KEGG   PATHWAY: bom04150
Entry
bom04150                    Pathway                                
Name
mTOR signaling pathway - Bos mutus (wild yak)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
bom04150  mTOR signaling pathway
bom04150

Organism
Bos mutus (wild yak) [GN:bom]
Gene
102264327  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102264473  WDR59; GATOR2 complex protein WDR59 isoform X2 [KO:K20409]
102264559  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102264704  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102264759  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
102264796  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
102265121  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
102265182  WDR24; LOW QUALITY PROTEIN: GATOR2 complex protein WDR24 [KO:K20408]
102265247  FZD6; frizzled-6 [KO:K02376]
102265427  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102265717  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
102265831  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102265959  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102266436  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
102266601  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
102266709  [KO:K02151]
102266913  WNT11; protein Wnt-11 [KO:K01384]
102266922  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102267219  [KO:K07208]
102267343  TSC2; tuberin isoform X1 [KO:K07207]
102267470  FZD10; frizzled-10 [KO:K02842]
102267833  RRAGD; ras-related GTP-binding protein D [KO:K16186]
102267865  WNT10B; protein Wnt-10b isoform X1 [KO:K01357]
102268143  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102268478  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102268519  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102268590  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
102268847  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
102268877  FLCN; folliculin [KO:K09594]
102269203  NRAS; GTPase NRas [KO:K07828]
102269211  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
102269403  CAB39; calcium-binding protein 39 [KO:K08272]
102269486  NPRL3; GATOR1 complex protein NPRL3 isoform X2 [KO:K20406]
102269700  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
102269858  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
102269934  FZD1; frizzled-1 [KO:K02432]
102270414  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102270467  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102271079  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102271370  CLIP1; LOW QUALITY PROTEIN: CAP-Gly domain-containing linker protein 1 [KO:K10421]
102271422  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
102271527  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102271710  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
102272009  IGF1; insulin-like growth factor 1 isoform X3 [KO:K05459]
102272039  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
102272136  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
102272181  SEC13; protein SEC13 homolog [KO:K14004]
102272368  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102272449  FZD9; frizzled-9 [KO:K02842]
102272754  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
102272775  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
102272835  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
102273173  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
102273776  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X2 [KO:K02353]
102273795  RRAGC; ras-related GTP-binding protein C [KO:K16186]
102273812  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102273993  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
102274116  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102274168  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
102274358  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
102274400  INS; insulin [KO:K04526]
102274461  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102274553  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102274851  WNT16; protein Wnt-16 [KO:K01558]
102275213  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102275255  FZD7; frizzled-7 [KO:K02432]
102275260  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102275454  SLC3A2; amino acid transporter heavy chain SLC3A2 [KO:K06519]
102275607  CASTOR2; LOW QUALITY PROTEIN: cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
102275609  WNT3A; protein Wnt-3a isoform X2 [KO:K00312]
102276323  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
102276331  FZD8; frizzled-8 [KO:K02375]
102276370  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
102276377  MIOS; GATOR2 complex protein MIOS [KO:K20407]
102276467  WNT5B; protein Wnt-5b [KO:K00444]
102276594  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102276671  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
102276805  WNT10A; protein Wnt-10a [KO:K01357]
102277011  HRAS; GTPase HRas isoform X1 [KO:K02833]
102277071  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
102277539  FZD2; frizzled-2 [KO:K02235]
102277548  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102277562  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
102277585  SOS2; son of sevenless homolog 2 [KO:K03099]
102277658  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
102277794  RRAGA; ras-related GTP-binding protein A [KO:K16185]
102277840  LRP6; low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068]
102277911  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102278105  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102278128  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
102278237  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102278321  WNT9A; protein Wnt-9a [KO:K01064]
102278355  LPIN1; phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
102278368  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102278591  [KO:K02833]
102278631  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102278724  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
102278820  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
102278863  STK11; serine/threonine-protein kinase STK11 isoform X4 [KO:K07298] [EC:2.7.11.1]
102278885  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X2 [KO:K02150]
102279465  LAMTOR2; ragulator complex protein LAMTOR2 isoform X1 [KO:K20398]
102279575  WNT7A; protein Wnt-7a [KO:K00572]
102279690  SLC38A9; LOW QUALITY PROTEIN: neutral amino acid transporter 9 [KO:K14995]
102279766  TBC1D7; TBC1 domain family member 7 [KO:K20396]
102280296  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102280462  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
102280554  RHOA; transforming protein RhoA [KO:K04513]
102280670  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102280709  TSC1; hamartin isoform X1 [KO:K07206]
102281123  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
102281377  WNT3; proto-oncogene Wnt-3 [KO:K00312]
102281443  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102281641  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102281727  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102281886  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102282064  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102282449  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
102282733  SESN2; sestrin-2 isoform X1 [KO:K20394]
102282841  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102282966  FZD5; frizzled-5 [KO:K02375]
102283149  WNT9B; protein Wnt-9b [KO:K01064]
102283200  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
102283212  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102284664  IRS1; insulin receptor substrate 1 [KO:K16172]
102284700  WNT7B; protein Wnt-7b [KO:K00572]
102284931  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102285045  WNT8A; protein Wnt-8a [KO:K00714]
102285050  SEH1L; nucleoporin SEH1 isoform X2 [KO:K14299]
102285317  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102285390  RPTOR; regulatory-associated protein of mTOR isoform X2 [KO:K07204]
102285482  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
102285569  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
102285570  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
102285599  PRR5L; LOW QUALITY PROTEIN: proline-rich protein 5-like [KO:K20411]
102285704  NPRL2; GATOR1 complex protein NPRL2 [KO:K20405]
102285710  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102285873  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102285959  WNT8B; protein Wnt-8b [KO:K00714]
102286241  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102286500  KRAS; GTPase KRas isoform X1 [KO:K07827]
102286685  FZD4; frizzled-4 [KO:K02354]
102286828  WNT6; protein Wnt-6 [KO:K00445]
102286868  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102286943  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102287075  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
102287485  DEPDC5; GATOR1 complex protein DEPDC5 isoform X1 [KO:K20404]
102287489  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
102287498  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
102287576  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102287796  LAMTOR4; ragulator complex protein LAMTOR4 [KO:K20399]
102287925  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
102287954  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
102288008  WNT2; protein Wnt-2 [KO:K00182]
102288216  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
138987977  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
138990405  [KO:K02144]
138990419  [KO:K16185]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
bom00561  Glycerolipid metabolism
bom04010  MAPK signaling pathway
bom04140  Autophagy - animal
bom04151  PI3K-Akt signaling pathway
bom04152  AMPK signaling pathway
bom04810  Regulation of actin cytoskeleton
bom04910  Insulin signaling pathway
KO pathway
ko04150   

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