KEGG   PATHWAY: panu04110
Entry
panu04110                   Pathway                                
Name
Cell cycle - Papio anubis (olive baboon)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
panu04110  Cell cycle
panu04110

Other DBs
GO: 0000278
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101019923  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101004371  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100137215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
101011004  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101013902  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
101017005  RB1; retinoblastoma-associated protein [KO:K06618]
100998071  RBL1; retinoblastoma-like protein 1 isoform X3 [KO:K04681]
101008150  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101007628  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101024777  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
101010160  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
101000533  E2F1; transcription factor E2F1 [KO:K17454]
101015623  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
101025116  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
101023767  E2F5; transcription factor E2F5 isoform X3 [KO:K04682]
101009868  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
100998258  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
101020513  TFDP2; transcription factor Dp-2 isoform X2 [KO:K09392]
100998800  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101006627  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
101009253  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100997116  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101004882  SMAD2; mothers against decapentaplegic homolog 2 isoform X2 [KO:K04500]
101013089  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101019266  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
101000645  MYC; myc proto-oncogene protein [KO:K04377]
101014210  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X4 [KO:K10500]
101017208  cyclin-dependent kinase inhibitor 2A isoform X2 [KO:K06621]
101015078  tumor suppressor ARF-like [KO:K06621]
101014127  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100998894  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100998492  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
101001461  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101005317  CDKN1C; cyclin-dependent kinase inhibitor 1C isoform X1 [KO:K09993]
100999911  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101000606  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101025307  CCNE2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
101025892  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101022453  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101000243  CUL1; cullin-1 [KO:K03347]
101025661  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
101000264  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
100999197  CCNA2; cyclin-A2 [KO:K06627]
101003474  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
101020075  CDC6; cell division control protein 6 homolog [KO:K02213]
101009087  CDT1; DNA replication factor Cdt1 [KO:K10727]
101007016  ORC1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
101004497  ORC2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
100998020  ORC3; origin recognition complex subunit 3 isoform X3 [KO:K02605]
101010044  ORC4; origin recognition complex subunit 4 [KO:K02606]
101008591  ORC5; origin recognition complex subunit 5 isoform X2 [KO:K02607]
101012479  ORC6; origin recognition complex subunit 6 isoform X1 [KO:K02608]
101002859  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
100998595  MCM3; DNA replication licensing factor MCM3 isoform X1 [KO:K02541] [EC:5.6.2.3]
101000051  MCM4; DNA replication licensing factor MCM4 isoform X2 [KO:K02212] [EC:5.6.2.3]
101000184  MCM5; DNA replication licensing factor MCM5 isoform X1 [KO:K02209] [EC:5.6.2.3]
101022033  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
101001377  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
101019197  CDC45; cell division control protein 45 homolog isoform X2 [KO:K06628]
101026210  TICRR; treslin isoform X1 [KO:K26117]
101008170  MTBP; mdm2-binding protein [KO:K26116]
100999141  CDC7; cell division cycle 7-related protein kinase isoform X2 [KO:K02214] [EC:2.7.11.1]
101004176  DBF4; protein DBF4 homolog A isoform X2 [KO:K06629]
101014974  DBF4B; protein DBF4 homolog B isoform X1 [KO:K06629]
101025881  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101007909  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
116272568  G2/mitotic-specific cyclin-B2 [KO:K21770]
101025984  G2/mitotic-specific cyclin-B2 [KO:K21770]
101024929  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
101007465  CDC25B; M-phase inducer phosphatase 2 isoform X7 [KO:K05866] [EC:3.1.3.48]
101017717  CDC25C; M-phase inducer phosphatase 3 isoform X5 [KO:K05867] [EC:3.1.3.48]
101022263  YWHAQ; 14-3-3 protein theta isoform X4 [KO:K16197]
101021050  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
101022352  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101012101  14-3-3 protein zeta/delta [KO:K16197]
101010193  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101005569  YWHAG; 14-3-3 protein gamma [KO:K16198]
100126764  YWHAH; 14-3-3 protein eta [KO:K16198]
101009200  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
101001148  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
101011958  WEE1; wee1-like protein kinase isoform X3 [KO:K06632] [EC:2.7.11.1]
101012253  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
101016184  CCNH; cyclin-H isoform X2 [KO:K06634]
101016788  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
101015415  ANAPC1; anaphase-promoting complex subunit 1 isoform X2 [KO:K03348]
101003223  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
101010691  CDC27; cell division cycle protein 27 homolog isoform X3 [KO:K03350]
101011179  ANAPC4; anaphase-promoting complex subunit 4 isoform X2 [KO:K03351]
101020484  ANAPC5; anaphase-promoting complex subunit 5 isoform X3 [KO:K03352]
101004072  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
101026357  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
101016424  CDC23; cell division cycle protein 23 homolog [KO:K03355]
101015461  ANAPC10; anaphase-promoting complex subunit 10 isoform X4 [KO:K03357]
101007414  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
103878141  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
101025444  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
100999272  ANAPC15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
101006219  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
101001004  CDC20; cell division cycle protein 20 homolog [KO:K03363]
101000383  PTTG1; securin [KO:K06635]
101001092  LOW QUALITY PROTEIN: putative pituitary tumor-transforming gene 3 protein [KO:K06635]
101019541  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
101007349  SMC1B; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
101012850  SMC1A; structural maintenance of chromosomes protein 1A isoform X1 [KO:K06636]
101019671  SMC3; structural maintenance of chromosomes protein 3 isoform X1 [KO:K06669]
100998068  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
101024103  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
101019578  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
101012492  ATRX; LOW QUALITY PROTEIN: transcriptional regulator ATRX [KO:K10779]
101005992  DDX11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
101002460  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
101000019  MAU2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
101021267  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
100998372  ESCO1; N-acetyltransferase ESCO1 isoform X1 [KO:K11268] [EC:2.3.1.-]
101026814  ESCO2; N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
101007536  PDS5A; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
101023132  PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
101006437  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
100998798  CDCA5; sororin isoform X4 [KO:K17390]
101005524  AURKB; aurora kinase B isoform X2 [KO:K11479] [EC:2.7.11.1]
101000567  SGO1; shugoshin 1 isoform X1 [KO:K11580]
101021745  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101011206  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101003925  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101000613  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101011174  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100997528  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
101006765  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101010611  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
100137475  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101007684  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
101018785  NDC80; kinetochore protein NDC80 homolog isoform X1 [KO:K11547]
101016674  KNL1; kinetochore scaffold 1 isoform X1 [KO:K11542]
101001155  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
101008228  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
101022443  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100137358  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
101016839  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X2 [KO:K13728]
101009307  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X4 [KO:K06637] [EC:2.7.11.1]
101011923  BUB3; mitotic checkpoint protein BUB3 isoform X2 [KO:K02180]
101007256  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
101020688  TRIP13; pachytene checkpoint protein 2 homolog [KO:K22399]
101024190  MAD2L1BP; MAD2L1-binding protein isoform X1 [KO:K26093]
101023610  FZR1; fizzy-related protein homolog isoform X2 [KO:K03364]
101007895  FBXO5; F-box only protein 5 isoform X1 [KO:K10292]
101018769  CDC14C; dual specificity protein phosphatase CDC14C [KO:K06639] [EC:3.1.3.16 3.1.3.48]
101007961  CDC14A; dual specificity protein phosphatase CDC14A isoform X2 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
101021000  CDC14B; dual specificity protein phosphatase CDC14B isoform X13 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
101027061  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101002586  CREBBP; CREB-binding protein isoform X5 [KO:K04498] [EC:2.3.1.48]
100999716  PRKDC; DNA-dependent protein kinase catalytic subunit isoform X2 [KO:K06642] [EC:2.7.11.1]
101017442  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101021695  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
101016712  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101006608  TP53; cellular tumor antigen p53 [KO:K04451]
101014806  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100997308  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101012106  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
101016590  PCNA; proliferating cell nuclear antigen [KO:K04802]
101021911  14-3-3 protein sigma [KO:K06644]
116274674  SFN; 14-3-3 protein sigma [KO:K06644]
101019580  CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
101015280  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
101017438  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
panu03030  DNA replication
panu04010  MAPK signaling pathway
panu04120  Ubiquitin mediated proteolysis
panu04210  Apoptosis
KO pathway
ko04110   
LinkDB

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