KEGG   PATHWAY: oas04144
Entry
oas04144                    Pathway                                
Name
Endocytosis - Ovis aries (sheep)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
oas04144  Endocytosis
oas04144

Other DBs
GO: 0006897
Organism
Ovis aries (sheep) [GN:oas]
Gene
100302306  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101114069  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X7 [KO:K00889] [EC:2.7.1.68]
101107667  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [KO:K00889] [EC:2.7.1.68]
101115537  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X7 [KO:K00889] [EC:2.7.1.68]
101109528  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X4 [KO:K13712] [EC:2.7.1.68]
101110687  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
101114661  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101108737  DNM1; dynamin-1 isoform X5 [KO:K01528] [EC:3.6.5.5]
101107117  DNM3; dynamin-3 isoform X3 [KO:K01528] [EC:3.6.5.5]
101115027  DNM2; dynamin-2 isoform X5 [KO:K23484] [EC:3.6.5.5]
101106572  CLTA; clathrin light chain A isoform X1 [KO:K04644]
101117328  CLTB; clathrin light chain B isoform X2 [KO:K04645]
101107114  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
101108595  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
101121898  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
101115974  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
101122320  AP2M1; AP-2 complex subunit mu isoform X2 [KO:K11826]
101107906  AP-2 complex subunit mu-like [KO:K11826]
114117536  AP-2 complex subunit mu-like [KO:K11826]
114117541  AP-2 complex subunit mu-like [KO:K11826]
101122460  AP2S1; AP-2 complex subunit sigma [KO:K11827]
101103177  EHD2; EH domain-containing protein 2 [KO:K12469]
554326  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
494191  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101120662  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X2 [KO:K04679]
101114400  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
101111580  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
101114231  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
443169  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100885768  TFRC; transferrin receptor protein 1 isoform X2 [KO:K06503]
780479  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101106012  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
443548  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
554324  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101120660  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
443515  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101115401  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
101114404  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
101111043  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
101110388  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X10 [KO:K12470]
106990245  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
101114868  SH3GL1; endophilin-A2 [KO:K11247]
101111833  SH3GL3; endophilin-A3 isoform X3 [KO:K11247]
101116521  SH3GLB1; endophilin-B1 isoform X3 [KO:K11248]
101106157  SH3GLB2; endophilin-B2 isoform X6 [KO:K21269]
101119119  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
101122270  AMPH; amphiphysin isoform X1 [KO:K12562]
101117262  EPN3; epsin-3 isoform X4 [KO:K12471]
101119060  EPN2; epsin-2 isoform X1 [KO:K12471]
101117189  EPN1; epsin-1 isoform X1 [KO:K12471]
101117929  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
101110462  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
101105830  SPART; spartin isoform X2 [KO:K19366]
101121425  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
101122748  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X7 [KO:K13305] [EC:2.3.2.26]
101104979  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101103187  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
101107132  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
101109689  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
101118041  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
101106698  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
101103370  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
101117426  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3 [KO:K05633] [EC:2.3.2.26]
101122347  NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
443535  LDLR; low-density lipoprotein receptor isoform X2 [KO:K12473]
101118341  LDLRAP1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
101104604  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
101117453  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101108811  C-X-C chemokine receptor type 2 isoform X1 [KO:K04175]
101110214  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
443532  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101106563  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
105606083  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
101108265  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
101117366  GRK3; beta-adrenergic receptor kinase 2 isoform X2 [KO:K00910] [EC:2.7.11.15]
101107151  GRK5; G protein-coupled receptor kinase 5 isoform X2 [KO:K08291] [EC:2.7.11.16]
101120060  LOW QUALITY PROTEIN: G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
101107019  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
101122439  GRK4; G protein-coupled receptor kinase 4 isoform X3 [KO:K08291] [EC:2.7.11.16]
101112493  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101108418  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101106932  WASL; actin nucleation-promoting factor WASL isoform X1 [KO:K23612]
101112965  ACTR2; actin-related protein 2 [KO:K17260]
101108990  ACTR3; actin-related protein 3 [KO:K18584]
101105653  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101113818  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101113558  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X2 [KO:K05757]
101105166  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
101110485  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101105028  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X2 [KO:K05756]
105601868  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755]
101106701  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100037671  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101110390  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
101107294  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
101111451  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
100913152  HSPA1A; heat shock 70 kDa protein 1A/1B [KO:K03283]
101112844  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101117117  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101107064  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101102392  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
114110979  heat shock cognate 71 kDa protein-like [KO:K03283]
121815981  heat shock 70 kDa protein 1B [KO:K03283]
101111237  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X4 [KO:K09526]
101114433  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
101104670  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
101119611  WASH complex subunit 2 isoform X1 [KO:K18462]
101119385  WASHC1; WASH complex subunit 1 isoform X2 [KO:K18461]
101109346  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
101117461  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
101122590  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
101109168  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
101121938  F-actin-capping protein subunit alpha-2-like [KO:K10364]
101108893  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
101105282  VPS29; vacuolar protein sorting-associated protein 29 isoform X2 [KO:K18467]
101104294  VPS26A; vacuolar protein sorting-associated protein 26A isoform X2 [KO:K18466]
101115482  VPS26B; vacuolar protein sorting-associated protein 26B isoform X2 [KO:K18466]
101109294  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
101102785  SNX12; sorting nexin-12 [KO:K17918]
101117083  SNX3; sorting nexin-3 [KO:K17918]
101106943  USP8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
101114002  STAMBP; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
100145880  RAB7A; ras-related protein Rab-7a [KO:K07897]
101116491  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
101111214  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
101117649  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
101118061  TSG101; tumor susceptibility gene 101 protein [KO:K12183]
101111622  MVB12B; multivesicular body subunit 12B isoform X2 [KO:K12186]
101115122  MVB12A; multivesicular body subunit 12A [KO:K12186]
101107800  VPS28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
101113456  VPS37D; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
101122144  VPS37C; vacuolar protein sorting-associated protein 37C isoform X2 [KO:K12185]
101120049  VPS37A; vacuolar protein sorting-associated protein 37A isoform X2 [KO:K12185]
101123071  VPS37B; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
101113773  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
101121612  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
101110159  CHMP6; charged multivesicular body protein 6 [KO:K12195]
101111216  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
114108645  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
101119649  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
101112505  CHMP2A; charged multivesicular body protein 2a isoform X2 [KO:K12191]
101121224  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101113461  CHMP7; charged multivesicular body protein 7 isoform X2 [KO:K15053]
101112669  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
101103111  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
101116660  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
101111221  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
101108355  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
101104370  CHMP5; charged multivesicular body protein 5 [KO:K12198]
101123009  charged multivesicular body protein 5 [KO:K12198]
105606367  charged multivesicular body protein 5-like [KO:K12198]
101102921  IST1; IST1 homolog isoform X1 [KO:K19476]
101113964  PDCD6IP; programmed cell death 6-interacting protein isoform X2 [KO:K12200]
101117420  SPG21; maspardin [KO:K19367]
443500  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
101110062  SNX1; sorting nexin-1 isoform X2 [KO:K17917]
101111279  SNX2; sorting nexin-2 [KO:K17917]
101120428  SNX5; sorting nexin-5 isoform X2 [KO:K17920]
101102945  SNX32; LOW QUALITY PROTEIN: sorting nexin-32 [KO:K17920]
101118137  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
101103084  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101104357  HRAS; GTPase HRas isoform X1 [KO:K02833]
114114919  GTPase HRas-like [KO:K02833]
443435  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
101107088  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
101103538  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
100302078  RHOA; transforming protein RhoA [KO:K04513]
114116812  transforming protein RhoA-like [KO:K04513]
101106246  transforming protein RhoA [KO:K04513]
100171394  OVAR; MHC class I antigen precursor [KO:K06751]
101107908  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X4 [KO:K06751]
106990117  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X4 [KO:K06751]
101107641  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
101119545  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
101104866  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6 [KO:K06751]
101111694  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
101112480  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
114109630  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X6 [KO:K06751]
101105609  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
132658253  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
101120775  FOLR3; folate receptor alpha [KO:K13649]
101121452  FOLR2; folate receptor beta [KO:K13649]
445468  CAV1; caveolin-1 [KO:K06278]
100126571  CAV2; caveolin-2 [KO:K12958]
101107228  CAV3; caveolin-3 [KO:K12959]
101104895  EHD3; EH domain-containing protein 3 [KO:K12476]
101115625  EHD4; EH domain-containing protein 4 [KO:K12477]
101114003  EEA1; early endosome antigen 1 [KO:K12478]
100302084  RAB5A; ras-related protein Rab-5A [KO:K07887]
101112211  RAB5B; ras-related protein Rab-5B [KO:K07888]
101122039  RAB5C; ras-related protein Rab-5C [KO:K07889]
101114539  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
101108345  RBSN; rabenosyn-5 [KO:K12481]
100302066  RAB4A; ras-related protein Rab-4A [KO:K07879]
101122780  RUFY1; RUN and FYVE domain-containing protein 1 isoform X2 [KO:K12482]
101102781  RUFY2; RUN and FYVE domain-containing protein 2 isoform X3 [KO:K12482]
101118911  EHD1; EH domain-containing protein 1 [KO:K12483]
101102352  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
101117464  SNX4; sorting nexin-4 isoform X2 [KO:K17919]
101116850  RAB22A; ras-related protein Rab-22A [KO:K07891]
101104195  RAB31; ras-related protein Rab-31 [KO:K07891]
100302064  RAB10; ras-related protein Rab-10 [KO:K07903]
100302063  RAB8A; ras-related protein Rab-8A [KO:K07901]
101111230  RAB35; ras-related protein Rab-35 isoform X2 [KO:K07876]
780464  RAB11A; ras-related protein Rab-11A [KO:K07904]
101103562  RAB11B; ras-related protein Rab-11B [KO:K07905]
101118246  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
101105457  RAB11FIP2; rab11 family-interacting protein 2 isoform X2 [KO:K12484]
101103391  RAB11FIP5; rab11 family-interacting protein 5 isoform X4 [KO:K12484]
101116270  ZFYVE27; protrudin isoform X3 [KO:K19368]
101119383  KIF5A; kinesin heavy chain isoform X2 [KO:K10396]
101113663  KIF5C; kinesin heavy chain [KO:K10396]
100037703  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
101117176  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
101123176  RAB11FIP3; rab11 family-interacting protein 3 [KO:K12485]
101110782  PARD3; partitioning defective 3 homolog isoform X3 [KO:K04237]
101118720  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101114893  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
101121649  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101122295  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
101118322  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101102792  CDC42; cell division control protein 42 homolog [KO:K04393]
114108599  cell division control protein 42 homolog [KO:K04393]
101122735  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
101102497  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
101122040  GIT1; ARF GTPase-activating protein GIT1 isoform X4 [KO:K05737]
101121803  GIT2; ARF GTPase-activating protein GIT2 isoform X17 [KO:K12487]
101122198  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6 [KO:K12488]
101120897  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
101102555  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
101119319  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
101107717  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
101102615  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12489]
101123146  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
101109800  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K18440]
101105821  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101111683  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X7 [KO:K12491]
101113584  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X4 [KO:K12491]
101112800  ADP-ribosylation factor GTPase-activating protein 1 isoform X3 [KO:K12492]
101115447  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X3 [KO:K12493]
101119250  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
101107649  PSD; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
101102782  PSD3; PH and SEC7 domain-containing protein 3 isoform X12 [KO:K12494]
101105738  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
101116827  PSD2; PH and SEC7 domain-containing protein 2 isoform X2 [KO:K12494]
101109678  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
101114514  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X2 [KO:K12495]
105606122  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X4 [KO:K12495]
100216436  CYTH2; cytohesin-2 [KO:K18441]
101112995  CYTH1; cytohesin-1 isoform X6 [KO:K18441]
101105381  CYTH3; cytohesin-3 isoform X2 [KO:K18441]
101103309  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
101102247  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X3 [KO:K18442]
101116164  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
101107150  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
100302302  ARF1; ADP-ribosylation factor 1 [KO:K07937]
101123118  ADP-ribosylation factor 1 [KO:K07937]
101120590  ADP-ribosylation factor 2 [KO:K07937]
100302303  ARF3; ADP-ribosylation factor 3 [KO:K07938]
100302304  ARF4; ADP-ribosylation factor 4 [KO:K07939]
100302305  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
oas04060  Cytokine-cytokine receptor interaction
oas04070  Phosphatidylinositol signaling system
oas04130  SNARE interactions in vesicular transport
oas04142  Lysosome
oas04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

DBGET integrated database retrieval system