Entry Name Mitophagy - animal - Cololabis saira (Pacific saury)
Description Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Other DBs Organism Cololabis saira (Pacific saury) [GN:
csai ]
Gene 133418577 eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237 ]
133418757 calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348 ]
133422682 rhot1a; mitochondrial Rho GTPase 1-A isoform X1 [KO:K07870 ] [EC:3.6.5.-]
133423799 samm50l; sorting and assembly machinery component 50 homolog B [KO:K07277 ]
133429874 tax1bp1b; tax1-binding protein 1 homolog B isoform X1 [KO:K21347 ]
133434362 zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
133441072 tomm40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518 ]
133441510 hif1al; hypoxia inducible factor 1 subunit alpha, like isoform X1 [KO:K08268 ]
133441808 rabgef1l; RAB guanine nucleotide exchange factor (GEF) 1, like [KO:K20131 ]
133442511 atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374 ]
133443856 map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
133443914 gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
133444077 ambra1b; activating molecule in BECN1-regulated autophagy protein 1B isoform X1 [KO:K17985 ]
133446126 map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
133447593 map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
133448115 tomm20b; mitochondrial import receptor subunit TOM20 homolog B [KO:K17770 ]
133449202 map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
133449522 mitfa; melanocyte inducing transcription factor a isoform X1 [KO:K09455 ]
133452596 zgc:136908; transitional endoplasmic reticulum ATPase [KO:K13525 ]
133454564 zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464 ]
133460281 si:dkey-71l1.1; mitochondrial import receptor subunit TOM40B [KO:K11518 ]
133461107 tomm7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771 ]
133461636 tax1bp1a; tax1-binding protein 1 homolog A isoform X1 [KO:K21347 ]
133463868 tomm20a; translocase of outer mitochondrial membrane 20 [KO:K17770 ]
Compound Reference Authors Pickrell AM, Youle RJ
Title The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
Journal Reference Authors Durcan TM, Fon EA
Title The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
Journal Reference Authors Shirihai OS, Song M, Dorn GW 2nd
Title How mitochondrial dynamism orchestrates mitophagy.
Journal Reference Authors Hamacher-Brady A, Brady NR
Title Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
Journal Reference Authors Yamano K, Matsuda N, Tanaka K
Title The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
Journal Reference Authors Yamaguchi O, Murakawa T, Nishida K, Otsu K
Title Receptor-mediated mitophagy.
Journal Reference Authors Roberts RF, Tang MY, Fon EA, Durcan TM
Title Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
Journal Reference Authors Arena G, Valente EM
Title PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
Journal Related KO pathway
