K07374]
126022235  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
126022266  [KO:K07374]
126022432  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
126022533  [KO:K07374]
126022562  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
126022618  TUBA8; tubulin alpha-8 chain [KO:K07374]
126022941  WHAMM; LOW QUALITY PROTEIN: WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
126023034  MYL6B; myosin light chain 6B [KO:K12751]
126023042  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
126023927  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
126024058  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
126024093  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
126024353  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
126024449  [KO:K06109]
126024665  [KO:K04393]
126024707  AFDN; afadin isoform X1 [KO:K05702]
126025610  CLDN14; claudin-14 [KO:K06087]
126025825  JAM2; junctional adhesion molecule B [KO:K06735]
126025898  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
126026065  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
126026097  CLDN8; claudin-8 [KO:K06087]
126026098  CLDN17; claudin-17 [KO:K06087]
126026136  TIAM1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
126026251  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
126027411  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
126027420  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
126027586  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
126027709  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
126027722  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
126027762  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
126027965  MYH14; myosin-14 isoform X1 [KO:K10352]
126027984  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
126028193  SYMPK; symplekin isoform X1 [KO:K06100]
126028574  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
126028736  [KO:K04393]
126029472  RAB8A; ras-related protein Rab-8A [KO:K07901]
126029587  CLDN15; claudin-15 [KO:K06087]
126029629  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
126029694  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
126030114  CRB3; protein crumbs homolog 3 [KO:K06090]
126030328  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126030444  ACTB; actin, cytoplasmic 1 [KO:K05692]
126030448  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
126030449  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
126030488  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126030507  TJP3; tight junction protein ZO-3 [KO:K06097]
126030514  MICALL2; MICAL-like protein 2 [KO:K21068]
126030586  NF2; merlin isoform X1 [KO:K16684]
126030640  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
126030661  [KO:K05756]
126030987  MYH11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
126030991  ARHGAP17; LOW QUALITY PROTEIN: rho GTPase-activating protein 17 [KO:K20638]
126031105  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
126031133  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
126031156  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
126031270  CLDN3; claudin-3 [KO:K06087]
126031273  CLDN4; claudin-4 [KO:K06087]
126032054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126033612  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
126033644  [KO:K07374]
126033690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126033730  [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
setr04520  Adherens junction
setr04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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