KEGG   PATHWAY: eee04371
Entry
eee04371                    Pathway                                
Name
Apelin signaling pathway - Electrophorus electricus (electric eel)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
eee04371  Apelin signaling pathway
eee04371

Other DBs
GO: 0060183
Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113588648  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
113582988  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
113578463  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
113590334  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
113583134  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
113591496  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
113567484  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
113591158  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
113583096  adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
113581231  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
113584128  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
113580690  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
113576829  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
113591278  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113581910  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113587857  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113592026  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
113571934  lipe; LOW QUALITY PROTEIN: hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
113578376  hormone-sensitive lipase-like isoform X1 [KO:K07188] [EC:3.1.1.79]
113582672  apelin [KO:K05225]
113586129  apela; apelin receptor early endogenous ligand [KO:K25355]
113588918  apelin receptor A-like [KO:K04174]
113582995  apelin receptor B [KO:K04174]
113588675  apelin receptor A [KO:K04174]
113579726  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
113575513  guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
113579153  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
113571585  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
113569349  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
113580458  gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
113571588  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
113586818  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
113570632  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like isoform X1 [KO:K07825]
113572607  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like [KO:K07825]
113590330  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
113578423  guanine nucleotide-binding protein subunit beta-4-like [KO:K04538]
113568349  guanine nucleotide-binding protein subunit beta-5b [KO:K04539]
113584500  gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
113585852  gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
113586013  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
113577746  gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
113570109  gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
113574358  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
113590918  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
113579828  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
113574510  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
113583621  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
113589328  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
113575198  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
113590856  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
113580926  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
113582199  gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
113578699  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
113574313  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2-like [KO:K04549]
113586947  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
113586948  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634]
113571340  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
113589181  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113571600  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
113572657  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113572658  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
113589466  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
113575990  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
113590571  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
113581076  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
113575434  ryanodine receptor 1-like [KO:K04961]
113576609  ryanodine receptor 1-like isoform X1 [KO:K04961]
113568004  ryanodine receptor 2-like [KO:K04962]
113568213  ryanodine receptor 2-like [KO:K04962]
113590411  ryanodine receptor 2-like [KO:K04962]
113571324  ryanodine receptor 3-like [KO:K04963]
113570521  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
113586011  calmodulin [KO:K02183]
113571726  calmodulin [KO:K02183]
113571128  calmodulin-like isoform X1 [KO:K02183]
113572741  calmodulin [KO:K02183]
113576685  calml4; calmodulin-like protein 4 [KO:K02183]
113572806  calmodulin [KO:K02183]
113571589  calml6; calmodulin-like protein 6 isoform X1 [KO:K02183]
113578627  calmodulin [KO:K02183]
113577767  nos1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
113591429  nitric oxide synthase, inducible-like [KO:K13241] [EC:1.14.13.39]
113572717  protein kinase C epsilon type-like isoform X1 [KO:K18050] [EC:2.7.11.13]
113572795  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
113583546  slc9a1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
113590159  Na(+)/H(+) exchanger beta-like isoform X1 [KO:K05742]
113591817  sodium/calcium exchanger 1-like [KO:K05849]
113591970  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
113574679  LOW QUALITY PROTEIN: sodium/calcium exchanger 3-like [KO:K05849]
113577715  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
113586005  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
113587000  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
113571569  sodium/calcium exchanger 1-like [KO:K05849]
113574000  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
113587239  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
113588908  mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
113570573  myosin light chain kinase family member 4-like [KO:K00907] [EC:2.7.11.18]
113583782  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
113588166  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
113580203  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
113583613  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
113571031  LOW QUALITY PROTEIN: myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
113567933  myosin light polypeptide 6-like [KO:K12750]
113587833  myosin light chain 3-like [KO:K12750]
113579694  GTPase HRas [KO:K02833]
113581312  hras; GTPase HRas [KO:K02833]
113588524  GTPase KRas isoform X1 [KO:K07827]
113589852  GTPase HRas-like [KO:K07827]
113577375  nras; GTPase NRas [KO:K07828]
113575754  rras2; ras-related protein R-Ras2 [KO:K07830]
113580274  rras; ras-related protein R-Ras [KO:K07830]
113581478  ras-related protein M-Ras-like [KO:K07831]
113592099  mras; ras-related protein M-Ras isoform X1 [KO:K07831]
113580611  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
113572287  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
113588584  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113588939  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113584672  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
113585589  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
113592047  mitogen-activated protein kinase 1-like isoform X1 [KO:K04371] [EC:2.7.11.24]
113584368  rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
113568160  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
113585876  rps6; 40S ribosomal protein S6 [KO:K02991]
113575802  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
113570029  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
113573215  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
113584794  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
113584796  pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
113571342  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113578378  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113568414  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113579639  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113584326  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
113570723  LOW QUALITY PROTEIN: early growth response protein 1-like [KO:K09203]
113570374  early growth response protein 1-B-like [KO:K09203]
113579641  protein jagged-1a-like [KO:K06052]
113579962  jag1; protein jagged-1 [KO:K06052]
113581871  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2-like [KO:K20995]
113578962  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
113588422  G1/S-specific cyclin-D1-like [KO:K04503]
113575781  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
113578319  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
113572798  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
113576843  becn1; beclin-1 [KO:K08334]
113589347  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
113586510  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
113585311  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
113590009  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
113589709  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
113570222  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
113584832  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
113568139  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
113592101  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
113587227  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
113578530  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
113573808  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
113581537  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
113570062  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
113573967  plin1; perilipin-1 isoform X1 [KO:K08768]
113580475  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
113591005  nrf1; nuclear respiratory factor 1 isoform X1 [KO:K11831]
113577015  tfam; transcription factor A, mitochondrial [KO:K11830]
113574479  Krueppel-like factor 2 [KO:K17845]
113582866  klf2; Krueppel-like factor 2 [KO:K17845]
113580757  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113587788  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113573083  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
113580257  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
113574856  guanine nucleotide-binding protein subunit alpha-13-like isoform X1 [KO:K04639]
113586933  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
113583690  histone deacetylase 4-like [KO:K11406] [EC:3.5.1.98]
113584724  hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
113577224  hdac4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
113573597  myocyte-specific enhancer factor 2A-like isoform X1 [KO:K09260]
113576187  myocyte-specific enhancer factor 2B-like [KO:K09261]
113583215  LOW QUALITY PROTEIN: myocyte-specific enhancer factor 2C-like [KO:K04454]
113572902  mef2c; LOW QUALITY PROTEIN: myocyte-specific enhancer factor 2C [KO:K04454]
113589097  mef2d; myocyte-specific enhancer factor 2D isoform X1 [KO:K09262]
113590741  tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
113590822  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
113585069  mothers against decapentaplegic homolog 3-like [KO:K23605]
113574086  mothers against decapentaplegic homolog 3 [KO:K23605]
113567946  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
113590440  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4-like [KO:K04501]
113571196  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
113573295  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
113579474  acta2; actin, aortic smooth muscle [KO:K12313]
113575713  cdh1; cadherin-1 isoform X1 [KO:K05689]
113575719  B-cadherin-like [KO:K05689]
113584020  connective tissue growth factor-like isoform X1 [KO:K06827]
113589763  ccn2; connective tissue growth factor [KO:K06827]
113584765  type-1 angiotensin II receptor-like [KO:K04166]
113580806  serpine1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
113584931  plat; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
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