Entry Name Neutrophil extracellular trap formation - Panthera pardus (leopard)
Description Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action is the formation of neutrophil extracellular traps (NETs), the extracellular structures composed of chromatin coated with histones, proteases and granular and cytosolic proteins that help catch and kill microorganisms. NETs are formed by a process known as "NETosis" that can be triggered by microorganisms and endogenous stimuli, such as damage-associated molecular patterns and immune complexes, and involves activation in most cases of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, which produces reactive oxygen species (ROS). Recent study has reported that there are two different mechanisms of NETosis, including a lytic NETosis and a vital NETosis. Lytic NETosis begins with nuclear delobulation and the disassembly of the nuclear envelope and continues with loss of cellular polarization, chromatin decondensation and plasma membrane rupture. Vital NETosis can occur independently of cell death and involves the secreted expulsion of nuclear chromatin that is accompanied by the release of granule proteins through degranulation.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ppad04613 Neutrophil extracellular trap formation
Ortholog table Organism Panthera pardus (leopard) [GN:
ppad ]
Gene 109276673 FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A isoform X1 [KO:K06463 ]
109251192 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
109250866 VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
109264442 VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040 ]
109262260 VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041 ]
109257074 LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498 ]
109259085 CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074 ]
109246661 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109274721 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109274722 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109263166 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109272437 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
109274075 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
109275159 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
109259912 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109266953 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
109275060 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
109247606 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
109247385 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
109246019 GP1BA; LOW QUALITY PROTEIN: platelet glycoprotein Ib alpha chain [KO:K06261 ]
109260522 AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05151 12-O-Tetradecanoylphorbol 13-acetate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11221 Formylmethionyl-leucyl-phenylalanine methyl ester
Reference Authors Van Avondt K, Hartl D
Title Mechanisms and disease relevance of neutrophil extracellular trap formation.
Journal Reference Authors Sorvillo N, Cherpokova D, Martinod K, Wagner DD
Title Extracellular DNA NET-Works With Dire Consequences for Health.
Journal Reference Authors Papayannopoulos V
Title Neutrophil extracellular traps in immunity and disease.
Journal Reference Authors Liu FC, Chuang YH, Tsai YF, Yu HP
Title Role of neutrophil extracellular traps following injury.
Journal Reference Authors Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M
Title New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation.
Journal Reference Authors Zawrotniak M, Bochenska O, Karkowska-Kuleta J, Seweryn-Ozog K, Aoki W, Ueda M, Kozik A, Rapala-Kozik M
Title Aspartic Proteases and Major Cell Wall Components in Candida albicans Trigger the Release of Neutrophil Extracellular Traps.
Journal Reference Authors Honda M, Kubes P
Title Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system.
Journal Reference Authors Hamam HJ, Palaniyar N
Title Post-Translational Modifications in NETosis and NETs-Mediated Diseases.
Journal Reference Authors Burgener SS, Schroder K
Title Neutrophil Extracellular Traps in Host Defense.
Journal Reference Authors Vorobjeva NV, Chernyak BV
Title NETosis: Molecular Mechanisms, Role in Physiology and Pathology.
Journal Reference Authors Ravindran M, Khan MA, Palaniyar N
Title Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology.
Journal Reference Authors Jorch SK, Kubes P
Title An emerging role for neutrophil extracellular traps in noninfectious disease.
Journal Reference Authors Goggs R, Jeffery U, LeVine DN, Li RHL
Title Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review.
Journal Reference Authors Kim SJ, Jenne CN
Title Role of platelets in neutrophil extracellular trap (NET) production and tissue injury.
Journal Reference Authors de Bont CM, Boelens WC, Pruijn GJM
Title NETosis, complement, and coagulation: a triangular relationship.
Journal Reference Authors Zawrotniak M, Bartnicka D, Rapala-Kozik M
Title UVA and UVB radiation induce the formation of neutrophil extracellular traps by human polymorphonuclear cells.
Journal Reference Authors Remijsen Q, Kuijpers TW, Wirawan E, Lippens S, Vandenabeele P, Vanden Berghe T
Title Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality.
Journal Reference Authors Zawrotniak M, Rapala-Kozik M
Title Neutrophil extracellular traps (NETs) - formation and implications.
Journal Acta Biochim Pol 60:277-84 (2013)
Reference Authors Rosales C
Title Fcgamma Receptor Heterogeneity in Leukocyte Functional Responses.
Journal Reference Authors Vorobjeva NV, Pinegin BV
Title Neutrophil extracellular traps: mechanisms of formation and role in health and disease.
Journal Reference Authors Delgado-Rizo V, Martinez-Guzman MA, Iniguez-Gutierrez L, Garcia-Orozco A, Alvarado-Navarro A, Fafutis-Morris M
Title Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview.
Journal Reference Authors Fonseca Z, Diaz-Godinez C, Mora N, Aleman OR, Uribe-Querol E, Carrero JC, Rosales C
Title Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation.
Journal Reference Authors Agraz-Cibrian JM, Giraldo DM, Mary FM, Urcuqui-Inchima S
Title Understanding the molecular mechanisms of NETs and their role in antiviral innate immunity.
Journal Reference Authors Schonrich G, Raftery MJ
Title Neutrophil Extracellular Traps Go Viral.
Journal Reference Authors Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S
Title Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
Journal Reference Authors Kumar S, Gupta E, Kaushik S, Jyoti A
Title Neutrophil Extracellular Traps: Formation and Involvement in Disease Progression.
Journal Iran J Allergy Asthma Immunol 17:208-220 (2018)
Related ppad04610 Complement and coagulation cascades
ppad04620 Toll-like receptor signaling pathway
ppad04621 NOD-like receptor signaling pathway
KO pathway LinkDB All DBs
