KEGG   PATHWAY: csyr04714
Entry
csyr04714                   Pathway                                
Name
Thermogenesis - Carlito syrichta (Philippine tarsier)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
csyr04714  Thermogenesis
csyr04714

Other DBs
GO: 1990845
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103274964  ADRB3; beta-3 adrenergic receptor [KO:K04143]
103251768  neuroendocrine secretory protein 55 [KO:K04632]
103255823  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
103252919  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103262642  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103272228  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
103254816  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103273462  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103259338  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103267869  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103273680  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103253311  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
103266092  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103252293  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103249547  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
103252136  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
103263755  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103265465  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
103257302  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103273492  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
103249480  PRDM16; PR domain zinc finger protein 16 [KO:K22410] [EC:2.1.1.367]
103263137  ZNF516; zinc finger protein 516 [KO:K22411]
103270779  KDM1A; LOW QUALITY PROTEIN: lysine-specific histone demethylase 1A [KO:K11450] [EC:1.14.99.66]
103257179  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
103255583  KDM3A; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
103261710  KDM3B; lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
103271400  SMARCA4; transcription activator BRG1 isoform X3 [KO:K11647] [EC:5.6.2.-]
103263670  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
103268856  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
103249537  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
103273868  SMARCC1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
103252071  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
103264583  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
103275303  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
103258097  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
103250241  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103258260  actin-like isoform X1 [KO:K05692]
103252825  actin, cytoplasmic 2 [KO:K05692]
103263822  actin, cytoplasmic 1-like isoform X1 [KO:K05692]
103262836  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
103250381  ACTL6B; actin-like protein 6B [KO:K11652]
103254063  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
103267521  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
103260887  zinc finger protein neuro-d4 [KO:K22198]
103258558  DPF3; zinc finger protein DPF3 [KO:K22198]
103263751  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
103256327  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103264569  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103249454  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103249455  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103263392  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103263391  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103256017  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
103264952  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103250473  FGF21; fibroblast growth factor 21 [KO:K22429]
103273204  PLIN1; perilipin-1 [KO:K08768]
103264729  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
103259188  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
103254435  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
103255089  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103271805  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
103266117  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
103261236  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
103273453  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
103275297  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X3 [KO:K07200]
103256182  GCG; glucagon [KO:K05259]
103256523  bone morphogenetic protein 8B-like [KO:K16622]
103266423  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
103266203  NPPA; natriuretic peptides A [KO:K12334]
103266207  NPPB; natriuretic peptides B [KO:K12335]
103261740  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
103275000  cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
103272881  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
103272300  KLB; beta-klotho [KO:K22404]
103274944  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103269046  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
103275922  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103270607  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103276422  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
103250130  HRAS; GTPase HRas isoform X1 [KO:K02833]
103263630  KRAS; GTPase KRas isoform X2 [KO:K07827]
103259236  NRAS; GTPase NRas [KO:K07828]
103260173  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
103265703  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103275091  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
103275641  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
103250930  TSC1; hamartin isoform X1 [KO:K07206]
103250119  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
103270389  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
103272783  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
103275306  RHEB; GTP-binding protein Rheb [KO:K07208]
103251875  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
103272291  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103252726  MLST8; target of rapamycin complex subunit LST8 isoform X2 [KO:K08266]
103258093  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
103251539  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103273417  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103273845  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
103270137  ACSL6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
103255842  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
103259567  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
103257034  ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
103275588  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
7944474  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
7944462  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
7944463  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
7944470  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
7944467  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
7944472  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
7944471  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
103262943  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
103260252  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
103253931  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
103258126  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
103266780  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
103267568  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
103252583  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
103250207  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
103271841  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial-like [KO:K03941] [EC:7.1.1.2]
103251659  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
103258337  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
103272691  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
110596544  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
103276211  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
103265401  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
103277104  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X3 [KO:K03946]
103276463  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
103249583  NDUFA4; cytochrome c oxidase subunit NDUFA4 isoform X1 [KO:K03948]
103256865  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
103250410  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
103262643  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X2 [KO:K03949]
103253105  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
103259404  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
103276353  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
103264348  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
103266338  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
103259129  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
103275551  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
103271430  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
103257860  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
103266003  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
103256260  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
103262897  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
110594486  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
103271180  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
103273362  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103256427  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
103262863  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
103263506  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
103261895  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
103261731  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
103250117  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
103252786  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
103252346  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
103271254  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
103262180  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
103264419  NDUFAF2; mimitin, mitochondrial isoform X1 [KO:K18160]
103270617  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform X1 [KO:K09008]
103264324  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
103259459  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
103252659  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 [KO:K18163]
103261058  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial [KO:K18164]
103251872  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
103275417  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
103257385  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
103251186  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
103260260  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
103268018  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
103254098  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
103265462  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
7944473  CYTB; cytochrome b [KO:K00412]
103272505  cytochrome c1, heme protein, mitochondrial [KO:K00413]
103270632  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
103260331  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
103249224  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
103258555  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
103267371  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 7-like [KO:K00417]
103259262  cytochrome b-c1 complex subunit 8 [KO:K00418]
103271686  cytochrome b-c1 complex subunit 9 [KO:K00419]
103251009  cytochrome b-c1 complex subunit 10 [KO:K00420]
7944468  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
7944469  COX2; cytochrome c oxidase subunit II [KO:K02261]
7944464  COX3; cytochrome c oxidase subunit III [KO:K02262]
103252018  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
103266174  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
103270898  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
103266568  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103251688  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
103251157  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
110595358  cytochrome c oxidase subunit 6B1-like [KO:K02267]
103263084  cytochrome c oxidase subunit 6B1-like [KO:K02267]
103273566  COX6B; cytochrome c oxidase subunit 6B1-like [KO:K02267]
110596473  cytochrome c oxidase subunit 6B1-like [KO:K02267]
110596696  cytochrome c oxidase subunit 6B1-like [KO:K02267]
110594497  cytochrome c oxidase subunit 6B1-like [KO:K02267]
110595091  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596061  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596332  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596375  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596503  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596727  cytochrome c oxidase subunit 6C-like [KO:K02268]
103268110  cytochrome c oxidase subunit 6C-like [KO:K02268]
103273442  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
103276236  COX7AH; cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
103276500  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
103274382  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
103267420  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
110594887  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
103256739  protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
103276044  LOW QUALITY PROTEIN: protoheme IX farnesyltransferase, mitochondrial-like [KO:K02257] [EC:2.5.1.141]
103277036  cytochrome c oxidase assembly protein COX11, mitochondrial isoform X1 [KO:K02258]
103264585  cytochrome c oxidase assembly protein COX14 [KO:K18181]
103274413  cytochrome c oxidase assembly protein COX15 homolog isoform X1 [KO:K02259] [EC:1.17.99.9]
103254392  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform X1 [KO:K18182]
103258365  cytochrome c oxidase copper chaperone [KO:K02260]
103269710  mitochondrial inner membrane protein COX18 [KO:K17797]
103255258  cytochrome c oxidase assembly protein COX19 [KO:K18183]
103272290  LOW QUALITY PROTEIN: cytochrome c oxidase protein 20 homolog [KO:K18184]
103249797  cytochrome c oxidase assembly factor 1 homolog [KO:K18173]
103270695  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
103267060  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
103268470  cytochrome c oxidase assembly factor 5 [KO:K18178]
103256728  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
103270022  cytochrome c oxidase assembly factor 7 isoform X2 [KO:K18180]
103267388  ATP5A1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
103251114  ATP synthase subunit beta, mitochondrial-like isoform X1 [KO:K02133] [EC:7.1.2.2]
103275145  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
103276345  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
103270009  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
110594963  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
110596205  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
110596280  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
110594496  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
103275990  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
103276196  ATP synthase subunit O, mitochondrial-like [KO:K02137]
7944466  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
103271456  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
103251673  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
103253408  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
103264736  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
103275931  ATP5H; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
103259490  ATP synthase subunit e, mitochondrial [KO:K02129]
110596202  ATP5I; ATP synthase subunit e, mitochondrial [KO:K02129]
103270235  ATP synthase subunit f, mitochondrial isoform X1 [KO:K02130]
103252336  ATP synthase subunit f, mitochondrial-like isoform X1 [KO:K02130]
103272789  ATP synthase subunit f, mitochondrial-like [KO:K02130]
103272985  ATP synthase subunit f, mitochondrial-like isoform X1 [KO:K02130]
103256373  ATP synthase subunit f, mitochondrial-like [KO:K02130]
103267300  ATP synthase subunit f, mitochondrial-like isoform X1 [KO:K02130]
103268075  ATP synthase subunit f, mitochondrial-like isoform X1 [KO:K02130]
110594341  ATP synthase subunit f, mitochondrial-like isoform X1 [KO:K02130]
103267552  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
7944465  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
103252216  ATP5L; ATP synthase subunit g, mitochondrial [KO:K02140]
103255442  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
103270623  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
103250067  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
103274022  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
103249234  carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
PMID:26482876
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
PMID:28448947
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
PMID:24872083
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
PMID:15545214
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
PMID:20935662
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
PMID:15964803
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
  Journal
Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
Reference
PMID:27045525
  Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
  Title
ASK1 signalling regulates brown and beige adipocyte function.
  Journal
Nat Commun 7:11158 (2016)
DOI:10.1038/ncomms11158
Reference
PMID:25948511
  Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
  Journal
Nat Commun 6:7052 (2015)
DOI:10.1038/ncomms8052
Reference
PMID:25578880
  Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
  Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
  Journal
Mol Cell 57:235-46 (2015)
DOI:10.1016/j.molcel.2014.12.005
Reference
PMID:27264172
  Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
  Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
  Journal
Cell Rep 15:2536-49 (2016)
DOI:10.1016/j.celrep.2016.05.019
Reference
PMID:27693079
  Authors
Villarroya F, Peyrou M, Giralt M
  Title
Transcriptional regulation of the uncoupling protein-1 gene.
  Journal
Biochimie 134:86-92 (2017)
DOI:10.1016/j.biochi.2016.09.017
Reference
PMID:15024092
  Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
  Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
  Journal
Mol Cell Biol 24:3057-67 (2004)
DOI:10.1128/MCB.24.7.3057-3067.2004
Reference
PMID:21317437
  Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
  Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
  Journal
J Biol Chem 286:12983-90 (2011)
DOI:10.1074/jbc.M110.215889
Reference
PMID:28723567
  Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
  Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
  Journal
Cell Rep 20:641-654 (2017)
DOI:10.1016/j.celrep.2017.06.069
Reference
PMID:27794497
  Authors
Klingenberg M
  Title
UCP1 - A sophisticated energy valve.
  Journal
Biochimie 134:19-27 (2017)
DOI:10.1016/j.biochi.2016.10.012
Reference
PMID:27984203
  Authors
Bertholet AM, Kirichok Y
  Title
UCP1: A transporter for H(+) and fatty acid anions.
  Journal
Biochimie 134:28-34 (2017)
DOI:10.1016/j.biochi.2016.10.013
Reference
PMID:29052591
  Authors
Betz MJ, Enerback S
  Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
  Journal
Nat Rev Endocrinol 14:77-87 (2018)
DOI:10.1038/nrendo.2017.132
Reference
PMID:20514071
  Authors
Tseng YH, Cypess AM, Kahn CR
  Title
Cellular bioenergetics as a target for obesity therapy.
  Journal
Nat Rev Drug Discov 9:465-82 (2010)
DOI:10.1038/nrd3138
Reference
PMID:25390014
  Authors
Fenzl A, Kiefer FW
  Title
Brown adipose tissue and thermogenesis.
  Journal
Horm Mol Biol Clin Investig 19:25-37 (2014)
DOI:10.1515/hmbci-2014-0022
Reference
PMID:27681418
  Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
  Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
  Journal
Cell Rep 17:29-36 (2016)
DOI:10.1016/j.celrep.2016.08.086
Reference
PMID:22302939
  Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
  Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
  Journal
Genes Dev 26:271-81 (2012)
DOI:10.1101/gad.177857.111
Reference
PMID:24820868
  Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
  Title
Natriuretic peptides in cardiometabolic regulation and disease.
  Journal
Nat Rev Cardiol 11:403-12 (2014)
DOI:10.1038/nrcardio.2014.64
Reference
PMID:22020112
  Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
  Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
  Journal
Mol Aspects Med 32:223-33 (2011)
DOI:10.1016/j.mam.2011.10.008
Reference
PMID:26303601
  Authors
McCoin CS, Knotts TA, Adams SH
  Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
  Journal
Nat Rev Endocrinol 11:617-25 (2015)
DOI:10.1038/nrendo.2015.129
Reference
PMID:28955734
  Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
  Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
  Journal
Biochem Biophys Rep 10:32-38 (2017)
DOI:10.1016/j.bbrep.2017.02.002
Related
pathway
csyr00020  Citrate cycle (TCA cycle)
csyr00190  Oxidative phosphorylation
csyr04010  MAPK signaling pathway
csyr04022  cGMP-PKG signaling pathway
csyr04024  cAMP signaling pathway
csyr04150  mTOR signaling pathway
csyr04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

DBGET integrated database retrieval system