Entry Name RIG-I-like receptor signaling pathway - Pan troglodytes (chimpanzee)
Description Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ptr04622 RIG-I-like receptor signaling pathway
Ortholog table Organism Pan troglodytes (chimpanzee) [GN:
ptr ]
Gene 459692 IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647 ] [EC:5.6.2.6 ]
458321 ZNFX1; NFX1-type zinc finger-containing protein 1 isoform X1 [KO:K27391 ]
470026 MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648 ]
453178 TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174 ]
459685 TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650 ]
460239 AZI2; 5-azacytidine-induced protein 2 isoform X3 [KO:K12651 ]
455177 TBKBP1; TANK-binding kinase 1-binding protein 1 isoform X1 [KO:K12652 ]
742813 IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211 ] [EC:2.7.11.10 ]
747565 IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411 ]
450927 IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447 ]
454154 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171 ]
451389 FADD; FAS-associated death domain protein [KO:K02373 ]
462397 RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861 ] [EC:2.7.11.1 ]
472749 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209 ] [EC:2.7.11.10 ]
456014 NFKBIB; NF-kappa-B inhibitor beta isoform X5 [KO:K02581 ]
461406 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580 ]
460816 IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406 ]
462107 STING1; stimulator of interferon genes protein isoform X1 [KO:K12654 ]
745021 PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X2 [KO:K09578 ] [EC:5.2.1.8 ]
Compound Reference Authors Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
Title The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Journal Reference Authors Takeuchi O, Akira S
Title MDA5/RIG-I and virus recognition.
Journal Reference Authors Yoneyama M, Fujita T
Title RNA recognition and signal transduction by RIG-I-like receptors.
Journal Reference Authors Nakhaei P, Genin P, Civas A, Hiscott J
Title RIG-I-like receptors: sensing and responding to RNA virus infection.
Journal Reference Authors Moore CB, Ting JP
Title Regulation of mitochondrial antiviral signaling pathways.
Journal Reference Authors Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
Title Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
Journal Reference Authors Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
Title Approaching the RNA ligand for RIG-I?
Journal Reference Authors Saito T, Gale M Jr
Title Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
Journal Reference Authors Kawai T, Akira S
Title Toll-like receptor and RIG-I-like receptor signaling.
Journal Reference Authors Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
Title TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Journal Reference Authors Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
Title TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
Journal Reference Authors Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
Title RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
Journal Reference Authors Liu G, Gack MU
Title Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
Journal Related KO pathway LinkDB All DBs
