KEGG   PATHWAY: char03013
Entry
char03013                   Pathway                                
Name
Nucleocytoplasmic transport - Clupea harengus (Atlantic herring)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
char03013  Nucleocytoplasmic transport
char03013

Other DBs
GO: 0050658
Organism
Clupea harengus (Atlantic herring) [GN:char]
Gene
105899309  aaas; aladin [KO:K14320]
105903667  nup42; nucleoporin NUP42 [KO:K14321]
105891605  gle1; nucleoporin GLE1 isoform X1 [KO:K18723]
105898138  ddx19b; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
105912710  ddx19a; ATP-dependent RNA helicase DDX19A isoform X2 [KO:K18655] [EC:5.6.2.7]
105912281  rae1; mRNA export factor isoform X2 [KO:K14298]
105892264  nup98; nuclear pore complex protein Nup98-Nup96 isoform X2 [KO:K14297]
105906400  nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
105892174  nup88; nucleoporin 88 [KO:K14318]
105897982  rangap1a; ran GTPase-activating protein 1a [KO:K14319]
105888898  rangap1b; ran GTPase-activating protein 1b [KO:K14319]
105910232  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
105890774  SUMO-conjugating enzyme UBC9-like [KO:K10577]
105898859  sumo2b; small ubiquitin-related modifier 2 [KO:K12160]
105901778  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
105901964  sumo2a; small ubiquitin like modifier 2a [KO:K12160]
105912103  small ubiquitin-related modifier 3 [KO:K12160]
105891136  sumo3b; small ubiquitin-related modifier 3 [KO:K12160]
105895432  small ubiquitin-related modifier 1-like [KO:K12160]
105889720  nup160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
105898855  nup85; nuclear pore complex protein Nup85 [KO:K14304]
105895939  sec13; protein SEC13 homolog [KO:K14004]
105892509  nup107; nuclear pore complex protein Nup107 [KO:K14301]
105907634  nup133; nuclear pore complex protein Nup133 [KO:K14300]
105892080  seh1l; nucleoporin SEH1 [KO:K14299]
105899464  nup43; nucleoporin Nup43 [KO:K14305]
105902613  nup37; nucleoporin Nup37 [KO:K14302]
105909925  ahctf1; protein ELYS isoform X1 [KO:K25129]
105903949  nup62l; nucleoporin 62 like [KO:K14306]
105905246  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
105889757  nup54; nucleoporin p54 isoform X4 [KO:K14308]
105905151  nup205; nuclear pore complex protein Nup205 [KO:K14310]
105902529  nup188; nucleoporin NUP188 isoform X3 [KO:K14311]
105893324  nup155; nuclear pore complex protein Nup155 [KO:K14312]
105892479  nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
105905960  nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
105908508  ndc1; nucleoporin NDC1 [KO:K14315]
105900177  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
105909191  pom121; nuclear envelope pore membrane protein POM 121 isoform X1 [KO:K14316]
105904403  tmem33; transmembrane protein 33 [KO:K20724]
105910796  tprb; translocated promoter region b, nuclear basket protein isoform X3 [KO:K09291]
105912428  nup50; nuclear pore complex protein Nup50 [KO:K14295]
105905331  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
105894557  senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
105890293  kpna1; importin subunit alpha-5 [KO:K23940]
105900225  importin subunit alpha-1 [KO:K15043]
105891896  importin subunit alpha-1-like [KO:K15043]
105909742  kpna4; importin subunit alpha-3 [KO:K23583]
105911846  kpna3; importin subunit alpha-4 [KO:K23583]
105897633  kpna5; importin subunit alpha-6 isoform X1 [KO:K15042]
105892054  kpna6; importin subunit alpha-7 [KO:K15042]
105913043  kpnb1; importin subunit beta-1 isoform X1 [KO:K14293]
105890836  tnpo1; transportin-1 [KO:K18752]
105896295  transportin-2 isoform X1 [KO:K18727]
105904101  tnpo3; transportin-3 isoform X1 [KO:K15436]
105890213  ipo4; importin-4 [KO:K20221]
122132015  kpnb3; importin-5 [KO:K20222]
105912345  ipo7; importin-7 isoform X1 [KO:K20223]
122132321  importin-7-like [KO:K20223]
105896972  ipo8; importin-8 isoform X1 [KO:K18755]
105901866  ipo9; importin-9 [KO:K20224]
105894190  ipo11; importin-11 [KO:K25201]
105910849  importin-13-like [KO:K25202]
105891344  importin-13-like [KO:K25202]
116219630  importin-13-like [KO:K25202]
105910303  snupn; snurportin-1 [KO:K13151]
105893487  xpo1b; LOW QUALITY PROTEIN: exportin-1 [KO:K14290]
105895789  xpo1a; exportin-1 isoform X1 [KO:K14290]
105909897  cse1l; exportin-2 [KO:K18423]
105912414  xpot; exportin-T [KO:K14288]
105913295  xpo4; exportin-4 [KO:K25203]
105910135  exportin-5 [KO:K14289]
105894966  xpo6; exportin-6 [KO:K25204]
105889661  xpo7; exportin-7 isoform X8 [KO:K18460]
116225282  ran; GTP-binding nuclear protein Ran [KO:K07936]
105906005  GTP-binding nuclear protein Ran [KO:K07936]
105889298  si:dkey-37o8.1; elongation factor 1-alpha-like [KO:K03231]
105911598  eef1a1a; elongation factor 1-alpha 1a [KO:K03231]
105912050  eef1a1b; elongation factor 1-alpha 1b [KO:K03231]
105892153  elongation factor 1-alpha-like [KO:K03231]
105892154  elongation factor 1-alpha [KO:K03231]
105906389  eef1a2; elongation factor 1-alpha 2 [KO:K03231]
105890960  phax; phosphorylated adapter RNA export protein [KO:K14291]
105888632  nuclear cap-binding protein subunit 1 [KO:K12882]
105912950  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
105909765  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
105891816  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
105900893  magoh; protein mago nashi homolog [KO:K12877]
105912829  casc3; protein CASC3 isoform X1 [KO:K14323]
105891552  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
105913270  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
105905291  RNA-binding protein with serine-rich domain 1 [KO:K14325]
105905426  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
105897413  THO complex subunit 4-like [KO:K12881]
105904970  THO complex subunit 4-like [KO:K12881]
116218716  alyref; THO complex subunit 4 [KO:K12881]
105900883  regulator of nonsense transcripts 1 isoform X2 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105907049  upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105898367  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
105905952  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
105913111  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
105897453  nuclear RNA export factor 1-like isoform X2 [KO:K14284]
105900387  nxf1b; nuclear RNA export factor 1 [KO:K14284]
116225174  nxt2; NTF2-related export protein 2 [KO:K14285]
105904710  ddx39b; LOW QUALITY PROTEIN: DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B [KO:K12812] [EC:5.6.2.7]
105894330  pym1; partner of Y14 and mago isoform X1 [KO:K14294]
105900589  thoc1; THO complex subunit 1 [KO:K12878]
105912006  thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
105895529  thoc5; THO complex subunit 5 homolog [KO:K13174]
122130886  thoc6; THO complex subunit 6 homolog [KO:K13175]
105912184  thoc7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
105906251  thoc3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
char03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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