KEGG   PATHWAY: ifu04145
Entry
ifu04145                    Pathway                                
Name
Phagosome - Ictalurus furcatus (blue catfish)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
ifu04145  Phagosome
ifu04145

Other DBs
GO: 0045335
Organism
Ictalurus furcatus (blue catfish) [GN:ifu]
Gene
128624868  vamp3; vesicle-associated membrane protein 3 [KO:K13505]
128611918  stx12l; syntaxin-12 [KO:K13813]
128618274  stx7l; syntaxin-7 [KO:K08488]
128600219  actb2; actin, cytoplasmic 2 [KO:K05692]
128601766  actb1; actin, cytoplasmic 1 [KO:K05692]
128604047  coro1a; coronin-1A isoform X1 [KO:K13882]
128622757  stx18; syntaxin-18 [KO:K08492]
128608331  sec22bb; vesicle-trafficking protein SEC22b-B [KO:K08517]
128615451  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
128615452  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
128615453  patr class I histocompatibility antigen, CH28 alpha chain-like [KO:K06751]
128615454  mamu class I histocompatibility antigen, alpha chain F-like [KO:K06751]
128599156  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
128599157  H-2 class I histocompatibility antigen, Q9 alpha chain isoform X1 [KO:K06751]
128599161  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
128599162  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
128599189  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
128599190  major histocompatibility complex class I-related gene protein-like [KO:K06751]
128599193  RLA class I histocompatibility antigen, alpha chain 11/11-like isoform X1 [KO:K06751]
128599195  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
128599276  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
128625480  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
128625496  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
128625497  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
128607327  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
128607328  HLA class II histocompatibility antigen, DR beta 4 chain [KO:K06752]
128607329  H-2 class II histocompatibility antigen, A-U alpha chain [KO:K06752]
128607330  H-2 class II histocompatibility antigen, A-U alpha chain [KO:K06752]
128600069  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
128608721  rab5b; ras-related protein Rab-5B isoform X1 [KO:K07888]
128616945  ras-related protein Rab-5C-like [KO:K07889]
128601990  rab5c; ras-related protein Rab-5C [KO:K07889]
128606624  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
128610292  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
128599803  tfr1b; transferrin receptor 1b [KO:K06503]
128624298  tfr1a; transferrin receptor 1a [KO:K06503]
128624299  transferrin receptor protein 1-like [KO:K06503]
128600368  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
128599802  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
128612427  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
128620597  V-type proton ATPase subunit B, brain isoform [KO:K02147]
128620599  V-type proton ATPase subunit B, brain isoform [KO:K02147]
128613155  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
128615512  atp6v1c1b; V-type proton ATPase subunit C 1-B isoform X1 [KO:K02148]
128599658  atp6v1c1a; V-type proton ATPase subunit C 1-A [KO:K02148]
128600951  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
128623392  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
128611696  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
128623688  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
128603533  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
128618324  atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
128624503  atpv0e2; ATPase H+ transporting V0 subunit e2 [KO:K02153]
128611047  tcirg1b; T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b [KO:K02154]
128620071  V-type proton ATPase 116 kDa subunit a 2-like [KO:K02154]
128599394  si:ch73-173p19.2; V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
128599556  atp6v0a1b; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
128601856  atp6v0a1a; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
128625690  atp6v0a2b; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
128603035  atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
128609599  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
128615597  atp6v0cb; ATPase H+ transporting V0 subunit cb [KO:K02155]
128601643  atp6v0ca; ATPase H+ transporting V0 subunit ca [KO:K02155]
128609527  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
128619540  atp6ap1a; ATPase H+ transporting accessory protein 1a [KO:K03662]
128619829  atp6ap1b; V-type proton ATPase subunit S1b [KO:K03662]
128607433  rab7b; ras-related protein Rab-7b [KO:K07897]
128614749  ras-related protein Rab-7a [KO:K07897]
128624678  rab7a; ras-related protein Rab-7a [KO:K07897]
128621884  rilp; rab-interacting lysosomal protein isoform X1 [KO:K13883]
128612858  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
128621001  cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
128606158  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
128614612  dync1i2b; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
128608875  dync1i2a; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
128600355  cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
128600098  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
128602736  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
128617298  tubulin alpha-1A chain-like [KO:K07374]
128608019  tuba5; tubulin alpha 5 isoform X1 [KO:K07374]
128619848  tubulin alpha-1A chain-like [KO:K07374]
128619849  tuba1c; tubulin alpha-1C chain isoform X1 [KO:K07374]
128619909  tubulin alpha-1A chain [KO:K07374]
128619910  tubulin alpha-1C chain [KO:K07374]
128608989  tuba8l3; tubulin, alpha 8 like 3 [KO:K07374]
128607083  tubulin alpha-1A chain-like isoform X1 [KO:K07374]
128610314  tubulin alpha-1A chain-like [KO:K07374]
128621645  tubulin alpha-1A chain-like [KO:K07374]
128600226  tubulin alpha-8 chain-like [KO:K07374]
128600227  tubulin alpha-8 chain-like [KO:K07374]
128601735  tuba8l2; tubulin, alpha 8 like 2 [KO:K07374]
128624794  tubulin alpha-1B chain [KO:K07374]
128624795  tubulin alpha-1A chain-like [KO:K07374]
128603569  zgc:55461; beta-tubulin family protein isoform X1 [KO:K07375]
128610620  tubb2; tubulin beta-2A chain [KO:K07375]
128607417  tubb2b; tubulin beta-2b chain [KO:K07375]
128611187  tubb4b; tubulin beta-4b chain [KO:K07375]
128611230  tubulin beta-4B chain-like [KO:K07375]
128611235  tubulin beta chain-like isoform X1 [KO:K07375]
128607661  tubb5; tubulin beta-5 chain [KO:K07375]
128613066  tubulin beta-4B chain-like [KO:K07375]
128603645  tubulin beta chain-like [KO:K07375]
128614152  tubulin beta chain-like [KO:K07375]
128614263  tubulin beta chain-like isoform X1 [KO:K07375]
128614603  tubb6; tubulin, beta 6 class V [KO:K07375]
128615957  tubb1; tubulin beta-1 chain [KO:K07375]
128605911  tubulin beta chain-like [KO:K07375]
128607179  mc1r; melanocyte-stimulating hormone receptor [KO:K07375]
128600551  tubb4bl; tubulin beta-4B chain [KO:K07375]
128601871  tubulin beta-4B chain-like [KO:K07375]
128602145  tubulin beta-4B chain-like [KO:K07375]
128625473  tubulin beta-4B chain-like [KO:K07375]
128625627  tubulin beta-4B chain-like [KO:K07375]
128625628  tubulin beta-4B chain-like [KO:K07375]
128609248  lamp1b; lysosome-associated membrane glycoprotein 1b [KO:K06528]
128601908  lamp1a; lysosome-associated membrane glycoprotein 1a [KO:K06528]
128609221  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
128610895  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
128625645  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
128612298  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
128612300  procathepsin L [KO:K01365] [EC:3.4.22.15]
128612616  procathepsin L [KO:K01365] [EC:3.4.22.15]
128612617  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
128613961  cts12; procathepsin L [KO:K01365] [EC:3.4.22.15]
128599078  ctsla; cathepsin La [KO:K01365] [EC:3.4.22.15]
128610342  ctss2.1; cathepsin S, ortholog2, tandem duplicate 1 [KO:K01368] [EC:3.4.22.27]
128614438  sec61a1l; protein transport protein Sec61 subunit alpha-like 2 [KO:K10956]
128614918  sec61a1; protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
128599787  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
128609602  protein transport protein Sec61 subunit gamma [KO:K07342]
128599622  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
128600046  tap1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
128617045  tap2t; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
128601939  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
128602001  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
128613606  calr3a; calreticulin 3a [KO:K08057]
128607970  calr; calreticulin [KO:K08057]
128624210  calr3b; calreticulin 3b [KO:K08057]
128611044  canx; calnexin [KO:K08054]
128611403  si:ch211-274f20.2; calnexin [KO:K08054]
128624165  high affinity immunoglobulin gamma Fc receptor I isoform X1 [KO:K06498]
128616901  uncharacterized protein LOC128616901 [KO:K06856]
128616964  uncharacterized protein LOC128616964 [KO:K06856]
128611049  complement C1s-1 subcomponent-like isoform X1 [KO:K01330] [EC:3.4.21.41]
128617257  complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
128616624  integrin alpha-M isoform X1 [KO:K06461]
128616625  integrin alpha-M-like [KO:K06461]
128609033  itgb2; integrin beta-2 [KO:K06464]
128601906  complement C3 [KO:K03990]
128602411  complement C3 [KO:K03990]
128602412  complement C3 [KO:K03990]
128612976  colec11; collectin-11 isoform X1 [KO:K10066]
128609589  LOW QUALITY PROTEIN: collectin-12-like [KO:K10062]
128609634  collectin-12-like [KO:K10062]
128608522  mannose-binding protein C-like isoform X1 [KO:K03991]
128608428  itgav; integrin alpha-V [KO:K06487]
128620269  integrin alpha-2-like [KO:K06481]
128620299  integrin alpha-2-like [KO:K06481]
128619381  itga5; integrin alpha-5 [KO:K06484]
128614535  itgb1a; integrin beta-1a [KO:K05719]
128623996  integrin beta-1 isoform X1 [KO:K05719]
128616898  itgb3b; integrin beta-3b [KO:K06493]
128601370  itgb3a; integrin beta-3a [KO:K06493]
128608845  itgb5; integrin beta-5 [KO:K06588]
128612280  thrombospondin-1 [KO:K16857]
128601263  thbs1b; thrombospondin-1 isoform X1 [KO:K16857]
128622531  thbs4b; thrombospondin-4-B [KO:K04659]
128613402  comp; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
128604134  thbs2a; thrombospondin-2 [KO:K04659]
128609672  thbs3a; thrombospondin-3a [KO:K04659]
128616277  thbs3b; thrombospondin-3b [KO:K04659]
128617008  thbs2b; thrombospondin-2 [KO:K04659]
128625485  thbs4a; thrombospondin-4a [KO:K04659]
128610284  tlr18; toll-like receptor 18 [KO:K10159]
128601965  tlr2; LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
128623343  toll-like receptor 1 [KO:K10169]
128605523  toll-like receptor 4 [KO:K10160]
128621982  macrophage mannose receptor 1 isoform X1 [KO:K06560]
128613816  pla2r1; secretory phospholipase A2 receptor [KO:K06560]
128609585  mrc1b; macrophage mannose receptor 1b [KO:K06560]
128609631  mrc1a; macrophage mannose receptor 1 isoform X1 [KO:K06560]
128601347  mrc2; C-type mannose receptor 2 isoform X1 [KO:K06560]
128608952  marco; macrophage receptor MARCO [KO:K13884]
128620447  scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
128623648  cd36; platelet glycoprotein 4 [KO:K06259]
128606426  cytochrome b-245 light chain [KO:K08009]
128602561  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
128617004  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
128625438  rac1b; ras-related C3 botulinum toxin substrate 1b isoform X1 [KO:K04392]
128603877  ncf1; neutrophil cytosol factor 1 [KO:K08011]
128609619  ncf2; neutrophil cytosol factor 2 [KO:K08010]
128602977  ncf4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
ifu04142  Lysosome
ifu04144  Endocytosis
ifu04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
LinkDB

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