KEGG   PATHWAY: cgob04060
Entry
cgob04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Cottoperca gobio
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cgob04060  Cytokine-cytokine receptor interaction
cgob04060

Organism
Cottoperca gobio [GN:cgob]
Gene
115007067  C-C motif chemokine 25-like [KO:K13072]
115022903  C-C motif chemokine 20-like [KO:K13072]
115013715  C-C motif chemokine 19-like [KO:K05512]
115010106  C-C motif chemokine 3-like [KO:K05408]
115009918  ccl17; C-C motif chemokine 17 [KO:K12964]
115006632  C-C motif chemokine 17-like [KO:K21083]
115013788  ccl28; C-C motif chemokine 28 [KO:K05513]
115025666  C-C motif chemokine 20-like [KO:K14625]
115021945  C-C motif chemokine 20-like [KO:K14625]
115022727  C-C motif chemokine 20-like [KO:K14625]
115015938  permeability factor 2-like [KO:K10030]
115023813  interleukin-8-like [KO:K10030]
115019974  LOW QUALITY PROTEIN: C-X-C motif chemokine 11-like [KO:K05416]
115013215  cxcl13; C-X-C motif chemokine 13 [KO:K10032]
115014055  stromal cell-derived factor 1-like [KO:K10031]
115019976  stromal cell-derived factor 1-like [KO:K10031]
115014994  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
115008663  interleukin-15-like isoform X1 [KO:K05434]
115023853  epo; erythropoietin isoform X1 [KO:K05437]
115017825  somatolactin [KO:K05438]
115012292  prolactin-like [KO:K05439]
115009427  prolactin-like [KO:K05439]
115028346  prolactin-like [KO:K05439]
115022335  thpo; thrombopoietin [KO:K06854]
115015308  interleukin-6-like [KO:K05405]
115021442  uncharacterized protein LOC115021442 [KO:K05417]
115018081  interleukin-12 subunit alpha-like [KO:K05406]
115012977  interleukin-12 subunit beta-like [KO:K05425]
115019119  interleukin-12 subunit beta-like [KO:K05425]
115014708  interleukin-12 subunit beta-like [KO:K05425]
115027506  ebi3; interleukin-27 subunit beta [KO:K24476]
115015018  clcf1; cardiotrophin-like cytokine factor 1 [KO:K05421]
115007961  il10; interleukin-10 [KO:K05443]
115007718  interleukin-20-like [KO:K22667]
115024686  interferon a3-like [KO:K05414]
115024709  interferon a3-like [KO:K05414]
115024715  interferon a3-like [KO:K05414]
115024716  interferon a3-like [KO:K05414]
115024718  interferon a3-like [KO:K05414]
115004918  interferon a3-like [KO:K05414]
115013355  il1b; interleukin-1 beta [KO:K04519]
115003939  interleukin-17F-like [KO:K05494]
115009121  il17c; interleukin-17C [KO:K05491]
115023756  interleukin-17C-like isoform X1 [KO:K05491]
115021779  uncharacterized protein LOC115021779 [KO:K22628]
115028757  il16; pro-interleukin-16 [KO:K22628]
115009137  il34; interleukin-34 isoform X1 [KO:K22633]
115015660  tumor necrosis factor-like [KO:K03156]
115016975  uncharacterized protein LOC115016975 [KO:K03156]
115021209  tumor necrosis factor-like [KO:K05468]
115011702  tumor necrosis factor ligand superfamily member 14-like isoform X1 [KO:K05477]
115011837  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
115007592  faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
115014829  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
115025734  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
115027364  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
115014609  eda; ectodysplasin-A [KO:K05480]
115008416  nerve growth factor-like [KO:K02582]
115010778  nerve growth factor-like [KO:K02582]
115010779  LOW QUALITY PROTEIN: nerve growth factor-like [KO:K02582]
115023923  tnfsf12; tumor necrosis factor ligand superfamily member 12 isoform X1 [KO:K05474]
115026128  tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
115014231  tumor necrosis factor ligand superfamily member 13B-like isoform X1 [KO:K05476]
115017895  LOW QUALITY PROTEIN: transforming growth factor beta-1 proprotein-like [KO:K13375]
115014648  transforming growth factor beta-2 proprotein-like [KO:K13376]
115021567  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
115027215  tgfb3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
115003471  transforming growth factor beta-3 proprotein-like [KO:K13377]
115022876  gdf15; growth/differentiation factor 15 [KO:K05504]
115024214  growth/differentiation factor 2-like [KO:K05503]
115014049  bone morphogenetic protein 10-like [KO:K22670]
115016951  bone morphogenetic protein 10-like [KO:K22670]
115019698  inha; inhibin alpha chain isoform X1 [KO:K05500]
115013750  bmp3; LOW QUALITY PROTEIN: bone morphogenetic protein 3 [KO:K05496]
115024212  growth/differentiation factor 10-like [KO:K22674]
115019678  growth/differentiation factor 10-like [KO:K22674]
115008938  growth/differentiation factor 11-like isoform X1 [KO:K22679]
115026624  mstn; growth/differentiation factor 8 [KO:K05497]
115017409  growth/differentiation factor 8-like [KO:K05497]
115005896  inhibin beta A chain-like isoform X1 [KO:K04667]
115005037  inhibin beta A chain-like [KO:K04667]
115005038  inhibin beta A chain-like [KO:K04667]
115026271  inhibin beta B chain-like [KO:K22687]
115008624  inhibin beta B chain-like [KO:K22687]
115020901  inhibin beta B chain-like [KO:K22687]
115026210  gdf3; growth/differentiation factor 3 [KO:K22672]
115024788  nodal; nodal homolog [KO:K04666]
115013701  LOW QUALITY PROTEIN: nodal homolog [KO:K04666]
115016949  LOW QUALITY PROTEIN: nodal homolog [KO:K04666]
115014603  gdf9; growth/differentiation factor 9 isoform X1 [KO:K22673]
115007372  amh; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665]
115024794  bone morphogenetic protein 2-like [KO:K21283]
115003426  bmp2; LOW QUALITY PROTEIN: bone morphogenetic protein 2 [KO:K21283]
115022925  bone morphogenetic protein 2-like [KO:K21283]
115017332  bone morphogenetic protein 4-like [KO:K21283]
115027803  bmp4; bone morphogenetic protein 4 [KO:K04662]
115008480  growth/differentiation factor 5-like [KO:K04664]
115021586  growth/differentiation factor 6-A-like [KO:K20012]
115015874  gdf6; growth/differentiation factor 6 [KO:K20012]
115023406  bmp15; bone morphogenetic protein 15 [KO:K05498]
115019722  bmp5; bone morphogenetic protein 5 [KO:K04663]
115025406  bmp6; bone morphogenetic protein 6 [KO:K16620]
115008387  LOW QUALITY PROTEIN: bone morphogenetic protein 7-like [KO:K16621]
115011404  bone morphogenetic protein 7-like isoform X1 [KO:K16621]
115015649  bmp8a; bone morphogenetic protein 8A [KO:K16622]
115025496  C-C chemokine receptor type 9-like [KO:K04184]
115025525  ackr4; atypical chemokine receptor 4 [KO:K04186]
115022698  atypical chemokine receptor 4-like [KO:K04186]
115011067  ccr7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
115025798  C-C chemokine receptor type 3-like [KO:K04179]
115021463  C-C chemokine receptor type 2-like isoform X1 [KO:K04179]
115021480  C-C chemokine receptor type 2-like [KO:K04179]
115021872  C-C chemokine receptor type 5-like isoform X1 [KO:K04179]
115003950  C3a anaphylatoxin chemotactic receptor-like [KO:K04179]
115023090  C-C chemokine receptor type 3-like [KO:K04179]
115021449  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
115027548  C-C chemokine receptor type 6-like [KO:K04181]
115019056  C-X-C chemokine receptor type 1-like isoform X1 [KO:K05050]
115026402  C-X-C chemokine receptor type 2-like isoform X1 [KO:K05050]
115026491  C-X-C chemokine receptor type 1-like [KO:K05050]
115021205  C-X-C chemokine receptor type 3-like [KO:K04188]
115021206  cxcr3; C-X-C chemokine receptor type 3 [KO:K04188]
115021454  C-X-C chemokine receptor type 3-2-like [KO:K04188]
115025932  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
115022626  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 4-like [KO:K04189]
115026496  atypical chemokine receptor 3-like [KO:K04304]
115004963  atypical chemokine receptor 3-like [KO:K04304]
115007609  chemokine XC receptor 1-like [KO:K04193]
115022633  chemokine XC receptor 1-like [KO:K04193]
115022721  chemokine XC receptor 1-like [KO:K04193]
115012725  interleukin-2 receptor subunit beta-like [KO:K05069]
115005484  uncharacterized protein LOC115005484 [KO:K05069]
115018623  cytokine receptor common subunit gamma-like [KO:K05070]
115006399  uncharacterized protein LOC115006399 isoform X1 [KO:K05071]
115028379  uncharacterized protein LOC115028379 isoform X1 [KO:K05074]
115024331  interleukin-21 receptor-like [KO:K05075]
115021365  interleukin-21 receptor-like [KO:K05075]
115012721  cytokine receptor common subunit beta-like [KO:K04738]
115018419  interleukin-13 receptor subunit alpha-2-like isoform X1 [KO:K05077]
115023439  interleukin-13 receptor subunit alpha-1-like [KO:K05077]
115012194  epor; erythropoietin receptor [KO:K05079]
115013290  ghr; LOW QUALITY PROTEIN: growth hormone receptor [KO:K05080]
115005116  prolactin receptor-like [KO:K05080]
115017159  growth hormone receptor-like isoform X1 [KO:K05080]
115016680  prolactin receptor-like [KO:K05081]
115006667  mpl; thrombopoietin receptor [KO:K05082]
115021859  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
115007266  lepr; LOW QUALITY PROTEIN: leptin receptor [KO:K05062]
115021636  LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha-like [KO:K05055]
115012860  interleukin-12 receptor subunit beta-2-like isoform X1 [KO:K05060]
115012984  interleukin-6 receptor subunit beta-like [KO:K05060]
115027698  interleukin-6 receptor subunit beta-like [KO:K05060]
115016624  il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
115016922  ciliary neurotrophic factor receptor subunit alpha-like isoform X1 [KO:K05056]
115006624  il12rb1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
115007368  interleukin-12 receptor subunit beta-2-like isoform X1 [KO:K05063]
115007152  interleukin-12 receptor subunit beta-2-like [KO:K05064]
115007153  interleukin-12 receptor subunit beta-2-like [KO:K05064]
115017097  ciliary neurotrophic factor receptor subunit alpha-like isoform X1 [KO:K05059]
115013654  LOW QUALITY PROTEIN: leukemia inhibitory factor receptor-like [KO:K05058]
115017137  LOW QUALITY PROTEIN: leukemia inhibitory factor receptor-like [KO:K05058]
115018172  interleukin-10 receptor subunit alpha-like [KO:K05134]
115026341  interleukin-10 receptor subunit beta-like [KO:K05135]
115026674  interferon alpha/beta receptor 1b-like [KO:K05135]
115003921  interleukin-20 receptor subunit alpha-like [KO:K05136]
115022276  il20rb; interleukin-20 receptor subunit beta [KO:K05137]
115026039  interferon alpha/beta receptor 2-like [KO:K05131]
115026040  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
115019913  interferon gamma receptor 1-like [KO:K05132]
115026861  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
115026366  interleukin-1 receptor type 2-like [KO:K04387]
115023726  interleukin-18 receptor 1-like [KO:K05173]
115028306  LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein-like [KO:K05174]
115026795  interleukin-1 receptor type 1-like isoform X1 [KO:K05171]
115009423  LOW QUALITY PROTEIN: interleukin-17 receptor A-like [KO:K05164]
115028296  interleukin-17 receptor A-like [KO:K05164]
115007765  LOW QUALITY PROTEIN: interleukin-17 receptor C-like [KO:K05166]
115010901  interleukin-17 receptor C-like [KO:K05166]
115010921  il17re; LOW QUALITY PROTEIN: interleukin-17 receptor E [KO:K05168]
115021281  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD4-like [KO:K06454]
115018832  macrophage colony-stimulating factor 1 receptor 2-like [KO:K05090] [EC:2.7.10.1]
115014344  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
115011263  tumor necrosis factor receptor superfamily member 25-like [KO:K03158]
115007687  tumor necrosis factor receptor superfamily member 1B-like isoform X1 [KO:K05141]
115011295  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
115021472  tumor necrosis factor receptor superfamily member 6B-like [KO:K05143]
115015822  tumor necrosis factor receptor superfamily member 6B-like isoform X1 [KO:K05143]
115019686  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
115013448  tumor necrosis factor receptor superfamily member 16-like [KO:K04722]
115017084  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
115003716  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
115026593  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
115024297  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
115012370  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
115020780  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
115021441  tumor necrosis factor receptor superfamily member 11B-like isoform X1 [KO:K05148]
115025504  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11A-like [KO:K05147]
115025118  tnfrsf12a; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
115011339  tumor necrosis factor receptor superfamily member 9-like [KO:K05144]
115021686  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
115011458  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160]
115008572  tumor necrosis factor receptor superfamily member 4-like [KO:K05142]
115024660  tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
115017312  tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
115017305  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
115005261  flocculation protein FLO11-like [KO:K26541]
115023932  rell1; RELT-like protein 1 [KO:K26541]
115005781  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115005886  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115015457  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
115010632  activin receptor type-1-like [KO:K13594] [EC:2.7.11.30]
115018276  acvr2a; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
115018188  bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
115004852  bone morphogenetic protein receptor type-2-like [KO:K04671] [EC:2.7.11.30]
115022968  acvr2b; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
115007915  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
115010633  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
115026287  acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
115026304  acvr1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
115027094  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
115020318  bone morphogenetic protein receptor type-1A-like [KO:K04673] [EC:2.7.11.30]
115013755  bmpr1b; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
115016468  bone morphogenetic protein receptor type-1B-like isoform X1 [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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