KEGG   PATHWAY: tpai04514
Entry
tpai04514                   Pathway                                
Name
Cell adhesion molecules - Tympanuchus pallidicinctus (lesser prairie-chicken)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
tpai04514  Cell adhesion molecules
tpai04514

Other DBs
GO: 0050839
Organism
Tympanuchus pallidicinctus (lesser prairie-chicken) [GN:tpai]
Gene
128071595  CLDN10; claudin-10 isoform X1 [KO:K06087]
128071708  CLDN34; claudin-34 isoform X1 [KO:K06087]
128071721  CD99; CD99 antigen isoform X1 [KO:K06520]
128071756  XG; glycoprotein Xg [KO:K06520]
128072108  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
128072258  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
128072266  SELP; P-selectin isoform X1 [KO:K06496]
128072384  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
128072675  SELE; E-selectin isoform X1 [KO:K06494]
128072761  NEGR1; neuronal growth regulator 1 isoform X1 [KO:K06775]
128072775  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
128072820  NTNG1; netrin-G1 isoform X1 [KO:K07522]
128072821  NRXN1; neurexin-1 isoform X1 [KO:K07377]
128072836  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
128072856  JAM2; junctional adhesion molecule B [KO:K06735]
128073101  NTNG2; netrin-G2 isoform X1 [KO:K16359]
128073490  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
128073785  CNTN1; contactin-1 [KO:K06759]
128074267  [KO:K06751]
128074272  [KO:K06752]
128074273  [KO:K06752]
128075448  NEO1; neogenin isoform X1 [KO:K06766]
128075458  CD276; CD276 antigen isoform X1 [KO:K06746]
128075862  CLDN2; claudin-2 [KO:K06087]
128075933  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
128076046  SLITRK4; SLIT and NTRK-like protein 4 isoform X1 [KO:K25835]
128076070  CD40LG; CD40 ligand [KO:K03161]
128076145  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
128076211  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
128076420  CLDN14; claudin-14 [KO:K06087]
128076433  [KO:K06087]
128076435  [KO:K06087]
128076501  [KO:K06710]
128076634  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
128076685  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
128076712  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
128076713  ICOS; inducible T-cell costimulator [KO:K06713]
128076714  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
128076949  ITGA4; integrin alpha-4 [KO:K06483]
128076982  ITGAV; integrin alpha-V [KO:K06487]
128077452  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
128079840  [KO:K06458]
128079851  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
128079883  [KO:K06087]
128079884  [KO:K06087]
128080254  CLDN23; claudin-23 [KO:K06087]
128080831  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
128081016  CDH4; cadherin-4 isoform X1 [KO:K06797]
128081162  SDC4; syndecan-4 isoform X1 [KO:K16338]
128081719  GLG1; Golgi apparatus protein 1 [KO:K06816]
128081763  CDH15; cadherin-15 [KO:K06809]
128081872  [KO:K06087]
128081933  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
128082077  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
128082161  CLDN18; claudin-18 [KO:K06087]
128082239  CLDN11; claudin-11 [KO:K06087]
128082496  CDH5; cadherin-5 [KO:K06533]
128082623  PDCD1; programmed cell death protein 1 [KO:K06744]
128082673  CLDN20; claudin-20 [KO:K06087]
128082825  CLDN16; claudin-16 [KO:K06087]
128082826  CLDN1; claudin-1 [KO:K06087]
128082962  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
128083470  [KO:K06087]
128083476  [KO:K06087]
128083531  [KO:K06087]
128083535  SDC1; syndecan-1 [KO:K06257]
128084662  CLDN5; claudin-5 [KO:K06087]
128084785  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
128085112  CLDN19; claudin-19 isoform X1 [KO:K06087]
128085131  [KO:K06087]
128085455  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
128085591  ITGA9; integrin alpha-9 [KO:K06585]
128085712  NRXN3; neurexin 3 isoform X1 [KO:K07377]
128085800  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
128085840  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
128086382  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
128087094  CD6; LOW QUALITY PROTEIN: T-cell differentiation antigen CD6 [KO:K06456]
128087318  CLDN12; claudin-12 [KO:K06087]
128087556  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
128087564  CLDN25; putative claudin-25 [KO:K06087]
128087585  NECTIN1; nectin-1 isoform X1 [KO:K06081]
128087616  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
128087651  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
128087668  [KO:K28137]
128087683  JAM3; junctional adhesion molecule C [KO:K06785]
128087768  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
128088077  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
128088220  NFASC; neurofascin [KO:K06757]
128088221  CNTN2; contactin-2 isoform X1 [KO:K06760]
128088479  SDC3; syndecan-3 isoform X1 [KO:K16337]
128088876  OCLN; occludin isoform X1 [KO:K06088]
128088960  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
128089107  CNTNAP1; contactin-associated protein 1 [KO:K07379]
128089247  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
128089258  [KO:K06708]
128089260  CD274; LOW QUALITY PROTEIN: programmed cell death 1 ligand 1 [KO:K06745]
128089271  VCAN; versican core protein isoform X1 [KO:K06793]
128089876  CD86; LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD86 [KO:K05413]
128089886  [KO:K06454]
128090375  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
128090381  ALCAM; CD166 antigen isoform X1 [KO:K06547]
128090755  SDC2; syndecan-2 [KO:K16336]
128090933  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
128091006  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
128091061  CD2; T-cell surface antigen CD2 [KO:K06449]
128091075  CD226; CD226 antigen isoform X1 [KO:K06567]
128091319  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
128091374  CDH2; cadherin-2 isoform X1 [KO:K06736]
128091568  IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
128091911  [KO:K10785]
128091986  [KO:K06752]
128091995  [KO:K06751]
128091996  [KO:K06751]
128091999  [KO:K06752]
128092000  [KO:K06752]
128092001  [KO:K06752]
128092002  [KO:K06752]
128092031  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
128092064  MPZ; myelin protein P0 [KO:K06770]
128092192  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
128092195  NECTIN3; nectin-3 isoform X1 [KO:K06592]
128092219  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
128092224  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
128092231  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
tpai04520  Adherens junction
tpai04530  Tight junction
KO pathway
ko04514   

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