KEGG   PATHWAY: mcal04145
Entry
mcal04145                   Pathway                                
Name
Phagosome - Mus caroli (Ryukyu mouse)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
mcal04145  Phagosome
mcal04145

Other DBs
GO: 0045335
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110292614  Vamp3; vesicle-associated membrane protein 3 [KO:K13505]
110293196  Stx12; syntaxin-12 [KO:K13813]
110303029  Stx7; syntaxin-7 [KO:K08488]
110304283  Actg1; actin, cytoplasmic 2 [KO:K05692]
110295381  Actb; actin, cytoplasmic 1 [KO:K05692]
110297755  Coro1a; coronin-1A [KO:K13882]
110294289  Stx18; syntaxin-18 isoform X1 [KO:K08492]
110291200  Sec22b; vesicle-trafficking protein SEC22b [KO:K08517]
110287975  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like isoform X1 [KO:K06751]
110312557  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
110283877  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110288427  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, K-B alpha chain-like [KO:K06751]
110288489  H-2 class I histocompatibility antigen, D-K alpha chain-like [KO:K06751]
110288539  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110312198  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X4 [KO:K06751]
110312199  H-2 class I histocompatibility antigen, D-B alpha chain-like isoform X1 [KO:K06751]
110312200  H-2 class I histocompatibility antigen, D-37 alpha chain [KO:K06751]
110312202  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
110312220  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110312221  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110312222  H-2 class I histocompatibility antigen, TLA(B) alpha chain-like [KO:K06751]
110287620  H-2 class I histocompatibility antigen, D-B alpha chain isoform X1 [KO:K06751]
110287649  H-2 class I histocompatibility antigen, D-K alpha chain-like [KO:K06751]
110287664  HLA class I histocompatibility antigen, A-25 alpha chain-like isoform X1 [KO:K06751]
110289160  H-2 class I histocompatibility antigen, K-K alpha chain-like [KO:K06751]
110288607  HLA class I histocompatibility antigen, A-32 alpha chain-like [KO:K06751]
110288635  H-2 class I histocompatibility antigen, Q7 alpha chain-like isoform X1 [KO:K06751]
110283629  H-2 class I histocompatibility antigen, TLA(B) alpha chain isoform X1 [KO:K06751]
110283630  H-2 class I histocompatibility antigen, D-K alpha chain-like isoform X1 [KO:K06751]
110288692  H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
110283690  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X3 [KO:K06751]
110283724  H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
110283726  HLA class I histocompatibility antigen, A-25 alpha chain-like isoform X1 [KO:K06751]
110283727  HLA class I histocompatibility antigen, A-24 alpha chain-like isoform X1 [KO:K06751]
110283728  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X1 [KO:K06751]
110283729  HLA class I histocompatibility antigen, A-25 alpha chain-like isoform X1 [KO:K06751]
110283730  HLA class I histocompatibility antigen, A-24 alpha chain-like isoform X1 [KO:K06751]
110312399  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
110312424  H-2 class I histocompatibility antigen, D-B alpha chain-like isoform X2 [KO:K06751]
110288817  HLA class I histocompatibility antigen, A-25 alpha chain-like isoform X1 [KO:K06751]
110312600  H-2 class II histocompatibility antigen, A-U alpha chain [KO:K06752]
110284034  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
110312138  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
110312714  class II histocompatibility antigen, M alpha chain [KO:K06752]
110284178  HLA class II histocompatibility antigen, DO alpha chain isoform X2 [KO:K06752]
110283646  H-2 class II histocompatibility antigen, E-D beta chain [KO:K06752]
110312394  class II histocompatibility antigen, M beta 1 chain isoform X1 [KO:K06752]
110283699  H-2 class II histocompatibility antigen, E-U alpha chain [KO:K06752]
110312454  H-2 class II histocompatibility antigen, A beta chain [KO:K06752]
110283753  H-2 class II histocompatibility antigen, I-E beta chain-like isoform X1 [KO:K06752]
110312675  Rab5a; ras-related protein Rab-5A [KO:K07887]
110291569  ras-related protein Rab-5B [KO:K07888]
110303170  Rab5b; ras-related protein Rab-5B [KO:K07888]
110305560  Rab5c; ras-related protein Rab-5C [KO:K07889]
110303118  Eea1; early endosome antigen 1 isoform X1 [KO:K12478]
110284734  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
110311683  Tfrc; transferrin receptor protein 1 [KO:K06503]
110304636  Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
110311958  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
110300753  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
110296652  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform isoform X2 [KO:K02147]
110310247  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
110306754  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X3 [KO:K02148]
110306911  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
110284052  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
110295768  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
110296591  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
110290013  V-type proton ATPase subunit G 1 [KO:K02152]
110292685  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
110304817  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
110312623  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
110296101  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
110283770  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
110294291  Atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
110285319  Tcirg1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
110305748  Atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X6 [KO:K02154]
110296561  Atp6v0a4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
110293484  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
110299833  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
110305043  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
110312576  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
110292638  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
110286977  Atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
110305273  ras-related protein Rab-7a [KO:K07897]
110295700  Rab7a; ras-related protein Rab-7a [KO:K07897]
110303526  Rab7b; ras-related protein Rab-7b isoform X1 [KO:K07898]
110305636  Rilp; rab-interacting lysosomal protein [KO:K13883]
110306413  Dync1h1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
110301164  Dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X2 [KO:K10414]
110290405  Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X3 [KO:K10415]
110295973  Dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X2 [KO:K10415]
110301252  Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
110299761  Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
110296015  tubulin alpha-3 chain [KO:K07374]
110308300  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
110304519  Tuba4a; tubulin alpha-4A chain isoform X1 [KO:K07374]
110310101  tubulin alpha-1C chain-like [KO:K07374]
110288534  tubulin alpha-1 chain-like [KO:K07374]
110297783  tubulin alpha-1C chain-like [KO:K07374]
110295773  Tuba8; tubulin alpha-8 chain [KO:K07374]
110291381  tubulin alpha-1B chain [KO:K07374]
110299689  Tubb3; tubulin beta-3 chain [KO:K07375]
110289733  Tubb1; tubulin beta-1 chain [KO:K07375]
110284210  Tubb4a; tubulin beta-4A chain [KO:K07375]
110284425  Tubb6; tubulin beta-6 chain [KO:K07375]
110312171  Tubb; tubulin beta chain [KO:K07375]
110307609  tubulin beta-2B chain isoform X1 [KO:K07375]
110290285  Tubb4b; tubulin beta-4B chain [KO:K07375]
110299641  Lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
110286453  Lamp2; lysosome-associated membrane glycoprotein 2 isoform X2 [KO:K06528]
110293039  Pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X3 [KO:K00921] [EC:2.7.1.150]
110296683  cation-dependent mannose-6-phosphate receptor [KO:K10089]
110294416  Nos1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
110305648  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
110307838  Ctsv; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
110308303  cathepsin 7 [KO:K01365] [EC:3.4.22.15]
110307683  cathepsin R [KO:K01365] [EC:3.4.22.15]
110307684  cathepsin 7-like [KO:K01365] [EC:3.4.22.15]
110308246  cathepsin M-like [KO:K01365] [EC:3.4.22.15]
110308067  cathepsin J isoform X1 [KO:K01365] [EC:3.4.22.15]
110308230  cathepsin M-like [KO:K01365] [EC:3.4.22.15]
110290972  Ctss; cathepsin S [KO:K01368] [EC:3.4.22.27]
110311759  Sec61a2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
110295994  Sec61a1; protein transport protein Sec61 subunit alpha [KO:K10956]
110293129  Sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
110293687  protein transport protein Sec61 subunit gamma-like [KO:K07342]
110309427  protein transport protein Sec61 subunit gamma-like [KO:K07342]
110305606  Sec61g; protein transport protein Sec61 subunit gamma isoform X1 [KO:K07342]
110312383  Tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
110312451  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
110299733  Calr; calreticulin [KO:K08057]
110292958  calreticulin-like isoform X1 [KO:K08057]
110305075  Canx; calnexin [KO:K08054]
110291166  Fcgr1a; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
110288995  low affinity immunoglobulin gamma Fc region receptor III-like isoform X1 [KO:K06472]
110299221  low affinity immunoglobulin gamma Fc region receptor II isoform X1 [KO:K12560]
110299183  low affinity immunoglobulin gamma Fc region receptor IV isoform X1 [KO:K06463]
110298307  Itgam; integrin alpha-M isoform X2 [KO:K06461]
110311769  integrin beta-2-like protein [KO:K06464]
110303281  Itgb2; integrin beta-2 [KO:K06464]
110312494  C3; complement C3 [KO:K03990]
110306900  Colec11; collectin-11 isoform X1 [KO:K10066]
110285103  Colec12; collectin-12 [KO:K10062]
110309221  mannose-binding protein A [KO:K03991]
110285489  Mbl2; mannose-binding protein C [KO:K03991]
110309760  pulmonary surfactant-associated protein A [KO:K10067]
110309847  Sftpd; pulmonary surfactant-associated protein D [KO:K10068]
110311058  Itgav; integrin alpha-V isoform X1 [KO:K06487]
110308074  Itga2; integrin alpha-2 isoform X2 [KO:K06481]
110310456  Itga5; integrin alpha-5 [KO:K06484]
110299930  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
110305072  Itgb3; integrin beta-3 [KO:K06493]
110311493  Itgb5; integrin beta-5 [KO:K06588]
110310932  Thbs1; thrombospondin-1 isoform X2 [KO:K16857]
110290706  Thbs3; thrombospondin-3 [KO:K04659]
110300418  Comp; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
110312609  Thbs2; thrombospondin-2 [KO:K04659]
110307848  Thbs4; thrombospondin-4 [KO:K04659]
110291353  Tlr2; toll-like receptor 2 [KO:K10159]
110295004  Tlr6; toll-like receptor 6 [KO:K10169]
110293229  Tlr4; toll-like receptor 4 [KO:K10160]
110284977  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
110289399  Mrc1; macrophage mannose receptor 1 [KO:K06560]
110305337  Mrc2; C-type mannose receptor 2 isoform X1 [KO:K06560]
110312531  Pla2r1; secretory phospholipase A2 receptor [KO:K06560]
110300670  LOW QUALITY PROTEIN: CD209 antigen-like protein A [KO:K06563]
110300028  CD209 antigen-like protein B isoform X1 [KO:K06563]
110300070  CD209 antigen-like [KO:K06563]
110300071  CD209 antigen-like protein C [KO:K06563]
110300451  LOW QUALITY PROTEIN: CD209 antigen-like protein C [KO:K06563]
110300493  CD209 antigen-like protein D isoform X1 [KO:K06563]
110296749  Clec7a; C-type lectin domain family 7 member A isoform X2 [KO:K10074]
110300229  Msr1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
110295979  Marco; macrophage receptor MARCO [KO:K13884]
110295814  Olr1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
110294031  Scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
110294084  Cd36; platelet glycoprotein 4 [KO:K06259]
110300473  cytochrome b-245 light chain [KO:K08009]
110286646  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
110293965  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110294592  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
110296918  Ncf2; neutrophil cytosol factor 2 [KO:K08010]
110310795  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
mcal04142  Lysosome
mcal04144  Endocytosis
mcal04610  Complement and coagulation cascades
mcal04612  Antigen processing and presentation
mcal04620  Toll-like receptor signaling pathway
mcal04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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