| Calcium signaling |
| N00984 |
Glutamate | → | GRM5 | → | GNAQ | → | PLCB | → | IP3 | → | ITPR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
| N01151 |
| | | | | | | | SIGMAR1* | → | ITPR | → | Ca2+ | − | MCU | → | Ca2+(mito) | − | MPTP | → | CYCS |
| | | |
| Ubiquitin-proteasome system |
| N01029 |
| | | | (Protein+UB) | − | 26S | → | Peptide |
| D1
| | | | | | | | | |
| N01144 |
SOD1* | ⊣ | DERL1 | → | (Protein+UB) | − | 26S | → | Peptide |
| N01145 |
| | VCP* | ⊣ | (Protein+UB) | − | 26S | → | Peptide |
| N01146 |
| | UBQLN2* | ⊣ | (Protein+UB) | − | 26S | → | Peptide |
| | | |
| Unfolded protein response (UPR) signaling |
| N01009 |
| | | | EIF2AK3 | → | EIF2S1 | → | ATF4 | ⇒ | DDIT3 |
| D1
| | | | | | | | | | | |
| N01149 |
SOD1* | ⊣ | BIP | ⊣ | EIF2AK3 | → | EIF2S1 | → | ATF4 | ⇒ | DDIT3 |
| N01011 |
| | | | ERN1 | → | XBP1 | ⇒ | DDIT3 |
| D1
| | | | | | | |
| N01148 |
SOD1* | ⊣ | BIP | ⊣ | ERN1 | → | XBP1 |
| N01015 |
| | | | ATF6 | ⇒ | (DDIT3,XBP1,HSPA5) |
| N01150 |
| | VAPB* | ⊣ | ATF6 |
| D1
| | | | | | | |
| N01147 |
SOD1* | ⊣ | BIP | ⊣ | ATF6 | ⇒ | DDIT3 |
| | | |
| Autophagy |
| N01142 |
RAB1A | → | (C9orf72+WDR41+SMC.. | → | ULK1_complex |
| N01143 |
RAB1A | ⌿ | (C9orf72*+WDR41+SM.. | ⌿ | (ULK1+RB1CC1+ATG10.. |
| | | |
| Mitophagy |
| N01137 |
PINK1 | → | PRKN | → | (CISD1,CISD2,FAF2,.. | = | (SQSTM1,OPTN,NDP52.. | = | LC3 |
| N01138 |
PINK1 | → | PRKN | → | (CISD1,CISD2,FAF2,.. | ⌿ | OPTN* |
| N01139 |
PINK1 | → | PRKN | → | (CISD1,CISD2,FAF2,.. | ⌿ | SQSTM1* | ⌿ | LC3 |
| N01140 |
TBK1 | → | (SQSTM1,OPTN,NDP52.. | = | LC3-II |
| N01141 |
TBK1* | ⌿ | (SQSTM1,OPTN,NDP52.. | = | LC3-II |
| | | |
| Apoptosis |
| N00098 |
(PMAIP1,BBC3,BAD,B.. | ⊣ | (BCL2,BCL2L1) | ⊣ | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
| D1
| | | | | | | | | | | | | |
| N01135 |
SOD1* | ⊣ | BCL2 | ⊣ | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | CASP3 |
| | | |
| PI3K signaling |
| N01163 |
NRG | → | ERBB4 | → | PI3K | → | PIP3 | → | AKT |
| N01164 |
NRG | ⌿ | ERBB4* |
| | | |
| Oxidative phosphorylation |
| N00995 |
NADH | − | CxI | → | Q |
| N01136 |
TARDBP* | ⊣ | CxI | → | Q |
| | | |
| Microtubule-based transport |
| N00976 |
| | (DCTN+DNAH+DNAI+DN.. | = | (TUBA+TUBB) |
| D1
| | | |
| N01160 |
SOD1* | ⊣ | (DCTN+DNAH+DNAI+DN.. |
| N01158 |
| | DCTN1* | ⌿ | (TUBA+TUBB) |
| N01159 |
| | (DCTN+DNAH+DNAI+DN.. | ⌿ | TUBA4A* |
| | | |
| Cytoskeletal regulation |
| N01161 |
Actin(monomeric) | = | PFN1 | → | Actin(filamentous) |
| N01162 |
Actin(monomeric) | ⌿ | PFN1* | ⌿ | Actin(filamentous) |
| | | |
| RNA processing |
| N01154 |
mRNA(pre) | − | TARDBP | → | mRNA |
| N01155 |
mRNA(pre) | ⌿ | TARDBP* | ⌿ | mRNA |
| N01156 |
mRNA(pre) | − | FUS | → | mRNA |
| N01157 |
mRNA(pre) | − | FUS* | ⌿ | mRNA |
| N01152 |
(mRNA(nuclear)+CBP.. | − | (NPC+GLE1+DDX19B) | → | (mRNA(cytoplasmic).. |
| N01153 |
(mRNA(nuclear)+CBP.. | ⌿ | (NPC+GLE1*+DDX19B) | ⌿ | (mRNA(cytoplasmic).. |
|
Network variation - Amyotrophic lateral sclerosis