KEGG    Network variation - Amyotrophic lateral sclerosis
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ENTRYnt06464
NameAmyotrophic lateral sclerosis
CategoryDisease view; Neurodegenerative disease
Pathwayhsa05014 Amyotrophic lateral sclerosis
DiseaseH00058 Amyotrophic lateral sclerosis
Display drug-target relation   disease type
Calcium signaling
N00984    GlutamateGRM5GNAQPLCBIP3ITPRCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N01151            SIGMAR1*ITPRCa2+MCUCa2+(mito)MPTPCYCS
 
Ubiquitin-proteasome system
N01029        (Protein+UB)26SPeptide
D1
 |
        
N01144    SOD1*DERL1(Protein+UB)26SPeptide
N01145      VCP*(Protein+UB)26SPeptide
N01146      UBQLN2*(Protein+UB)26SPeptide
 
Unfolded protein response (UPR) signaling
N01009        EIF2AK3EIF2S1ATF4DDIT3
D1
 |
          
N01149    SOD1*BIPEIF2AK3EIF2S1ATF4DDIT3
N01011        ERN1XBP1DDIT3
D1
 |
      
N01148    SOD1*BIPERN1XBP1
N01015        ATF6(DDIT3,XBP1,HSPA5)
N01150      VAPB*ATF6
D1
 |
      
N01147    SOD1*BIPATF6DDIT3
 
Autophagy
N01142    RAB1A(C9orf72+WDR41+SMC..ULK1_complex
N01143    RAB1A(C9orf72*+WDR41+SM..(ULK1+RB1CC1+ATG10..
 
Mitophagy
N01137    PINK1PRKN(CISD1,CISD2,FAF2,..=(SQSTM1,OPTN,NDP52..=LC3
N01138    PINK1PRKN(CISD1,CISD2,FAF2,..OPTN*
N01139    PINK1PRKN(CISD1,CISD2,FAF2,..SQSTM1*LC3
N01140    TBK1(SQSTM1,OPTN,NDP52..=LC3-II
N01141    TBK1*(SQSTM1,OPTN,NDP52..=LC3-II
 
Apoptosis
N00098    (PMAIP1,BBC3,BAD,B..(BCL2,BCL2L1)(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
D1
 |
            
N01135    SOD1*BCL2(BAX,BAK1)CYCS=APAF1CASP9CASP3
 
PI3K signaling
N01163    NRGERBB4PI3KPIP3AKT
N01164    NRGERBB4*
 
Oxidative phosphorylation
N00995    NADHCxIQ
N01136    TARDBP*CxIQ
 
Microtubule-based transport
N00976      (DCTN+DNAH+DNAI+DN..=(TUBA+TUBB)
D1
 |
  
N01160    SOD1*(DCTN+DNAH+DNAI+DN..
N01158      DCTN1*(TUBA+TUBB)
N01159      (DCTN+DNAH+DNAI+DN..TUBA4A*
 
Cytoskeletal regulation
N01161    Actin(monomeric)=PFN1Actin(filamentous)
N01162    Actin(monomeric)PFN1*Actin(filamentous)
 
RNA processing
N01154    mRNA(pre)TARDBPmRNA
N01155    mRNA(pre)TARDBP*mRNA
N01156    mRNA(pre)FUSmRNA
N01157    mRNA(pre)FUS*mRNA
N01152    (mRNA(nuclear)+CBP..(NPC+GLE1+DDX19B)(mRNA(cytoplasmic)..
N01153    (mRNA(nuclear)+CBP..(NPC+GLE1*+DDX19B)(mRNA(cytoplasmic)..


Drug name
D1D11811Tofersen (JAN/USAN/INN)