KEGG   PATHWAY: dne04148
Entry
dne04148                    Pathway                                
Name
Efferocytosis - Dromaius novaehollandiae (emu)
Class
Cellular Processes; Transport and catabolism
Pathway map
dne04148  Efferocytosis
dne04148

Organism
Dromaius novaehollandiae (emu) [GN:dne]
Gene
112986139  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
112993680  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
112987315  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
112988583  PANX1; pannexin-1 isoform X1 [KO:K03443]
112981941  P2RY2; P2Y purinoceptor 2 [KO:K04269]
112981923  P2RY6; P2Y purinoceptor 6 [KO:K04272]
112981341  P2RY12; P2Y purinoceptor 12 [KO:K04298]
112985338  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
112979820  S1PR1; sphingosine 1-phosphate receptor 1 isoform X1 [KO:K04288]
112984354  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
112988093  ABCA7; ATP-binding cassette sub-family A member 7 [KO:K05641]
112982179  ABCA1; ATP-binding cassette sub-family A member 1 [KO:K05641]
112991667  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
112981540  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
112991137  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
112985407  CX3CL1; fractalkine [KO:K05508]
112994520  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
112982902  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
112992526  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
112984298  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
112991390  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
112990035  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
112981649  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
112985606  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112982872  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
112982856  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
112979897  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
112996038  MFGE8; lactadherin isoform X1 [KO:K17253]
112981375  GAS6; growth arrest-specific protein 6 [KO:K05464]
112989390  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
112980301  CD36; platelet glycoprotein 4 [KO:K06259]
112980711  THBS1; thrombospondin-1 [KO:K16857]
112996257  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
112994722  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112983769  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
112988539  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
112983600  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
112984763  DNMT3A; DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
112989830  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
112987338  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
112985068  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
112991845  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
112986149  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
112980209  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
112996935  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
112990255  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
112990256  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112990935  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112990942  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
112990346  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
112990662  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
112993668  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112989292  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112991515  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112978965  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112986954  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112983062  ANO6; anoctamin-6 isoform X1 [KO:K19500]
112996305  ANO3; anoctamin-3 isoform X1 [KO:K19498]
112988783  ANO4; anoctamin-4 [KO:K19499]
112979974  ANO5; LOW QUALITY PROTEIN: anoctamin-5 [KO:K19480]
112988680  ANO7; anoctamin-7 [KO:K19501]
112991578  ANO9; anoctamin-9 [KO:K19503]
112988060  BSG; basigin [KO:K06535]
112984560  XKR8; XK-related protein 8 [KO:K26813]
112992220  XKR9; LOW QUALITY PROTEIN: XK-related protein 9 [KO:K26814]
112987236  XKR7; XK-related protein 7 [KO:K26811]
112992464  XKR6; XK-related protein 6 [KO:K26811]
112981908  XKR4; XK-related protein 4 [KO:K26811]
112988414  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
112979462  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
112989661  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
112980152  ATP11B; probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
112981383  ATP11A; probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
112984429  TMEM30A; cell cycle control protein 50A [KO:K26935]
112996789  PROS1; vitamin K-dependent protein S isoform X1 [KO:K03908]
112989242  ITGAV; integrin alpha-V [KO:K06487]
112982807  ITGB3; integrin beta-3 [KO:K06493]
112996357  ITGB5; integrin beta-5 [KO:K06588]
112980671  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
112991285  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
112994326  T-cell immunoglobulin and mucin domain-containing protein 4-like [KO:K26936]
112994377  HAVCR2; hepatitis A virus cellular receptor 2 isoform X1 [KO:K20413]
112986935  STAB1; stabilin-1 [KO:K19020]
112993921  STAB2; stabilin-2 isoform X1 [KO:K19013]
112991286  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
112987467  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
112994640  CRKL; crk-like protein [KO:K04438]
112986346  CRK; adapter molecule crk isoform X1 [KO:K04438]
112984329  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
112992655  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
112992828  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
112994031  LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
112991605  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
112986596  CALR3; calreticulin-3 [KO:K08057]
112988464  C1QA; complement C1q subcomponent subunit A [KO:K03986]
112988471  C1QB; complement C1q subcomponent subunit B [KO:K03987]
112988463  C1QC; complement C1q subcomponent subunit C [KO:K03988]
112992707  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
112996296  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
112992391  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
112986341  SCARF1; scavenger receptor class F member 1 [KO:K24318]
112980344  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
112985791  RAB17; ras-related protein Rab-17 [KO:K07909]
112985288  RAB5A; ras-related protein Rab-5A [KO:K07887]
112995188  RAB5B; ras-related protein Rab-5B [KO:K07888]
112992608  RAB5C; ras-related protein Rab-5C [KO:K07889]
112984955  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 isoform X1 [KO:K20177]
112983435  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
112991631  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
112993989  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
112987577  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
112991822  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
112979910  RAB14; ras-related protein Rab-14 [KO:K07881]
112980675  VPS39; vam6/Vps39-like protein [KO:K20183]
112996116  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
112995196  RAB7A; ras-related protein Rab-7a [KO:K07897]
112990375  RAB7B; ras-related protein Rab-7b [KO:K07898]
112981346  PQLC2L; LOW QUALITY PROTEIN: putative uncharacterized protein PQLC2L [KO:K23678]
112990641  PQLC2; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
112980743  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
112981513  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
112979724  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
112979212  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
112991581  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
112984409  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
112986862  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
112997383  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
112990134  IL10; interleukin-10 [KO:K05443]
112981630  lysosomal acid lipase/cholesteryl ester hydrolase-like isoform X1 [KO:K01052] [EC:3.1.1.13]
112979725  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
112997044  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
112979746  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
112984301  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
112990289  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
112980576  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
112990224  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
112995692  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
112990514  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
112995167  CD24; signal transducer CD24 [KO:K06469]
112982600  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
112987259  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
112991073  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
112983482  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
112991774  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
dne00010  Glycolysis / Gluconeogenesis
dne04140  Autophagy - animal
dne04145  Phagosome
KO pathway
ko04148   
LinkDB

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