KEGG   PATHWAY: bom04150
Entry
bom04150                    Pathway                                
Name
mTOR signaling pathway - Bos mutus (wild yak)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
bom04150  mTOR signaling pathway
bom04150

Organism
Bos mutus (wild yak) [GN:bom]
Gene
102272835  SLC7A5; solute carrier family 7 member 5 [KO:K13780]
102275454  SLC3A2; solute carrier family 3 member 2 [KO:K06519]
102279690  SLC38A9; solute carrier family 38 member 9 [KO:K14995]
102276594  ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
102274358  ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
102273812  ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
102265121  ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
102265717  ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
102270467  ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
102278885  ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
102264759  ATP6V1E2; ATPase H+ transporting V1 subunit E2 [KO:K02150]
102266709  V-type proton ATPase subunit F [KO:K02151]
102264704  ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
102276671  ATP6V1G2; ATPase H+ transporting V1 subunit G2 [KO:K02152]
102272754  ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
102281641  ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
102282064  V-type proton ATPase subunit H [KO:K02144]
102268823  V-type proton ATPase subunit H-like [KO:K02144]
102273993  LAMTOR1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [KO:K20397]
102279465  LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [KO:K20398]
102268519  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102287796  LAMTOR4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [KO:K20399]
102278128  LAMTOR5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [KO:K16344]
102268877  FLCN; folliculin [KO:K09594]
102276323  FNIP1; folliculin interacting protein 1 [KO:K20400]
102276370  FNIP2; folliculin interacting protein 2 [KO:K20401]
102281123  ras-related GTP-binding protein B-like [KO:K16185]
102277794  RRAGA; Ras related GTP binding A [KO:K16185]
102267833  RRAGD; Ras related GTP binding D [KO:K16186]
102273795  RRAGC; Ras related GTP binding C [KO:K16186]
102282733  SESN2; sestrin 2 [KO:K20394]
102272136  GATSL3; GATS protein like 3 [KO:K23080]
102275607  GATSL2; GATS protein like 2 [KO:K23081]
102276377  MIOS; meiosis regulator for oocyte development [KO:K20407]
102285050  SEH1L; SEH1 like nucleoporin [KO:K14299]
102265182  WDR24; WD repeat domain 24 [KO:K20408]
102264473  WDR59; WD repeat domain 59 [KO:K20409]
102272181  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
102287485  DEPDC5; DEP domain containing 5 [KO:K20404]
102285704  NPRL2; NPR2-like, GATOR1 complex subunit [KO:K20405]
102269486  NPRL3; NPR3 like, GATOR1 complex subunit [KO:K20406]
102269700  SKP2; S-phase kinase associated protein 2 [KO:K03875]
102277531  S-phase kinase-associated protein 2-like [KO:K03875]
102272775  RNF152; ring finger protein 152 [KO:K15705] [EC:2.3.2.27]
102285390  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102264796  AKT1S1; AKT1 substrate 1 [KO:K16184]
102281727  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102282235  DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
102266601  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102285569  TELO2; telomere maintenance 2 [KO:K11137]
102283200  TTI1; TELO2 interacting protein 1 [KO:K20403]
102271370  CLIP1; CAP-Gly domain containing linker protein 1 [KO:K10421]
102264736  growth factor receptor-bound protein 10 [KO:K20064]
102287489  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
102271422  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
102278355  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
102277562  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102268847  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102278368  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102275213  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
102266436  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
102282841  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102285710  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102271079  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102287925  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
102278820  RPS6; ribosomal protein S6 [KO:K02991]
102274168  STRADA; STE20-related kinase adaptor alpha [KO:K08271]
102273173  STRADB; STE20-related kinase adaptor beta [KO:K17532]
102278863  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102269403  CAB39; calcium binding protein 39 [KO:K08272]
102287075  CAB39L; calcium binding protein 39 like [KO:K08272]
102270414  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102265959  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102280709  TSC1; tuberous sclerosis 1 [KO:K07206]
102267343  TSC2; tuberous sclerosis 2 [KO:K07207]
102279766  TBC1D7; TBC1 domain family member 7 [KO:K20396]
102277658  RHEB; Ras homolog enriched in brain [KO:K07208]
102267219  GTP-binding protein Rheb [KO:K07208]
102285482  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102268143  WNT1; Wnt family member 1 [KO:K03209]
102285570  WNT2B; Wnt family member 2B [KO:K00182]
102288008  WNT2; Wnt family member 2 [KO:K00182]
102275609  WNT3A; Wnt family member 3A [KO:K00312]
102281377  WNT3; Wnt family member 3 [KO:K00312]
102269858  WNT4; Wnt family member 4 [KO:K00408]
102269211  WNT5A; Wnt family member 5A [KO:K00444]
102276467  WNT5B; Wnt family member 5B [KO:K00444]
102286828  WNT6; Wnt family member 6 [KO:K00445]
102279575  WNT7A; Wnt family member 7A [KO:K00572]
102284700  protein Wnt-7b-like [KO:K00572]
102287042  protein Wnt-7b [KO:K00572]
102285959  WNT8B; Wnt family member 8B [KO:K00714]
102285045  WNT8A; Wnt family member 8A [KO:K00714]
102278321  WNT9A; Wnt family member 9A [KO:K01064]
102283149  WNT9B; Wnt family member 9B [KO:K01064]
102276805  WNT10A; Wnt family member 10A [KO:K01357]
102267865  WNT10B; Wnt family member 10B [KO:K01357]
102266913  WNT11; Wnt family member 11 [KO:K01384]
102274851  WNT16; Wnt family member 16 [KO:K01558]
102269934  FZD1; frizzled class receptor 1 [KO:K02432]
102275255  FZD7; frizzled class receptor 7 [KO:K02432]
102277539  FZD2; frizzled class receptor 2 [KO:K02235]
102273339  FZD3; frizzled class receptor 3 [KO:K02329]
102286685  FZD4; frizzled class receptor 4 [KO:K02354]
102282966  FZD5; frizzled class receptor 5 [KO:K02375]
102276331  FZD8; frizzled class receptor 8 [KO:K02375]
102265247  FZD6; frizzled class receptor 6 [KO:K02376]
102267470  FZD10; frizzled class receptor 10 [KO:K02842]
102272449  FZD9; frizzled class receptor 9 [KO:K02842]
102277840  LRP6; LDL receptor related protein 6 [KO:K03068]
102268590  LRP5; LDL receptor related protein 5 [KO:K03068]
102273776  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
102287954  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102280462  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102275260  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102277911  TNF; tumor necrosis factor [KO:K03156]
102285873  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102281443  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102274400  INS; insulin [KO:K04526]
102272009  IGF1; insulin like growth factor 1 [KO:K05459]
102285317  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102278105  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102286241  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102286943  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102277585  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102278591  GTPase HRas [KO:K02833]
102277011  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102286500  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102269203  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102278631  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102288216  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102280670  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102271710  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102272368  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102284931  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102264559  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102278237  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102271527  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102287576  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102284664  IRS1; insulin receptor substrate 1 [KO:K16172]
102266922  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102280296  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102286868  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102274553  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102274461  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102277548  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102268478  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102264327  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102275199  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102265427  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102283212  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102281886  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102282449  MAPKAP1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
102277071  RICTOR; RPTOR independent companion of MTOR complex 2 [KO:K08267]
102285599  PRR5L; proline rich 5 like [KO:K20411]
102280554  RHOA; ras homolog family member A [KO:K04513]
102278724  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102274116  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102265831  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102272039  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
bom00561  Glycerolipid metabolism
bom04010  MAPK signaling pathway
bom04140  Autophagy - animal
bom04151  PI3K-Akt signaling pathway
bom04152  AMPK signaling pathway
bom04810  Regulation of actin cytoskeleton
bom04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system