KEGG   PATHWAY: ggo05020
Entry
ggo05020                    Pathway                                
Name
Prion disease - Gorilla gorilla gorilla (western lowland gorilla)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ggo05020  Prion disease
ggo05020

Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101135304  PRNP; major prion protein [KO:K05634]
101149455  NCAM1; neural cell adhesion molecule 1 isoform X19 [KO:K06491]
101124856  NCAM2; neural cell adhesion molecule 2 isoform X3 [KO:K06491]
101132251  LAMC1; laminin subunit gamma-1 [KO:K05635]
101127142  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101146109  STIP1; stress-induced-phosphoprotein 1 [KO:K09553]
101151469  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
101134260  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101152769  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
101143006  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101146203  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101124569  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
101127573  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101146970  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101128942  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101144498  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101127983  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101123776  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101134060  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101140987  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
101131714  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101150507  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101125975  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101147776  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101129388  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101139584  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101140706  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
101143735  RYR1; ryanodine receptor 1 [KO:K04961]
101152456  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101140612  RYR3; ryanodine receptor 3 [KO:K04963]
101151145  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101151502  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101124725  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X6 [KO:K04960]
101137790  inactive caspase-12 isoform X1 [KO:K04741] [EC:3.4.22.-]
101144930  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101146305  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101132713  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101144871  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
115933538  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101151128  BAD; bcl2-associated agonist of cell death [KO:K02158]
101127243  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
101148105  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101142297  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101132025  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101143704  SLC25A31; ADP/ATP translocase 4 isoform X2 [KO:K05863]
101138376  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101128634  PPIF; LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
115932634  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101135722  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101135431  cytochrome c [KO:K08738]
101126237  LOW QUALITY PROTEIN: cytochrome c 2-like [KO:K08738]
101152462  cytochrome c-like [KO:K08738]
101129170  cytochrome c-like [KO:K08738]
109025909  cytochrome c [KO:K08738]
109027916  cytochrome c-like [KO:K08738]
115932158  cytochrome c-like [KO:K08738]
101130414  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101126742  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
109028462  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
6742683  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
6742677  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
6742686  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
6742687  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
6742685  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
6742681  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
6742680  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
101142811  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101146734  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
115930449  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
101147133  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
101144612  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101147705  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101124353  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101139475  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
101148914  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101135077  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101132047  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
115936016  NDUFA8; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101144771  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101146483  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101140479  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101123984  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X1 [KO:K03956]
101148753  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101124593  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101132014  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
109025103  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101132493  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101129506  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101148993  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101133566  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
115931649  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101140954  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101125598  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101130361  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101130165  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101139264  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101153768  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101133932  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101125075  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101146625  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
101141794  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101151434  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101149494  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101148614  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial precursor [KO:K03941] [EC:7.1.1.2]
101134553  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101142450  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101141874  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
101124208  uncharacterized protein LOC101124208 isoform X1 [KO:K00234] [EC:1.3.5.1]
101131972  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101127794  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
109028866  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
101151822  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
101131106  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
6742684  CYTB; cytochrome b [KO:K00412]
101133451  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101150911  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
101130739  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101132095  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101132458  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
101127528  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
101144095  cytochrome b-c1 complex subunit 8 [KO:K00418]
101132438  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
101152996  cytochrome b-c1 complex subunit 10 [KO:K00420]
6742679  COX3; cytochrome c oxidase subunit III [KO:K02262]
6742689  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
6742682  COX2; cytochrome c oxidase subunit II [KO:K02261]
101151536  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101141650  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101135385  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
101134792  COX5A; cytochrome c oxidase subunit 5A [KO:K02264]
101138406  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101131208  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101133285  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101131776  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101140152  cytochrome c oxidase subunit 6B2 isoform X2 [KO:K02267]
101139203  cytochrome c oxidase subunit 6B1 [KO:K02267]
101144243  cytochrome c oxidase subunit 6C [KO:K02268]
101129299  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101144032  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101148899  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
115934363  putative cytochrome c oxidase subunit 7A3, mitochondrial [KO:K02270]
101147253  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
101133386  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
109024487  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
101133649  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
101144277  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101140105  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
101128101  ATP5F1A; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
101151032  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101133917  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101146631  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
109029312  ATP5F1E; ATP synthase subunit epsilon-like protein, mitochondrial [KO:K02135]
115931706  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
6742688  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
101153285  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101131806  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
101133231  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101125761  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
101152743  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
101145094  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
101130400  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
6742678  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
101131305  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
101125092  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101137931  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
101141876  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
101151568  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101151849  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
109028113  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101147397  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
101143558  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
101136619  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
101151594  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
101150208  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
101148938  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
101128203  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
101127135  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101128397  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101139085  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101148521  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101135054  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101153204  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
101128863  PSMC3; LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6A [KO:K03065]
101153929  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
101152961  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101153440  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101143222  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101152227  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
101126621  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101147218  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101151153  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
101126869  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101126459  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
101154371  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
101138770  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101138477  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101153136  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
101152290  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
109026848  26S proteasome complex subunit SEM1-like [KO:K10881]
101138867  C5; complement C5 isoform X1 [KO:K03994]
101148425  C6; complement component C6 isoform X1 [KO:K03995]
101123977  C7; complement component C7 [KO:K03996]
101138636  C8A; complement component C8 alpha chain [KO:K03997]
101138999  C8B; complement component C8 beta chain isoform X3 [KO:K03998]
101129591  C8G; complement component C8 gamma chain isoform X3 [KO:K03999]
101131679  C9; complement component C9 [KO:K04000]
101124764  C1QB; complement C1q subcomponent subunit B [KO:K03987]
101141927  C1QC; complement C1q subcomponent subunit C isoform X2 [KO:K03988]
101129102  LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
101134225  heat shock 70 kDa protein 1 [KO:K03283]
101135640  heat shock 70 kDa protein 1-like isoform X2 [KO:K03283]
101128042  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101131586  heat shock 70 kDa protein 1 [KO:K03283]
115932977  heat shock 70 kDa protein 6 [KO:K03283]
109024942  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
101125469  CAV1; caveolin-1 isoform X1 [KO:K06278]
101124237  CAV2; caveolin-2 isoform X1 [KO:K12958]
101128051  CAV3; caveolin-3 [KO:K12959]
101143811  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101146434  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101152123  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101130978  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101135298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101129336  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101133370  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
101144859  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101141497  cytochrome b-245 light chain [KO:K08009]
101135662  NCF4; neutrophil cytosol factor 4 [KO:K08012]
101154464  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101133476  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101135430  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101141534  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101134492  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101134843  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101148438  MAPK13; mitogen-activated protein kinase 13 isoform X3 [KO:K04441] [EC:2.7.11.24]
101152640  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101152026  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101124033  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
101133141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101140164  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101135988  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101144410  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X4 [KO:K05870]
101135003  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101128609  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101144135  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101144628  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101152081  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101153965  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101146740  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
101153225  EGR1; early growth response protein 1 [KO:K09203]
101125807  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
101129849  IL1A; interleukin-1 alpha [KO:K04383]
101130571  IL1B; interleukin-1 beta [KO:K04519]
101151687  IL6; interleukin-6 isoform X1 [KO:K05405]
101125534  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101123844  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101148559  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101125572  CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115]
101145639  KIF5A; kinesin heavy chain [KO:K10396]
101136770  KIF5B; kinesin-1 heavy chain [KO:K10396]
101130460  KIF5C; kinesin heavy chain [KO:K10396]
101142449  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
101136859  KLC3; kinesin light chain 3 [KO:K10407]
101146998  KLC4; kinesin light chain 4 [KO:K10407]
101145175  KLC1; kinesin light chain 1 isoform X10 [KO:K10407]
101145095  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101149435  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
101148972  tubulin alpha-1B chain [KO:K07374]
101150168  tubulin alpha-1A chain [KO:K07374]
101136583  tubulin alpha-3 chain [KO:K07374]
101148853  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
101128742  LOW QUALITY PROTEIN: tubulin alpha-8 chain [KO:K07374]
115933728  tubulin alpha-3 chain-like [KO:K07374]
101129375  TUBA1C; tubulin alpha-1C chain isoform X1 [KO:K07374]
101135000  tubulin alpha-3 chain [KO:K07374]
109025051  tubulin beta-8 chain-like isoform X1 [KO:K07375]
101135202  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
101125081  tubulin beta-2B chain [KO:K07375]
101129890  TUBB; tubulin beta chain [KO:K07375]
101134220  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
109025561  TUBB2A; tubulin beta-2A chain [KO:K07375]
101125238  TUBB8; tubulin beta-8 chain isoform X3 [KO:K07375]
101142053  TUBB4B; tubulin beta-4B chain [KO:K07375]
101137576  TUBB4A; tubulin beta-4A chain [KO:K07375]
101153430  tubulin beta-8 chain-like isoform X5 [KO:K07375]
101131674  LOW QUALITY PROTEIN: melanocyte-stimulating hormone receptor [KO:K07375]
115935411  tubulin beta-8 chain isoform X1 [KO:K07375]
115935017  tubulin beta-1 chain-like [KO:K07375]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
PMID:27055367
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  Title
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Expert Rev Mol Med 18:e5 (2016)
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PMID:25584786
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Prion degradation pathways: Potential for therapeutic intervention.
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Mol Cell Neurosci 66:12-20 (2015)
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Reference
PMID:20889378
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The intricate mechanisms of neurodegeneration in prion diseases.
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Trends Mol Med 17:14-24 (2011)
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Reference
PMID:27060771
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Brain Res 1648:553-560 (2016)
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Reference
PMID:32565065
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Neurobiol Dis 142:104973 (2020)
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Reference
PMID:18245809
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Prion diseases: from protein to cell pathology.
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Am J Pathol 172:555-65 (2008)
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Reference
PMID:15695097
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The highways and byways of prion protein trafficking.
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Trends Cell Biol 15:102-11 (2005)
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Reference
PMID:17051207
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Prions and their partners in crime.
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Nature 443:803-10 (2006)
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Reference
PMID:11592845
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Chiesa R, Harris DA
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Prion diseases: what is the neurotoxic molecule?
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Neurobiol Dis 8:743-63 (2001)
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Reference
PMID:17085779
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Fasano C, Campana V, Zurzolo C
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Prions: protein only or something more? Overview of potential prion cofactors.
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J Mol Neurosci 29:195-214 (2006)
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Reference
PMID:14705136
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Neuroprotective functions of prion protein.
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J Neurosci Res 75:153-61 (2004)
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Reference
PMID:10398674
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Harris DA
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Cellular biology of prion diseases.
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Reference
PMID:15890824
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Prion biology relevant to bovine spongiform encephalopathy.
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J Anim Sci 83:1455-76 (2005)
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Reference
PMID:27581199
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Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
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Biochem Biophys Res Commun 483:1148-1155 (2017)
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Reference
PMID:31618844
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Int J Mol Sci 20:E5107 (2019)
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Reference
PMID:31795242
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The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
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Int J Mol Sci 20:E6004 (2019)
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Reference
PMID:30710214
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Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
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Mol Neurobiol 56:6035-6045 (2019)
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Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
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Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
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Reference
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Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
PMID:29194372
  Authors
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What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
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Pathogens 6:E63 (2017)
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Reference
PMID:24619348
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Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
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Nat Rev Neurosci 15:233-49 (2014)
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Reference
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The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
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FEBS J 286:342-355 (2019)
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Reference
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Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
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J Cell Mol Med 15:2025-39 (2011)
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PMID:18420416
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Neurobiol Dis 30:331-42 (2008)
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Reference
PMID:16844381
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An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
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Neurobiol Dis 23:669-78 (2006)
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Commun Integr Biol 4:258-61 (2011)
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Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
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Exp Mol Med 47:e147 (2015)
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Reference
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Disease-associated prion protein oligomers inhibit the 26S proteasome.
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Mol Cell 26:175-88 (2007)
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Reference
PMID:10195903
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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
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Science 284:339-43 (1999)
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Reference
PMID:14532116
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Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
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EMBO J 22:5435-45 (2003)
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Reference
PMID:31417367
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Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
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Front Cell Neurosci 13:350 (2019)
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Reference
PMID:29261664
  Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
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PLoS One 12:e0188340 (2017)
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Reference
PMID:21196165
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Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
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Understanding the neurospecificity of Prion protein signaling.
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Front Biosci (Landmark Ed) 16:169-86 (2011)
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Reference
PMID:23479001
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  Title
Prion protein and its role in signal transduction.
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Cell Mol Biol Lett 18:209-30 (2013)
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Reference
PMID:28507517
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The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
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Front Aging Neurosci 9:120 (2017)
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Reference
PMID:15528202
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
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J Biol Chem 280:1529-34 (2005)
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Reference
PMID:15640354
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
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Proc Natl Acad Sci U S A 102:886-91 (2005)
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Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
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Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
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Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
DOI:10.1172/JCI90605
Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
ggo00190  Oxidative phosphorylation
ggo03050  Proteasome
ggo04020  Calcium signaling pathway
ggo04140  Autophagy - animal
ggo04141  Protein processing in endoplasmic reticulum
ggo04142  Lysosome
ggo04144  Endocytosis
ggo04210  Apoptosis
ggo04330  Notch signaling pathway
ggo04610  Complement and coagulation cascades
ggo04668  TNF signaling pathway
KO pathway
ko05020   
LinkDB

DBGET integrated database retrieval system