KEGG   PATHWAY: biu04921
Entry
biu04921                    Pathway                                
Name
Oxytocin signaling pathway - Bos indicus (zebu cattle)
Description
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation.
Class
Organismal Systems; Endocrine system
Pathway map
biu04921  Oxytocin signaling pathway
biu04921

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109567741  OXT; oxytocin-neurophysin 1 [KO:K05243]
109576336  OXTR; oxytocin receptor [KO:K04229]
109562978  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
109560940  GTPase HRas-like [KO:K02833]
109559581  KRAS; GTPase KRas isoform X1 [KO:K07827]
109555890  NRAS; GTPase NRas [KO:K07828]
109576053  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109564697  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109561751  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109578667  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109570973  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109570696  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109564977  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
109564980  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
109564981  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
109564982  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
109570734  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
109564709  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
109574161  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
109556235  JUN; transcription factor AP-1 [KO:K04448]
109565363  FOS; proto-oncogene c-Fos [KO:K04379]
109562320  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
109554439  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
109555031  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
109553606  RYR2; ryanodine receptor 2 [KO:K04962]
109564326  RYR3; ryanodine receptor 3 [KO:K04963]
109560687  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
109561012  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
109574141  KCNJ2; inward rectifier potassium channel 2 [KO:K04996]
109573917  KCNJ12; LOW QUALITY PROTEIN: ATP-sensitive inward rectifier potassium channel 12 [KO:K05005]
109571775  KCNJ14; ATP-sensitive inward rectifier potassium channel 14 [KO:K05007]
109554384  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
109567852  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
109567854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
109564927  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
109573366  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
109578560  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109572998  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
109578373  EEF2K; eukaryotic elongation factor 2 kinase isoform X1 [KO:K08292] [EC:2.7.11.20]
109561756  EEF2; LOW QUALITY PROTEIN: elongation factor 2 [KO:K03234]
109558615  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
109576190  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109554975  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
109574047  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
109567989  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
109559157  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
109567608  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
109557331  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
109575879  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
109575867  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
109558613  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
109574221  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
109558790  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
109578260  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
109573367  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
109574234  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
109572794  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
109573007  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
109571845  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
109576135  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
109558547  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
109576552  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
109565417  CALM1; calmodulin [KO:K02183]
109575003  calmodulin-alpha-like [KO:K02183]
109566056  CALM2; calmodulin [KO:K02183]
109568081  calmodulin-like [KO:K02183]
109570679  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
109572535  CALM3; calmodulin isoform X1 [KO:K02183]
109564712  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
109563107  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109553732  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109560300  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109566227  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
109563306  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
109577750  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109567554  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
109572084  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109564198  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
109557438  regulator of G-protein signaling 2-like [KO:K18154]
109570661  RGS2; regulator of G-protein signaling 2 [KO:K18154]
109563480  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
109571288  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
109574812  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
109556244  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
109574695  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
109555847  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
109571380  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
109570727  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
109557811  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
109559147  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
109567581  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
109576206  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
109570799  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
109553698  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109560236  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109557541  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109562200  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
109557793  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
109570022  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
109571318  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
109566993  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
109570892  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
109570893  uncharacterized protein LOC109570893 [KO:K12319] [EC:4.6.1.2]
109570145  NPPA; natriuretic peptides A [KO:K12334]
109554550  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
109563021  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
109577322  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
109567347  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
109572727  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
109559372  MYL6B; myosin light chain 6B [KO:K12751]
109559373  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
109567416  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
109573916  ACTG1; actin, cytoplasmic 2 [KO:K05692]
109578544  ACTB; actin, cytoplasmic 1 [KO:K05692]
109576171  RHOA; transforming protein RhoA [KO:K04513]
109577829  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109566382  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
109554414  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109571193  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
109566263  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109558936  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109571856  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
109567291  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
109567292  neuroendocrine secretory protein 55 [KO:K04632]
109557525  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
109574822  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
109566330  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
109564199  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
109555842  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
109559159  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
109572478  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
109568647  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
109578364  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
109556827  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
109561498  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109557337  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
109576257  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
109555970  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
109572786  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
109557383  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
109574415  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
109573250  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
109567428  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
109567564  KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
109564739  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
109578735  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
109554202  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
109576048  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109577247  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C13050  Cyclic ADP-ribose
Reference
PMID:18655881
  Authors
Devost D, Wrzal P, Zingg HH
  Title
Oxytocin receptor signalling.
  Journal
Prog Brain Res 170:167-76 (2008)
DOI:10.1016/S0079-6123(08)00415-9
Reference
PMID:20626426
  Authors
Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G
  Title
REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.
  Journal
CNS Neurosci Ther 16:e138-56 (2010)
DOI:10.1111/j.1755-5949.2010.00185.x
Reference
PMID:21981277
  Authors
Gutkowska J, Jankowski M
  Title
Oxytocin revisited: its role in cardiovascular regulation.
  Journal
J Neuroendocrinol 24:599-608 (2012)
DOI:10.1111/j.1365-2826.2011.02235.x
Reference
PMID:22190926
  Authors
Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z
  Title
The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.
  Journal
Int J Endocrinol 2011:350546 (2011)
DOI:10.1155/2011/350546
Reference
PMID:19840865
  Authors
Tom N, Assinder SJ
  Title
Oxytocin in health and disease.
  Journal
Int J Biochem Cell Biol 42:202-5 (2010)
DOI:10.1016/j.biocel.2009.10.008
Reference
PMID:9575824
  Authors
Strakova Z, Copland JA, Lolait SJ, Soloff MS
  Title
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
  Journal
Am J Physiol 274:E634-41 (1998)
DOI:10.1152/ajpendo.1998.274.4.E634
Reference
PMID:12009385
  Authors
Slater DM, Zervou S, Thornton S
  Title
Prostaglandins and prostanoid receptors in human pregnancy and parturition.
  Journal
J Soc Gynecol Investig 9:118-24 (2002)
Reference
PMID:16787565
  Authors
Shmygol A, Gullam J, Blanks A, Thornton S
  Title
Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility.
  Journal
Acta Pharmacol Sin 27:827-32 (2006)
DOI:10.1111/j.1745-7254.2006.00393.x
Reference
PMID:11861513
  Authors
Tahara M, Morishige K, Sawada K, Ikebuchi Y, Kawagishi R, Tasaka K, Murata Y
  Title
RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction.
  Journal
Endocrinology 143:920-9 (2002)
DOI:10.1210/endo.143.3.8696
Reference
PMID:12433531
  Authors
Slattery MM, Morrison JJ
  Title
Preterm delivery.
  Journal
Lancet 360:1489-97 (2002)
DOI:10.1016/S0140-6736(02)11476-0
Reference
PMID:22902539
  Authors
Pont JN, McArdle CA, Lopez Bernal A
  Title
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
  Journal
Mol Endocrinol 26:1743-56 (2012)
DOI:10.1210/me.2012-1057
Reference
PMID:9326674
  Authors
Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM
  Title
Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart.
  Journal
Proc Natl Acad Sci U S A 94:11704-9 (1997)
DOI:10.1073/pnas.94.21.11704
Reference
PMID:14715914
  Authors
Antunes-Rodrigues J, de Castro M, Elias LL, Valenca MM, McCann SM
  Title
Neuroendocrine control of body fluid metabolism.
  Journal
Physiol Rev 84:169-208 (2004)
DOI:10.1152/physrev.00017.2003
Reference
PMID:18555543
  Authors
Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH
  Title
Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.
  Journal
Regul Pept 151:71-4 (2008)
DOI:10.1016/j.regpep.2008.05.001
Reference
PMID:9219843
  Authors
Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G
  Title
Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A.
  Journal
Int J Cancer 72:340-4 (1997)
DOI:10.1002/(SICI)1097-0215(19970717)72:2<340::AID-IJC23>3.0.CO;2-I
Reference
PMID:23356278
  Authors
Busnelli M, Peverelli E, Mantovani G, Spada A, Chini B
  Title
Deciphering the specific role of G(alphai/o) isoforms: functional selective oxytocin ligands and somatostatin SST5 receptor mutants.
  Journal
Biochem Soc Trans 41:166-71 (2013)
DOI:10.1042/BST20120306
Reference
PMID:16966388
  Authors
Reversi A, Rimoldi V, Brambillasca S, Chini B
  Title
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
  Journal
Am J Physiol Regul Integr Comp Physiol 291:R861-9 (2006)
DOI:10.1152/ajpregu.00333.2006
Reference
PMID:20141572
  Authors
Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H
  Title
CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.
  Journal
J Neuroendocrinol 22:380-92 (2010)
DOI:10.1111/j.1365-2826.2010.01970.x
Reference
PMID:22227279
  Authors
Higashida H, Yokoyama S, Kikuchi M, Munesue T
  Title
CD38 and its role in oxytocin secretion and social behavior.
  Journal
Horm Behav 61:351-8 (2012)
DOI:10.1016/j.yhbeh.2011.12.011
Reference
PMID:23335873
  Authors
Lopatina O, Inzhutova A, Salmina AB, Higashida H
  Title
The roles of oxytocin and CD38 in social or parental behaviors.
  Journal
Front Neurosci 6:182 (2012)
DOI:10.3389/fnins.2012.00182
Reference
PMID:16156781
  Authors
Guse AH
  Title
Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
  Journal
FEBS J 272:4590-7 (2005)
DOI:10.1111/j.1742-4658.2005.04863.x
Related
pathway
biu00590  Arachidonic acid metabolism
biu04010  MAPK signaling pathway
biu04020  Calcium signaling pathway
biu04110  Cell cycle
KO pathway
ko04921   
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