KEGG   PATHWAY: rno04151
Entry
rno04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Rattus norvegicus (rat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
rno04151  PI3K-Akt signaling pathway
rno04151

Other DBs
GO: 0043491
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100362453  Ppp2cal1; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
100911527  Ifna4l1; interferon alpha-11-like [KO:K05414]
100912314  [KO:K05414]
100912356  [KO:K05414]
103691134  Flt3lg; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
113970  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
114110  Flt4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
114111  Vegfc; vascular endothelial growth factor C precursor [KO:K05449]
114117  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114118  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
114119  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114120  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114483  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114517  Itga6; integrin alpha-6 precursor [KO:K06485]
114562  Cdc37; hsp90 co-chaperone Cdc37 [KO:K09554]
114851  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
116499  Fgf4; fibroblast growth factor 4 precursor [KO:K04358]
116562  Il2; interleukin-2 precursor [KO:K05429]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116636  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
116640  Tnc; tenascin precursor [KO:K06252]
116669  Vwf; von Willebrand factor precursor [KO:K03900]
116683  Efna5; ephrin-A5 precursor [KO:K05462]
116744  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
117036  Lamc1; laminin subunit gamma-1 precursor [KO:K05635]
117045  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
117104  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
117256  Ppp2r2c; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1 [KO:K04354]
117281  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
134484121  [KO:K00922] [EC:2.7.1.153]
134487075  [KO:K05414]
134487077  [KO:K05414]
140433  Lama5; laminin subunit alpha-5 precursor [KO:K06240]
140635  Flt3; receptor-type tyrosine-protein kinase FLT3 precursor [KO:K05092] [EC:2.7.10.1]
140924  Il2rg; cytokine receptor common subunit gamma precursor [KO:K05070]
140942  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
170579  Fgf22; fibroblast growth factor 22 precursor [KO:K04358]
170580  Fgf21; fibroblast growth factor 21 precursor [KO:K22429]
170582  Fgf19; fibroblast growth factor 19 precursor [KO:K22603]
170583  Fgf23; fibroblast growth factor 23 precursor [KO:K22428]
170633  Fgf3; fibroblast growth factor 3 precursor [KO:K04358]
170700  Fgf6; fibroblast growth factor 6 [KO:K04358]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
170901  Efna3; ephrin-A3 isoform X1 [KO:K05462]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
170921  Itga2; integrin alpha-2 precursor [KO:K06481]
171497  Sgk2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
171498  Sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
171556  Prl5a1; prolactin-5A1 precursor [KO:K05439]
192362  Lamc2; laminin subunit gamma-2 precursor [KO:K06246]
207122  Pkn2; serine/threonine-protein kinase N2 [KO:K23691]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24224  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
24225  Bdnf; brain-derived neurotrophic factor isoform 3 preproprotein [KO:K04355]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
24335  Epo; erythropoietin precursor [KO:K05437]
24336  Epor; erythropoietin receptor precursor [KO:K05079]
24337  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
24391  Gh1; somatotropin precursor [KO:K05438]
24400  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
24446  Hgf; hepatocyte growth factor preproprotein [KO:K05460]
24477  Ibsp; bone sialoprotein 2 precursor [KO:K06253]
24481  Ifnb1; interferon beta precursor [KO:K05415]
24482  Igf1; insulin-like growth factor I isoform d preproprotein [KO:K05459]
24483  Igf2; insulin-like growth factor II isoform 2 preproprotein [KO:K13769]
24495  Il3; interleukin-3 precursor [KO:K04736]
24498  Il6; interleukin-6 precursor [KO:K05405]
24499  Il6r; interleukin-6 receptor subunit alpha precursor [KO:K05055]
24505  Ins1; insulin-1 preproprotein [KO:K04526]
24506  Ins2; insulin-2 preproprotein [KO:K04526]
24511  Itgb1; integrin beta-1 precursor [KO:K05719]
24514  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
24525  Kras; GTPase KRas [KO:K07827]
24553  Met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
24577  Myc; myc proto-oncogene protein [KO:K04377]
24596  Ngfr; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583]
245986  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
24600  Nos3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
24605  Nras; GTPase NRas [KO:K07828]
246144  Il3ra; interleukin-3 receptor subunit alpha precursor [KO:K04737]
246255  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
24628  Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386]
24629  Pdgfrb; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
24657  Prl6a1; prolactin-6A1 precursor [KO:K05439]
24672  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
24673  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
24683  Prl; prolactin precursor [KO:K05439]
24684  Prlr; prolactin receptor isoform a precursor [KO:K05081]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
24716  Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor [KO:K05126] [EC:2.7.10.1]
24718  Reln; reelin precursor [KO:K06249] [EC:3.4.21.-]
24827  Tgfa; protransforming growth factor alpha preproprotein [KO:K08774]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
24855  Tsc2; tuberin [KO:K07207]
24888  Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570]
24954  Insr; insulin receptor preproprotein [KO:K04527] [EC:2.7.10.1]
25022  Fgfr2; fibroblast growth factor receptor 2 isoform b [KO:K05093] [EC:2.7.10.1]
25054  Ntrk2; BDNF/NT-3 growth factors receptor isoform 1 precursor [KO:K04360] [EC:2.7.10.1]
25084  Il4r; interleukin-4 receptor subunit alpha precursor [KO:K05071]
25114  Fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
25118  Itga1; integrin alpha-1 precursor [KO:K06480]
25155  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
25193  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
25229  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25235  Ghr; growth hormone receptor precursor [KO:K05080]
25266  Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359]
25267  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
25271  Rxra; retinoic acid receptor RXR-alpha [KO:K08524]
25304  Comp; cartilage oligomeric matrix protein precursor [KO:K04659]
25313  Egf; pro-epidermal growth factor precursor [KO:K04357]
25317  Fgf1; fibroblast growth factor 1 [KO:K18496]
25326  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
25353  Spp1; osteopontin precursor [KO:K06250]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
25412  Col2a1; collagen alpha-1(II) chain isoform 2 precursor [KO:K19719]
25439  F2r; proteinase-activated receptor 1 precursor [KO:K03914]
25443  Fgf10; fibroblast growth factor 10 precursor [KO:K04358]
25444  Fgf9; fibroblast growth factor 9 [KO:K04358]
25453  Gdnf; glial cell line-derived neurotrophic factor isoform 1 [KO:K05452]
25467  Irs1; insulin receptor substrate 1 [KO:K16172]
25473  Lamb2; laminin subunit beta-2 precursor [KO:K06243]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25525  Pspn; persephin precursor [KO:K25416]
25567  Tnr; tenascin-R precursor [KO:K06252]
25576  Ywhah; 14-3-3 protein eta [KO:K16198]
25577  Ywhaq; 14-3-3 protein theta [KO:K16197]
25578  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
25589  Kdr; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
25610  Csf3; granulocyte colony-stimulating factor precursor [KO:K05423]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
25623  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
25634  G6pc1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
25647  Il7; interleukin-7 precursor [KO:K05431]
25661  Fn1; fibronectin precursor [KO:K05717]
25704  Il2ra; interleukin-2 receptor subunit alpha precursor [KO:K05068]
25713  Itgb7; integrin beta-7 precursor [KO:K06590]
25718  Igf1r; insulin-like growth factor 1 receptor isoform 2 precursor [KO:K05087] [EC:2.7.10.1]
25724  Itgb4; integrin beta-4 precursor [KO:K06525]
25729  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
25730  Ntf4; neurotrophin-4 precursor [KO:K12457]
25746  Il2rb; interleukin-2 receptor subunit beta precursor [KO:K05069]
257645  Itgb5; integrin beta-5 precursor [KO:K06588]
26954  Rheb; GTP-binding protein Rheb [KO:K07208]
287287  Il4; interleukin-4 precursor [KO:K05430]
287871  Rptor; regulatory-associated protein of mTOR [KO:K07204]
288264  Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130]
289747  Osm; oncostatin-M precursor [KO:K05418]
290905  Col4a1; collagen alpha-1(IV) chain precursor [KO:K06237]
29169  Vtn; vitronectin precursor [KO:K06251]
29183  Areg; amphiregulin preproprotein [KO:K09782]
29195  Chad; chondroadherin precursor [KO:K06248]
29220  Thbs4; thrombospondin-4 precursor [KO:K04659]
292406  Thbs2; thrombospondin-2 precursor [KO:K04659]
29260  Tlr4; toll-like receptor 4 precursor [KO:K10160]
29302  Itgb3; integrin beta-3 precursor [KO:K06493]
29304  Rps6; small ribosomal subunit protein eS6 [KO:K02991]
29348  Fgf7; fibroblast growth factor 7 precursor [KO:K04358]
29349  Fgf8; fibroblast growth factor 8 isoform 1 precursor [KO:K04358]
29355  Pkn1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
293621  Hras; GTPase HRas [KO:K02833]
29368  Fgf17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358]
29369  Fgf18; fibroblast growth factor 18 precursor [KO:K04358]
29393  Col1a1; collagen alpha-1(I) chain precursor [KO:K06236]
294048  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 isoform 2 [KO:K12230]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
294337  Col6a1; collagen alpha-1(VI) chain precursor [KO:K06238]
294515  Foxo3; forkhead box protein O3 [KO:K09408]
294797  Il7r; interleukin-7 receptor subunit alpha precursor [KO:K05072]
29496  Erbb3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
294962  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
29517  Sgk1; serine/threonine-protein kinase Sgk1 isoform 1 [KO:K13302] [EC:2.7.11.1]
296269  Angpt4; angiopoietin-4 precursor [KO:K05467]
296456  Itgav; integrin alpha-V isoform 1 precursor [KO:K06487]
296619  Pkn3; serine/threonine-protein kinase N3 [KO:K23692]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
29753  Ywhae; 14-3-3 protein epsilon [KO:K06630]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
298400  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
298518  Csf3r; granulocyte colony-stimulating factor receptor precursor [KO:K05061]
298941  Lamb1; laminin subunit beta-1 precursor [KO:K05636]
298947  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
299147  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
299331  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
300253  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
301252  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
302378  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
303565  G6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
304913  Tnn; tenascin-N precursor [KO:K06252]
305078  Lamb3; laminin subunit beta-3 precursor [KO:K06244]
305104  Col9a1; collagen alpha-1(IX) chain precursor [KO:K08131]
306628  Col4a2; collagen alpha-2(IV) chain precursor [KO:K06237]
307403  Csf1r; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
307582  Lama3; laminin subunit alpha-3 isoform B precursor [KO:K06240]
309165  Rela; transcription factor p65 [KO:K04735]
309179  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
309368  Lama2; laminin subunit alpha-2 precursor [KO:K05637]
309816  Lama4; laminin subunit alpha-4 precursor [KO:K06241]
310132  Osmr; oncostatin-M-specific receptor subunit beta precursor [KO:K05057]
310553  Tlr2; toll-like receptor 2 precursor [KO:K10159]
310615  Crtc2; CREB-regulated transcription coactivator 2 [KO:K16333]
310616  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [KO:K09048]
310643  Efna4; ephrin-A4 precursor [KO:K05462]
310683  Itga10; integrin alpha-10 precursor [KO:K06586]
310738  Ngf; beta-nerve growth factor precursor [KO:K02582]
311061  Itgb6; integrin beta-6 precursor [KO:K06589]
311144  Itga4; integrin alpha-4 [KO:K06483]
311862  Lamc3; laminin subunit gamma-3 precursor [KO:K06247]
312754  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
314621  Stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
314638  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
314856  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
315346  Itga5; integrin alpha-5 [KO:K06484]
315648  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
315744  Itga11; integrin alpha-11 precursor [KO:K06587]
315979  Col6a6; collagen alpha-6(VI) chain isoform X3 [KO:K06238]
315981  Col6a4; collagen alpha-4(VI) chain precursor [KO:K06238]
316758  Lama1; laminin subunit alpha-1 precursor [KO:K05637]
360457  Vegfd; vascular endothelial growth factor D precursor [KO:K05449]
360606  Itga3; integrin alpha-3 isoform 1 [KO:K06482]
361042  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
361696  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
361821  Col6a2; collagen alpha-2(VI) chain precursor [KO:K06238]
361992  Them4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
362165  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
362282  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
362285  Col9a3; collagen alpha-3(IX) chain precursor [KO:K08131]
362339  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
362485  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
362572  Artn; artemin precursor [KO:K25415]
362584  Col9a2; collagen alpha-2(IX) chain precursor [KO:K08131]
362739  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
362800  Itgb8; integrin beta-8 precursor [KO:K06591]
362817  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
362862  Hsp90b1; endoplasmin precursor [KO:K09487]
363122  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
363193  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
363265  Col4a3; collagen alpha-3(IV) chain precursor [KO:K06237]
363275  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform 1 [KO:K03259]
363457  Col4a5; collagen alpha-5(IV) chain precursor [KO:K06237]
363458  Col4a6; collagen type IV alpha 6 chain precursor [KO:K06237]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
364786  Itga8; integrin alpha-8 [KO:K06584]
365367  Cd19; B-lymphocyte antigen CD19 precursor [KO:K06465]
366492  Epha2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
367313  Col6a3; collagen alpha-3(VI) chain precursor [KO:K06238]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
406169  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
445442  Thbs1; thrombospondin-1 isoform 1 precursor [KO:K16857]
497672  Brca1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
497931  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
497932  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
498609  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
498814  Mtcp1; protein p13 MTCP-1 [KO:K16837]
498949  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
498982  Myb; transcriptional activator Myb isoform X1 [KO:K09420]
500131  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
500261  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 2 [KO:K05631]
500317  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
500491  Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414]
501047  Col6a5; collagen alpha-5(VI) chain isoform X3 [KO:K06238]
502959  Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414]
502961  Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414]
50557  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54250  Fgf2; fibroblast growth factor 2 [KO:K18497]
54251  Flt1; vascular endothelial growth factor receptor 1 isoform 2 precursor [KO:K05096] [EC:2.7.10.1]
56010  Ywhag; 14-3-3 protein gamma [KO:K16198]
56011  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
56718  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
58918  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
58919  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
58979  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
59109  Ntrk1; high affinity nerve growth factor receptor precursor [KO:K03176] [EC:2.7.10.1]
59265  Phlpp1; PH domain leucine-rich repeat protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
59323  Erbb4; receptor tyrosine-protein kinase erbB-4 precursor [KO:K05085] [EC:2.7.10.1]
59325  Ereg; proepiregulin preproprotein [KO:K09784]
60427  Kitlg; kit ligand isoform 1 precursor [KO:K05461]
60430  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
60445  Tsc1; hamartin [KO:K07206]
60449  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
60464  Fgf16; fibroblast growth factor 16 [KO:K04358]
60660  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1 [KO:K04354]
60662  Fgf5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
64030  Kit; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
64033  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
64199  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
64226  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
64547  Bcl2l11; bcl-2-like protein 11 [KO:K16341]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
65248  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
66017  Fgf20; fibroblast growth factor 20 [KO:K04358]
66018  Pdgfd; platelet-derived growth factor D precursor [KO:K05450]
66025  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
680149  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
681309  Thbs3; thrombospondin-3 precursor [KO:K04659]
682033  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
685004  Itga9; integrin alpha-9 precursor [KO:K06585]
685269  Itga2b; integrin alpha-IIb precursor [KO:K06476]
685451  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
685513  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
686104  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
686326  Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131]
690575  Tcl1a; T-cell leukemia/lymphoma protein 1A [KO:K10167]
690825  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
690894  Ifna1; interferon alpha family, gene 5 precursor [KO:K05414]
690987  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
691318  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 4 [KO:K11584]
691774  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
78965  Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
78975  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
79114  Fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
79218  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
79240  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
79255  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
79429  Pdgfc; platelet-derived growth factor C precursor [KO:K05450]
80850  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
81008  Itga7; integrin alpha-7 precursor [KO:K06583]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
81645  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
81647  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
81667  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81737  Ntf3; neurotrophin-3 isoform 3 precursor [KO:K04356]
81745  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
81758  Rbl2; retinoblastoma-like protein 2 [KO:K16332]
83571  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
83579  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
83785  Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448]
83840  Rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
84027  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84352  Col1a2; collagen alpha-2(I) chain precursor [KO:K06236]
84358  Efna2; ephrin-A2 precursor [KO:K05462]
84423  Nrtn; neurturin precursor [KO:K25414]
84489  Fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
89804  Tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
89805  Angpt2; angiopoietin-2 precursor [KO:K05466]
89807  Angpt1; angiopoietin-1 precursor [KO:K05465]
89811  Vegfb; vascular endothelial growth factor B precursor [KO:K16858]
94201  Cdk4; cyclin-dependent kinase 4 isoform 1 [KO:K02089] [EC:2.7.11.22]
94203  Pgf; placenta growth factor precursor [KO:K16859]
94268  Efna1; ephrin-A1 precursor [KO:K05462]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
rno00010  Glycolysis / Gluconeogenesis
rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04062  Chemokine signaling pathway
rno04064  NF-kappa B signaling pathway
rno04068  FoxO signaling pathway
rno04110  Cell cycle
rno04115  p53 signaling pathway
rno04150  mTOR signaling pathway
rno04210  Apoptosis
rno04370  VEGF signaling pathway
rno04510  Focal adhesion
rno04620  Toll-like receptor signaling pathway
rno04630  JAK-STAT signaling pathway
rno04662  B cell receptor signaling pathway
rno04910  Insulin signaling pathway
KO pathway
ko04151   

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