KEGG   PATHWAY: biu04010
Entry
biu04010                    Pathway                                
Name
MAPK signaling pathway - Bos indicus (zebu cattle)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
biu04010  MAPK signaling pathway
biu04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109553030  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
109553086  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109553142  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109553192  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109553304  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109553316  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
109553353  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
109553379  FGF20; fibroblast growth factor 20 [KO:K04358]
109553451  ANGPT2; angiopoietin-2 [KO:K05466]
109553526  VEGFC; vascular endothelial growth factor C [KO:K05449]
109553555  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109553732  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109553755  EFNA1; ephrin-A1 [KO:K05462]
109553773  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109553774  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
109553783  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
109553788  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
109553877  MAP3K21; mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
109554073  [KO:K12361]
109554117  VEGFB; vascular endothelial growth factor B [KO:K16858]
109554123  [KO:K04414] [EC:2.7.11.1]
109554125  [KO:K12361]
109554126  [KO:K04414] [EC:2.7.11.1]
109554150  FGF19; fibroblast growth factor 19 [KO:K22603]
109554163  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109554256  [KO:K04358]
109554270  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
109554335  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
109554336  INS; insulin isoform X1 [KO:K04526]
109554392  RELA; transcription factor p65 [KO:K04735]
109554525  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109554595  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
109554692  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
109554975  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
109555011  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
109555027  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
109555031  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
109555118  FLNA; filamin-A [KO:K04437]
109555127  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
109555285  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
109555471  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
109555562  FGF16; fibroblast growth factor 16 [KO:K04358]
109555882  NGF; beta-nerve growth factor [KO:K02582]
109555890  NRAS; GTPase NRas [KO:K07828]
109555931  RAP1A; ras-related protein Rap-1A [KO:K04353]
109555962  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
109556175  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109556176  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109556235  JUN; transcription factor AP-1 [KO:K04448]
109556334  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
109556715  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
109556725  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109556827  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
109556891  ARTN; artemin [KO:K25415]
109557274  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
109557331  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
109557411  MET; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109557698  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109557878  HGF; hepatocyte growth factor [KO:K05460]
109558333  KITLG; kit ligand [KO:K05461]
109558403  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
109558613  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
109558615  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
109558630  [KO:K17386]
109558631  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
109558790  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
109558960  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109559030  MAP3K12; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
109559075  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
109559157  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
109559201  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
109559223  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
109559248  RAP1B; ras-related protein Rap-1b [KO:K07836]
109559326  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
109559378  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
109559448  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109559531  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109559581  KRAS; GTPase KRas isoform X1 [KO:K07827]
109559646  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109559667  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
109559729  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109559734  NTF3; neurotrophin-3 [KO:K04356]
109559742  FGF6; fibroblast growth factor 6 [KO:K04358]
109559743  FGF23; fibroblast growth factor 23 [KO:K22428]
109559825  [KO:K17386]
109559827  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
109559832  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109559860  MRAS; ras-related protein M-Ras [KO:K07831]
109559983  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
109560175  AREG; amphiregulin [KO:K09782]
109560296  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109560300  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109560308  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
109560475  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109560477  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109560478  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
109560583  EREG; proepiregulin [KO:K09784]
109560650  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109560724  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109560900  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
109560940  [KO:K02833]
109560948  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
109561058  FGF22; fibroblast growth factor 22 [KO:K04358]
109561127  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
109561209  PSPN; persephin [KO:K25416]
109561327  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109561331  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109561413  JUND; transcription factor jun-D [KO:K04449]
109561498  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109561546  [KO:K04347]
109561627  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
109561711  NRTN; neurturin [KO:K25414]
109561751  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109561788  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109561807  MKNK2; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
109561893  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109561985  EFNA2; ephrin-A2 [KO:K05462]
109562104  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
109562156  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109562194  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109562197  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109562314  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
109562320  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
109562374  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
109562825  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
109563078  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
109563107  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109563216  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
109563283  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109563306  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
109563601  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
109563902  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
109563980  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
109564026  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109564113  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
109564346  SOS2; son of sevenless homolog 2 [KO:K03099]
109564697  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109564709  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
109564913  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
109564977  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
109564980  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
109564981  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
109564982  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
109565142  FGF7; fibroblast growth factor 7 [KO:K04358]
109565218  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
109565255  MAX; protein max isoform X1 [KO:K04453]
109565306  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
109565311  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
109565356  PGF; placenta growth factor isoform X1 [KO:K16859]
109565363  FOS; proto-oncogene c-Fos [KO:K04379]
109565371  TGFB3; transforming growth factor beta-3 [KO:K13377]
109565420  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
109565501  MAP4K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
109565502  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
109565742  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109565956  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
109565967  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
109565970  [KO:K03175] [EC:2.3.2.27]
109566002  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109566008  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
109566034  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
109566132  IL1A; interleukin-1 alpha [KO:K04383]
109566133  IL1B; interleukin-1 beta [KO:K04519]
109566227  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
109566270  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
109566425  MAP3K20; mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
109566626  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109566823  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
109567013  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
109567047  FGF9; fibroblast growth factor 9 [KO:K04358]
109567187  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
109567329  ANGPT4; angiopoietin-4 [KO:K05467]
109567475  STK4; serine/threonine-protein kinase 4 [KO:K04411]
109567608  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
109567989  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
109568007  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
109568496  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
109568594  MYC; myc proto-oncogene protein [KO:K04377]
109568635  ANGPT1; angiopoietin-1 [KO:K05465]
109569050  MAPK8IP1; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
109569212  BDNF; brain-derived neurotrophic factor [KO:K04355]
109569622  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
109569642  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
109569777  RRAS2; ras-related protein R-Ras2 [KO:K07830]
109569805  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
109570101  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
109570286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109570445  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
109570480  [KO:K04389]
109570509  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
109570696  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109570739  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
109570785  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109570879  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
109570973  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109570977  CRKL; crk-like protein [KO:K04438]
109571167  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
109571249  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
109571368  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
109571395  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
109571845  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
109571969  NTF4; neurotrophin-4 [KO:K12457]
109571970  [KO:K12457]
109571998  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
109572074  FGF21; fibroblast growth factor 21 [KO:K22429]
109572084  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109572222  RRAS; ras-related protein R-Ras [KO:K07829]
109572496  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109572519  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109572550  [KO:K04460] [EC:3.1.3.16]
109572644  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
109572794  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
109572800  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
109572866  TGFB1; transforming growth factor beta-1 [KO:K13375]
109572909  RELB; transcription factor RelB [KO:K09253]
109572992  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
109572998  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
109573007  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
109573153  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
109573187  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
109573366  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
109573367  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
109573377  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
109573385  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
109573611  STMN1; stathmin [KO:K04381]
109573661  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
109573732  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
109573821  ARRB2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
109573844  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109573847  CRK; adapter molecule crk isoform X1 [KO:K04438]
109573853  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109573969  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
109573971  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
109574040  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
109574047  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
109574056  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
109574074  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
109574100  CDC42; cell division control protein 42 homolog [KO:K04393]
109574161  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
109574182  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
109574221  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
109574234  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
109574238  TP53; cellular tumor antigen p53 [KO:K04451]
109574240  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
109574290  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109574393  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109574718  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
109574889  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
109574921  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
109575026  FGF18; fibroblast growth factor 18 [KO:K04358]
109575031  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
109575038  FGF10; fibroblast growth factor 10 [KO:K04358]
109575129  [KO:K05087] [EC:2.7.10.1]
109575777  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
109575867  [KO:K04860]
109575879  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
109576048  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109576053  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109576148  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109576190  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109576279  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
109576294  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109576356  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
109576576  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
109576585  DAXX; death domain-associated protein 6 [KO:K02308]
109576924  SRF; serum response factor [KO:K04378]
109577010  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109577025  [KO:K03283]
109577026  [KO:K03283]
109577419  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
109577428  TNF; tumor necrosis factor [KO:K03156]
109577750  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109578051  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
109578169  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
109578192  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109578204  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109578226  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
109578260  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
109578402  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
109578560  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109578611  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109578667  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109578689  HSPB1; heat shock protein beta-1 [KO:K04455]
109579084  FGF8; fibroblast growth factor 8 [KO:K04358]
109579171  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
biu04070  Phosphatidylinositol signaling system
biu04110  Cell cycle
biu04115  p53 signaling pathway
biu04210  Apoptosis
biu04310  Wnt signaling pathway
biu04668  TNF signaling pathway
KO pathway
ko04010   

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