KEGG   PATHWAY: aam04060
Entry
aam04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Apteryx mantelli mantelli (North Island brown kiwi)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
aam04060  Cytokine-cytokine receptor interaction
aam04060

Organism
Apteryx mantelli mantelli (North Island brown kiwi) [GN:aam]
Gene
106481985  [KO:K05494]
106481986  [KO:K05489]
106482148  INHBC; inhibin beta C subunit [KO:K22688]
106482155  [KO:K22688]
106482415  IL20RB; interleukin 20 receptor subunit beta [KO:K05137]
106482436  TNFRSF8; TNF receptor superfamily member 8 [KO:K05145]
106482459  TNFRSF1B; TNF receptor superfamily member 1B [KO:K05141]
106482592  TNFRSF17; TNF receptor superfamily member 17 [KO:K05153]
106482877  TGFB3; transforming growth factor beta 3 [KO:K13377]
106483309  PRL; prolactin [KO:K05439]
106483538  IL6; interleukin 6 [KO:K05405]
106483860  GDF6; growth differentiation factor 6 [KO:K20012]
106484141  EDA; ectodysplasin A [KO:K05480]
106484418  [KO:K05414]
106484445  ACKR3; atypical chemokine receptor 3 [KO:K04304]
106484511  [KO:K12964]
106484576  [KO:K05431]
106485113  [KO:K10030]
106485114  [KO:K10030]
106485181  CXCR5; C-X-C motif chemokine receptor 5 [KO:K04190]
106485254  NGF; nerve growth factor [KO:K02582]
106485705  [KO:K04722]
106485764  TNFRSF14; TNF receptor superfamily member 14 [KO:K05152]
106485874  CCL20; C-C motif chemokine ligand 20 [KO:K14625]
106486017  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
106486041  BMP10; bone morphogenetic protein 10 [KO:K22670]
106486127  [KO:K05073]
106486130  IL21R; interleukin 21 receptor [KO:K05075]
106486134  IL4R; interleukin 4 receptor [KO:K05071]
106486430  [KO:K20013]
106486447  [KO:K05438]
106486484  [KO:K05483]
106486508  IL23R; interleukin 23 receptor [KO:K05065]
106486526  IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064]
106486546  ACVR1C; activin A receptor type 1C [KO:K13568] [EC:2.7.11.30]
106486557  ACVR1; activin A receptor type 1 [KO:K04675] [EC:2.7.11.30]
106486566  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
106486760  CCR6; C-C motif chemokine receptor 6 [KO:K04181]
106486832  TNFRSF13B; TNF receptor superfamily member 13B [KO:K05150]
106486891  [KO:K22630]
106487168  [KO:K05428]
106487195  CXCL14; C-X-C motif chemokine ligand 14 [KO:K10033]
106487209  GDF9; growth differentiation factor 9 [KO:K22673]
106487280  LEPR; leptin receptor [KO:K05062]
106487624  CCR7; C-C motif chemokine receptor 7 [KO:K04182]
106487830  FAS; Fas cell surface death receptor [KO:K04390]
106487990  [KO:K05068]
106488077  RELL2; RELT like 2 [KO:K26541]
106488151  IL26; interleukin 26 [KO:K05446]
106488218  TNFRSF13C; TNF receptor superfamily member 13C [KO:K05151]
106488249  [KO:K04738]
106488250  [KO:K04738]
106488409  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
106488479  IFNG; interferon gamma [KO:K04687]
106488545  IL22; interleukin 22 [KO:K05445]
106488872  IL17RA; interleukin 17 receptor A [KO:K05164]
106488989  [KO:K04183]
106489018  CX3CR1; C-X3-C motif chemokine receptor 1 [KO:K04192]
106489022  [KO:K04183]
106489059  CCR4; C-C motif chemokine receptor 4 [KO:K04179]
106489200  TNFSF11; tumor necrosis factor superfamily member 11 [KO:K05473]
106489300  [KO:K04738]
106489438  [KO:K21083]
106489439  [KO:K05508]
106489456  [KO:K21083]
106489521  [KO:K04665]
106489527  AMH; anti-Mullerian hormone [KO:K04665]
106489764  [KO:K05490]
106489786  IL13RA2; interleukin 13 receptor subunit alpha 2 [KO:K05077]
106490212  RELL1; RELT like 1 [KO:K26541]
106490270  ACVR2B; activin A receptor type 2B [KO:K13596] [EC:2.7.11.30]
106490352  BMP2; bone morphogenetic protein 2 [KO:K21283]
106490440  TGFB2; transforming growth factor beta 2 [KO:K13376]
106490634  [KO:K05507]
106490786  IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
106490870  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
106490908  [KO:K05066]
106490917  [KO:K05066]
106490964  IL17B; interleukin 17B [KO:K05490]
106491015  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
106491098  CCR10; C-C motif chemokine receptor 10 [KO:K04185]
106491164  CCR9; C-C motif chemokine receptor 9 [KO:K04184]
106491178  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
106491185  [KO:K04180]
106491187  [KO:K04183]
106491188  [KO:K04180]
106491195  XCR1; X-C motif chemokine receptor 1 [KO:K04193]
106491221  ACKR4; atypical chemokine receptor 4 [KO:K04186]
106491240  CXCR6; C-X-C motif chemokine receptor 6 [KO:K04191]
106491249  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
106491541  IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
106491732  BMP7; bone morphogenetic protein 7 [KO:K16621]
106491800  [KO:K10030]
106491802  [KO:K10030]
106491815  CXCL13; C-X-C motif chemokine ligand 13 [KO:K10032]
106491882  BMPR1B; bone morphogenetic protein receptor type 1B [KO:K13578] [EC:2.7.11.30]
106491895  [KO:K10030]
106491934  IL21; interleukin 21 [KO:K05434]
106492121  IL15; interleukin 15 [KO:K05433]
106492266  [KO:K03161]
106492371  MSTN; myostatin [KO:K05497]
106492422  BMPR2; bone morphogenetic protein receptor type 2 [KO:K04671] [EC:2.7.11.30]
106492723  IL34; interleukin 34 [KO:K22633]
106492747  [KO:K22669]
106492903  [KO:K05059]
106492904  IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
106492911  [KO:K16062]
106492912  [KO:K05512]
106492954  [KO:K22679]
106493227  TNFRSF6B; TNF receptor superfamily member 6b [KO:K05143]
106493255  BMP5; bone morphogenetic protein 5 [KO:K04663]
106493315  IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
106493316  IFNLR1; interferon lambda receptor 1 [KO:K05140]
106493440  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
106493589  EDA2R; ectodysplasin A2 receptor [KO:K05163]
106493613  IL12B; interleukin 12B [KO:K05425]
106493708  TNFSF15; tumor necrosis factor superfamily member 15 [KO:K05478]
106493709  TNFSF8; tumor necrosis factor superfamily member 8 [KO:K05471]
106493962  TNFSF13B; tumor necrosis factor superfamily member 13b [KO:K05476]
106493969  IL18RAP; interleukin 18 receptor accessory protein [KO:K05174]
106493972  EDAR; ectodysplasin A receptor [KO:K05162]
106493981  IL1R2; interleukin 1 receptor type 2 [KO:K04387]
106494010  [KO:K05172]
106494012  IL1RL1; interleukin 1 receptor like 1 [KO:K05171]
106494064  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
106494075  IL18R1; interleukin 18 receptor 1 [KO:K05173]
106494212  THPO; thrombopoietin [KO:K06854]
106494283  BMP3; bone morphogenetic protein 3 [KO:K05496]
106494517  LIF; leukemia inhibitory factor [KO:K05419]
106494596  BMP4; bone morphogenetic protein 4 [KO:K04662]
106494952  IFNGR2; interferon gamma receptor 2 [KO:K05133]
106494971  IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
106494988  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
106494990  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
106495014  [KO:K05414]
106495099  IL12A; interleukin 12A [KO:K05406]
106495214  TNFRSF21; TNF receptor superfamily member 21 [KO:K05157]
106495279  INHBA; inhibin beta A subunit [KO:K04667]
106495358  [KO:K05514]
106495560  TNFRSF4; TNF receptor superfamily member 4 [KO:K05142]
106495577  TNFRSF18; TNF receptor superfamily member 18 [KO:K05154]
106495584  GDF15; growth differentiation factor 15 [KO:K05504]
106495798  [KO:K22667]
106495801  IL10; interleukin 10 [KO:K05443]
106496023  IL18; interleukin 18 [KO:K05482]
106496079  [KO:K04666]
106496100  [KO:K12964]
106496101  [KO:K12964]
106496102  [KO:K12499]
106496306  TNFRSF11B; TNF receptor superfamily member 11b [KO:K05148]
106496354  [KO:K05060]
106496414  IL16; interleukin 16 [KO:K22628]
106496699  TNFRSF9; TNF receptor superfamily member 9 [KO:K05146]
106496802  [KO:K05495]
106496997  [KO:K04722]
106497174  [KO:K06454]
106497278  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
106497360  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
106497403  BMP15; bone morphogenetic protein 15 [KO:K05498]
106497584  CD40; CD40 molecule [KO:K03160]
106497798  GDF10; growth differentiation factor 10 [KO:K22674]
106497803  GDF2; growth differentiation factor 2 [KO:K05503]
106497809  [KO:K21283]
106497894  IFNGR1; interferon gamma receptor 1 [KO:K05132]
106497921  IL20RA; interleukin 20 receptor subunit alpha [KO:K05136]
106498193  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
106498424  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
106498480  [KO:K04388] [EC:2.7.11.30]
106498516  ACVR2A; activin A receptor type 2A [KO:K04670] [EC:2.7.11.30]
106498530  [KO:K21283]
106499052  INHBB; inhibin beta B subunit [KO:K22687]
106499092  INHA; inhibin alpha subunit [KO:K05500]
106499143  [KO:K05050]
106499420  ACVRL1; activin A receptor like type 1 [KO:K13594] [EC:2.7.11.30]
106499430  ACVR1B; activin A receptor type 1B [KO:K13567] [EC:2.7.11.30]
106499448  MPL; MPL proto-oncogene, thrombopoietin receptor [KO:K05082]
106499484  CCL28; C-C motif chemokine ligand 28 [KO:K05513]
106499487  GHR; growth hormone receptor [KO:K05080]
106499523  IL7R; interleukin 7 receptor [KO:K05072]
106499536  LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
106499543  OSMR; oncostatin M receptor [KO:K05057]
106499553  PRLR; prolactin receptor [KO:K05081]
106499691  TNFSF4; tumor necrosis factor superfamily member 4 [KO:K05469]
106499698  FASLG; Fas ligand [KO:K04389]
106499867  BMPR1A; bone morphogenetic protein receptor type 1A [KO:K04673] [EC:2.7.11.30]
106499905  GDF5; growth differentiation factor 5 [KO:K04664]
106500204  TNFRSF11A; TNF receptor superfamily member 11a [KO:K05147]
106500407  TNFRSF19; TNF receptor superfamily member 19 [KO:K05155]
106500447  BMP6; bone morphogenetic protein 6 [KO:K16620]
Reference
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

DBGET integrated database retrieval system