KEGG   PATHWAY: cjc04620
Entry
cjc04620                    Pathway                                
Name
Toll-like receptor signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
cjc04620  Toll-like receptor signaling pathway
cjc04620

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385107  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X2 [KO:K04415] [EC:2.7.11.25]
100385441  [KO:K12964]
100385800  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
100385835  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100386168  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
100387372  [KO:K05414]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100387401  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100387686  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100388391  IFNB1; interferon beta [KO:K05415]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100389780  CCL5; C-C motif chemokine 5 [KO:K12499]
100390054  FOS; protein c-Fos [KO:K04379]
100390109  MAPK10; mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
100390201  [KO:K05414]
100390258  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100390587  CXCL8; interleukin-8 [KO:K10030]
100390591  TLR6; toll-like receptor 6 [KO:K10169]
100390723  LBP; lipopolysaccharide-binding protein isoform X2 [KO:K05399]
100390958  TLR1; toll-like receptor 1 [KO:K05398]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100392260  CD80; T-lymphocyte activation antigen CD80 precursor [KO:K05412]
100392518  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100392721  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100393190  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100393440  IL6; interleukin-6 precursor [KO:K05405]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100395220  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100395364  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
100395403  IL12B; interleukin-12 subunit beta [KO:K05425]
100396202  IRF5; interferon regulatory factor 5 isoform X2 [KO:K09446]
100396611  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100396967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100397389  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
100397484  TNF; tumor necrosis factor [KO:K03156]
100398462  TLR7; toll-like receptor 7 [KO:K05404]
100398593  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100398832  TLR8; toll-like receptor 8 [KO:K10170]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100398947  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100399012  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100399701  TBK1; serine/threonine-protein kinase TBK1 isoform X6 [KO:K05410] [EC:2.7.11.10]
100399957  TOLLIP; toll-interacting protein isoform X4 [KO:K05402]
100400411  JUN; transcription factor Jun [KO:K04448]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100401630  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100402266  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100402978  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X3 [KO:K04733] [EC:2.7.11.1]
100403175  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100404377  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100404611  TLR2; toll-like receptor 2 [KO:K10159]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100405036  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
100405093  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100405343  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100405583  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100405930  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
100406098  [KO:K05414]
100406466  [KO:K05414]
100406669  IL12A; interleukin-12 subunit alpha [KO:K05406]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100406769  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
100407388  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
100407519  TLR5; toll-like receptor 5 isoform X1 [KO:K10168]
100409449  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
100409573  TLR3; toll-like receptor 3 isoform X2 [KO:K05401]
100409771  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
100410169  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
100410306  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
100410616  FADD; FAS-associated death domain protein [KO:K02373]
100411708  TLR9; toll-like receptor 9 isoform X2 [KO:K10161]
100411857  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
100412217  SPP1; osteopontin [KO:K06250]
100412218  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
100412930  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100413151  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
100414129  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100414132  IRF3; interferon regulatory factor 3 isoform X4 [KO:K05411]
100414273  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100414516  [KO:K05414]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100415219  CCL3L3; C-C motif chemokine 3-like 1 [KO:K05408]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100415562  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100894965  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100895294  [KO:K04392]
100895453  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103793369  [KO:K05414]
128928024  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
128928158  [KO:K05414]
128930881  [KO:K05402]
128932203  [KO:K05414]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
cjc04010  MAPK signaling pathway
cjc04060  Cytokine-cytokine receptor interaction
cjc04064  NF-kappa B signaling pathway
cjc04120  Ubiquitin mediated proteolysis
cjc04151  PI3K-Akt signaling pathway
cjc04210  Apoptosis
cjc04610  Complement and coagulation cascades
cjc04630  JAK-STAT signaling pathway
KO pathway
ko04620   

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