KEGG   Homo sapiens (human): 7124
Entry
7124              CDS       T01001                                 
Symbol
TNF, DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F
Name
(RefSeq) tumor necrosis factor
  KO
K03156  tumor necrosis factor superfamily, member 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa01523  Antifolate resistance
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04064  NF-kappa B signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04150  mTOR signaling pathway
hsa04210  Apoptosis
hsa04217  Necroptosis
hsa04350  TGF-beta signaling pathway
hsa04380  Osteoclast differentiation
hsa04612  Antigen processing and presentation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04650  Natural killer cell mediated cytotoxicity
hsa04657  IL-17 signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04668  TNF signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04936  Alcoholic liver disease
hsa04940  Type I diabetes mellitus
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05205  Proteoglycans in cancer
hsa05310  Asthma
hsa05321  Inflammatory bowel disease
hsa05322  Systemic lupus erythematosus
hsa05323  Rheumatoid arthritis
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
hsa05410  Hypertrophic cardiomyopathy
hsa05414  Dilated cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06223  TNF signaling (cancer)
nt06231  Apoptosis (cancer)
nt06263  Hepatocellular carcinoma
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06466  Pathways of neurodegeneration
nt06516  TNF signaling
nt06517  TLR signaling
nt06524  Apoptosis
nt06527  Necroptosis
  Element
N00145  Extrinsic apoptotic pathway
N00151  TNF-NFKB signaling pathway
N00374  TNF-IRF1 signaling pathway
N00435  TLR1/2/4-NFKB signaling pathway
N00436  HIV Tat to TLR2/4-NFKB signaling pathway
N00444  TNF-p38 signaling pathway
N00446  TNF-JNK signaling pathway
N00994  AGE-RAGE signaling pathway
N00996  Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01566  TLR5-NFKB signaling pathway
N01621  TNF-RIPK1/3 signaling pathway
Disease
H00079  Asthma
H00080  Systemic lupus erythematosus
H00083  Allograft rejection
H00084  Graft-versus-host disease
H00361  Malaria
Drug target
Adalimumab: D02597<JP/US>
Adalimumab fosimdesonide: D12790
Afelimomab: D07436
Certolizumab pegol: D03441<JP/US>
Etanercept: D00742<JP/US>
Golimumab: D04358<JP/US>
Infliximab: D02598<JP/US>
Lenalidomide (DG00744): D04687<JP/US> D09813<JP>
Lenercept: D04690
Licaminlimab: D12420
Nerelimomab: D05146
Onercept: D05263
Opinercept: D11703
Ozoralizumab: D09944<JP>
Pegsunercept: D05393
Pirfenidone: D01583<JP/US>
Placulumab: D10320
Pomalidomide: D08976<JP/US>
Thalidomide: D00754<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7124 (TNF)
   04350 TGF-beta signaling pathway
    7124 (TNF)
   04064 NF-kappa B signaling pathway
    7124 (TNF)
   04668 TNF signaling pathway
    7124 (TNF)
   04071 Sphingolipid signaling pathway
    7124 (TNF)
   04150 mTOR signaling pathway
    7124 (TNF)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    7124 (TNF)
   04061 Viral protein interaction with cytokine and cytokine receptor
    7124 (TNF)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    7124 (TNF)
   04217 Necroptosis
    7124 (TNF)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    7124 (TNF)
   04620 Toll-like receptor signaling pathway
    7124 (TNF)
   04621 NOD-like receptor signaling pathway
    7124 (TNF)
   04622 RIG-I-like receptor signaling pathway
    7124 (TNF)
   04625 C-type lectin receptor signaling pathway
    7124 (TNF)
   04650 Natural killer cell mediated cytotoxicity
    7124 (TNF)
   04612 Antigen processing and presentation
    7124 (TNF)
   04660 T cell receptor signaling pathway
    7124 (TNF)
   04657 IL-17 signaling pathway
    7124 (TNF)
   04664 Fc epsilon RI signaling pathway
    7124 (TNF)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    7124 (TNF)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    7124 (TNF)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    7124 (TNF)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    7124 (TNF)
   05170 Human immunodeficiency virus 1 infection
    7124 (TNF)
   05161 Hepatitis B
    7124 (TNF)
   05160 Hepatitis C
    7124 (TNF)
   05171 Coronavirus disease - COVID-19
    7124 (TNF)
   05164 Influenza A
    7124 (TNF)
   05168 Herpes simplex virus 1 infection
    7124 (TNF)
   05163 Human cytomegalovirus infection
    7124 (TNF)
   05169 Epstein-Barr virus infection
    7124 (TNF)
   05165 Human papillomavirus infection
    7124 (TNF)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    7124 (TNF)
   05132 Salmonella infection
    7124 (TNF)
   05131 Shigellosis
    7124 (TNF)
   05135 Yersinia infection
    7124 (TNF)
   05133 Pertussis
    7124 (TNF)
   05134 Legionellosis
    7124 (TNF)
   05152 Tuberculosis
    7124 (TNF)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    7124 (TNF)
   05144 Malaria
    7124 (TNF)
   05145 Toxoplasmosis
    7124 (TNF)
   05140 Leishmaniasis
    7124 (TNF)
   05142 Chagas disease
    7124 (TNF)
   05143 African trypanosomiasis
    7124 (TNF)
  09163 Immune disease
   05310 Asthma
    7124 (TNF)
   05322 Systemic lupus erythematosus
    7124 (TNF)
   05323 Rheumatoid arthritis
    7124 (TNF)
   05321 Inflammatory bowel disease
    7124 (TNF)
   05330 Allograft rejection
    7124 (TNF)
   05332 Graft-versus-host disease
    7124 (TNF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7124 (TNF)
   05014 Amyotrophic lateral sclerosis
    7124 (TNF)
   05020 Prion disease
    7124 (TNF)
   05022 Pathways of neurodegeneration - multiple diseases
    7124 (TNF)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    7124 (TNF)
   05418 Fluid shear stress and atherosclerosis
    7124 (TNF)
   05410 Hypertrophic cardiomyopathy
    7124 (TNF)
   05414 Dilated cardiomyopathy
    7124 (TNF)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    7124 (TNF)
   04940 Type I diabetes mellitus
    7124 (TNF)
   04936 Alcoholic liver disease
    7124 (TNF)
   04932 Non-alcoholic fatty liver disease
    7124 (TNF)
   04931 Insulin resistance
    7124 (TNF)
   04933 AGE-RAGE signaling pathway in diabetic complications
    7124 (TNF)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    7124 (TNF)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    7124 (TNF)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7124 (TNF)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Tumor necrosis fators
   7124 (TNF)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Cytokines
   7124 (TNF)
SSDB
Motif
Pfam: TNF
Other DBs
NCBI-GeneID: 7124
NCBI-ProteinID: NP_000585
OMIM: 191160
HGNC: 11892
Ensembl: ENSG00000232810
UniProt: P01375 Q5STB3
Structure
LinkDB
Position
6:31575565..31578336
AA seq 233 aa
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
NT seq 702 nt   +upstreamnt  +downstreamnt
atgagcactgaaagcatgatccgggacgtggagctggccgaggaggcgctccccaagaag
acaggggggccccagggctccaggcggtgcttgttcctcagcctcttctccttcctgatc
gtggcaggcgccaccacgctcttctgcctgctgcactttggagtgatcggcccccagagg
gaagagttccccagggacctctctctaatcagccctctggcccaggcagtcagatcatct
tctcgaaccccgagtgacaagcctgtagcccatgttgtagcaaaccctcaagctgagggg
cagctccagtggctgaaccgccgggccaatgccctcctggccaatggcgtggagctgaga
gataaccagctggtggtgccatcagagggcctgtacctcatctactcccaggtcctcttc
aagggccaaggctgcccctccacccatgtgctcctcacccacaccatcagccgcatcgcc
gtctcctaccagaccaaggtcaacctcctctctgccatcaagagcccctgccagagggag
accccagagggggctgaggccaagccctggtatgagcccatctatctgggaggggtcttc
cagctggagaagggtgaccgactcagcgctgagatcaatcggcccgactatctcgacttt
gccgagtctgggcaggtctactttgggatcattgccctgtga

KEGG   Homo sapiens (human): 3569
Entry
3569              CDS       T01001                                 
Symbol
IL6, BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6
Name
(RefSeq) interleukin 6
  KO
K05405  interleukin 6
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01523  Antifolate resistance
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04657  IL-17 signaling pathway
hsa04659  Th17 cell differentiation
hsa04668  TNF signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05332  Graft-versus-host disease
hsa05410  Hypertrophic cardiomyopathy
hsa05417  Lipid and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06183  Yersinia
nt06219  JAK-STAT signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06240  Transcription (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06360  Cushing syndrome
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06517  TLR signaling
nt06518  JAK-STAT signaling
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00139  FUS-DDIT3 fusion to CEBPB-mediated transcription
N00317  AhR signaling pathway
N00435  TLR1/2/4-NFKB signaling pathway
N00994  AGE-RAGE signaling pathway
N00996  Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01306  AngII-AT1R-NOX2 signaling pathway
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01556  IL6 family to Jak-STAT signaling pathway
N01566  TLR5-NFKB signaling pathway
Disease
H00084  Graft-versus-host disease
H00286  Crohn disease
H00630  Rheumatoid arthritis
H01479  Castleman disease
H01672  Juvenile idiopathic arthritis
Drug target
Olokizumab: D12487
Pirfenidone: D01583<JP/US>
Pomalidomide: D08976<JP/US>
Siltuximab: D09669<US>
Sirukumab: D10080
Vamikibart: D12929
Ziltivekimab: D12807
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3569 (IL6)
   04668 TNF signaling pathway
    3569 (IL6)
   04066 HIF-1 signaling pathway
    3569 (IL6)
   04068 FoxO signaling pathway
    3569 (IL6)
   04151 PI3K-Akt signaling pathway
    3569 (IL6)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3569 (IL6)
   04061 Viral protein interaction with cytokine and cytokine receptor
    3569 (IL6)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    3569 (IL6)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3569 (IL6)
   04620 Toll-like receptor signaling pathway
    3569 (IL6)
   04621 NOD-like receptor signaling pathway
    3569 (IL6)
   04623 Cytosolic DNA-sensing pathway
    3569 (IL6)
   04625 C-type lectin receptor signaling pathway
    3569 (IL6)
   04659 Th17 cell differentiation
    3569 (IL6)
   04657 IL-17 signaling pathway
    3569 (IL6)
   04672 Intestinal immune network for IgA production
    3569 (IL6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3569 (IL6)
   05202 Transcriptional misregulation in cancer
    3569 (IL6)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    3569 (IL6)
   05161 Hepatitis B
    3569 (IL6)
   05171 Coronavirus disease - COVID-19
    3569 (IL6)
   05164 Influenza A
    3569 (IL6)
   05162 Measles
    3569 (IL6)
   05168 Herpes simplex virus 1 infection
    3569 (IL6)
   05163 Human cytomegalovirus infection
    3569 (IL6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3569 (IL6)
   05169 Epstein-Barr virus infection
    3569 (IL6)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    3569 (IL6)
   05132 Salmonella infection
    3569 (IL6)
   05135 Yersinia infection
    3569 (IL6)
   05133 Pertussis
    3569 (IL6)
   05134 Legionellosis
    3569 (IL6)
   05152 Tuberculosis
    3569 (IL6)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    3569 (IL6)
   05144 Malaria
    3569 (IL6)
   05142 Chagas disease
    3569 (IL6)
   05143 African trypanosomiasis
    3569 (IL6)
  09163 Immune disease
   05323 Rheumatoid arthritis
    3569 (IL6)
   05321 Inflammatory bowel disease
    3569 (IL6)
   05332 Graft-versus-host disease
    3569 (IL6)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3569 (IL6)
   05020 Prion disease
    3569 (IL6)
   05022 Pathways of neurodegeneration - multiple diseases
    3569 (IL6)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    3569 (IL6)
   05410 Hypertrophic cardiomyopathy
    3569 (IL6)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    3569 (IL6)
   04932 Non-alcoholic fatty liver disease
    3569 (IL6)
   04931 Insulin resistance
    3569 (IL6)
   04933 AGE-RAGE signaling pathway in diabetic complications
    3569 (IL6)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    3569 (IL6)
   01523 Antifolate resistance
    3569 (IL6)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3569 (IL6)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Interleukins
   3569 (IL6)
SSDB
Motif
Pfam: IL6 IL11 IL23 Phage_int_SAM_1 GCSF
Other DBs
NCBI-GeneID: 3569
NCBI-ProteinID: NP_000591
OMIM: 147620
HGNC: 6018
Ensembl: ENSG00000136244
UniProt: P05231 Q75MH2 B4DVM1
Structure
LinkDB
Position
7:22727200..22731998
AA seq 212 aa
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
NT seq 639 nt   +upstreamnt  +downstreamnt
atgaactccttctccacaagcgccttcggtccagttgccttctccctggggctgctcctg
gtgttgcctgctgccttccctgccccagtacccccaggagaagattccaaagatgtagcc
gccccacacagacagccactcacctcttcagaacgaattgacaaacaaattcggtacatc
ctcgacggcatctcagccctgagaaaggagacatgtaacaagagtaacatgtgtgaaagc
agcaaagaggcactggcagaaaacaacctgaaccttccaaagatggctgaaaaagatgga
tgcttccaatctggattcaatgaggagacttgcctggtgaaaatcatcactggtcttttg
gagtttgaggtatacctagagtacctccagaacagatttgagagtagtgaggaacaagcc
agagctgtgcagatgagtacaaaagtcctgatccagttcctgcagaaaaaggcaaagaat
ctagatgcaataaccacccctgacccaaccacaaatgccagcctgctgacgaagctgcag
gcacagaaccagtggctgcaggacatgacaactcatctcattctgcgcagctttaaggag
ttcctgcagtccagcctgagggctcttcggcaaatgtag

KEGG   Homo sapiens (human): 4843
Entry
4843              CDS       T01001                                 
Symbol
NOS2, HEP-NOS, INOS, NOS, NOS2A
Name
(RefSeq) nitric oxide synthase 2
  KO
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00220  Arginine biosynthesis
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
hsa04020  Calcium signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04146  Peroxisome
hsa04371  Apelin signaling pathway
hsa04926  Relaxin signaling pathway
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05133  Pertussis
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05222  Small cell lung cancer
Network
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
  Element
N00994  AGE-RAGE signaling pathway
N00996  Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
Disease
H00017  Esophageal cancer
H00361  Malaria
Drug target
Cindunistat (DG01391): D10386 D10419
Pimagedine hydrochloride: D05479
Tilarginine acetate: D09018
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    4843 (NOS2)
   00330 Arginine and proline metabolism
    4843 (NOS2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    4843 (NOS2)
   04066 HIF-1 signaling pathway
    4843 (NOS2)
   04020 Calcium signaling pathway
    4843 (NOS2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    4843 (NOS2)
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    4843 (NOS2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4843 (NOS2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    4843 (NOS2)
  09171 Infectious disease: bacterial
   05133 Pertussis
    4843 (NOS2)
   05152 Tuberculosis
    4843 (NOS2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    4843 (NOS2)
   05145 Toxoplasmosis
    4843 (NOS2)
   05140 Leishmaniasis
    4843 (NOS2)
   05142 Chagas disease
    4843 (NOS2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4843 (NOS2)
   05014 Amyotrophic lateral sclerosis
    4843 (NOS2)
   05022 Pathways of neurodegeneration - multiple diseases
    4843 (NOS2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     4843 (NOS2)
SSDB
Motif
Pfam: NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1
Other DBs
NCBI-GeneID: 4843
NCBI-ProteinID: NP_000616
OMIM: 163730
HGNC: 7873
Ensembl: ENSG00000007171
UniProt: P35228
Structure
LinkDB
Position
17:complement(27756766..27800529)
AA seq 1153 aa
MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL
NT seq 3462 nt   +upstreamnt  +downstreamnt
atggcctgtccttggaaatttctgttcaagaccaaattccaccagtatgcaatgaatggg
gaaaaagacatcaacaacaatgtggagaaagccccctgtgccacctccagtccagtgaca
caggatgaccttcagtatcacaacctcagcaagcagcagaatgagtccccgcagcccctc
gtggagacgggaaagaagtctccagaatctctggtcaagctggatgcaaccccattgtcc
tccccacggcatgtgaggatcaaaaactggggcagcgggatgactttccaagacacactt
caccataaggccaaagggattttaacttgcaggtccaaatcttgcctggggtccattatg
actcccaaaagtttgaccagaggacccagggacaagcctacccctccagatgagcttcta
cctcaagctatcgaatttgtcaaccaatattacggctccttcaaagaggcaaaaatagag
gaacatctggccagggtggaagcggtaacaaaggagatagaaacaacaggaacctaccaa
ctgacgggagatgagctcatcttcgccaccaagcaggcctggcgcaatgccccacgctgc
attgggaggatccagtggtccaacctgcaggtcttcgatgcccgcagctgttccactgcc
cgggaaatgtttgaacacatctgcagacacgtgcgttactccaccaacaatggcaacatc
aggtcggccatcaccgtgttcccccagcggagtgatggcaagcacgacttccgggtgtgg
aatgctcagctcatccgctatgctggctaccagatgccagatggcagcatcagaggggac
cctgccaacgtggaattcactcagctgtgcatcgacctgggctggaagcccaagtacggc
cgcttcgatgtggtccccctggtcctgcaggccaatggccgtgaccctgagctcttcgaa
atcccacctgaccttgtgcttgaggtggccatggaacatcccaaatacgagtggtttcgg
gaactggagctaaagtggtacgccctgcctgcagtggccaacatgctgcttgaggtgggc
ggcctggagttcccagggtgccccttcaatggctggtacatgggcacagagatcggagtc
cgggacttctgtgacgtccagcgctacaacatcctggaggaagtgggcaggagaatgggc
ctggaaacgcacaagctggcctcgctctggaaagaccaggctgtcgttgagatcaacatt
gctgtgctccatagtttccagaagcagaatgtgaccatcatggaccaccactcggctgca
gaatccttcatgaagtacatgcagaatgaataccggtcccgtgggggctgcccggcagac
tggatttggctggtccctcccatgtctgggagcatcacccccgtgtttcaccaggagatg
ctgaactacgtcctgtcccctttctactactatcaggtagaggcctggaaaacccatgtc
tggcaggacgagaagcggagacccaagagaagagagattccattgaaagtcttggtcaaa
gctgtgctctttgcctgtatgctgatgcgcaagacaatggcgtcccgagtcagagtcacc
atcctctttgcgacagagacaggaaaatcagaggcgctggcctgggacctgggggcctta
ttcagctgtgccttcaaccccaaggttgtctgcatggataagtacaggctgagctgcctg
gaggaggaacggctgctgttggtggtgaccagtacgtttggcaatggagactgccctggc
aatggagagaaactgaagaaatcgctcttcatgctgaaagagctcaacaacaaattcagg
tacgctgtgtttggcctcggctccagcatgtaccctcggttctgcgcctttgctcatgac
attgatcagaagctgtcccacctgggggcctctcagctcaccccgatgggagaaggggat
gagctcagtgggcaggaggacgccttccgcagctgggccgtgcaaaccttcaaggcagcc
tgtgagacgtttgatgtccgaggcaaacagcacattcagatccccaagctctacacctcc
aatgtgacctgggacccgcaccactacaggctcgtgcaggactcacagcctttggacctc
agcaaagccctcagcagcatgcatgccaagaacgtgttcaccatgaggctcaaatctcgg
cagaatctacaaagtccgacatccagccgtgccaccatcctggtggaactctcctgtgag
gatggccaaggcctgaactacctgccgggggagcaccttggggtttgcccaggcaaccag
ccggccctggtccaaggtatcctggagcgagtggtggatggccccacaccccaccagaca
gtgcgcctggaggccctggatgagagtggcagctactgggtcagtgacaagaggctgccc
ccctgctcactcagccaggccctcacctacttcctggacatcaccacacccccaacccag
ctgctgctccaaaagctggcccaggtggccacagaagagcctgagagacagaggctggag
gccctgtgccagccctcagagtacagcaagtggaagttcaccaacagccccacattcctg
gaggtgctagaggagttcccgtccctgcgggtgtctgctggcttcctgctttcccagctc
cccattctgaagcccaggttctactccatcagctcctcccgggatcacacgcccacagag
atccacctgactgtggccgtggtcacctaccacacccgagatggccagggtcccctgcac
cacggcgtctgcagcacatggctcaacagcctgaagccccaagacccagtgccctgcttt
gtgcggaatgccagcggcttccacctccccgaggatccctcccatccttgcatcctcatc
gggcctggcacaggcatcgcgcccttccgcagtttctggcagcaacggctccatgactcc
cagcacaagggagtgcggggaggccgcatgaccttggtgtttgggtgccgccgcccagat
gaggaccacatctaccaggaggagatgctggagatggcccagaagggggtgctgcatgcg
gtgcacacagcctattcccgcctgcctggcaagcccaaggtctatgttcaggacatcctg
cggcagcagctggccagcgaggtgctccgtgtgctccacaaggagccaggccacctctat
gtttgcggggatgtgcgcatggcccgggacgtggcccacaccctgaagcagctggtggct
gccaagctgaaattgaatgaggagcaggtcgaggactatttctttcagctcaagagccag
aagcgctatcacgaagatatctttggtgctgtatttccttacgaggcgaagaaggacagg
gtggcggtgcagcccagcagcctggagatgtcagcgctctga

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