KEGG   PATHWAY: pcoq05020
Entry
pcoq05020                   Pathway                                
Name
Prion disease - Propithecus coquereli (Coquerel's sifaka)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pcoq05020  Prion disease
pcoq05020

Disease
H00061  Prion disease
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804919  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
105804976  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
105805171  NCF4; neutrophil cytosol factor 4 [KO:K08012]
105805204  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105805232  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105805267  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105805290  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105805390  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
105805391  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105805862  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
105805900  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105806197  PRNP; major prion protein [KO:K05634]
105806237  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105806385  C8B; complement component C8 beta chain [KO:K03998]
105806386  C8A; complement component C8 alpha chain [KO:K03997]
105806400  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
105806434  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105806470  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
105806582  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
105806589  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
105806701  [KO:K02271]
105806763  LAMC1; laminin subunit gamma-1 [KO:K05635]
105806792  NCF2; neutrophil cytosol factor 2 [KO:K08010]
105806914  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
105807023  [KO:K02266]
105807046  NCF1; neutrophil cytosol factor 1 [KO:K08011]
105807267  [KO:K02264]
105807308  [KO:K02136]
105807372  [KO:K09047]
105807375  [KO:K08738]
105807458  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105807577  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105807599  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105807952  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105808189  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
105808354  [KO:K02265]
105808432  [KO:K21421] [EC:1.-.-.-]
105808520  ATP5C1; ATP synthase subunit gamma, mitochondrial [KO:K02136]
105808623  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
105808667  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105808789  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
105808883  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105808983  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105809025  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105809082  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
105809316  BAX; apoptosis regulator BAX [KO:K02159]
105809322  [KO:K02267]
105809381  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105809466  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105809556  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105809719  [KO:K03946]
105809747  [KO:K02268]
105809797  [KO:K00417]
105810108  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105810111  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105810204  [KO:K00419]
105810299  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105810555  [KO:K08738]
105810742  [KO:K02272]
105810840  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105810895  [KO:K00415]
105810924  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105811066  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
105811072  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105811104  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105811110  [KO:K02270]
105811230  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105811261  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
105811286  [KO:K00420]
105811289  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
105811799  [KO:K02270]
105811880  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
105811892  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105811984  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105812037  EGR1; early growth response protein 1 [KO:K09203]
105812112  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105812168  [KO:K02263]
105812191  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
105812227  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105812283  CAV3; caveolin-3 [KO:K12959]
105812318  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105812491  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
105812509  [KO:K08738]
105812563  [KO:K00411] [EC:7.1.1.8]
105812612  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812706  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
105813016  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
105813050  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105813220  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
105813404  [KO:K00413]
105813564  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105813610  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105813718  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
105813849  CCL5; C-C motif chemokine 5 [KO:K12499]
105813949  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105813961  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105814072  [KO:K00416]
105814216  RYR3; ryanodine receptor 3 [KO:K04963]
105814447  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
105814532  C9; complement component C9 [KO:K04000]
105814548  C7; complement component C7 [KO:K03996]
105814561  C6; complement component C6 [KO:K03995]
105814632  [KO:K02128]
105814705  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105814731  [KO:K02730] [EC:3.4.25.1]
105815072  [KO:K02266]
105815191  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
105815301  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105815312  [KO:K04857]
105815384  TUBA1A; tubulin alpha-1A chain isoform X1 [KO:K07374]
105815399  [KO:K07374]
105815409  [KO:K07374]
105815498  [KO:K07374]
105815570  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105815572  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105815609  [KO:K08738]
105815702  C1QA; complement C1q subcomponent subunit A [KO:K03986]
105815703  C1QC; complement C1q subcomponent subunit C [KO:K03988]
105815704  C1QB; complement C1q subcomponent subunit B [KO:K03987]
105815718  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105815768  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
105815791  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105815811  TUBA8; tubulin alpha-8 chain [KO:K07374]
105815885  [KO:K07374]
105815896  [KO:K03237]
105815999  [KO:K04440] [EC:2.7.11.24]
105816029  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105816045  [KO:K00418]
105816062  [KO:K07375]
105816214  [KO:K02270]
105816235  [KO:K02267]
105816363  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105816408  KIF5A; kinesin heavy chain isoform 5A isoform X1 [KO:K10396]
105816458  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
105816542  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
105816545  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105816683  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105816719  PSMD1; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
105816783  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105816836  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105817103  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
105817144  CAV1; caveolin-1 isoform X1 [KO:K06278]
105817145  CAV2; caveolin-2 isoform X1 [KO:K12958]
105817257  [KO:K03030]
105817283  TUBB; tubulin beta chain [KO:K07375]
105817554  [KO:K02136]
105817696  KLC3; kinesin light chain 3 [KO:K10407]
105817755  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105817861  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105817877  [KO:K03283]
105817878  [KO:K03283]
105817879  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
105817894  CSNK2B; casein kinase II subunit beta [KO:K03115]
105817905  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105817968  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105817990  [KO:K02270]
105818168  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105818236  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
105818541  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
105818550  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
105818640  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
105818686  TUBB4B; tubulin beta-4B chain [KO:K07375]
105818693  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
105818713  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105818745  KIF5B; kinesin-1 heavy chain [KO:K10396]
105818751  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105819043  [KO:K02273]
105819128  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
105819421  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105819542  PSMD14; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
105819624  [KO:K07374]
105819681  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
105819858  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105820021  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105820072  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
105820319  IL1A; interleukin-1 alpha [KO:K04383]
105820326  IL1B; interleukin-1 beta [KO:K04519]
105820356  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105820430  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
105820495  RYR1; ryanodine receptor 1 [KO:K04961]
105820583  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
105820609  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
105820631  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
105820645  [KO:K07375]
105820827  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
105820831  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
105821044  [KO:K08009]
105821498  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
105821611  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105821681  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105821892  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
105821904  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105821915  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105822085  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105822197  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
105822247  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
105822336  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105822445  IL6; interleukin-6 [KO:K05405]
105822459  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
105822845  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
105822913  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
105823056  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105823069  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105823339  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105823587  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105823905  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105823945  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
105823955  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
105823972  [KO:K02263]
105824035  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105824114  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105824126  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105824308  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105824355  [KO:K00414]
105824734  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105824768  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105824794  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
105824812  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105824864  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105825008  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105825283  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
105825486  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
105825488  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105825498  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105825513  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
105825547  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105825671  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
105825847  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
105825876  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
105826075  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105826090  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105826139  [KO:K04849]
105826189  [KO:K02271]
105826272  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105826411  C5; complement C5 [KO:K03994]
105826451  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105826892  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105826943  [KO:K04857]
105827242  [KO:K07375]
105827296  BAD; bcl2-associated agonist of cell death [KO:K02158]
105827305  STIP1; stress-induced-phosphoprotein 1 [KO:K09553]
105827373  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
105827391  KLC2; kinesin light chain 2 [KO:K10407]
105827413  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105827532  [KO:K00237]
105827580  [KO:K02263]
6458115  COX2; cytochrome c oxidase subunit II [KO:K02261]
6458116  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
6458117  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
6458118  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
6458119  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
6458120  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
6458121  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
6458122  CYTB; cytochrome b [KO:K00412]
6458123  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
6458124  COX3; cytochrome c oxidase subunit III [KO:K02262]
6458125  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
6458126  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
6458127  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
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  Title
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Expert Rev Mol Med 18:e5 (2016)
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Mol Cell Neurosci 66:12-20 (2015)
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Trends Mol Med 17:14-24 (2011)
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Front Aging Neurosci 9:120 (2017)
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PMID:20205843
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PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
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PMID:29998397
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Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
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Mol Neurobiol 56:2159-2173 (2019)
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Reference
PMID:28714865
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J Clin Invest 127:3230-3239 (2017)
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Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
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Curr Opin Immunol 16:587-93 (2004)
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Reference
PMID:15611724
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Mallucci G, Collinge J
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Rational targeting for prion therapeutics.
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Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
pcoq00190  Oxidative phosphorylation
pcoq03050  Proteasome
pcoq04020  Calcium signaling pathway
pcoq04140  Autophagy - animal
pcoq04141  Protein processing in endoplasmic reticulum
pcoq04142  Lysosome
pcoq04144  Endocytosis
pcoq04210  Apoptosis
pcoq04330  Notch signaling pathway
pcoq04610  Complement and coagulation cascades
pcoq04668  TNF signaling pathway
KO pathway
ko05020   

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