KEGG   PATHWAY: pvp05415
Entry
pvp05415                    Pathway                                
Name
Diabetic cardiomyopathy - Pteropus vampyrus (large flying fox)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
pvp05415  Diabetic cardiomyopathy
pvp05415

Disease
H02498  Diabetic cardiomyopathy
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288306  NCF4; neutrophil cytosol factor 4 [KO:K08012]
105288781  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105288866  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
105288878  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105288974  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105289209  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105289220  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105289274  [KO:K02266]
105289542  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
105289568  COL3A1; collagen alpha-1(III) chain [KO:K19720]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105290042  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
105290165  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X2 [KO:K03949]
105290188  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105290810  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
105291172  PLN; cardiac phospholamban [KO:K05852]
105291195  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
105291606  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105291714  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
105291989  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
105292047  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
105292451  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105292546  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
105292609  PARP1; LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1 [KO:K24070]
105292640  SMAD2; mothers against decapentaplegic homolog 2 isoform X3 [KO:K04500]
105292672  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105292810  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105292938  [KO:K02270]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105293112  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105293278  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105293340  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
105293469  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105293648  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105293916  [KO:K02271]
105294027  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
105294061  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105294259  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
105294330  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105294361  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105294703  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105294748  IRS1; insulin receptor substrate 1 [KO:K16172]
105294854  [KO:K00134] [EC:1.2.1.12]
105294887  PTPA; serine/threonine-protein phosphatase 2A activator [KO:K17605]
105294928  [KO:K02271]
105294948  AGTR1; type-1 angiotensin II receptor [KO:K04166]
105295040  NCF2; neutrophil cytosol factor 2 [KO:K08010]
105295410  PDK2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
105295430  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105295516  [KO:K05863]
105295518  CD36; platelet glycoprotein 4 [KO:K06259]
105295633  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
105295797  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
105295843  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
105295969  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
105295986  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105296096  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105296163  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105296192  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105296245  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105296558  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X2 [KO:K11353]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105296904  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105297140  [KO:K02649]
105297147  [KO:K00416]
105297603  [KO:K03968]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105297764  [KO:K01283] [EC:3.4.15.1]
105297765  [KO:K01283] [EC:3.4.15.1]
105297836  [KO:K02273]
105297846  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105297999  RELA; transcription factor p65 [KO:K04735]
105298025  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105298131  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
105298192  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
105298415  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105298481  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105298737  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105298839  [KO:K02263]
105298970  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X2 [KO:K08766] [EC:2.3.1.21]
105299132  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105299206  TGFB3; transforming growth factor beta-3 [KO:K13377]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299441  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
105299444  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105299530  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
105299667  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
105299839  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
105299919  [KO:K08009]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105299979  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
105300159  [KO:K04456] [EC:2.7.11.1]
105300538  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105300597  [KO:K00417]
105300684  REN; renin [KO:K01380] [EC:3.4.23.15]
105300789  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X2 [KO:K03957]
105300845  GSR; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
105300868  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105300922  [KO:K00419]
105301035  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105301036  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105301070  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105301194  [KO:K00411] [EC:7.1.1.8]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105301308  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105301309  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
105301498  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
105301553  [KO:K00134] [EC:1.2.1.12]
105301667  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105301759  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
105301970  [KO:K00413]
105302046  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
105302219  [KO:K00420]
105302238  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
105302414  [KO:K00414]
105302504  G6PD; glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105302549  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
105302566  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105302646  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105302655  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
105302767  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105302898  [KO:K02268]
105303324  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
105303396  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105303403  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
105303610  PRKCZ; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
105303769  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105303918  [KO:K02272]
105304017  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
105304348  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
105304499  [KO:K02266]
105304583  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
105304627  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105304910  [KO:K02267]
105304920  TNNI3; troponin I, cardiac muscle [KO:K12044]
105305214  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105305278  AGER; advanced glycosylation end product-specific receptor isoform X9 [KO:K19722]
105305394  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
105305449  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105305502  [KO:K02263]
105305546  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105305558  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105305799  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
105305916  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
105306022  AGT; angiotensinogen [KO:K09821]
105306053  [KO:K00415]
105306380  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105306407  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
105306545  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
105306559  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
105306564  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105306643  [KO:K02267]
105306783  [KO:K02265]
105306845  [KO:K02264]
105306877  [KO:K00134] [EC:1.2.1.12]
105306976  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105307095  PDK3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307242  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105307368  MPC1; mitochondrial pyruvate carrier 1 isoform X1 [KO:K22138]
105307438  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105307507  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105307710  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105307875  [KO:K02270]
105307890  [KO:K02270]
105307945  TGFB1; transforming growth factor beta-1 [KO:K13375]
105308002  [KO:K05863]
105308270  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
105308283  [KO:K04441] [EC:2.7.11.24]
105308512  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105308561  [KO:K21421] [EC:1.-.-.-]
105308762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
105308818  [KO:K19662] [EC:2.7.11.13]
105308883  [KO:K02271]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309412  CMA1; LOW QUALITY PROTEIN: chymase [KO:K01329] [EC:3.4.21.39]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105309466  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105309746  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
105309924  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105310426  [KO:K08012]
105311019  [KO:K00418]
105311066  [KO:K03954]
105311532  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
105311653  [KO:K01379] [EC:3.4.23.5]
105311654  [KO:K01379] [EC:3.4.23.5]
111734519  [KO:K03939]
111742157  [KO:K03944]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
Zamora M, Villena JA
  Title
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
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Int J Mol Sci 20:E2833 (2019)
DOI:10.3390/ijms20112833
Reference
PMID:29605388
  Authors
Palomer X, Pizarro-Delgado J, Vazquez-Carrera M
  Title
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
  Journal
Trends Pharmacol Sci 39:452-467 (2018)
DOI:10.1016/j.tips.2018.02.010
Reference
PMID:28439258
  Authors
Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK
  Title
Diabetic Cardiomyopathy: An Immunometabolic Perspective.
  Journal
Front Endocrinol (Lausanne) 8:72 (2017)
DOI:10.3389/fendo.2017.00072
Reference
PMID:28177068
  Authors
Chong CR, Clarke K, Levelt E
  Title
Metabolic Remodeling in Diabetic Cardiomyopathy.
  Journal
Cardiovasc Res 113:422-430 (2017)
DOI:10.1093/cvr/cvx018
Reference
PMID:11742414
  Authors
Brownlee M
  Title
Biochemistry and molecular cell biology of diabetic complications.
  Journal
Nature 414:813-20 (2001)
DOI:10.1038/414813a
Reference
PMID:32821697
  Authors
Gollmer J, Zirlik A, Bugger H
  Title
Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
  Journal
J Lipid Atheroscler 8:26-47 (2019)
DOI:10.12997/jla.2019.8.1.26
Reference
PMID:17592090
  Authors
Boudina S, Abel ED
  Title
Diabetic cardiomyopathy revisited.
  Journal
Circulation 115:3213-23 (2007)
DOI:10.1161/CIRCULATIONAHA.106.679597
Reference
PMID:29109032
  Authors
Varma U, Koutsifeli P, Benson VL, Mellor KM, Delbridge LMD
  Title
Molecular mechanisms of cardiac pathology in diabetes - Experimental insights.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1949-1959 (2018)
DOI:10.1016/j.bbadis.2017.10.035
Reference
PMID:23147391
  Authors
Mandavia CH, Aroor AR, Demarco VG, Sowers JR
  Title
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
  Journal
Life Sci 92:601-8 (2013)
DOI:10.1016/j.lfs.2012.10.028
Reference
PMID:21626163
  Authors
Falcao-Pires I, Leite-Moreira AF
  Title
Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.
  Journal
Heart Fail Rev 17:325-44 (2012)
DOI:10.1007/s10741-011-9257-z
Reference
PMID:27148064
  Authors
Westermeier F, Riquelme JA, Pavez M, Garrido V, Diaz A, Verdejo HE, Castro PF, Garcia L, Lavandero S
  Title
New Molecular Insights of Insulin in Diabetic Cardiomyopathy.
  Journal
Front Physiol 7:125 (2016)
DOI:10.3389/fphys.2016.00125
Reference
PMID:33276047
  Authors
Randhawa VK, Dhanvantari S, Connelly K
  Title
How Diabetes and Heart Failure Modulate Each Other and Condition Management.
  Journal
Can J Cardiol S0828-282X(20)31115-6 (2020)
DOI:10.1016/j.cjca.2020.11.014
Reference
PMID:31641426
  Authors
Athithan L, Gulsin GS, McCann GP, Levelt E
  Title
Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date.
  Journal
World J Diabetes 10:490-510 (2019)
DOI:10.4239/wjd.v10.i10.490
Reference
PMID:21111987
  Authors
Murarka S, Movahed MR
  Title
Diabetic cardiomyopathy.
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J Card Fail 16:971-9 (2010)
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PMID:25085967
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Thomas CM, Yong QC, Rosa RM, Seqqat R, Gopal S, Casarini DE, Jones WK, Gupta S, Baker KM, Kumar R
  Title
Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
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Am J Physiol Heart Circ Physiol 307:H1036-45 (2014)
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PMID:28236380
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Brahma MK, Pepin ME, Wende AR
  Title
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
  Journal
Diabetes Metab J 41:1-9 (2017)
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PMID:18829990
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Singh VP, Le B, Khode R, Baker KM, Kumar R
  Title
Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis.
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Diabetes 57:3297-306 (2008)
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PMID:18296558
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Singh VP, Baker KM, Kumar R
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Am J Physiol Heart Circ Physiol 294:H1675-84 (2008)
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PMID:26678809
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Jia G, DeMarco VG, Sowers JR
  Title
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
  Journal
Nat Rev Endocrinol 12:144-53 (2016)
DOI:10.1038/nrendo.2015.216
Reference
PMID:18309108
  Authors
Kim JA, Wei Y, Sowers JR
  Title
Role of mitochondrial dysfunction in insulin resistance.
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Circ Res 102:401-14 (2008)
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Association between insulin resistance and the development of cardiovascular disease.
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Cardiovasc Diabetol 17:122 (2018)
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Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
  Title
Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
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Int J Mol Sci 20:E3264 (2019)
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Joshi M, Kotha SR, Malireddy S, Selvaraju V, Satoskar AR, Palesty A, McFadden DW, Parinandi NL, Maulik N
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Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria.
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Mol Cell Biochem 386:233-49 (2014)
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Knapp M, Tu X, Wu R
  Title
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
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Acta Pharmacol Sin 40:1-8 (2019)
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Reference
PMID:16487830
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Asbun J, Villarreal FJ
  Title
The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.
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J Am Coll Cardiol 47:693-700 (2006)
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Reference
PMID:32024054
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Levick SP, Widiapradja A
  Title
The Diabetic Cardiac Fibroblast: Mechanisms Underlying Phenotype and Function.
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Int J Mol Sci 21:E970 (2020)
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Related
pathway
pvp00010  Glycolysis / Gluconeogenesis
pvp00020  Citrate cycle (TCA cycle)
pvp00190  Oxidative phosphorylation
pvp00520  Amino sugar and nucleotide sugar metabolism
pvp03320  PPAR signaling pathway
pvp04071  Sphingolipid signaling pathway
pvp04150  mTOR signaling pathway
pvp04210  Apoptosis
pvp04260  Cardiac muscle contraction
pvp04350  TGF-beta signaling pathway
pvp04614  Renin-angiotensin system
pvp04910  Insulin signaling pathway
pvp04930  Type II diabetes mellitus
pvp04931  Insulin resistance
pvp04933  AGE-RAGE signaling pathway in diabetic complications
pvp04940  Type I diabetes mellitus
KO pathway
ko05415   

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