KEGG   PATHWAY: eee04020
Entry
eee04020                    Pathway                                
Name
Calcium signaling pathway - Electrophorus electricus (electric eel)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
eee04020  Calcium signaling pathway
eee04020

Other DBs
GO: 0019722
Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113591817  sodium/calcium exchanger 1-like [KO:K05849]
113591970  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
113574679  LOW QUALITY PROTEIN: sodium/calcium exchanger 3-like [KO:K05849]
113577715  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
113586005  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
113587000  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
113571569  sodium/calcium exchanger 1-like [KO:K05849]
113570024  atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
113583600  plasma membrane calcium-transporting ATPase 2-like [KO:K05850] [EC:7.2.2.10]
113583795  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
113579739  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
113587287  plasma membrane calcium-transporting ATPase 3-like isoform X1 [KO:K05850] [EC:7.2.2.10]
113589437  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
113573364  muscarinic acetylcholine receptor M1-like [KO:K04129]
113591632  muscarinic acetylcholine receptor M1-like [KO:K04129]
113591380  muscarinic acetylcholine receptor M3-like [KO:K04131]
113591659  muscarinic acetylcholine receptor M3-like [KO:K04131]
113571331  muscarinic acetylcholine receptor M5-like [KO:K04133]
113570523  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
113573461  adora2a; adenosine receptor A2a [KO:K04266]
113573789  adora2b; adenosine receptor A2b [KO:K04267]
113586622  adrb1; beta-1 adrenergic receptor [KO:K04141]
113571309  beta-2 adrenergic receptor-like [KO:K04142]
113587185  beta-2 adrenergic receptor-like [KO:K04142]
113578746  beta-2 adrenergic receptor-like [KO:K04143]
113582475  adrb3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
113581740  D(1) dopamine receptor-like [KO:K04144]
113587625  drd1; D(1A) dopamine receptor [KO:K04144]
113581883  drd5; D(1B) dopamine receptor [KO:K05840]
113589748  D(1C) dopamine receptor-like [KO:K05840]
113588734  histamine H2 receptor-like [KO:K04150]
113577160  histamine H2 receptor-like [KO:K04150]
113573376  5-hydroxytryptamine receptor 4-like [KO:K04160]
113578990  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 4-like [KO:K04160]
113589044  htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
113585056  5-hydroxytryptamine receptor 5A-like [KO:K04161]
113572024  5-hydroxytryptamine receptor 5A-like [KO:K04161]
113580174  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
113579512  htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
113588539  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 7-like [KO:K04163]
113590407  5-hydroxytryptamine receptor 7-like [KO:K04163]
113577854  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
113578881  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
113582412  gnal; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
113581643  guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
113588648  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
113582988  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
113578463  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
113590334  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
113583134  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
113591496  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
113581231  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
113584128  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
113580690  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
113576829  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
113591278  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113581910  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113587857  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113592026  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
113571139  cardiac phospholamban-like [KO:K05852]
113572237  pln; cardiac phospholamban [KO:K05852]
113581592  sln; sarcolipin [KO:K22642]
113571494  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
113573746  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
113577360  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
113592052  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
113570277  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
113576848  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
113590848  sarcoplasmic reticulum histidine-rich calcium-binding protein-like [KO:K23450]
113586756  stromal interaction molecule 1-like isoform X1 [KO:K16059]
113573898  stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
113582942  stromal interaction molecule 2-like isoform X1 [KO:K18196]
113573499  stim2; stromal interaction molecule 2 [KO:K18196]
113586910  calcium release-activated calcium channel protein 1 [KO:K16056]
113567671  orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
113573712  LOW QUALITY PROTEIN: protein orai-2-like [KO:K16057]
113576556  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
113580442  cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
113579158  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
113579098  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
113578747  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
113586976  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
113581084  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
113586749  LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
113568055  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
113573427  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
113577940  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
113589212  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
113580060  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
113583212  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
113584941  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
113572852  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
113580342  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
113583653  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
113588279  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
113572604  LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
113577807  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
113577933  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1-like [KO:K05208]
113573772  glutamate receptor ionotropic, NMDA 1-like isoform X1 [KO:K05208]
113572860  grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
113580928  glutamate receptor ionotropic, NMDA 2A-like isoform X1 [KO:K05209]
113589370  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
113580353  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
113579410  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
113573251  glutamate receptor ionotropic, NMDA 2C-like isoform X1 [KO:K05211]
113570691  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
113576302  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
113577623  glutamate receptor ionotropic, NMDA 3A-like [KO:K05213]
113576462  glutamate receptor ionotropic, NMDA 3B-like isoform X1 [KO:K05214]
113568601  grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
113583936  P2X purinoceptor 1-like [KO:K05215]
113585601  P2X purinoceptor 2-like [KO:K05216]
113571509  p2rx3; P2X purinoceptor 3 [KO:K05217]
113570727  P2X purinoceptor 3-like [KO:K05217]
113590048  p2rx4; P2X purinoceptor 4 [KO:K05218]
113588026  P2X purinoceptor 4-like [KO:K05218]
113589997  P2X purinoceptor 5-like [KO:K05219]
113586516  P2X purinoceptor 5-like [KO:K05219]
113589473  P2X purinoceptor 4-like [KO:K05220]
113575434  ryanodine receptor 1-like [KO:K04961]
113576609  ryanodine receptor 1-like isoform X1 [KO:K04961]
113568004  ryanodine receptor 2-like [KO:K04962]
113568213  ryanodine receptor 2-like [KO:K04962]
113590411  ryanodine receptor 2-like [KO:K04962]
113571324  ryanodine receptor 3-like [KO:K04963]
113570521  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
113569880  trdn; triadin isoform X1 [KO:K23449]
113580325  calsequestrin-2-like [KO:K23445]
113591840  calsequestrin-2-like [KO:K23445]
113579299  asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
113574192  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
113571595  cysteinyl leukotriene receptor 2-like [KO:K04322]
113583034  cysteinyl leukotriene receptor 2-like [KO:K04323]
113575074  cysteinyl leukotriene receptor 2-like [KO:K04323]
113578650  cysteinyl leukotriene receptor 2-like isoform X1 [KO:K04323]
113579735  muscarinic acetylcholine receptor M2-like [KO:K04130]
113573657  chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
113570980  alpha-1A adrenergic receptor-like [KO:K04135]
113585277  adra1b; alpha-1B adrenergic receptor [KO:K04136]
113568456  alpha-1A adrenergic receptor-like isoform X1 [KO:K04136]
113578997  adra1d; alpha-1D adrenergic receptor [KO:K04137]
113584765  type-1 angiotensin II receptor-like [KO:K04166]
113570313  endothelin receptor type B-like [KO:K04197]
113590200  ednra; endothelin-1 receptor [KO:K04197]
113574169  endothelin receptor type B-like isoform X1 [KO:K04198]
113578525  endothelin receptor type B-like [KO:K04198]
113580495  f2r; proteinase-activated receptor 1 [KO:K03914]
113568043  proteinase-activated receptor 1-like [KO:K03914]
113578142  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
113580773  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
113578739  metabotropic glutamate receptor 5-like [KO:K04604]
113581659  metabotropic glutamate receptor 5-like [KO:K04604]
113578262  grpr; gastrin-releasing peptide receptor [KO:K04169]
113583802  hrh1; histamine H1 receptor [KO:K04149]
113582305  5-hydroxytryptamine receptor 2C-like [KO:K04157]
113585665  htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
113587726  5-hydroxytryptamine receptor 2A-like [KO:K04157]
113585741  htr2b; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B [KO:K04157]
113591974  5-hydroxytryptamine receptor 2C-like [KO:K04157]
113587858  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
113591105  lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
113585412  pyrokinin-1 receptor-like [KO:K04211]
113575484  ntsr1; neurotensin receptor type 1 [KO:K04211]
113577999  isotocin receptor-like [KO:K04229]
113569651  isotocin receptor-like [KO:K04229]
113584427  arg8-vasotocin receptor-like isoform X1 [KO:K04226]
113583660  arg8-vasotocin receptor-like [KO:K04226]
113588826  leukotriene B4 receptor 1-like [KO:K04297]
113592191  ptafr; platelet-activating factor receptor [KO:K04279]
113575183  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
113581855  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
113588795  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
113570469  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
113575421  prostaglandin F2-alpha receptor-like [KO:K04262]
113572682  B1 bradykinin receptor-like [KO:K03915]
113571697  B2 bradykinin receptor-like [KO:K03916]
113572638  B2 bradykinin receptor-like isoform X1 [KO:K03916]
113589569  substance-P receptor-like [KO:K04222]
113584323  substance-P receptor-like [KO:K04222]
113571537  tacr2; substance-K receptor [KO:K04223]
113590358  neuromedin-K receptor-like [KO:K04224]
113583877  neuromedin-K receptor-like [KO:K04224]
113584738  tacr3; neuromedin-K receptor [KO:K04224]
113591726  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
113586267  trhr; LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor [KO:K04282]
113582284  thyrotropin-releasing hormone receptor-like [KO:K04282]
113583295  thyrotropin-releasing hormone receptor-like isoform X1 [KO:K04282]
113589457  thyrotropin-releasing hormone receptor-like [KO:K04282]
113578488  cholecystokinin receptor-like isoform X1 [KO:K04194]
113573505  cckar; cholecystokinin receptor type A [KO:K04194]
113582600  C-X-C chemokine receptor type 4-like [KO:K04189]
113585300  C-X-C chemokine receptor type 4-like [KO:K04189]
113586947  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
113586948  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634]
113583372  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
113591267  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04635]
113588175  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
113591269  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
113579942  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
113575949  protransforming growth factor alpha-like [KO:K08774]
113581484  platelet-derived growth factor subunit A-like [KO:K04359]
113576794  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113585737  bromodomain-containing protein 4B-like isoform X1 [KO:K17386]
113578705  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
113582430  pdgfc; platelet-derived growth factor C [KO:K05450]
113585519  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
113589363  fgf2; fibroblast growth factor 2 [KO:K18497]
113576222  fgf22; fibroblast growth factor 22 [KO:K04358]
113577848  fgf4; fibroblast growth factor 4 [KO:K04358]
113579240  fgf20; fibroblast growth factor 20 [KO:K04358]
113585459  fibroblast growth factor 8 [KO:K04358]
113586200  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
113590621  fibroblast growth factor 4A-like [KO:K04358]
113568362  fibroblast growth factor 20-like [KO:K04358]
113578087  fibroblast growth factor 4B-like [KO:K04358]
113581460  fibroblast growth factor 18-like [KO:K04358]
113589387  fgf16; fibroblast growth factor 16 [KO:K04358]
113589856  fgf5; fibroblast growth factor 5 [KO:K04358]
113577153  fibroblast growth factor 8b [KO:K04358]
113575586  fibroblast growth factor 18-like isoform X1 [KO:K04358]
113577967  fgf3; fibroblast growth factor 3 [KO:K04358]
113584976  fibroblast growth factor 4B-like [KO:K04358]
113585352  fgf7; fibroblast growth factor 7 [KO:K04358]
113588416  fibroblast growth factor 4B-like [KO:K04358]
113590517  fibroblast growth factor 18-like [KO:K04358]
113570786  fgf10; fibroblast growth factor 10 [KO:K04358]
113578786  fgf19; fibroblast growth factor 19 [KO:K22603]
113589172  fibroblast growth factor 19-like [KO:K22429]
113578091  fgf23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
113578974  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
113578092  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
113578240  vegfd; vascular endothelial growth factor D [KO:K05449]
113582024  vegfc; vascular endothelial growth factor C [KO:K05449]
113589593  nerve growth factor-like [KO:K02582]
113587808  neurotrophin-7-like [KO:K02582]
113588284  hepatocyte growth factor-like [KO:K05460]
113577168  hepatocyte growth factor-like [KO:K05460]
113571630  mst1; hepatocyte growth factor-like protein [KO:K23441]
113573338  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
113587946  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
113590490  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
113576854  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
113581542  erbb3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
113581376  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
113579187  erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
113579192  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
113586382  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113575581  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113588173  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
113588015  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113589671  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
113571264  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113573874  vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
113582440  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
113576525  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
113586383  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
113571898  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
113578767  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
113586931  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
113584773  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
113573962  ntrk3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
113581523  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
113584980  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
113586646  mst1r; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
113571635  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
113585232  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
113577202  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
113579499  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
113586837  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
113571983  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like [KO:K05857] [EC:3.1.4.11]
113581223  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
113588890  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
113571340  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
113589181  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113571600  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
113572657  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
113572658  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
113589466  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
113588884  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
113577174  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
113584760  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
113575990  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
113590571  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
113581076  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
113582404  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
113582405  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
113591062  LOW QUALITY PROTEIN: two pore calcium channel protein 1-like [KO:K16896]
113578608  tpcn2; two pore calcium channel protein 2 [KO:K14077]
113584857  mucolipin-1-like [KO:K04992]
113580333  mcoln1; mucolipin-1 [KO:K04992]
113586109  mcoln2; mucolipin-2 [KO:K04993]
113591484  mucolipin-3-like [KO:K04994]
113590509  mucolipin-3-like isoform X1 [KO:K04994]
113580757  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113587788  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113573083  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
113585469  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
113578039  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
113583300  voltage-dependent anion-selective channel protein 2 [KO:K15040]
113576328  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
113584917  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
113591667  voltage-dependent anion-selective channel protein 2-like [KO:K15041]
113592058  ADP/ATP translocase 1-like [KO:K05863]
113582436  slc25a5; ADP/ATP translocase 2 [KO:K05863]
113583269  ADP/ATP translocase 1-like [KO:K05863]
113587350  ADP/ATP translocase 2-like [KO:K05863]
113568074  ADP/ATP translocase 2-like [KO:K05863]
113580965  peptidyl-prolyl cis-trans isomerase A-like isoform X1 [KO:K09565] [EC:5.2.1.8]
113589028  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
113572331  tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
113582010  troponin C, slow skeletal and cardiac muscles-like isoform X1 [KO:K05865]
113569988  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
113569976  troponin C, skeletal muscle isoform X1 [KO:K12042]
113569977  troponin C, skeletal muscle-like [KO:K12042]
113586011  calmodulin [KO:K02183]
113571726  calmodulin [KO:K02183]
113571128  calmodulin-like isoform X1 [KO:K02183]
113572741  calmodulin [KO:K02183]
113576685  calml4; calmodulin-like protein 4 [KO:K02183]
113572806  calmodulin [KO:K02183]
113571589  calml6; calmodulin-like protein 6 isoform X1 [KO:K02183]
113578627  calmodulin [KO:K02183]
113584646  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
113573644  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
113583965  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
113568700  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
113579823  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform-like isoform X1 [KO:K07190]
113574000  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
113587239  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
113588908  mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
113570573  myosin light chain kinase family member 4-like [KO:K00907] [EC:2.7.11.18]
113583782  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
113588166  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
113580203  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
113584493  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
113583904  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
113583921  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
113568206  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
113578016  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
113577666  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
113571482  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
113587336  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
113587439  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
113572944  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
113579297  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
113583472  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
113586933  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
113581750  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113589577  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
113572343  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
113577345  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113589813  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like [KO:K04348] [EC:3.1.3.16]
113579658  calcineurin subunit B type 1 [KO:K06268]
113585612  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
113583606  tfeb; transcription factor EB [KO:K15590]
113581708  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
113583287  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
113576315  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
113571665  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
113573155  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
113587328  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
113584133  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
113577767  nos1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
113591429  nitric oxide synthase, inducible-like [KO:K13241] [EC:1.14.13.39]
113581429  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
113585089  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
113580669  pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
113584341  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
113572664  ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
113573003  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
113577462  itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
113576636  inositol-trisphosphate 3-kinase A-like isoform X1 [KO:K00911] [EC:2.7.1.127]
113585380  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
113575194  inositol-trisphosphate 3-kinase C-like isoform X1 [KO:K00911] [EC:2.7.1.127]
113575317  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
113590761  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113588773  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
113580901  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
eee04010  MAPK signaling pathway
eee04070  Phosphatidylinositol signaling system
eee04210  Apoptosis
KO pathway
ko04020   
LinkDB

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