KEGG   PATHWAY: mmma00230
Entry
mmma00230                   Pathway                                
Name
Purine metabolism - Marmota marmota marmota (Alpine marmot)
Class
Metabolism; Nucleotide metabolism
Pathway map
mmma00230  Purine metabolism
mmma00230

Module
mmma_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:mmma00230]
mmma_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mmma00230]
mmma_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mmma00230]
mmma_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mmma00230]
mmma_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mmma00230]
mmma_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mmma00230]
Other DBs
GO: 0006163 0042278
Organism
Marmota marmota marmota (Alpine marmot) [GN:mmma]
Gene
107135256  [KO:K12305] [EC:3.6.1.6]
107135549  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2 [KO:K18283] [EC:3.1.4.17]
107135576  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107135644  Ampd3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
107136445  Gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
107136508  Pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
107137043  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
107137159  Allc; probable inactive allantoicase [KO:K01477] [EC:3.5.3.4]
107137376  Xdh; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
107137479  [KO:K01081] [EC:3.1.3.5]
107137505  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
107138262  [KO:K03783] [EC:2.4.2.1]
107138506  Pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
107138523  Pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2 [KO:K13755] [EC:3.1.4.17]
107138668  Atic; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
107138790  Pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
107139058  Pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
107139174  Pgm2; phosphopentomutase isoform X2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
107139249  Paics; LOW QUALITY PROTEIN: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase [KO:K01587] [EC:4.1.1.21 6.3.2.6]
107139293  [KO:K01081] [EC:3.1.3.5]
107139430  Ak6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
107139551  Itpa; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
107140470  Adss2; adenylosuccinate synthetase isozyme 2 isoform X2 [KO:K01939] [EC:6.3.4.4]
107140796  [KO:K12319] [EC:4.6.1.2]
107140960  Urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
107141064  [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
107141283  Gucy1a1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
107141284  Gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
107141373  Papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
107141681  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3 [KO:K13293] [EC:3.1.4.53]
107141688  Ak4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
107141691  Pgm1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
107141919  Nt5c1a; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
107141985  Ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
107142422  Pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
107142639  Pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
107142750  [KO:K01081] [EC:3.1.3.5]
107142842  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
107143016  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107143060  [KO:K07127] [EC:3.5.2.17]
107143106  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
107143126  Gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
107143162  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
107143400  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
107143500  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
107143525  Nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
107143968  Enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
107144125  Prps2; ribose-phosphate pyrophosphokinase 2 isoform X2 [KO:K00948] [EC:2.7.6.1]
107144524  Impdh1; LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
107144878  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
107144930  Adss1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
107145063  Pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
107145128  [KO:K01756] [EC:4.3.2.2]
107145179  Pde4a; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
107145477  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
107145705  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
107146155  Pde1c; dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X7 [KO:K13755] [EC:3.1.4.17]
107146235  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107146314  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107146428  Ak5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
107146665  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
107146788  Nme4; nucleoside diphosphate kinase, mitochondrial isoform X2 [KO:K00940] [EC:2.7.4.6]
107147405  Nme7; nucleoside diphosphate kinase 7 isoform X5 [KO:K00940] [EC:2.7.4.6]
107147421  Adcy10; adenylate cyclase type 10 isoform X4 [KO:K11265] [EC:4.6.1.1]
107147463  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
107147651  Gmpr2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
107147801  Npr2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
107147842  Nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
107148242  Ak3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
107148278  Gda; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
107148396  Pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
107148411  Hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X2 [KO:K21138] [EC:3.1.7.2]
107148494  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X5 [KO:K01511] [EC:3.6.1.6]
107148587  Adcy6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
107148831  Pde1b; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
107149107  Entpd5; LOW QUALITY PROTEIN: nucleoside diphosphate phosphatase ENTPD5 [KO:K01511] [EC:3.6.1.6]
107149382  Gmpr; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
107149709  Fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
107149751  [KO:K01510] [EC:3.6.1.5]
107149852  Nt5c2; cytosolic purine 5'-nucleotidase isoform X4 [KO:K01081] [EC:3.1.3.5]
107149929  [KO:K01510] [EC:3.6.1.5]
107150240  Nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
107150392  Ak7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
107150435  Nme2; nucleoside diphosphate kinase B isoform X2 [KO:K00940] [EC:2.7.4.6]
107150795  [KO:K07127] [EC:3.5.2.17]
107150821  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
107151605  Nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
107151871  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X10 [KO:K13293] [EC:3.1.4.53]
107151906  Ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
107152059  Ak1; adenylate kinase isoenzyme 1 isoform X2 [KO:K00939] [EC:2.7.4.3]
107152157  Ak8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
107152235  Pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
107152301  Pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
107152410  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
107152442  Gucy2f; LOW QUALITY PROTEIN: retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
107152657  Prps1l1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
107152688  Gucy2c; guanylyl cyclase C [KO:K12320] [EC:4.6.1.2]
107152764  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
107152795  Pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
107153163  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
107153238  Guk1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
107153338  Papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X3 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
107153642  Nudt9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
107153914  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
107154035  Nt5dc4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
107154209  Dguok; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
107154412  Pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
107154426  [KO:K13988] [EC:3.6.1.13]
107154553  [KO:K00940] [EC:2.7.4.6]
107155030  Ada2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
107155136  Hddc2; 5'-deoxynucleotidase HDDC2 isoform X1 [KO:K07023] [EC:3.1.3.89]
107155415  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
107155437  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
107155860  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
107156176  Ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
107156770  Npr1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
107156799  [KO:K12321] [EC:4.6.1.2]
107156824  Prune1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
107157154  Nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
107157703  Pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
107157868  Nt5c; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
107157912  Ntpcr; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
107158019  Gucy2d; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
107158027  Pfas; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
107158046  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
107158110  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
107158151  Adk; adenosine kinase isoform X2 [KO:K00856] [EC:2.7.1.20]
107158292  [KO:K00365] [EC:1.7.3.3]
107158348  [KO:K00939] [EC:2.7.4.3]
107158608  Ampd2; AMP deaminase 2 isoform X2 [KO:K01490] [EC:3.5.4.6]
107158810  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
107159114  [KO:K01509] [EC:3.6.1.-]
107159203  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X2 [KO:K01510] [EC:3.6.1.5]
107159565  Hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
107160621  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X4 [KO:K13762] [EC:3.1.4.35]
125612050  [KO:K18532] [EC:2.7.4.3]
125619557  [KO:K00939] [EC:2.7.4.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mmma00030  Pentose phosphate pathway
mmma00220  Arginine biosynthesis
mmma00250  Alanine, aspartate and glutamate metabolism
mmma00260  Glycine, serine and threonine metabolism
mmma00340  Histidine metabolism
mmma00630  Glyoxylate and dicarboxylate metabolism
mmma00730  Thiamine metabolism
mmma00740  Riboflavin metabolism
mmma00790  Folate biosynthesis
KO pathway
ko00230   

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