KEGG   PATHWAY: ocz03013
Entry
ocz03013                    Pathway                                
Name
Nucleocytoplasmic transport - Ochotona curzoniae (black-lipped pika)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ocz03013  Nucleocytoplasmic transport
ocz03013

Other DBs
GO: 0050658
Organism
Ochotona curzoniae (black-lipped pika) [GN:ocz]
Gene
121144667  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
121145099  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
121145486  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
121145839  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
121146137  NUP43; nucleoporin Nup43 [KO:K14305]
121146263  [KO:K14285]
121146423  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
121146906  THOC3; THO complex subunit 3 [KO:K12880]
121147157  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
121147823  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
121148101  [KO:K12160]
121148110  [KO:K12877]
121148125  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
121148144  AHCTF1; protein ELYS isoform X1 [KO:K25129]
121148577  IPO4; importin-4 isoform X1 [KO:K20221]
121148672  PNN; pinin [KO:K13114]
121148815  SNUPN; snurportin-1 [KO:K13151]
121149101  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
121149352  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
121150408  XPO7; exportin-7 isoform X1 [KO:K18460]
121150710  NUP35; nucleoporin NUP35 [KO:K14313]
121151043  IPO8; importin-8 isoform X1 [KO:K18755]
121151443  [KO:K14316]
121151590  XPO6; exportin-6 isoform X1 [KO:K25204]
121151734  [KO:K13175]
121151759  [KO:K14325]
121151795  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
121152128  THOC1; THO complex subunit 1 [KO:K12878]
121152191  KPNA6; importin subunit alpha-7 [KO:K15042]
121152319  IPO13; importin-13 [KO:K25202]
121152698  KPNA4; importin subunit alpha-3 [KO:K23583]
121152701  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
121153070  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
121153989  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
121154485  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
121154572  IPO11; importin-11 [KO:K25201]
121154896  NUP62; nuclear pore glycoprotein p62 isoform X1 [KO:K14306]
121155266  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
121155270  MAGOH; protein mago nashi homolog [KO:K12877]
121156042  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
121156259  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
121156474  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
121156622  KPNA7; importin subunit alpha-8 [KO:K15043]
121157275  CSE1L; exportin-2 [KO:K18423]
121157471  NXT1; NTF2-related export protein 1 [KO:K14285]
121157611  NXF1; nuclear RNA export factor 1 [KO:K14284]
121157674  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
121157924  [KO:K18655] [EC:5.6.2.7]
121157925  [KO:K18655] [EC:5.6.2.7]
121157969  XPOT; exportin-T [KO:K14288]
121158067  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
121158604  XPO5; exportin-5 [KO:K14289]
121158709  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
121158745  [KO:K03231]
121159025  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
121159378  NUP37; nucleoporin Nup37 [KO:K14302]
121159407  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
121159911  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
121159942  IPO9; importin-9 isoform X1 [KO:K20224]
121160384  TNPO1; transportin-1 isoform X1 [KO:K18752]
121160510  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
121160672  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
121160712  SUMO3; small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
121160828  RAN; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
121161066  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
121161598  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
121161639  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
121161663  RAE1; mRNA export factor [KO:K14298]
121161752  XPO4; exportin-4 isoform X1 [KO:K25203]
121161754  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
121161950  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
121162233  IPO7; importin-7 [KO:K20223]
121162274  AAAS; aladin isoform X1 [KO:K14320]
121162450  ALYREF; THO complex subunit 4 [KO:K12881]
121162497  KPNA2; importin subunit alpha-1 [KO:K15043]
121162578  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
121162581  SUMO2; small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
121162642  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
121163134  TNPO2; transportin-2 isoform X1 [KO:K18727]
121163557  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
121163606  IPO5; importin-5 isoform X1 [KO:K20222]
121163711  KPNA3; importin subunit alpha-4 [KO:K23583]
121165001  [KO:K14316]
121165012  XPO1; exportin-1 isoform X1 [KO:K14290]
121165599  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
121165824  THOC7; THO complex subunit 7 homolog [KO:K13176]
121165866  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
121166103  SEC13; protein SEC13 homolog [KO:K14004]
121166695  [KO:K25201]
121166817  [KO:K12812] [EC:5.6.2.7]
121167527  [KO:K14291]
121167859  [KO:K14325]
121167903  [KO:K13175]
121167990  [KO:K14316]
121168105  [KO:K12160]
121168646  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
121168662  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
121169072  [KO:K14284]
121169073  [KO:K14284]
121169076  [KO:K14284]
121169077  [KO:K14284]
121169082  NXF5; nuclear RNA export factor 5 [KO:K14284]
121169189  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
121169388  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
121169419  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
121169508  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
121169814  CASC3; protein CASC3 [KO:K14323]
121170353  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
121170464  KPNB1; importin subunit beta-1 [KO:K14293]
121170771  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
121170959  TNPO3; transportin-3 isoform X1 [KO:K15436]
121171146  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
121171273  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
121171366  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
121171931  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
121172018  [KO:K13176]
121172425  NUP188; nucleoporin NUP188 [KO:K14311]
121172528  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ocz03015  mRNA surveillance pathway
KO pathway
ko03013   

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