KEGG   PATHWAY: dsp03013
Entry
dsp03013                    Pathway                                
Name
Nucleocytoplasmic transport - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
dsp03013  Nucleocytoplasmic transport
dsp03013

Other DBs
GO: 0050658
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122094931  Kpna2; importin subunit alpha-1 [KO:K15043]
122094937  Sumo2; small ubiquitin-related modifier 2 [KO:K12160]
122094948  Nup85; nuclear pore complex protein Nup85 [KO:K14304]
122096057  Nxt1; NTF2-related export protein 1 [KO:K14285]
122096184  Xpo6; exportin-6 isoform X1 [KO:K25204]
122096454  Sumo1; small ubiquitin-related modifier 1 [KO:K12160]
122096512  Thoc3; THO complex subunit 3 [KO:K12880]
122096617  Xpo7; exportin-7 isoform X1 [KO:K18460]
122097156  [KO:K13174]
122097839  [KO:K12160]
122097964  Senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
122098076  [KO:K12160]
122098133  Ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
122098424  Snupn; snurportin-1 isoform X1 [KO:K13151]
122098509  Kpna1; importin subunit alpha-5 [KO:K23940]
122099369  Eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
122099414  Alyref; THO complex subunit 4 [KO:K12881]
122099549  Nup205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
122100237  Tnpo2; transportin-2 isoform X1 [KO:K18727]
122100816  Upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
122101292  Sumo3; small ubiquitin-related modifier 3 [KO:K12160]
122101512  Xpo5; exportin-5 [KO:K14289]
122101817  Eef1a2; elongation factor 1-alpha 2 [KO:K03231]
122101873  Ranbp17; ran-binding protein 17 isoform X1 [KO:K24115]
122101938  Ran; GTP-binding nuclear protein Ran [KO:K07936]
122102160  Nup50; nuclear pore complex protein Nup50 [KO:K14295]
122102415  [KO:K12160]
122102869  [KO:K12877]
122102977  [KO:K12160]
122103184  Casc3; protein CASC3 [KO:K14323]
122103397  Kpnb1; importin subunit beta-1 [KO:K14293]
122103706  [KO:K14308]
122103722  Tpr; nucleoprotein TPR [KO:K09291]
122103985  Phax; phosphorylated adapter RNA export protein [KO:K14291]
122104433  Thoc1; THO complex subunit 1 [KO:K12878]
122104902  Nxf1; nuclear RNA export factor 1 [KO:K14284]
122104951  Magoh; protein mago nashi homolog [KO:K12877]
122105018  Nup160; nuclear pore complex protein Nup160 [KO:K14303]
122105944  Nup43; nucleoporin Nup43 [KO:K14305]
122106300  Ipo8; importin-8 [KO:K18755]
122106455  Rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
122106463  Pnn; pinin [KO:K13114]
122106602  Tmem33; transmembrane protein 33 isoform X1 [KO:K20724]
122106793  [KO:K12160]
122106796  Nup54; nucleoporin p54 [KO:K14308]
122106966  Nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
122107287  Nmd3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
122107960  Nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
122108180  Sec13; protein SEC13 homolog [KO:K14004]
122108237  Thoc7; THO complex subunit 7 homolog [KO:K13176]
122108572  Kpna6; importin subunit alpha-7 isoform X1 [KO:K15042]
122108586  [KO:K12160]
122108643  Nup88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
122108935  Ipo13; importin-13 [KO:K25202]
122108940  Nup188; nucleoporin NUP188 isoform X1 [KO:K14311]
122108996  Nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
122109042  Gle1; nucleoporin GLE1 isoform X1 [KO:K18723]
122109420  Nup210l; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
122109983  Thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
122110133  Ipo5; importin-5 [KO:K20222]
122110749  [KO:K12160]
122110755  Ndc1; nucleoporin NDC1 [KO:K14315]
122110848  [KO:K12160]
122110949  Seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
122111063  Ddx39b; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
122111514  Pom121l2; POM121-like protein 2 [KO:K14316]
122111787  [KO:K12160]
122112135  Nup42; nucleoporin NUP42 isoform X1 [KO:K14321]
122112529  Xpo4; exportin-4 isoform X1 [KO:K25203]
122112541  Nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
122112543  Kpna4; importin subunit alpha-3 [KO:K23583]
122112544  [KO:K12160]
122112561  Kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
122112576  Sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
122112693  [KO:K12160]
122113048  Nup133; nuclear pore complex protein Nup133 [KO:K14300]
122113061  Upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
122113320  [KO:K12160]
122113389  Ipo4; importin-4 isoform X1 [KO:K20221]
122113476  Acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
122113516  [KO:K14316]
122113675  Kpna7; importin subunit alpha-8 [KO:K15043]
122113981  Eef1a1; elongation factor 1-alpha 1 [KO:K03231]
122114314  [KO:K14285]
122114423  Nup98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
122114818  [KO:K12160]
122114924  Nxf3; nuclear RNA export factor 3 [KO:K14284]
122115007  Nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
122115179  Srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
122116302  Nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
122116385  Nup62cl; nucleoporin-62 C-terminal-like protein [KO:K14306]
122116399  Nxt2; NTF2-related export protein 2 isoform X1 [KO:K14285]
122116977  Nup155; nuclear pore complex protein Nup155 [KO:K14312]
122117122  Ipo11; importin-11 isoform X1 [KO:K25201]
122117154  Tnpo1; transportin-1 isoform X1 [KO:K18752]
122117216  [KO:K12160]
122117430  Xpo1; exportin-1 [KO:K14290]
122117765  [KO:K12160]
122117857  Ipo7; importin-7 [KO:K20223]
122119279  Nup37; nucleoporin Nup37 [KO:K14302]
122120764  [KO:K12160]
122121203  Ranbp2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
122121864  Ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
122121888  Tnpo3; transportin-3 [KO:K15436]
122121954  Kpna5; importin subunit alpha-6 isoform X1 [KO:K15042]
122122798  Upf3a; regulator of nonsense transcripts 3A [KO:K14328]
122123122  [KO:K13176]
122123546  Rangap1; ran GTPase-activating protein 1 [KO:K14319]
122123798  Ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
122123815  Rnps1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
122123846  Thoc6; THO complex subunit 6 homolog [KO:K13175]
122124051  Pym1; partner of Y14 and mago isoform X1 [KO:K14294]
122124113  Aaas; aladin [KO:K14320]
122124189  Xpot; exportin-T [KO:K14288]
122124337  Nup107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
122124410  [KO:K12160]
122124578  Rae1; mRNA export factor [KO:K14298]
122125701  Nup62; nuclear pore glycoprotein p62 [KO:K14306]
122126213  [KO:K18655] [EC:5.6.2.7]
122126239  Ddx19b; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
122126707  Ahctf1; protein ELYS [KO:K25129]
122126714  Ipo9; importin-9 isoform X1 [KO:K20224]
122127062  [KO:K13176]
122127889  Cse1l; exportin-2 [KO:K18423]
122128213  Upf3b; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
dsp03015  mRNA surveillance pathway
KO pathway
ko03013   

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