Entry Name Endometrial cancer - Rattus norvegicus (rat)
Description Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class Human Diseases; Cancer: specific typesBRITE hierarchy
Pathway map Disease Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 114851 Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
24205 Apc; adenomatous polyposis coli protein [KO:K02085 ]
25112 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
25313 Egf; pro-epidermal growth factor precursor [KO:K04357 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
291005 Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
299611 Apc2; adenomatous polyposis coli protein 2 [KO:K02085 ]
299626 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
314436 Elk1; ETS domain-containing protein Elk-1 [KO:K04375 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
64639 Bad; bcl2-associated agonist of cell death [KO:K02158 ]
81504 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
81685 Mlh1; DNA mismatch repair protein Mlh1 [KO:K08734 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Ryan AJ, Susil B, Jobling TW, Oehler MK.
Title Endometrial cancer.
Journal Reference Authors Lax SF.
Title Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
Journal Reference Authors Shiozawa T, Konishi I.
Title Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
Journal Reference Authors Hecht JL, Mutter GL.
Title Molecular and pathologic aspects of endometrial carcinogenesis.
Journal Reference Authors Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
Title Molecular pathology of endometrial hyperplasia and carcinoma.
Journal Reference Authors Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
Title Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
Journal Reference Authors Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
Title Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
Journal Cancer Res 55:5693-8 (1995)
Reference Authors Kim D, Chung J.
Title Akt: versatile mediator of cell survival and beyond.
Journal Related rno04060 Cytokine-cytokine receptor interaction
KO pathway
