KEGG   PATHWAY: mdo04151
Entry
mdo04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Monodelphis domestica (gray short-tailed opossum)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mdo04151  PI3K-Akt signaling pathway
mdo04151

Other DBs
GO: 0043491
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100009839  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
100009879  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
100010071  F2R; coagulation factor II thrombin receptor [KO:K03914]
100010172  RPS6; ribosomal protein S6 [KO:K02991]
100010184  [KO:K04347]
100010246  NGF; nerve growth factor [KO:K02582]
100010269  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
100010412  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100010452  GNG3; G protein subunit gamma 3 [KO:K04540]
100010505  LAMB4; laminin subunit beta 4 [KO:K06245]
100010605  LAMB1; laminin subunit beta 1 [KO:K05636]
100010618  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
100010654  BCL2L1; BCL2 like 1 [KO:K04570]
100010720  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
100010736  GNB1; G protein subunit beta 1 [KO:K04536]
100010758  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
100010880  EPOR; erythropoietin receptor [KO:K05079]
100011015  GNG5; G protein subunit gamma 5 [KO:K04542]
100011161  G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
100011261  PDGFD; platelet derived growth factor D [KO:K05450]
100011289  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
100011431  TSC2; tuberous sclerosis 2 [KO:K07207]
100011484  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
100011544  LAMA3; laminin subunit alpha 3 [KO:K06240]
100011562  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
100011566  [KO:K04688] [EC:2.7.11.1]
100011681  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
100011688  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
100012132  VEGFA; vascular endothelial growth factor A [KO:K05448]
100012224  ATF4; activating transcription factor 4 [KO:K04374]
100012276  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
100012415  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100012447  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100012457  ANGPT4; angiopoietin 4 [KO:K05467]
100012464  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
100012499  FGF16; fibroblast growth factor 16 [KO:K04358]
100012652  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
100012692  FGF10; fibroblast growth factor 10 [KO:K04358]
100012885  CDC37; cell division cycle 37 [KO:K09554]
100012899  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100013036  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100013088  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100013102  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
100013112  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
100013257  CCND1; cyclin D1 [KO:K04503]
100013301  VEGFC; vascular endothelial growth factor C [KO:K05449]
100013311  PKN3; protein kinase N3 [KO:K23692]
100013384  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
100013546  GNB4; G protein subunit beta 4 [KO:K04538]
100013663  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
100013711  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
100013715  IBSP; integrin binding sialoprotein [KO:K06253]
100013759  GNB3; G protein subunit beta 3 [KO:K07825]
100013788  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
100013879  RELN; reelin [KO:K06249] [EC:3.4.21.-]
100013925  TNC; tenascin C [KO:K06252]
100014049  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
100014105  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100014118  FN1; fibronectin 1 [KO:K05717]
100014202  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
100014272  NTF3; neurotrophin 3 [KO:K04356]
100014283  GDNF; glial cell derived neurotrophic factor [KO:K05452]
100014446  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100014453  VWF; von Willebrand factor [KO:K03900]
100014467  TLR4; toll like receptor 4 [KO:K10160]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100014573  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
100014623  CCNE1; cyclin E1 [KO:K06626]
100014675  MTCP1; mature T-cell proliferation 1 [KO:K16837]
100014687  GNG7; G protein subunit gamma 7 [KO:K04543]
100014690  FGF5; fibroblast growth factor 5 [KO:K04358]
100014854  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
100014865  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
100014893  ITGA10; integrin subunit alpha 10 [KO:K06586]
100014923  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
100014991  PRLR; prolactin receptor [KO:K05081]
100015046  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
100015122  [KO:K06856]
100015252  [KO:K06856]
100015395  NRTN; neurturin [KO:K25414]
100015410  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100015424  [KO:K06856]
100015472  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100015499  [KO:K06856]
100015641  [KO:K06856]
100015707  EFNA5; ephrin A5 [KO:K05462]
100015877  LAMC3; laminin subunit gamma 3 [KO:K06247]
100015923  LAMA1; laminin subunit alpha 1 [KO:K05637]
100016023  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
100016122  HGF; hepatocyte growth factor [KO:K05460]
100016186  COMP; cartilage oligomeric matrix protein [KO:K04659]
100016259  CCND2; cyclin D2 [KO:K10151]
100016488  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
100016521  EFNA1; ephrin A1 [KO:K05462]
100016570  BCL2; BCL2, apoptosis regulator [KO:K02161]
100016573  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
100016607  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100016618  CSF3; colony stimulating factor 3 [KO:K05423]
100016723  SPP1; secreted phosphoprotein 1 [KO:K06250]
100016805  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
100016914  GNG12; G protein subunit gamma 12 [KO:K04347]
100016961  GNG8; G protein subunit gamma 8 [KO:K04544]
100017028  MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 [KO:K05629]
100017080  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
100017172  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
100017208  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
100017262  MCL1; BCL2 family apoptosis regulator [KO:K02539]
100017311  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
100017332  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100017392  GNB2; G protein subunit beta 2 [KO:K04537]
100017439  GNG13; G protein subunit gamma 13 [KO:K04547]
100017469  [KO:K05096] [EC:2.7.10.1]
100017501  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
100017519  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
100017591  TSC1; tuberous sclerosis 1 [KO:K07206]
100017761  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
100017824  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
100017831  PRL; prolactin [KO:K05439]
100017930  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
100017951  COL6A3; collagen type VI alpha 3 chain [KO:K06238]
100018035  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
100018044  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100018121  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
100018159  EPO; erythropoietin [KO:K05437]
100018189  GNG10; G protein subunit gamma 10 [KO:K04545]
100018342  ITGB1; integrin subunit beta 1 [KO:K05719]
100018376  ITGA6; integrin subunit alpha 6 [KO:K06485]
100018410  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018731  ITGB8; integrin subunit beta 8 [KO:K06591]
100018830  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100018838  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
100018870  RHEB; Ras homolog enriched in brain [KO:K07208]
100019066  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
100019136  RBL2; RB transcriptional corepressor like 2 [KO:K16332]
100019300  OSMR; oncostatin M receptor [KO:K05057]
100019317  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100019354  COL1A1; collagen type I alpha 1 chain [KO:K06236]
100019466  RXRA; retinoid X receptor alpha [KO:K08524]
100019563  FGF6; fibroblast growth factor 6 [KO:K04358]
100019656  FGF23; fibroblast growth factor 23 [KO:K22428]
100019816  ITGA9; integrin subunit alpha 9 [KO:K06585]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100019951  CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
100020067  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
100020074  ITGB5; integrin subunit beta 5 [KO:K06588]
100020095  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100020275  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100020561  IL6R; interleukin 6 receptor [KO:K05055]
100020565  IL7R; interleukin 7 receptor [KO:K05072]
100020680  COL9A1; collagen type IX alpha 1 chain [KO:K08131]
100020771  PHLPP2; PH domain and leucine rich repeat protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
100020951  PDGFA; platelet derived growth factor subunit A [KO:K04359]
100021132  GNG4; G protein subunit gamma 4 [KO:K04541]
100021250  EFNA2; ephrin A2 [KO:K05462]
100021258  IFNB1; interferon beta [KO:K05415]
100021290  IFN3; type I interferon 3 [KO:K05414]
100021295  IGF1; insulin like growth factor 1 [KO:K05459]
100021303  TNN; tenascin N [KO:K06252]
100021311  IFN7; type I interferon 7 [KO:K05414]
100021328  TNR; tenascin R [KO:K06252]
100021340  IFN4; type I interferon 4 [KO:K05414]
100021368  [KO:K05414]
100021398  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
100021399  KITLG; KIT ligand [KO:K05461]
100021419  [KO:K05414]
100021467  [KO:K05414]
100021487  IFN2; type I interferon 2 [KO:K05414]
100021575  FGF19; fibroblast growth factor 19 [KO:K22603]
100021625  EFNA4; ephrin A4 [KO:K05462]
100021631  FGF4; fibroblast growth factor 4 [KO:K04358]
100021649  LAMB3; laminin subunit beta 3 [KO:K06244]
100021663  COL4A3; collagen type IV alpha 3 chain [KO:K06237]
100021675  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100021692  FGF3; fibroblast growth factor 3 [KO:K04358]
100021705  FOXO3; forkhead box O3 [KO:K09408]
100021728  COL4A4; collagen type IV alpha 4 chain [KO:K06237]
100021774  NGFR; nerve growth factor receptor [KO:K02583]
100021838  IRS1; insulin receptor substrate 1 [KO:K16172]
100021885  FGF20; fibroblast growth factor 20 [KO:K04358]
100022025  THBS3; thrombospondin 3 [KO:K04659]
100022034  ITGB6; integrin subunit beta 6 [KO:K06589]
100022186  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
100022246  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
100022409  PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]
100022489  ITGA3; integrin subunit alpha 3 [KO:K06482]
100022523  [KO:K07828]
100022547  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
100022654  CCNE2; cyclin E2 [KO:K06626]
100022847  G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
100022894  GRB2; growth factor receptor bound protein 2 [KO:K04364]
100022918  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100023197  FGF1; fibroblast growth factor 1 [KO:K18496]
100023250  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
100023287  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100023354  ITGA2B; integrin subunit alpha 2b [KO:K06476]
100023400  FGF8; fibroblast growth factor 8 [KO:K04358]
100023623  PGF; placental growth factor [KO:K16859]
100023678  COL4A2; collagen type IV alpha 2 chain [KO:K06237]
100023701  PDGFC; platelet derived growth factor C [KO:K05450]
100023705  COL4A1; collagen type IV alpha 1 chain [KO:K06237]
100023749  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
100023928  FGF9; fibroblast growth factor 9 [KO:K04358]
100023929  EREG; epiregulin [KO:K09784]
100023945  LAMC1; laminin subunit gamma 1 [KO:K05635]
100023958  [KO:K04354]
100023967  LAMC2; laminin subunit gamma 2 [KO:K06246]
100023978  AREG; amphiregulin [KO:K09782]
100024059  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
100024331  ANGPT1; angiopoietin 1 [KO:K05465]
100024550  VTN; vitronectin [KO:K06251]
100024558  TLR2; toll like receptor 2 [KO:K10159]
100024639  FGF22; fibroblast growth factor 22 [KO:K04358]
100024674  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100024744  PHLPP1; PH domain and leucine rich repeat protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
100024769  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100024870  [KO:K02583]
100025262  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
100025304  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
100025359  ITGB3; integrin subunit beta 3 [KO:K06493]
100025378  ARTN; artemin [KO:K25415]
100025393  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
100025435  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
100025499  MYB; MYB proto-oncogene, transcription factor [KO:K09420]
100025514  [KO:K06237]
100025581  TNXB; tenascin XB [KO:K06252]
100025603  ATF6B; activating transcription factor 6 beta [KO:K09049]
100025683  COL9A3; collagen type IX alpha 3 chain [KO:K08131]
100025727  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100025923  FGF7; fibroblast growth factor 7 [KO:K04358]
100025939  ATF2; activating transcription factor 2 [KO:K04450]
100025947  ITGA11; integrin subunit alpha 11 [KO:K06587]
100026103  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
100026192  LAMA5; laminin subunit alpha 5 [KO:K06240]
100026420  COL6A2; collagen type VI alpha 2 chain [KO:K06238]
100026472  PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
100026516  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100027090  ITGA8; integrin subunit alpha 8 [KO:K06584]
100027188  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
100027215  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
100027264  ITGB4; integrin subunit beta 4 [KO:K06525]
100027338  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100027449  ITGA4; integrin subunit alpha 4 [KO:K06483]
100027514  LAMB2; laminin subunit beta 2 [KO:K06243]
100027538  CCND3; cyclin D3 [KO:K10152]
100027540  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
100027775  PKN2; protein kinase N2 [KO:K23691]
100027887  [KO:K19719]
100027952  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100028072  [KO:K05084] [EC:2.7.10.1]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100028103  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
100028127  ITGAV; integrin subunit alpha V [KO:K06487]
100028356  [KO:K05855] [EC:2.7.10.2]
100028411  VEGFB; vascular endothelial growth factor B [KO:K16858]
100028805  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
100028850  ANGPT2; angiopoietin 2 [KO:K05466]
100028926  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100028943  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100029103  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
100029105  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
100029120  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
100029256  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100029389  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
100029499  LAMA4; laminin subunit alpha 4 [KO:K06241]
100029625  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100029774  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
100029852  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
100030053  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
100030355  [KO:K03259]
100030389  COL6A6; collagen type VI alpha 6 chain [KO:K06238]
100030416  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
100030421  [KO:K06626]
100030435  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
100030437  [KO:K06238]
100030474  FGF17; fibroblast growth factor 17 [KO:K04358]
100030479  NTF4; neurotrophin 4 [KO:K12457]
100030700  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
100030704  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
100030895  LAMA2; laminin subunit alpha 2 [KO:K05637]
100031074  FGF18; fibroblast growth factor 18 [KO:K04358]
100031246  BAD; BCL2 associated agonist of cell death [KO:K02158]
100031307  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
100031383  GNB5; G protein subunit beta 5 [KO:K04539]
100031492  ITGA1; integrin subunit alpha 1 [KO:K06480]
100031498  ITGA2; integrin subunit alpha 2 [KO:K06481]
100031592  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
100031767  THBS1; thrombospondin 1 [KO:K16857]
100031803  VEGFD; vascular endothelial growth factor D [KO:K05449]
100031838  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100032061  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
100032078  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
100032118  COL9A2; collagen type IX alpha 2 chain [KO:K08131]
100032285  [KO:K06236]
100032344  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
100032579  THBS4; thrombospondin 4 [KO:K04659]
100032629  SGK2; SGK2, serine/threonine kinase 2 [KO:K13303] [EC:2.7.11.1]
100032634  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
100032659  THBS2; thrombospondin 2 [KO:K04659]
100032726  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100032790  TGFA; transforming growth factor alpha [KO:K08774]
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
100033031  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100033077  CSF1; colony stimulating factor 1 [KO:K05453]
100033215  BCL2L11; BCL2 like 11 [KO:K16341]
100616957  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100617157  EFNA3; ephrin A3 [KO:K05462]
100617168  CHAD; chondroadherin [KO:K06248]
100617684  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
100617956  COL6A1; collagen type VI alpha 1 chain [KO:K06238]
100618058  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100618744  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
100619143  EGF; epidermal growth factor [KO:K04357]
100619184  IL2; interleukin 2 [KO:K05429]
100619507  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
100619627  [KO:K06243]
100619675  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
100619759  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
100619897  G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
103092514  IL4R; interleukin 4 receptor [KO:K05071]
103092556  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103092862  [KO:K06643] [EC:2.3.2.27]
103093188  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
103094214  OSM; oncostatin M [KO:K05418]
103094311  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
103098203  [KO:K06856]
103100618  CD19; CD19 molecule [KO:K06465]
103102093  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
103103209  [KO:K04289]
103103582  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
103104339  IL6; interleukin 6 [KO:K05405]
103104366  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
103106447  IL7; interleukin 7 [KO:K05431]
497248  TP53; tumor protein p53 [KO:K04451]
554178  BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
554180  GHR; growth hormone receptor [KO:K05080]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
554233  BDNF; brain derived neurotrophic factor [KO:K04355]
554243  GH1; growth hormone 1 [KO:K05438]
619384  FGF2; fibroblast growth factor 2 [KO:K18497]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mdo00010  Glycolysis / Gluconeogenesis
mdo04010  MAPK signaling pathway
mdo04012  ErbB signaling pathway
mdo04062  Chemokine signaling pathway
mdo04064  NF-kappa B signaling pathway
mdo04068  FoxO signaling pathway
mdo04110  Cell cycle
mdo04115  p53 signaling pathway
mdo04150  mTOR signaling pathway
mdo04210  Apoptosis
mdo04370  VEGF signaling pathway
mdo04510  Focal adhesion
mdo04620  Toll-like receptor signaling pathway
mdo04630  JAK-STAT signaling pathway
mdo04662  B cell receptor signaling pathway
mdo04910  Insulin signaling pathway
KO pathway
ko04151   

DBGET integrated database retrieval system