KEGG   PATHWAY: mdo04662
Entry
mdo04662                    Pathway                                
Name
B cell receptor signaling pathway - Monodelphis domestica (gray short-tailed opossum)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
Pathway map
mdo04662  B cell receptor signaling pathway
mdo04662

Other DBs
GO: 0050853
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100010412  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100011077  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
100011769  NFKBIA; NFKB inhibitor alpha [KO:K04734]
100011950  BCL10; B-cell CLL/lymphoma 10 [KO:K07368]
100012447  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100012814  CARD11; caspase recruitment domain family member 11 [KO:K07367]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100013226  NFKBIE; NFKB inhibitor epsilon [KO:K05872]
100013346  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
100013691  NFKBIB; NFKB inhibitor beta [KO:K02581]
100014446  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100014900  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100015122  [KO:K06856]
100015202  [KO:K12560]
100015252  [KO:K06856]
100015350  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100015410  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100015424  [KO:K06856]
100015430  DAPP1; dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [KO:K12229]
100015499  [KO:K06856]
100015500  INPPL1; inositol polyphosphate phosphatase like 1 [KO:K15909] [EC:3.1.3.86]
100015641  [KO:K06856]
100015727  CD22; CD22 molecule [KO:K06467]
100016169  MALT1; MALT1 paracaspase [KO:K07369] [EC:3.4.22.-]
100016514  PTPN6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
100017332  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100017517  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
100018044  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100018285  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
100018410  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018774  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
100019317  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100020150  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
100020467  [KO:K04012]
100021361  INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
100021991  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
100022409  PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]
100022523  [KO:K07828]
100022658  BLNK; B-cell linker [KO:K07371]
100022891  BTK; Bruton tyrosine kinase [KO:K07370] [EC:2.7.10.2]
100022894  GRB2; growth factor receptor bound protein 2 [KO:K04364]
100022918  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100023153  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
100024769  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100026330  CD79B; CD79b molecule [KO:K06507]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100027579  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
100027952  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100028145  [KO:K06512]
100028356  [KO:K05855] [EC:2.7.10.2]
100028435  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
100029256  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100029844  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
100029873  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
100030053  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
100031591  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
100032697  BLK; BLK proto-oncogene, Src family tyrosine kinase [KO:K08890] [EC:2.7.10.2]
100032726  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
100033031  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100033104  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
100033302  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
100500766  [KO:K06506]
100616821  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
100616957  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100618058  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100619042  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560]
100619118  [KO:K04012]
103092129  [KO:K06512]
103095206  [KO:K04012]
103098203  [KO:K06856]
103100618  CD19; CD19 molecule [KO:K06465]
103100828  [KO:K06512]
103101413  [KO:K06512]
103103214  [KO:K06512]
103103515  [KO:K06512]
103105735  CD72; CD72 molecule [KO:K06504]
103105947  [KO:K06512]
103106134  BANK1; B-cell scaffold protein with ankyrin repeats 1 [KO:K26239]
107649186  [KO:K06512]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12461567
  Authors
Niiro H, Clark EA.
  Title
Regulation of B-cell fate by antigen-receptor signals.
  Journal
Nat Rev Immunol 2:945-56 (2002)
DOI:10.1038/nri955
Reference
PMID:10358768
  Authors
Kurosaki T.
  Title
Genetic analysis of B cell antigen receptor signaling.
  Journal
Annu Rev Immunol 17:555-92 (1999)
DOI:10.1146/annurev.immunol.17.1.555
Reference
PMID:15886119
  Authors
Nitschke L.
  Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
  Journal
Curr Opin Immunol 17:290-7 (2005)
DOI:10.1016/j.coi.2005.03.005
Reference
PMID:15752555
  Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
  Title
Complement: central to innate immunity and bridging to adaptive responses.
  Journal
Immunol Lett 97:171-9 (2005)
DOI:10.1016/j.imlet.2004.11.010
Reference
PMID:12033741
  Authors
Kurosaki T.
  Title
Regulation of B-cell signal transduction by adaptor proteins.
  Journal
Nat Rev Immunol 2:354-63 (2002)
DOI:10.1038/nri801
Reference
PMID:15364057
  Authors
Nitschke L, Tsubata T.
  Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
  Journal
Trends Immunol 25:543-50 (2004)
DOI:10.1016/j.it.2004.08.002
Reference
PMID:15771577
  Authors
Jumaa H, Hendriks RW, Reth M.
  Title
B cell signaling and tumorigenesis.
  Journal
Annu Rev Immunol 23:415-45 (2005)
DOI:10.1146/annurev.immunol.23.021704.115606
Reference
PMID:15886112
  Authors
Rickert RC.
  Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
  Journal
Curr Opin Immunol 17:237-43 (2005)
DOI:10.1016/j.coi.2005.03.001
Reference
PMID:15457440
  Authors
Zouali M, Sarmay G
  Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
  Journal
Arthritis Rheum 50:2730-41 (2004)
DOI:10.1002/art.20487
Reference
PMID:15322145
  Authors
Chiles TC.
  Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
  Journal
J Immunol 173:2901-7 (2004)
DOI:10.4049/jimmunol.173.5.2901
Reference
PMID:15626471
  Authors
Allam A, Marshall AJ
  Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
  Journal
Immunol Lett 97:7-17 (2005)
DOI:10.1016/j.imlet.2004.09.019
Reference
PMID:12119152
  Authors
Gold MR
  Title
To make antibodies or not: signaling by the B-cell antigen receptor.
  Journal
Trends Pharmacol Sci 23:316-24 (2002)
DOI:10.1016/S0165-6147(02)02045-X
Reference
PMID:9697839
  Authors
Fu C, Turck CW, Kurosaki T, Chan AC
  Title
BLNK: a central linker protein in B cell activation.
  Journal
Immunity 9:93-103 (1998)
DOI:10.1016/S1074-7613(00)80591-9
Reference
PMID:11163197
  Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
  Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
  Journal
Immunity 13:817-27 (2000)
DOI:10.1016/S1074-7613(00)00079-0
Reference
PMID:18086859
  Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
  Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
  Journal
J Exp Med 204:3285-93 (2007)
DOI:10.1084/jem.20070379
Related
pathway
mdo04010  MAPK signaling pathway
mdo04020  Calcium signaling pathway
mdo04064  NF-kappa B signaling pathway
mdo04120  Ubiquitin mediated proteolysis
mdo04151  PI3K-Akt signaling pathway
mdo04610  Complement and coagulation cascades
mdo04810  Regulation of actin cytoskeleton
KO pathway
ko04662   

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