KEGG ORTHOLOGY: K25428

ORTHOLOGY: K25428

Entry

K25428                      KO

Symbol

LGI1

Name

leucine-rich repeat LGI family member 1

Disease

H00809

Familial epilepsy temporal lobe (ETL)

Brite

KEGG Orthology (KO) [BR:ko00001]
09190 Not Included in Pathway or Brite
  09193 Unclassified: signaling and cellular processes
   99995 Signaling proteins
    K25428  LGI1; leucine-rich repeat LGI family member 1

Genes

HSA:	9211(LGI1)

PTR:	450619(LGI1)

PPS:	100991781(LGI1)

GGO:	101147759(LGI1)

PON:	100172937(LGI1)

PPYG:

129006643(LGI1)

NLE:	100597927(LGI1)

HMH:	116457367(LGI1)

SSYN:

129469018(LGI1)

MCC:	700520(LGI1)

MCF:	102139711(LGI1)

MTHB:

126962026

MNI:	105480022(LGI1)

CSAB:

103216283(LGI1)

CATY:

105587046(LGI1)

PANU:

101016826(LGI1)

TGE:	112631434(LGI1)

MLEU:

105545519(LGI1)

RRO:	104658027(LGI1)

RBB:	108532606(LGI1)

TFN:	117091938(LGI1)

PTEH:

111552199(LGI1)

CANG:

105506239(LGI1)

CJC:	100415038(LGI1)

SBQ:	101045106(LGI1)

CIMI:

108282291(LGI1)

ANAN:

105718952(LGI1)

CSYR:

103253981(LGI1)

MMUR:

105872263(LGI1)

LCAT:

123649629(LGI1)

PCOQ:

105822666(LGI1)

OGA:

105886341

MMU:	56839(Lgi1)

MCAL:

110285653(Lgi1)

MPAH:

110327032(Lgi1)

RNO:	252892(Lgi1)

MCOC:

116103805(Lgi1)

ANU:	117697906(Lgi1)

ASYL:

127677268(Lgi1)

MUN:	110558285(Lgi1)

CGE:	100753918(Lgi1)

MAUA:

101833713(Lgi1)

PROB:

127233318(Lgi1)

PLEU:

114702460(Lgi1)

MORG:

121454326(Lgi1)

MFOT:

126511911

AAMP:

119799845(Lgi1)

NGI:	103750133(Lgi1)

HGL:	101703526(Lgi1)

CPOC:

100726518(Lgi1)

CCAN:

109689972(Lgi1)

DORD:

105999369(Lgi1)

DSP:	122115912(Lgi1)

PLOP:

125342956(Lgi1)

NCAR:

124984449

MMMA:

107154494(Lgi1)

ITI:	101975991(Lgi1)

OCU:

100344253

OPI:	101530758(LGI1)

TUP:	102497227(LGI1)

GVR:	103594711(LGI1)

CLUD:

112672087(LGI1)

VVP:	112913956(LGI1)

VLG:	121485724(LGI1)

NPO:	129493623(LGI1)

AML:	100479811(LGI1)

UMR:	103667969(LGI1)

UAH:	113243181(LGI1)

UAR:	123800348(LGI1)

ELK:

111145230

LLV:

125084565

MPUF:

101690630(LGI1)

MNP:	132016637(LGI1)

MLK:	131828632(LGI1)

NVS:	122900939(LGI1)

ORO:	101369075(LGI1)

EJU:	114205419(LGI1)

ZCA:	113923681(LGI1)

MLX:	118023881(LGI1)

NSU:	110589338(LGI1)

LWW:	102727235(LGI1)

FCA:	101088030(LGI1)

PYU:	121037016(LGI1)

PCOO:

112854558(LGI1)

PBG:	122493045(LGI1)

PVIV:

125147984(LGI1)

LRUF:

124506698

LGF:	123576845(LGI1)

AJU:

106965828

PTG:	102956754(LGI1)

PPAD:

109264675(LGI1)

PUC:

125933404

PLEZ:

122202166(LGI1)

HHV:	120230601(LGI1)

BTA:	617080(LGI1)

BOM:	102268786(LGI1)

BIU:	109553224(LGI1)

BBUB:

102411638(LGI1)

BBIS:

104990192(LGI1)

CHX:	102178505(LGI1)

OAS:	101105294(LGI1)

BTAX:

128067887(LGI1)

CSUM:

138070413(LGI1)

ODA:	120873710(LGI1)

CCAD:

122446120(LGI1)

MREE:

136158232(LGI1)

OVR:	110147254(LGI1)

MBEZ:

129555530(LGI1)

SSC:	100157335(LGI1)

CFR:	102523071(LGI1)

CBAI:

105081819(LGI1)

CDK:	105084244(LGI1)

VPC:	102543150(LGI1)

BACU:

103020727(LGI1)

BMUS:

118882546(LGI1)

LVE:	103079578(LGI1)

OOR:	101279840(LGI1)

LALB:

132506770(LGI1)

DLE:	111172476(LGI1)

PCAD:

102982541(LGI1)

PSIU:

116741689(LGI1)

NASI:

112396054(LGI1)

ECB:	100061710(LGI1)

EPZ:	103551256(LGI1)

EAI:	106845098(LGI1)

MYB:	102241120(LGI1)

MYD:	102755230(LGI1)

MMYO:

118669946(LGI1)

MLF:	102441933(LGI1)

MDT:	132215018(LGI1)

MYUM:

139021878(LGI1)

PKL:	118719312(LGI1)

EFUS:

103300036(LGI1)

MNA:	107543293(LGI1)

DRO:	112307399(LGI1)

SHON:

118987997(LGI1)

AJM:	119057747(LGI1)

PDIC:

114498025(LGI1)

PHAS:

123828902(LGI1)

MMF:	118632323(LGI1)

PPAM:

129070027(LGI1)

HAI:	109380948(LGI1)

RFQ:	117035816(LGI1)

PALE:

102893060(LGI1)

PGIG:

120609289(LGI1)

PVP:	105293066(LGI1)

RAY:	107520446(LGI1)

MJV:	108408188(LGI1)

TOD:	119233742(LGI1)

SARA:

101543112(LGI1)

SFUM:

130038581(LGI1)

SETR:

126033832(LGI1)

LAV:	100677728(LGI1)

TMU:

101344682

ETF:	101657291(LGI1)

DNM:	101437193(LGI1)

MDO:	100017973(LGI1)

GAS:	123238223(LGI1)

SHR:	100934294(LGI1)

AFZ:

127551715

PCW:	110192804(LGI1)

TVP:	118827840(LGI1)

PBRV:

138169627(LGI1)

OAA:	103165899(LGI1)

TACU:

119943455(LGI1)

GGA:	423802(LGI1)

PCOC:

116231774(LGI1)

MGP:	100540330(LGI1)

CJO:	107316060(LGI1)

TPAI:

128078082(LGI1)

LMUT:

125692930(LGI1)

NMEL:

110399338(LGI1)

APLA:

101794361(LGI1)

ACYG:

106041699(LGI1)

CATA:

118244723(LGI1)

AFUL:

116491299(LGI1)

TGU:	100219007(LGI1)

LSR:	110475481(LGI1)

SCAN:

103813921(LGI1)

PMOA:

120501982(LGI1)

OTC:	121341736(LGI1)

PRUF:

121350156(LGI1)

ATRC:

139595625(LGI1)

GFR:	102031869(LGI1)

FAB:	101810423(LGI1)

OMA:	130255103(LGI1)

PHI:	102105055(LGI1)

PMAJ:

107206864(LGI1)

CCAE:

111945584(LGI1)

CCW:	104696300(LGI1)

CBRC:

103624509(LGI1)

ACOE:

138112486(LGI1)

ETL:	114071526(LGI1)

ZAB:	102070041(LGI1)

ZLE:	135449851(LGI1)

ACHL:

103800499(LGI1)

SVG:	106852635(LGI1)

MMEA:

130582547(LGI1)

HRT:	120755623(LGI1)

SATI:

136364165(LGI1)

CCIC:

134046118(LGI1)

FPG:	101916993(LGI1)

FCH:	102052464(LGI1)

CCRI:

104163885(LGI1)

NNT:	104400236(LGI1)

SHAB:

115609139(LGI1)

ACUN:

113481446(LGI1)

TALA:

104357540(LGI1)

ACHC:

115348488(LGI1)

HALD:

104311168(LGI1)

HLE:	104830172(LGI1)

AGEN:

126042476

HHAR:

128147393(LGI1)

GCL:

127017520

CSTI:

104551033(LGI1)

LDI:	104340955(LGI1)

MNB:	103779244(LGI1)

DPUB:

104297739(LGI1)

PPUS:

135176075(LGI1)

AVIT:

104278590(LGI1)

BRHI:

104494929(LGI1)

EGZ:	104129162(LGI1)

NNI:	104013013(LGI1)

PCRI:

104025451(LGI1)

PCAO:

104047718(LGI1)

PADL:

103926001(LGI1)

AFOR:

103897661(LGI1)

FGA:	104073334(LGI1)

GSTE:

104251672(LGI1)

CBOY:

140644969 140655317(LGI1)

CLV:	102091996(LGI1)

MUI:	104544466(LGI1)

PGUU:

104467193(LGI1)

PLET:

104624616(LGI1)

EHS:	104514224(LGI1)

CMAC:

104477428(LGI1)

CUCA:

104067864(LGI1)

TEO:	104384543(LGI1)

BREG:

104630316(LGI1)

OHA:	104330449(LGI1)

ACAR:

104526255(LGI1)

CPEA:

104390833(LGI1)

CVF:	104289706(LGI1)

RTD:	128910917(LGI1)

CRID:

134517858(LGI1)

AAM:	106491523(LGI1)

AROW:

112966505(LGI1)

NPD:	112957442(LGI1)

TGT:	104564727(LGI1)

DNE:	112979755(LGI1)

SCAM:

104145980(LGI1)

ASN:	102375225(LGI1)

AMJ:	106737167(LGI1)

CPOO:

109324079(LGI1)

GGN:	109287493(LGI1)

PSS:	102462622(LGI1)

CMY:	102943019(LGI1)

CCAY:

125640169(LGI1)

DCC:	119858721(LGI1)

CPIC:

101945926(LGI1)

TST:	117880797(LGI1)

CABI:

116832407(LGI1)

MRV:	120369564(LGI1)

ACS:	100552473(lgi1)

ASAO:

132771095(LGI1) 132783376

PVT:	110073600(LGI1)

SUND:

121927111(LGI1)

PBI:	103060657(LGI1)

PMUR:

107293537(LGI1)

CTIG:

120304912(LGI1)

TSR:

106553079

PGUT:

117673186(LGI1)

APRI:

131201096(LGI1)

PTEX:

113442801(LGI1)

NSS:	113414055(LGI1)

VKO:	123018244(LGI1)

PMUA:

114597325(LGI1)

PRAF:

128414052(LGI1)

ZVI:	118096304(LGI1)

HCG:	128352044(LGI1)

GJA:	107106481(LGI1)

STOW:

125437956(LGI1)

EMC:	129332932(LGI1)

XLA:	108696184(lgi1.L) 108697461(lgi1.S)

XTR:	779819(lgi1)

NPR:	108788835(LGI1)

RTEM:

120946930(LGI1)

BBUF:

121005142(LGI1)

BGAR:

122941793(LGI1)

PWL:	138246466 138300450(LGI1)

MUO:	115471130(LGI1) 115476538(LGI4)

GSH:	117360003(LGI1) 117368824(LGI4)

DRE:	323011(lgi1a) 654829(lgi1b)

SRX:	107708938 107743957 107753733

SANH:

107654035 107664615 107701579

SGH:	107565913 107598600

CCAR:

109067309 109067328(lgi1b) 109071543(lgi1a)

CAUA:

113056370 113057432 113111965

CGIB:

127969407 127969633 128025022

PTET:

122355405(lgi1b) 122356453(lgi1a)

LROH:

127174500(lgi1b) 127175153(lgi1a)

OMC:	131550678(lgi1b) 131552262(lgi1a)

PPRM:

120474454(lgi1b) 120492346(lgi1a)

RKG:	130080560(lgi1b) 130103804(lgi1a)

MAMB:

125255781(lgi1b) 125277574(lgi1a)

CIDE:

127523535 127524390

CERY:

137007639(lgi1b) 137020219(lgi1a)

MASI:

127413744 127423129 127427390

TROS:

130550697 130568859(lgi1b)

TDW:	130438609(lgi1b)

MANU:

129416461(lgi1a) 129420414(lgi1b)

PDAB:

135720544(lgi1b) 135731940(lgi1a)

IPU:	108260544(lgi1a) 108273424(lgi1b)

IFU:	128604157 128617084(lgi1b)

PHYP:

113527070(lgi1) 113544403

SMEO:

124381353(lgi1a) 124389444(lgi1b)

TFD:	113653593(lgi1b) 113660785(lgi1a)

TVC:	132841575(lgi1b) 132841815(lgi1a)

CGAR:

128508855(lgi1a) 128541704(lgi1b)

NGRA:

132883364(lgi1a) 132897547(lgi1b)

TRN:	134321655(lgi1b) 134326532(lgi1a)

AMEX:

103024095(lgi1a) 103038693(lgi1b)

CMAO:

118809148(lgi1b) 118816732(lgi1a)

EEE:	113584746(lgi1) 113586679

CHAR:

105891217(lgi1b) 105909768

SPIL:

134069547(lgi1b)

TRU:	100653409(lgi1a) 100653410(lgi1)

TFS:	130523482(lgi1b) 130533566

TNG:	GSTEN00016467G001 GSTEN00034998G001

LCO:	104932511 109140625

NCC:

104964613

TBEN:

117473421(lgi1b) 117499707

CGOB:

115019763 115024270(lgi1)

PGEO:

117459582 117464894(lgi1b)

GACU:

117538183 117544812(lgi1b)

EMAC:

134858759 134870654(lgi1b)

ELY:	117246762(lgi1b) 117248037

EFO:	125880808(lgi1b) 125903445

PLEP:

121954221 121959057(lgi1b)

SLUC:

116054413 116061356(lgi1b)

ECRA:

117937119(lgi1b) 117960780

ESP:	116671291(lgi1) 116704874

PFLV:

114547775 114571833

GAT:	120818884(lgi1b) 120820492

PPUG:

119213103(lgi1b) 119213984

AFB:	129091379(lgi1b) 129092399

CLUM:

117748533(lgi1b)

PSWI:

130203202(lgi1b) 130206988

CANA:

137780304 137789900(lgi1b)

CVE:

137880528

MSAM:

119915833(lgi1b) 119917268

SCHU:

122867685(lgi1b) 122884208

CUD:	121511356 121528457(lgi1b)

SPUL:

138588328 138593224(lgi1b)

LMIX:

132955900(lgi1b) 132975343

ALAT:

119009554(lgi1b) 119033607

ASTR:

137588108(lgi1b) 137603386

MZE:	101473814 101479496

ONL:	100696113 100712447

OAU:	116316570 116329836(lgi1b)

OLA:	101157966 101163854(lgi1)

OML:	112154421(lgi1b) 112161595

CSAI:

133419188(lgi1b) 133463955

XMA:	102224330(lgi1) 102234009

XCO:	114137736 114152006(lgi1)

XHE:	116713014 116727283(lgi1)

PRET:

103476861 103481303(lgi1)

PFOR:

103147745 103151214(lgi1)

PLAI:

106959707 106964858(lgi1)

PMEI:

106915432(lgi1) 106918089

GAF:	122823057(lgi1b) 122843037

PPRL:

129353340(lgi1b) 129359594

CVG:	107085090(lgi1) 107093683

CTUL:

119780511(lgi1b) 119788530

GMU:	124858805 124875137(lgi1b)

NFU:	107375723 107387900(lgi1)

KMR:	108244465 108248022(lgi1b)

ALIM:

106516967(lgi1) 106536097

NWH:	119423654(lgi1b) 119429258

AOCE:

111564392 111573046(lgi1b)

EJA:	138195325 138201958(lgi1b)

BFRE:

138617048(lgi1b) 138617586

MCEP:

125018637 125022170(lgi1b)

CSEM:

103381426(lgi1) 103387209

POV:

109630797

SSEN:

122759015(lgi1b) 122782250

SSOE:

131448165(lgi1b) 131474242

HHIP:

117752464(lgi1b) 117775199

HSP:	118100406(lgi1b) 118118825

PPLT:

128426631(lgi1b) 128453589

SMAU:

118283827 118287829(lgi1b)

LCF:	108880374 108898743

SDU:	111219719 111235175

SLAL:

111654645 111669661

XGL:	120794813(lgi1b) 120796895(lgi1a)

HCQ:	109509943 109523894(lgi1)

SSCV:

125978825 125991414(lgi1b)

SBIA:

133495202(lgi1b) 133509486

PEE:	133409999 133417750(lgi1b)

PTAO:

133469304(lgi1b) 133485843

BPEC:

110159149 110171008(lgi1)

ENY:	140351337 140368857(lgi1b)

MALB:

109961939 109963063(lgi1)

BSPL:

114842066 114846420(lgi1b)

SJO:	128373158 128381233(lgi1b)

SSCO:

133991759 134003214(lgi1b)

GMH:	115530626 115560095

SASA:

100195253(lgi1) 106589372(lgi1)

STRU:

115157359 115201142(lgi1)

OTW:	112223467 112224255

OMY:	110491406 110499008

OGO:	124017959 124040013(lgi1b)

ONE:	115106377 115144031

OKI:	109865527 109870134(lgi1)

OKE:	118357498 118368109

OMM:	135505116 135523858

OCLA:

139367991 139376554

SALP:

111967752 111978042

SNH:	120029762 120046151

CCLU:

121534720 121547312 121553551

ELS:	105025140(lgi1)

OEP:	134022117 134031021(lgi1b)

SFM:	108939460(lgi1)

PKI:	111859578(lgi1)

AANG:

118217610 118221390(lgi1b)

AROT:

135244894 135245945(lgi1b)

CCOG:

133117389(lgi1b) 133118182

LOC:	102684061(lgi1)

PSPA:

121321865 121326181

ARUT:

117414662 117418590(lgi1b)

PSEX:

120540961(lgi1b)

LCM:	102367021(LGI1)

CMK:

103179646

RTP:	109938330(lgi1b) 125482987

CPLA:

122548844 122561086(lgi1b)

HOC:	132815519 132826445(lgi1b)

LERI:

129696450 129703900(lgi1b)

PMRN:

116941260(LGI1)

LRJ:	133345594(LGI1)

BFO:

BBEL:

CRG:

OSN:

Reference

PMID:9879993

Authors

Chernova OB, Somerville RP, Cowell JK

Title

A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors.

Journal

Oncogene 17:2873-81 (1998)
DOI:10.1038/sj.onc.1202481

Sequence

[hsa:9211]

Reference

PMID:15047712

Authors

Kunapuli P, Kasyapa CS, Hawthorn L, Cowell JK

Title

LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway.

Journal

J Biol Chem 279:23151-7 (2004)
DOI:10.1074/jbc.M314192200

LinkDB

DBGET integrated database retrieval system