KEGG   PATHWAY: plet04060
Entry
plet04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Phaethon lepturus (White-tailed tropicbird)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
plet04060  Cytokine-cytokine receptor interaction
plet04060

Organism
Phaethon lepturus (White-tailed tropicbird) [GN:plet]
Gene
104619614  C-C motif chemokine 19-like [KO:K05512]
104623837  C-C motif chemokine 4 homolog isoform X1 [KO:K12964]
104620752  C-C motif chemokine 3-like [KO:K21083]
104621418  C-C motif chemokine 5-like [KO:K21083]
104628599  CCL5; C-C motif chemokine 5 [KO:K12499]
104627535  C-C motif chemokine 28-like [KO:K05513]
104626327  CCL20; C-C motif chemokine 20 [KO:K14625]
104623935  interleukin-8-like isoform X1 [KO:K10030]
104623938  interleukin-8-like [KO:K10030]
104623939  interleukin-8-like [KO:K10030]
104617413  interleukin-8-like [KO:K10030]
104616109  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104620498  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
104618093  lymphotactin-like [KO:K05507]
104617543  flocculation protein FLO11-like [KO:K05508]
104615308  uncharacterized protein LOC104615308 [KO:K05432]
104622940  IL15; interleukin-15 [KO:K05433]
104623391  somatotropin [KO:K05438]
104624416  PRL; prolactin [KO:K05439]
104622091  THPO; thrombopoietin [KO:K06854]
104615743  IL6; interleukin-6 [KO:K05405]
104622095  IL12A; interleukin-12 subunit alpha [KO:K05406]
104619834  IL12B; interleukin-12 subunit beta [KO:K05425]
104618454  EBI3; interleukin-27 subunit beta [KO:K24476]
104621032  IL10; interleukin-10 [KO:K05443]
104622334  interleukin-20-like [KO:K22667]
104613751  IL22; interleukin-22 [KO:K05445]
104618467  interferon lambda-3-like [KO:K22669]
104614046  interferon epsilon-like [KO:K05414]
104616955  IFNG; interferon gamma [KO:K04687]
104626322  interleukin-1 beta-like [KO:K04519]
104615404  IL18; interleukin-18 isoform X1 [KO:K05482]
104624027  interleukin-17A-like [KO:K05489]
104624029  interleukin-17F-like [KO:K05494]
104628076  IL17B; interleukin-17B [KO:K05490]
104615930  IL17D; interleukin-17D [KO:K05492]
104616388  IL16; pro-interleukin-16 [KO:K22628]
104619306  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
104618161  FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104626431  tumor necrosis factor ligand superfamily member 15-like [KO:K05478]
104618310  TNFSF10; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104619953  EDA; ectodysplasin-A [KO:K05480]
104616993  NGF; beta-nerve growth factor [KO:K02582]
104615248  TNFSF11; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 11 [KO:K05473]
104626730  CD40LG; CD40 ligand [KO:K03161]
104619791  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
104619128  TGFB2; transforming growth factor beta-2 [KO:K13376]
104617813  TGFB3; transforming growth factor beta-3 [KO:K13377]
104624502  GDF2; growth/differentiation factor 2 [KO:K05503]
104619778  BMP10; bone morphogenetic protein 10 [KO:K22670]
104624503  GDF10; bone morphogenetic protein 3B [KO:K22674]
104614877  MSTN; growth/differentiation factor 8 isoform X1 [KO:K05497]
104616681  INHBA; inhibin beta A chain [KO:K04667]
104616526  INHBB; inhibin beta B chain [KO:K22687]
104617838  GDF1; LOW QUALITY PROTEIN: embryonic growth/differentiation factor 1 [KO:K05495]
104619934  NODAL; nodal homolog [KO:K04666]
104624122  GDF9; growth/differentiation factor 9 [KO:K22673]
104618972  INHBC; inhibin beta C chain [KO:K22688]
104622159  inhibin beta C chain-like [KO:K22689]
104620148  bone morphogenetic protein 7-like [KO:K21283]
104619902  bone morphogenetic protein 2 [KO:K21283]
104618873  BMP4; bone morphogenetic protein 4 [KO:K04662]
104613785  GDF5; growth/differentiation factor 5 [KO:K04664]
104621011  BMP15; bone morphogenetic protein 15 [KO:K05498]
104619062  BMP5; bone morphogenetic protein 5 [KO:K04663]
104621977  BMP6; bone morphogenetic protein 6 [KO:K16620]
104617165  C-C chemokine receptor type 8-like [KO:K04183]
104627716  C-C chemokine receptor type 9-like [KO:K04184]
104624782  ACKR4; atypical chemokine receptor 4 [KO:K04186]
104618345  CCR7; C-C chemokine receptor type 7 [KO:K04182]
104618362  CCR4; C-C chemokine receptor type 4 [KO:K04179]
104613768  C-C chemokine receptor type 5-like [KO:K04180]
104613767  C-C chemokine receptor type 2-like [KO:K04180]
104621257  CCR6; C-C chemokine receptor type 6 [KO:K04181]
104624479  C-X-C chemokine receptor type 2-like [KO:K05050]
104621354  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 5-like [KO:K04190]
104627741  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104617320  ACKR3; atypical chemokine receptor 3 [KO:K04304]
104619858  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
104617162  XCR1; chemokine XC receptor 1 [KO:K04193]
104618361  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104623060  interleukin-2 receptor subunit alpha-like [KO:K05068]
104623814  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
104628689  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
104616776  interleukin-7 receptor subunit alpha-like [KO:K05072]
104618606  interleukin-7 receptor subunit alpha-like [KO:K05072]
104628352  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
104625417  IL21R; interleukin-21 receptor [KO:K05075]
104627457  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
104617470  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
104619647  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
104616026  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104615897  LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104622675  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
104625013  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
104621670  GHR; growth hormone receptor [KO:K05080]
104614970  PRLR; prolactin receptor [KO:K05081]
104618581  MPL; thrombopoietin receptor [KO:K05082]
104625801  LEPR; LOW QUALITY PROTEIN: leptin receptor [KO:K05062]
104625570  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
104623061  IL11RA; LOW QUALITY PROTEIN: interleukin-11 receptor subunit alpha [KO:K05056]
104625858  LIFR; leukemia inhibitory factor receptor [KO:K05058]
104621941  oncostatin-M-specific receptor subunit beta-like [KO:K05057]
104626312  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
104616539  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
104616468  IL20RB; LOW QUALITY PROTEIN: interleukin-20 receptor subunit beta [KO:K05137]
104627337  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
104615984  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
104626004  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
104627150  IFNGR2; interferon gamma receptor 2 [KO:K05133]
104626063  interleukin-1 receptor type 1-like [KO:K04386]
104618397  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104615484  interleukin-1 receptor type 2-like [KO:K04387]
104623919  interleukin-1 receptor type 1-like [KO:K05172]
104617078  IL18R1; interleukin-18 receptor 1 [KO:K05173]
104617077  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
104623920  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
104623038  IL17RA; interleukin-17 receptor A [KO:K05164]
104615388  T-cell surface glycoprotein CD4-like [KO:K06454]
104627577  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104622040  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104614458  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
104623743  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
104625522  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
104622519  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
104628293  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
104625571  uncharacterized protein LOC104625571 [KO:K05163]
104619537  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
104617313  tumor necrosis factor receptor superfamily member 11A-like [KO:K05147]
104620253  tumor necrosis factor receptor superfamily member 8-like [KO:K05145]
104619590  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
104618910  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
104622550  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
104622553  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
104619329  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
104627197  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
104628841  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
104619948  RELL2; RELT-like protein 2 [KO:K26541]
104614164  RELL1; RELT-like protein 1 [KO:K26541]
104619050  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
104617793  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104621568  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104625396  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
104621598  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104618121  activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
104624160  LOW QUALITY PROTEIN: activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
104627015  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
104627811  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
104620495  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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