KEGG   PATHWAY: lav04217
Entry
lav04217                    Pathway                                
Name
Necroptosis - Loxodonta africana (African savanna elephant)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
lav04217  Necroptosis
lav04217

Organism
Loxodonta africana (African savanna elephant) [GN:lav]
Gene
100677125  TNF; tumor necrosis factor isoform X2 [KO:K03156]
100672143  TNFRSF1A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100657751  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X4 [KO:K03171]
100670400  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
100663885  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
100666489  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100659163  baculoviral IAP repeat-containing protein 3 [KO:K16060]
100659446  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
100657657  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100654220  RBCK1; LOW QUALITY PROTEIN: ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
100653883  RNF31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
111752566  spermatogenesis-associated protein 2-like protein [KO:K17595]
100663168  SPATA2L; spermatogenesis-associated protein 2-like protein [KO:K17595]
100660622  SPATA2; spermatogenesis-associated protein 2 isoform X2 [KO:K17595]
100677482  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
100662633  FADD; FAS-associated death domain protein [KO:K02373]
100663575  caspase-8 [KO:K04398] [EC:3.4.22.61]
100660542  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100660836  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
100675807  RIPK3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
100655878  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
104846071  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
100653927  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100663321  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
100658516  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
100664844  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100669563  SLC25A31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
100655324  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100662489  SLC25A4; LOW QUALITY PROTEIN: ADP/ATP translocase 1 [KO:K05863]
100670745  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
100663098  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100667776  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100656308  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100668104  GLUD1; glutamate dehydrogenase 1, mitochondrial [KO:K00261] [EC:1.4.1.3]
100673871  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
100661005  PYGM; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
100661899  PYGL; LOW QUALITY PROTEIN: glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
100670338  PYGB; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
100654943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100674229  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100673395  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111753081  ferritin, mitochondrial-like [KO:K00522] [EC:1.16.3.1]
100658724  ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
100657876  ferritin heavy chain-like [KO:K00522] [EC:1.16.3.1]
100676364  FTH1; LOW QUALITY PROTEIN: ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
100660264  FTL; ferritin light chain [KO:K13625]
111753010  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
100675131  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100675410  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100658490  PLA2G4A; cytosolic phospholipase A2 isoform X2 [KO:K16342] [EC:3.1.1.4]
100667057  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100660599  arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
104845446  LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase-like [KO:K00460] [EC:1.13.11.33]
100658150  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
100663804  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100668454  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
100657680  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
100665946  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
100669613  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
100664299  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
100674746  IL1B; interleukin-1 beta [KO:K04519]
100664909  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
100662105  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
100654545  CHMP3; LOW QUALITY PROTEIN: charged multivesicular body protein 3 [KO:K12193]
100663611  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
100660184  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
100661938  CHMP6; LOW QUALITY PROTEIN: charged multivesicular body protein 6 [KO:K12195]
100674984  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
100661089  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
104845540  CHMP1B; LOW QUALITY PROTEIN: charged multivesicular body protein 1b [KO:K12197]
100664014  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
100654989  charged multivesicular body protein 1b-1-like [KO:K12197]
100659612  CHMP5; charged multivesicular body protein 5 [KO:K12198]
100671948  CHMP7; LOW QUALITY PROTEIN: charged multivesicular body protein 7 [KO:K15053]
100672088  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
100675032  IL1A; interleukin-1 alpha [KO:K04383]
100674796  IL33; interleukin-33 [KO:K12967]
100673297  HMGB1; high mobility group protein B1 [KO:K10802]
100659733  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
104846103  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
104846102  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
100662586  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100657715  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100665583  interferon alpha-5-like [KO:K05414]
100659984  interferon alpha-5-like [KO:K05414]
100660270  interferon alpha-5-like [KO:K05414]
100661986  interferon alpha-5-like [KO:K05414]
100662831  interferon alpha-5-like [KO:K05414]
100663685  interferon alpha-6-like [KO:K05414]
100660554  interferon alpha-5-like [KO:K05414]
100661135  interferon alpha-5-like [KO:K05414]
100666438  IFNB1; interferon beta [KO:K05415]
100663285  IFNG; interferon gamma [KO:K04687]
100667586  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100672898  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
100665172  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100667304  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
100655548  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100676652  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100665896  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100672245  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100668424  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100656374  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100669583  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
100668145  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
100672448  signal transducer and activator of transcription 5A [KO:K11223]
100669299  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
100675819  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
100673235  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
100665908  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [KO:K16195] [EC:2.7.11.1]
100654493  TLR4; toll-like receptor 4 [KO:K10160]
100662155  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
100654083  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100672439  TLR3; toll-like receptor 3 [KO:K05401]
100677499  ZBP1; LOW QUALITY PROTEIN: Z-DNA-binding protein 1 [KO:K12965]
100654144  USP21; ubiquitin carboxyl-terminal hydrolase 21 [KO:K21634] [EC:3.4.19.12]
100675905  SQSTM1; sequestosome-1 [KO:K14381]
100656361  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100676217  HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
100670852  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
100660971  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
100662196  BID; BH3-interacting domain death agonist [KO:K04726]
100673560  BAX; apoptosis regulator BAX [KO:K02159]
100653663  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
111752374  histone H2A type 1-D [KO:K11251]
100666599  core histone macro-H2A.1 isoform X1 [KO:K11251]
100676393  histone H2A.J [KO:K11251]
100669940  core histone macro-H2A.2 [KO:K11251]
100656492  histone H2A type 2-B [KO:K11251]
100656778  histone H2A type 2-C [KO:K11251]
100657634  histone H2A type 2-A [KO:K11251]
100658203  histone H2A type 2-A [KO:K11251]
100659990  histone H2A type 1-D-like [KO:K11251]
100667708  histone H2A type 1 [KO:K11251]
100669688  histone H2A type 1-C [KO:K11251]
100671396  histone H2A type 1-D [KO:K11251]
100674832  histone H2A type 1-H-like [KO:K11251]
100675681  histone H2A type 1-A isoform X2 [KO:K11251]
100653969  histone H2A-beta, sperm-like [KO:K11251]
100670379  histone H2A type 3-like [KO:K11251]
100670474  histone H2A-Bbd type 2/3-like [KO:K11251]
100659586  histone H2A-Bbd type 1 [KO:K11251]
100662424  histone H2A type 1-J [KO:K11251]
100655117  histone H2A type 1-D [KO:K11251]
100655685  histone H2A type 1 [KO:K11251]
100673728  histone H2A type 1 [KO:K11251]
100659941  histone H2A.V [KO:K11251]
100661296  histone H2A type 1-D [KO:K11251]
100662984  histone H2A type 1 [KO:K11251]
111748619  histone H2A-Bbd type 1-like [KO:K11251]
100671226  histone H2A type 3 [KO:K11251]
100672861  histone H2A type 1-H [KO:K11251]
100666850  histone H2A type 1-B/E [KO:K11251]
100660481  histone H2A.Y [KO:K11251]
100670838  PPIA; peptidyl-prolyl cis-trans isomerase A isoform X1 [KO:K03767] [EC:5.2.1.8]
100675268  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
lav00250  Alanine, aspartate and glutamate metabolism
lav04210  Apoptosis
lav04668  TNF signaling pathway
lav04922  Glucagon signaling pathway
KO pathway
ko04217   
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