KEGG   PATHWAY: asao04148
Entry
asao04148                   Pathway                                
Name
Efferocytosis - Anolis sagrei ordinatus (Brown anole)
Class
Cellular Processes; Transport and catabolism
Pathway map
asao04148  Efferocytosis
asao04148

Organism
Anolis sagrei ordinatus (Brown anole) [GN:asao]
Gene
132760742  TMEM30A; cell cycle control protein 50A [KO:K26935]
132760985  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
132761341  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
132761529  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
132761624  XKR6; XK-related protein 6 [KO:K26811]
132761714  DNMT3A; DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
132761805  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
132762176  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
132762309  MFGE8; lactadherin isoform X1 [KO:K17253]
132762403  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
132762408  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132762580  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
132763078  ATP11C; phospholipid-transporting ATPase IG [KO:K26934]
132763274  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
132763419  [KO:K01370] [EC:3.4.22.36]
132763461  CRK; adapter molecule crk [KO:K04438]
132763481  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
132763674  RAB14; ras-related protein Rab-14 [KO:K07881]
132763720  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
132764181  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
132764659  C1QB; complement C1q subcomponent subunit B [KO:K03987]
132764660  C1QC; complement C1q subcomponent subunit C [KO:K03988]
132764661  C1QA; complement C1q subcomponent subunit A [KO:K03986]
132764665  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
132764763  SLC66A1; lysosomal amino acid transporter 1 homolog [KO:K23678]
132764778  [KO:K19501]
132764841  [KO:K07293] [EC:3.1.3.48]
132764960  [KO:K03986]
132765023  [KO:K07909]
132765589  [KO:K26936]
132765864  THBS1; thrombospondin-1 [KO:K16857]
132766234  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
132766371  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
132766537  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
132766945  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
132767251  [KO:K01581] [EC:4.1.1.17]
132767256  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
132767395  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
132767422  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
132767528  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
132767586  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132767732  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
132767787  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
132767843  [KO:K07897]
132767940  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
132768014  EPOR; erythropoietin receptor [KO:K05079]
132768032  CALR; calreticulin [KO:K08057]
132768074  ABCA1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
132768155  ITGAV; integrin alpha-V [KO:K06487]
132768208  RAB5B; ras-related protein Rab-5B [KO:K07888]
132768583  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
132768951  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
132769134  ANO5; anoctamin-5 isoform X1 [KO:K19480]
132769179  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132769183  STAB1; stabilin-1 [KO:K19020]
132769202  ANO3; anoctamin-3 isoform X1 [KO:K19498]
132769226  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
132769312  RAB7A; ras-related protein Rab-7a [KO:K07897]
132769848  P2RY12; P2Y purinoceptor 12 [KO:K04298]
132769909  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
132770474  ATP11B; phospholipid-transporting ATPase IF isoform X1 [KO:K26934]
132770560  [KO:K23678]
132770717  ANO7; anoctamin-7 [KO:K19501]
132770773  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
132770945  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132770963  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
132771032  [KO:K06834] [EC:3.4.24.-]
132771053  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
132771114  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
132771118  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132771119  [KO:K01052] [EC:3.1.1.13]
132771123  [KO:K01052] [EC:3.1.1.13]
132771124  [KO:K01052] [EC:3.1.1.13]
132771204  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
132771306  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
132771513  ATP11A; phospholipid-transporting ATPase IH isoform X1 [KO:K26934]
132771528  GAS6; growth arrest-specific protein 6 isoform X1 [KO:K05464]
132771557  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
132771647  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
132771709  ANO9; anoctamin-9 isoform X1 [KO:K19503]
132771983  PROS1; LOW QUALITY PROTEIN: vitamin K-dependent protein S [KO:K03908]
132772005  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
132772131  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
132772226  PANX1; pannexin-1 [KO:K03443]
132772301  P2RY2; P2Y purinoceptor 2 [KO:K04269]
132772302  P2RY6; P2Y purinoceptor 6 [KO:K04272]
132772637  IL10; interleukin-10 [KO:K05443]
132772979  XKR7; XK-related protein 7 [KO:K26811]
132773012  SIRPB1; signal-regulatory protein beta-1 [KO:K06551]
132773014  [KO:K06551]
132773129  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
132773139  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
132773375  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
132773604  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
132773614  RAB7B; ras-related protein Rab-7b [KO:K07898]
132773738  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
132773739  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
132773917  [KO:K08057]
132774186  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
132774296  ALOX5; polyunsaturated fatty acid 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
132774315  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
132774418  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
132774662  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132774700  ITGB5; integrin beta-5 [KO:K06588]
132774833  XKR4; XK-related protein 4 [KO:K26811]
132774908  XKR9; XK-related protein 9 [KO:K26814]
132775134  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
132775139  [KO:K04596]
132775593  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
132775853  STAB2; stabilin-2 [KO:K19013]
132776056  ANO4; anoctamin-4 isoform X1 [KO:K19499]
132776215  ANO6; anoctamin-6 isoform X1 [KO:K19500]
132776292  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
132776293  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
132776439  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132776536  CD36; platelet glycoprotein 4 [KO:K06259]
132776614  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
132776702  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
132776902  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
132777115  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
132777497  EPO; erythropoietin [KO:K05437]
132777699  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
132777812  [KO:K04438]
132777818  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132777836  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
132777851  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
132777963  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
132778086  NR1H2; oxysterols receptor LXR-beta [KO:K08535]
132778105  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
132778216  RAB5C; ras-related protein Rab-5C [KO:K07889]
132778319  ITGB3; integrin beta-3 [KO:K06493]
132778547  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
132778552  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
132778704  RAB5A; ras-related protein Rab-5A [KO:K07887]
132779029  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
132779752  [KO:K04192]
132779841  RAB17; ras-related protein Rab-17 [KO:K07909]
132780051  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
132780054  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
132780327  XKR8; XK-related protein 8 [KO:K26813]
132780946  CALR3; LOW QUALITY PROTEIN: calreticulin-3 [KO:K08057]
132781109  BSG; basigin isoform X1 [KO:K06535]
132781163  [KO:K05641]
132781335  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
132781607  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132781655  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
132781695  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
132781741  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
132782023  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
132782500  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
132782619  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132782657  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
132782703  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
132782732  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
132782791  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
132782799  [KO:K04397] [EC:3.4.22.60]
132782949  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
132783049  TMEM30B; cell cycle control protein 50B [KO:K26935]
132783100  [KO:K00411] [EC:7.1.1.8]
132783239  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
132783354  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
asao00010  Glycolysis / Gluconeogenesis
asao04140  Autophagy - animal
asao04145  Phagosome
KO pathway
ko04148   

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