KEGG   PATHWAY: puc04360
Entry
puc04360                    Pathway                                
Name
Axon guidance - Panthera uncia (snow leopard)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
puc04360  Axon guidance
puc04360

Other DBs
GO: 0007411
Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125912326  netrin-G1 [KO:K07522]
125923554  netrin-G2 [KO:K16359]
125934468  leucine-rich repeat-containing protein 4C [KO:K07523]
125930888  leucine-rich repeat-containing protein 4 [KO:K16351]
125926170  netrin-1 [KO:K06843]
125927194  netrin-3 [KO:K06844]
125919433  netrin-4 isoform X1 [KO:K06845]
125936595  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
125916347  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
125921265  short transient receptor potential channel 1 isoform X1 [KO:K04964]
125922416  short transient receptor potential channel 3 [KO:K04966]
125933727  short transient receptor potential channel 4 [KO:K04967]
125931912  short transient receptor potential channel 5 [KO:K04968]
125910903  short transient receptor potential channel 6 isoform X1 [KO:K04969]
125922973  protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
125923333  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125932723  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125937053  calcineurin subunit B type 1 isoform X1 [KO:K06268]
125926203  calcineurin subunit B type 2 [KO:K06268]
125936041  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
125916650  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
125909624  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
125924709  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125937963  tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
125936631  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
125928294  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
125919577  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
125927618  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
125928145  cell division control protein 42 homolog [KO:K04393]
125912993  cell division control protein 42 homolog isoform X1 [KO:K04393]
125923925  actin-binding LIM protein 2 [KO:K07520]
125932997  actin-binding LIM protein 1 isoform X1 [KO:K07520]
125934569  actin-binding LIM protein 3 isoform X1 [KO:K07520]
125921305  cytoplasmic protein NCK1 isoform X1 [KO:K07365]
125937841  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
125921804  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
125931907  serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
125915456  serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
125935986  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
125909855  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
125929348  transforming protein RhoA [KO:K04513]
125914402  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
125937677  rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
125922479  netrin receptor UNC5D [KO:K07521]
125922943  netrin receptor UNC5C isoform X1 [KO:K07521]
125933266  netrin receptor UNC5B isoform X1 [KO:K07521]
125935264  netrin receptor UNC5A [KO:K07521]
125914556  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
125913251  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
125910269  repulsive guidance molecule A [KO:K23096]
125910122  neogenin isoform X1 [KO:K06766]
125923544  myosin light chain 5 [KO:K12753]
125936652  myosin regulatory light polypeptide 9 [KO:K12755]
125914431  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
125908805  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
125913299  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609]
125925721  ephrin-A1 [KO:K05462]
125925728  ephrin-A4 [KO:K05462]
125917495  LOW QUALITY PROTEIN: ephrin-A2-like [KO:K05462]
125917498  ephrin-A2-like [KO:K05462]
125925844  ephrin-A3 [KO:K05462]
125934955  ephrin-A5 [KO:K05462]
125931715  ephrin-B1 [KO:K05463]
125933944  ephrin-B2 [KO:K05463]
125930228  ephrin type-A receptor 1 isoform X1 [KO:K05102] [EC:2.7.10.1]
125913061  ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
125920851  ephrin type-A receptor 3 [KO:K05104] [EC:2.7.10.1]
125911735  ephrin type-A receptor 4 isoform X1 [KO:K05105] [EC:2.7.10.1]
125922767  ephrin type-A receptor 5 isoform X1 [KO:K05106] [EC:2.7.10.1]
125920864  ephrin type-A receptor 6 [KO:K05107] [EC:2.7.10.1]
125938700  ephrin type-A receptor 7 isoform X1 [KO:K05108] [EC:2.7.10.1]
125912988  ephrin type-A receptor 8 [KO:K05109] [EC:2.7.10.1]
125921318  ephrin type-B receptor 1 [KO:K05110] [EC:2.7.10.1]
125912987  LOW QUALITY PROTEIN: ephrin type-B receptor 2 [KO:K05111] [EC:2.7.10.1]
125921111  LOW QUALITY PROTEIN: ephrin type-B receptor 3 [KO:K05112] [EC:2.7.10.1]
125928222  ephrin type-B receptor 4 [KO:K05113] [EC:2.7.10.1]
125930227  ephrin type-B receptor 6 [KO:K05114] [EC:2.7.10.1]
125922598  tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
125926017  LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
125935809  ras GTPase-activating protein 1 [KO:K04352]
125911060  ephexin-1 [KO:K07525]
125937753  GTPase HRas isoform X1 [KO:K02833]
125918906  GTPase KRas isoform X1 [KO:K07827]
125912218  GTPase NRas [KO:K07828]
125914884  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
125928028  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125936885  cytoplasmic protein NCK2 [KO:K19862]
125920629  regulator of G-protein signaling 3 isoform X1 [KO:K07524]
125933365  stromal cell-derived factor 1 isoform X1 [KO:K10031]
125911659  C-X-C chemokine receptor type 4 [KO:K04189]
125929389  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
125929845  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
125912291  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
125933144  slit homolog 1 protein [KO:K06838]
125922669  slit homolog 2 protein isoform X1 [KO:K06839]
125934437  slit homolog 3 protein isoform X1 [KO:K06850]
125920822  roundabout homolog 1 [KO:K06753]
125920821  roundabout homolog 2 [KO:K06754]
125939571  roundabout homolog 3 [KO:K06755]
125929602  SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526]
125925485  SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526]
125919280  SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526]
125929378  semaphorin-3F isoform X1 [KO:K06840]
125929382  semaphorin-3B isoform X1 [KO:K06840]
125929443  semaphorin-3G [KO:K06840]
125929848  semaphorin-3C [KO:K06840]
125929855  semaphorin-3E [KO:K06840]
125929856  semaphorin-3A [KO:K06840]
125929858  semaphorin-3D [KO:K06840]
125929707  plexin-A1 [KO:K06820]
125930152  plexin-A4 [KO:K06820]
125925330  plexin-A2 [KO:K06820]
125932093  plexin-A3 [KO:K06820]
125918679  neuropilin-1 isoform X1 [KO:K06724]
125931430  neural cell adhesion molecule L1 [KO:K06550]
125928179  LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
125913971  LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
125909579  cofilin-2 [KO:K05765]
125911864  cofilin-2-like [KO:K05765]
125912337  cofilin-1 isoform X1 [KO:K05765]
125911915  rho-related GTP-binding protein RhoD [KO:K07530]
125919011  rho-related GTP-binding protein Rho6 [KO:K07531]
125910737  tyrosine-protein kinase Fes/Fps isoform X1 [KO:K07527] [EC:2.7.10.2]
125937609  dihydropyrimidinase-related protein 5 isoform X1 [KO:K07529]
125923368  dihydropyrimidinase-related protein 2 [KO:K07528]
125930306  cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
125921776  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125929391  LOW QUALITY PROTEIN: semaphorin-4D [KO:K06521]
125936951  semaphorin-4C [KO:K06521]
125937146  semaphorin-4F isoform X1 [KO:K06521]
125925685  semaphorin-4A isoform X1 [KO:K06521]
125933424  semaphorin-4G [KO:K06521]
125910794  semaphorin-4B isoform X1 [KO:K06521]
125934723  semaphorin-5A [KO:K06841]
125921023  semaphorin-5B [KO:K06841]
125909978  semaphorin-6D [KO:K06842]
125912108  semaphorin-6C isoform X1 [KO:K06842]
125935409  semaphorin-6A [KO:K06842]
125928885  LOW QUALITY PROTEIN: semaphorin-6B [KO:K06842]
125930657  plexin-B1 [KO:K06821]
125917085  plexin-B3 isoform X1 [KO:K06821]
125917093  plexin-B3 isoform X1 [KO:K06821]
125919936  plexin-B2 [KO:K06821]
125930874  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
125930728  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125915969  ras-related protein R-Ras [KO:K07829]
125910143  semaphorin-7A [KO:K06529]
125920315  plexin-C1 isoform X1 [KO:K06572]
125918681  integrin beta-1 isoform X1 [KO:K05719]
125930503  sonic hedgehog protein [KO:K11988]
125925310  LOW QUALITY PROTEIN: protein patched homolog 1-like [KO:K06225]
125930137  smoothened homolog [KO:K06226]
125927372  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125936751  LOW QUALITY PROTEIN: integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
125921570  brother of CDO [KO:K20020]
125929490  protein Wnt-5a [KO:K00444]
125920070  protein Wnt-5b [KO:K00444]
125923798  frizzled-3 isoform X1 [KO:K02329]
125921985  tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
125929736  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
125923042  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
125933297  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
125934558  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
125913720  protein Wnt-4 [KO:K00408]
125921850  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125913143  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125921289  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125913493  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125935698  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125929237  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125927192  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
125920035  partitioning defective 3 homolog isoform X1 [KO:K04237]
125913204  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
125914741  partitioning defective 6 homolog gamma [KO:K06093]
125916500  partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
125936053  partitioning defective 6 homolog beta [KO:K06093]
125914057  protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
125930661  protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
125927517  protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
125936471  bone morphogenetic protein 7 [KO:K16621]
125937342  growth/differentiation factor 7 [KO:K20013]
125911301  bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
125922942  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
puc04010  MAPK signaling pathway
puc04060  Cytokine-cytokine receptor interaction
puc04310  Wnt signaling pathway
puc04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
LinkDB

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